{"id":"https://openalex.org/W154649151","doi":null,"title":"[A case of HER2-positive and AFP-producing gastric cancer successfully treated by trastuzumab/docetaxel/S-1 combination therapy].","display_name":"[A case of HER2-positive and AFP-producing gastric cancer successfully treated by trastuzumab/docetaxel/S-1 combination therapy].","publication_year":2012,"publication_date":"2012-12-01","ids":{"openalex":"https://openalex.org/W154649151","mag":"154649151","pmid":"https://pubmed.ncbi.nlm.nih.gov/23235175"},"language":"ja","primary_location":{"id":"pmid:23235175","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23235175","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gan to kagaku ryoho. Cancer & chemotherapy","raw_type":"Case Reports"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Ichiro Amano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210125884","display_name":"Saiseikai Suita Hospital","ror":"https://ror.org/03ehcbt32","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210125884"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ichiro Amano","raw_affiliation_strings":["Dept. of Gastroenterology and Hepatology, Saiseikai Suita Hospital, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Gastroenterology and Hepatology, Saiseikai Suita Hospital, Japan","institution_ids":["https://openalex.org/I4210125884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112328841","display_name":"Naoki Sawai","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Naoki Sawai","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003789381","display_name":"Chiemi Mizuno","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chiemi Mizuno","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031053430","display_name":"Yukie Shaura","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yukie Shaura","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055705671","display_name":"M Nishiwaki","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Masatake Nishiwaki","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025548144","display_name":"Ryuji Horimoto","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ryuji Horimoto","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087118681","display_name":"Hirohisa Oya","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hirohisa Oya","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110346740","display_name":"Ryusuke Kato","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ryusuke Kato","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059229967","display_name":"Kojiro Seki","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kojiro Seki","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079984773","display_name":"Hiroaki Hashimoto","orcid":"https://orcid.org/0000-0003-4057-4466","observed_orcids":["https://orcid.org/0000-0003-4057-4466"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hiroaki Hashimoto","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012798509","display_name":"Y Amakata","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yoshiro Amakata","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085524522","display_name":"Junko Matsumoto","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Junko Matsumoto","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089590872","display_name":"Izumi Tanaka","orcid":"https://orcid.org/0000-0001-8013-2502","observed_orcids":["https://orcid.org/0000-0001-8013-2502","https://orcid.org/0009-0004-7270-2244"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Izumi Tanaka","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103134247","display_name":"Masayuki Mizuno","orcid":"https://orcid.org/0000-0002-9530-5960","observed_orcids":["https://orcid.org/0000-0002-9530-5960"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Masayuki Mizuno","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018203897","display_name":"Toshihide Shima","orcid":"https://orcid.org/0000-0002-4120-9121","observed_orcids":["https://orcid.org/0000-0002-4120-9121"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Toshihide Shima","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5017078328","display_name":"Takeshi Okanoue","orcid":"https://orcid.org/0000-0002-2390-3400","observed_orcids":["https://orcid.org/0000-0002-2390-3400"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Takeshi Okanoue","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.515,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.71158938,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"39","issue":"13","first_page":"2541","last_page":"4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10696","display_name":"Gastric Cancer Management and Outcomes","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10696","display_name":"Gastric Cancer Management and Outcomes","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12064","display_name":"Intraperitoneal and Appendiceal Malignancies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/her2-positive-gastric-cancer","display_name":"HER2-positive gastric cancer","score":0.9729999899864197},{"id":"https://openalex.org/keywords/alpha-fetoprotein-producing-gastric-cancer","display_name":"alpha-fetoprotein-producing gastric cancer","score":0.8790000081062317},{"id":"https://openalex.org/keywords/trastuzumab","display_name":"trastuzumab","score":0.9070000052452087},{"id":"https://openalex.org/keywords/docetaxel","display_name":"docetaxel","score":0.9990000128746033},{"id":"https://openalex.org/keywords/s-1","display_name":"S-1","score":0.9440000057220459},{"id":"https://openalex.org/keywords/combination-chemotherapy","display_name":"combination chemotherapy","score":0.9679999947547913},{"id":"https://openalex.org/keywords/peritoneal-metastases","display_name":"peritoneal carcinomatosis","score":0.8939999938011169},{"id":"https://openalex.org/keywords/advanced-gastric-cancer","display_name":"advanced gastric cancer","score":0.7960000038146973},{"id":"https://openalex.org/keywords/early-gastric-cancer","display_name":"early gastric cancer","score":0.8899999856948853},{"id":"https://openalex.org/keywords/neutropenia","display_name":"neutropenia","score":0.703000009059906}],"concepts":[{"id":"https://openalex.org/C2781190966","wikidata":"https://www.wikidata.org/wiki/Q420436","display_name":"Docetaxel","level":3,"score":0.9419811964035034},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9206467866897583},{"id":"https://openalex.org/C2779786085","wikidata":"https://www.wikidata.org/wiki/Q412616","display_name":"Trastuzumab","level":4,"score":0.8373169898986816},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.6323938965797424},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6231482625007629},{"id":"https://openalex.org/C2780873365","wikidata":"https://www.wikidata.org/wiki/Q496812","display_name":"Leukopenia","level":3,"score":0.6032445430755615},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5683170557022095},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4823407828807831},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4636915922164917},{"id":"https://openalex.org/C2777063308","wikidata":"https://www.wikidata.org/wiki/Q1435822","display_name":"Neutropenia","level":3,"score":0.4588218033313751},{"id":"https://openalex.org/C3019864225","wikidata":"https://www.wikidata.org/wiki/Q5867482","display_name":"Combination chemotherapy","level":3,"score":0.44463613629341125},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.32867568731307983},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.20697012543678284}],"mesh":[{"descriptor_ui":"D000068878","descriptor_name":"Trastuzumab","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077143","descriptor_name":"Docetaxel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000509","descriptor_name":"alpha-Fetoproteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D004338","descriptor_name":"Drug Combinations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005641","descriptor_name":"Tegafur","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010094","descriptor_name":"Oxonic Acid","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D013274","descriptor_name":"Stomach Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D013274","descriptor_name":"Stomach Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013274","descriptor_name":"Stomach Neoplasms","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D018719","descriptor_name":"Erb-b2 Receptor Tyrosine Kinases","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D043823","descriptor_name":"Taxoids","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:23235175","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23235175","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gan to kagaku ryoho. Cancer & chemotherapy","raw_type":"Case Reports"},{"id":"mag:154649151","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23235175","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2205054243","https://openalex.org/W2769693366","https://openalex.org/W2421395585","https://openalex.org/W2563787255","https://openalex.org/W4415041803","https://openalex.org/W2412074871","https://openalex.org/W2765373040","https://openalex.org/W2213954001","https://openalex.org/W2443781384","https://openalex.org/W108403458"],"abstract_inverted_index":{"A":[0],"74-year-old":[1],"man":[2],"was":[3,36,44,65,71],"referred":[4],"to":[5,107],"our":[6],"hospital":[7],"because":[8],"of":[9,56,60,98,110],"abdominal":[10],"distension.":[11],"Upper":[12],"gastrointestinal":[13],"endoscopy":[14],"revealed":[15],"advanced":[16],"gastric":[17,21,26,118],"cancer":[18,27,119],"and":[19,24,40,49,70,91,102,116],"early":[20],"cancer.":[22],"HER2-positive":[23,115],"AFP-producing":[25,117],"with":[28,46,73],"peritonitis":[29],"carcinomatosa":[30],"showing":[31],"no":[32,122],"indication":[33,123],"for":[34,87,114,124],"operation":[35],"diagnosed":[37],"by":[38],"histopathological":[39],"radiological":[41],"examinations.":[42],"He":[43],"treated":[45],"trastuzumab,":[47],"docetaxel,":[48,101],"S-1":[50,103],"combination":[51,104],"chemotherapy.":[52,99],"At":[53],"the":[54,57,62,111],"end":[55],"second":[58],"course":[59],"therapy,":[61],"primary":[63],"lesion":[64],"remarkably":[66],"decreased":[67],"in":[68,77],"size":[69],"associated":[72],"a":[74],"significant":[75],"decrease":[76],"serum":[78],"AFP":[79],"level.":[80],"No":[81],"serious":[82],"adverse":[83],"events":[84],"occurred":[85],"except":[86],"grade":[88],"3-4":[89],"leukopenia":[90],"neutropenia.":[92],"We":[93],"carried":[94],"out":[95],"eight":[96],"courses":[97],"Trastuzumab,":[100],"chemotherapy":[105],"promise":[106],"be":[108],"one":[109],"effective":[112],"treatments":[113],"that":[120],"have":[121],"radical":[125],"cure":[126],"excision.":[127]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2016-06-24T00:00:00"}