{"id":"https://openalex.org/W1546351266","doi":null,"title":"Dysregulation of Apoptosis Involves the Extrinsic Pathway in Human Prostate Cancer","display_name":"Dysregulation of Apoptosis Involves the Extrinsic Pathway in Human Prostate Cancer","publication_year":2009,"publication_date":"2009-09-01","ids":{"openalex":"https://openalex.org/W1546351266","mag":"1546351266"},"language":"en","primary_location":{"id":"pmh:oai:CiteSeerX.psu:10.1.1.500.2095","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.500.2095","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.tua.org.tw/magazine/FileM/dw200991815504_4.pdf","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086077355","display_name":"Jane-Dar Lee","orcid":"https://orcid.org/0000-0001-5068-4023","observed_orcids":["https://orcid.org/0000-0001-5068-4023"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jane-Dar Lee","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5068-4023","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028773265","display_name":"Lieng-Yi Lu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lieng-Yi Lu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022358675","display_name":"Wen-Hsuan Cheng","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wen-Hsuan Cheng","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101757668","display_name":"Ya\u2010Tang Yang","orcid":"https://orcid.org/0000-0002-0562-4512","observed_orcids":["https://orcid.org/0000-0002-0562-4512"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ya\u2010Tang Yang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0562-4512","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5006783348","display_name":"Shaw-Yeu Jeng","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shaw-Yeu Jeng","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1099,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.42487252,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"20","issue":"3","first_page":"120","last_page":"126"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.8389999866485596},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9150000214576721},{"id":"https://openalex.org/keywords/extrinsic-apoptotic-pathway","display_name":"extrinsic apoptotic pathway","score":0.9789999723434448},{"id":"https://openalex.org/keywords/caspase-8","display_name":"caspase-8","score":0.9900000095367432},{"id":"https://openalex.org/keywords/cleaved-caspase-3","display_name":"cleaved caspase-3","score":0.968999981880188},{"id":"https://openalex.org/keywords/bcl-2","display_name":"Bcl-2","score":0.9340000152587891},{"id":"https://openalex.org/keywords/caspase-9","display_name":"caspase-9","score":0.9959999918937683},{"id":"https://openalex.org/keywords/benign-prostatic-hyperplasia","display_name":"benign prostatic hyperplasia","score":0.996999979019165},{"id":"https://openalex.org/keywords/malignant-transformation","display_name":"malignant transformation","score":0.41100001335144043}],"concepts":[{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.7715667486190796},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.7002992630004883},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.6869708299636841},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.6243588328361511},{"id":"https://openalex.org/C12519072","wikidata":"https://www.wikidata.org/wiki/Q14914370","display_name":"Caspase 3","level":4,"score":0.6205427646636963},{"id":"https://openalex.org/C2777562237","wikidata":"https://www.wikidata.org/wiki/Q835051","display_name":"Hyperplasia","level":2,"score":0.5646084547042847},{"id":"https://openalex.org/C2779466945","wikidata":"https://www.wikidata.org/wiki/Q1765251","display_name":"Prostatectomy","level":4,"score":0.5475444197654724},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4957598149776459},{"id":"https://openalex.org/C48297814","wikidata":"https://www.wikidata.org/wiki/Q14911965","display_name":"Caspase 8","level":5,"score":0.4914175271987915},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.4843210279941559},{"id":"https://openalex.org/C85265743","wikidata":"https://www.wikidata.org/wiki/Q885458","display_name":"Blot","level":3,"score":0.43236014246940613},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.42317983508110046},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4115189015865326},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.40173113346099854},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.39285990595817566},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3393527865409851},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2965722978115082},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.054350465536117554},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:CiteSeerX.psu:10.1.1.500.2095","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.500.2095","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.tua.org.tw/magazine/FileM/dw200991815504_4.pdf","raw_type":"text"},{"id":"mag:1546351266","doi":null,"is_oa":false,"landing_page_url":"https://www.airitilibrary.com/Publication/alDetailedMesh?DocID=10163220-200909-20-3-120-126-a","pdf_url":null,"source":{"id":"https://openalex.org/S50263657","display_name":"Urological Science","issn_l":"1879-5226","issn":["1879-5226","1879-5234"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\u81fa\u7063\u6ccc\u5c3f\u79d1\u91ab\u5b78\u6703\u96dc\u8a8c","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W107605353","https://openalex.org/W1591176056","https://openalex.org/W1796435846","https://openalex.org/W1978093163","https://openalex.org/W1978402006","https://openalex.org/W1981137243","https://openalex.org/W2009183786","https://openalex.org/W2017836748","https://openalex.org/W2033150312","https://openalex.org/W2061050258","https://openalex.org/W2070692423","https://openalex.org/W2084691941","https://openalex.org/W2097989971","https://openalex.org/W2099273851","https://openalex.org/W2108494968","https://openalex.org/W2125536365","https://openalex.org/W2130351801","https://openalex.org/W2131036797","https://openalex.org/W2134897395","https://openalex.org/W2143406829","https://openalex.org/W2160959615","https://openalex.org/W2167791620","https://openalex.org/W2472285172"],"related_works":["https://openalex.org/W2131036797","https://openalex.org/W7170033026","https://openalex.org/W1966630607","https://openalex.org/W2307143033","https://openalex.org/W2166648250","https://openalex.org/W1977968770","https://openalex.org/W16259293","https://openalex.org/W1894773994","https://openalex.org/W2009524760","https://openalex.org/W1501456434"],"abstract_inverted_index":{"OBJECTIVE:":[0],"Apoptosis":[1],"or":[2,70,152],"programmed":[3],"cell":[4],"death":[5],"is":[6,27],"a":[7,30,88],"key":[8],"regulator":[9],"of":[10,16,23,36,44,81,95,104,126,150,164,192,210],"physiological":[11],"growth":[12],"control":[13,92],"and":[14,20,51,62,118,131,166,184,194],"regulation":[15],"tissue":[17],"homeostasis.":[18],"Transformation":[19],"malignant":[21],"progression":[22],"prostate":[24,106],"cancer":[25],"(CaP)":[26],"due":[28],"to":[29,32,65,174],"failure":[31],"regulate":[33],"the":[34,42,68,105,114,124,148,155,162,170,175,190,199,208,213],"apoptosis":[35,211],"prostatic":[37,53],"epithelial":[38],"cells.":[39],"To":[40],"investigate":[41],"expression":[43,125,149],"apoptotic":[45,72,127],"proteins":[46,128],"in":[47,147,154,161,169,198,216],"patients":[48,83,97],"with":[49,84,98],"CaP":[50,85,171,200],"benign":[52],"hyperplasia":[54],"(BPH),":[55],"we":[56],"respectively":[57,111,179],"examined":[58],"Bcl-2,":[59],"caspase-9,":[60],"caspase-8":[61,165,193],"cleaved":[63,167,195],"caspase-3":[64,168,196],"further":[66],"determine":[67],"intrinsic":[69],"extrinsic":[71,214],"pathway.":[73],"MATERIALS":[74],"AND":[75],"METHODS:":[76],"The":[77,91,203],"study":[78,188,205],"group":[79,93,172,177],"consisted":[80,94],"18":[82],"who":[86,100],"underwent":[87,101],"radical":[89],"prostatectomy.":[90],"36":[96],"BPH":[99,176],"transurethral":[102],"resection":[103],"(TURP).":[107],"Tissue":[108],"samples":[109],"were":[110,135,178],"acquired":[112],"from":[113,119],"gross":[115],"tumor":[116],"site":[117],"resected":[120],"chips.":[121],"We":[122],"detected":[123],"by":[129,181],"immunoblotting":[130],"immunohistochemical":[132,185],"staining.":[133,186],"Data":[134],"ana-lyzed":[136],"using":[137],"Student's":[138],"t-test.":[139],"RESULTS:":[140],"There":[141],"was":[142],"no":[143],"statistically":[144],"significant":[145],"difference":[146],"Bcl-2":[151],"caspase-9":[153],"2":[156],"groups.":[157],"But":[158],"statistical":[159],"decreases":[160],"expressions":[163,197],"compared":[173],"demonstrated":[180,189],"Western":[182],"blotting":[183],"This":[187],"downregulation":[191],"group.":[201],"CONCLUSIONS:":[202],"present":[204],"shows":[206],"that":[207],"dysregulation":[209],"involved":[212],"pathway":[215],"pa-":[217]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}