{"id":"https://openalex.org/W1545579092","doi":"https://doi.org/10.1016/s0021-9258(17)42110-7","title":"Expression of a mutant Gi2 alpha subunit inhibits ATP and thrombin stimulation of cytoplasmic phospholipase A2-mediated arachidonic acid release independent of Ca2+ and mitogen-activated protein kinase regulation.","display_name":"Expression of a mutant Gi2 alpha subunit inhibits ATP and thrombin stimulation of cytoplasmic phospholipase A2-mediated arachidonic acid release independent of Ca2+ and mitogen-activated protein kinase regulation.","publication_year":1994,"publication_date":"1994-01-01","ids":{"openalex":"https://openalex.org/W1545579092","doi":"https://doi.org/10.1016/s0021-9258(17)42110-7","mag":"1545579092","pmid":"https://pubmed.ncbi.nlm.nih.gov/8294438"},"language":"en","primary_location":{"id":"doi:10.1016/s0021-9258(17)42110-7","doi":"https://doi.org/10.1016/s0021-9258(17)42110-7","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(17)42110-7","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/s0021-9258(17)42110-7","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027873978","display_name":"Sim Winitz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3019586173","display_name":"National Jewish Health","ror":"https://ror.org/016z2bp30","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019586173"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. Winitz","raw_affiliation_strings":["Division of Basic Sciences, National Jewish Center for Immunology and Respiratory Medicine, 1400 Jackson St., Denver, CO 80206","From the $Division of Basic Sciences, National Jewish Center for Immunology and Respiratory Medicine, Denvec Colorado 80206 and Departments of $Pharmacology and Wedicine,","University of Colorado Medical School, Denver, Coloado 80262"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Basic Sciences, National Jewish Center for Immunology and Respiratory Medicine, 1400 Jackson St., Denver, CO 80206","institution_ids":["https://openalex.org/I3019586173"]},{"raw_affiliation_string":"From the $Division of Basic Sciences, National Jewish Center for Immunology and Respiratory Medicine, Denvec Colorado 80206 and Departments of $Pharmacology and Wedicine,","institution_ids":["https://openalex.org/I3019586173"]},{"raw_affiliation_string":"University of Colorado Medical School, Denver, Coloado 80262","institution_ids":["https://openalex.org/I921990950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067185856","display_name":"Sunil Gupta","orcid":"https://orcid.org/0000-0001-6810-6483","observed_orcids":["https://orcid.org/0000-0001-6810-6483"]},"institutions":[{"id":"https://openalex.org/I3019586173","display_name":"National Jewish Health","ror":"https://ror.org/016z2bp30","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019586173"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S.K. Gupta","raw_affiliation_strings":["Division of Basic Sciences, National Jewish Center for Immunology and Respiratory Medicine, 1400 Jackson St., Denver, CO 80206","From the $Division of Basic Sciences, National Jewish Center for Immunology and Respiratory Medicine, Denvec Colorado 80206 and Departments of $Pharmacology and Wedicine,","University of Colorado Medical School, Denver, Coloado 80262"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Basic Sciences, National Jewish Center for Immunology and Respiratory Medicine, 1400 Jackson St., Denver, CO 80206","institution_ids":["https://openalex.org/I3019586173"]},{"raw_affiliation_string":"From the $Division of Basic Sciences, National Jewish Center for Immunology and Respiratory Medicine, Denvec Colorado 80206 and Departments of $Pharmacology and Wedicine,","institution_ids":["https://openalex.org/I3019586173"]},{"raw_affiliation_string":"University of Colorado Medical School, Denver, Coloado 80262","institution_ids":["https://openalex.org/I921990950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109864123","display_name":"N.X. Qian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3019586173","display_name":"National Jewish Health","ror":"https://ror.org/016z2bp30","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019586173"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"N.X. Qian","raw_affiliation_strings":["Division of Basic Sciences, National Jewish Center for Immunology and Respiratory Medicine, 1400 Jackson St., Denver, CO 80206","From the $Division of Basic Sciences, National Jewish Center for Immunology and Respiratory Medicine, Denvec Colorado 80206 and Departments of $Pharmacology and Wedicine,","University of Colorado Medical School, Denver, Coloado 80262"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Basic Sciences, National Jewish Center for Immunology and Respiratory Medicine, 1400 Jackson St., Denver, CO 80206","institution_ids":["https://openalex.org/I3019586173"]},{"raw_affiliation_string":"From the $Division of Basic Sciences, National Jewish Center for Immunology and Respiratory Medicine, Denvec Colorado 80206 and Departments of $Pharmacology and Wedicine,","institution_ids":["https://openalex.org/I3019586173"]},{"raw_affiliation_string":"University of Colorado Medical School, Denver, Coloado 80262","institution_ids":["https://openalex.org/I921990950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057844697","display_name":"Lynn E. Heasley","orcid":"https://orcid.org/0000-0001-8056-0208","observed_orcids":["https://orcid.org/0000-0001-8056-0208"]},"institutions":[{"id":"https://openalex.org/I3019586173","display_name":"National Jewish Health","ror":"https://ror.org/016z2bp30","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019586173"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L.E. Heasley","raw_affiliation_strings":["Division of Basic Sciences, National Jewish Center for Immunology and Respiratory Medicine, 1400 Jackson St., Denver, CO 80206","From the $Division of Basic Sciences, National Jewish Center for Immunology and Respiratory Medicine, Denvec Colorado 80206 and Departments of $Pharmacology and Wedicine,","University of Colorado Medical School, Denver, Coloado 80262"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Basic Sciences, National Jewish Center for Immunology and Respiratory Medicine, 1400 Jackson St., Denver, CO 80206","institution_ids":["https://openalex.org/I3019586173"]},{"raw_affiliation_string":"From the $Division of Basic Sciences, National Jewish Center for Immunology and Respiratory Medicine, Denvec Colorado 80206 and Departments of $Pharmacology and Wedicine,","institution_ids":["https://openalex.org/I3019586173"]},{"raw_affiliation_string":"University of Colorado Medical School, Denver, Coloado 80262","institution_ids":["https://openalex.org/I921990950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047707609","display_name":"Raphael A. Nemenoff","orcid":"https://orcid.org/0000-0002-2369-2535","observed_orcids":["https://orcid.org/0000-0002-2369-2535","https://orcid.org/0000-0002-9051-814X"]},"institutions":[{"id":"https://openalex.org/I3019586173","display_name":"National Jewish Health","ror":"https://ror.org/016z2bp30","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019586173"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R.A. Nemenoff","raw_affiliation_strings":["Division of Basic Sciences, National Jewish Center for Immunology and Respiratory Medicine, 1400 Jackson St., Denver, CO 80206","From the $Division of Basic Sciences, National Jewish Center for Immunology and Respiratory Medicine, Denvec Colorado 80206 and Departments of $Pharmacology and Wedicine,","University of Colorado Medical School, Denver, Coloado 80262"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Basic Sciences, National Jewish Center for Immunology and Respiratory Medicine, 1400 Jackson St., Denver, CO 80206","institution_ids":["https://openalex.org/I3019586173"]},{"raw_affiliation_string":"From the $Division of Basic Sciences, National Jewish Center for Immunology and Respiratory Medicine, Denvec Colorado 80206 and Departments of $Pharmacology and Wedicine,","institution_ids":["https://openalex.org/I3019586173"]},{"raw_affiliation_string":"University of Colorado Medical School, Denver, Coloado 80262","institution_ids":["https://openalex.org/I921990950"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047612906","display_name":"Gary L. Johnson","orcid":"https://orcid.org/0000-0003-2867-0551","observed_orcids":["https://orcid.org/0000-0003-2867-0551"]},"institutions":[{"id":"https://openalex.org/I3019586173","display_name":"National Jewish Health","ror":"https://ror.org/016z2bp30","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019586173"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G.L. Johnson","raw_affiliation_strings":["Division of Basic Sciences, National Jewish Center for Immunology and Respiratory Medicine, 1400 Jackson St., Denver, CO 80206","From the $Division of Basic Sciences, National Jewish Center for Immunology and Respiratory Medicine, Denvec Colorado 80206 and Departments of $Pharmacology and Wedicine,","University of Colorado Medical School, Denver, Coloado 80262"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Basic Sciences, National Jewish Center for Immunology and Respiratory Medicine, 1400 Jackson St., Denver, CO 80206","institution_ids":["https://openalex.org/I3019586173"]},{"raw_affiliation_string":"From the $Division of Basic Sciences, National Jewish Center for Immunology and Respiratory Medicine, Denvec Colorado 80206 and Departments of $Pharmacology and Wedicine,","institution_ids":["https://openalex.org/I3019586173"]},{"raw_affiliation_string":"University of Colorado Medical School, Denver, Coloado 80262","institution_ids":["https://openalex.org/I921990950"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":5.5206,"has_fulltext":false,"cited_by_count":112,"citation_normalized_percentile":{"value":0.97084332,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"269","issue":"3","first_page":"1889","last_page":"1895"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.0034000000450760126,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/g-protein-alpha-i2","display_name":"G protein alpha i2","score":0.7020000219345093},{"id":"https://openalex.org/keywords/cytosolic-phospholipase-a2","display_name":"cytosolic phospholipase A2","score":0.9089999794960022},{"id":"https://openalex.org/keywords/arachidonic-acid-release","display_name":"arachidonic acid release","score":0.9959999918937683},{"id":"https://openalex.org/keywords/thrombin","display_name":"thrombin","score":0.7670000195503235},{"id":"https://openalex.org/keywords/atp-receptors","display_name":"ATP receptors","score":0.8270000219345093},{"id":"https://openalex.org/keywords/mitogen-activated-protein-kinase","display_name":"mitogen-activated protein kinase","score":0.8029999732971191},{"id":"https://openalex.org/keywords/protein-kinase-c","display_name":"protein kinase C","score":0.824999988079071},{"id":"https://openalex.org/keywords/pertussis-toxin","display_name":"pertussis toxin","score":0.7760000228881836},{"id":"https://openalex.org/keywords/adp-ribosylation","display_name":"ADP-ribosylation","score":0.8619999885559082},{"id":"https://openalex.org/keywords/intracellular-calcium","display_name":"intracellular calcium","score":0.7590000033378601},{"id":"https://openalex.org/keywords/g-protein-regulation","display_name":"G protein regulation","score":0.4449999928474426}],"concepts":[{"id":"https://openalex.org/C2778078955","wikidata":"https://www.wikidata.org/wiki/Q407699","display_name":"Arachidonic acid","level":3,"score":0.6917343139648438},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.5786874294281006},{"id":"https://openalex.org/C104292427","wikidata":"https://www.wikidata.org/wiki/Q899781","display_name":"Protein subunit","level":3,"score":0.5750147700309753},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5700763463973999},{"id":"https://openalex.org/C2777292125","wikidata":"https://www.wikidata.org/wiki/Q409166","display_name":"Thrombin","level":3,"score":0.5558298826217651},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.5502830743789673},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.5128028988838196},{"id":"https://openalex.org/C12927208","wikidata":"https://www.wikidata.org/wiki/Q210430","display_name":"Phospholipase","level":3,"score":0.49802613258361816},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.48669368028640747},{"id":"https://openalex.org/C64943373","wikidata":"https://www.wikidata.org/wiki/Q2651003","display_name":"Alpha (finance)","level":4,"score":0.4700395464897156},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.43332964181900024},{"id":"https://openalex.org/C66135807","wikidata":"https://www.wikidata.org/wiki/Q24726231","display_name":"Gq alpha subunit","level":4,"score":0.42963898181915283},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.38923680782318115},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35169151425361633},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.32649368047714233},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3016681671142578},{"id":"https://openalex.org/C80631254","wikidata":"https://www.wikidata.org/wiki/Q407438","display_name":"G protein","level":3,"score":0.2854890823364258},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.21897879242897034},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.15222463011741638},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.08187201619148254},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.0},{"id":"https://openalex.org/C49453240","wikidata":"https://www.wikidata.org/wiki/Q1592163","display_name":"Construct validity","level":3,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C2775944032","wikidata":"https://www.wikidata.org/wiki/Q22907659","display_name":"Patient satisfaction","level":2,"score":0.0},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.0},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002772","descriptor_name":"Cholera Toxin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002999","descriptor_name":"Clone Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003593","descriptor_name":"Cytoplasm","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006224","descriptor_name":"Cricetinae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008970","descriptor_name":"Molecular Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009838","descriptor_name":"Oligodeoxyribonucleotides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010741","descriptor_name":"Phospholipases A","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D010741","descriptor_name":"Phospholipases A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010743","descriptor_name":"Phospholipids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011493","descriptor_name":"Protein Kinase C","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013755","descriptor_name":"Tetradecanoylphorbol Acetate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013917","descriptor_name":"Thrombin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016297","descriptor_name":"Mutagenesis, Site-Directed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016466","descriptor_name":"CHO Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016718","descriptor_name":"Arachidonic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017871","descriptor_name":"Calcium-Calmodulin-Dependent Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019204","descriptor_name":"GTP-Binding Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D019204","descriptor_name":"GTP-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D046911","descriptor_name":"Macromolecular Substances","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054467","descriptor_name":"Phospholipases A2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0021-9258(17)42110-7","doi":"https://doi.org/10.1016/s0021-9258(17)42110-7","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(17)42110-7","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:8294438","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8294438","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/s0021-9258(17)42110-7","doi":"https://doi.org/10.1016/s0021-9258(17)42110-7","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(17)42110-7","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.46810001134872437,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G185295266","display_name":null,"funder_award_id":"GM 30324","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G5451701411","display_name":"CYTOSOLIC PHOSPHOLIPASE A2 TRANSFORMED CELLS","funder_award_id":"R01DK039902","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G7737505099","display_name":"Regulation of Sequential Protein Kinase Pathways","funder_award_id":"R01DK037871","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":50,"referenced_works":["https://openalex.org/W5462217","https://openalex.org/W48759033","https://openalex.org/W1038394818","https://openalex.org/W1487365829","https://openalex.org/W1489654012","https://openalex.org/W1490772051","https://openalex.org/W1495419857","https://openalex.org/W1499995013","https://openalex.org/W1504158642","https://openalex.org/W1512490426","https://openalex.org/W1513857523","https://openalex.org/W1517887854","https://openalex.org/W1518781107","https://openalex.org/W1538215265","https://openalex.org/W1543557663","https://openalex.org/W1560653093","https://openalex.org/W1565496454","https://openalex.org/W1581760931","https://openalex.org/W1588749554","https://openalex.org/W1594758412","https://openalex.org/W1601592083","https://openalex.org/W1662189542","https://openalex.org/W1979591208","https://openalex.org/W2001013796","https://openalex.org/W2010049654","https://openalex.org/W2022037486","https://openalex.org/W2025657240","https://openalex.org/W2027892263","https://openalex.org/W2031683755","https://openalex.org/W2041104433","https://openalex.org/W2051958752","https://openalex.org/W2052295727","https://openalex.org/W2052372063","https://openalex.org/W2060426330","https://openalex.org/W2070132447","https://openalex.org/W2078411762","https://openalex.org/W2080413833","https://openalex.org/W2080875376","https://openalex.org/W2084287390","https://openalex.org/W2090575139","https://openalex.org/W2094816576","https://openalex.org/W2128635872","https://openalex.org/W2130964473","https://openalex.org/W2144444239","https://openalex.org/W2146388445","https://openalex.org/W2152311269","https://openalex.org/W2161798777","https://openalex.org/W2173886481","https://openalex.org/W2314217713","https://openalex.org/W2401074156"],"related_works":["https://openalex.org/W1819423476","https://openalex.org/W2001534326","https://openalex.org/W1513857523","https://openalex.org/W2042596629","https://openalex.org/W1589012667","https://openalex.org/W1495419857","https://openalex.org/W2031683755","https://openalex.org/W2048939907","https://openalex.org/W2021284850","https://openalex.org/W1502486752"],"abstract_inverted_index":{"The":[0,154],"85-kDa":[1],"cytoplasmic":[2],"phospholipase":[3],"A2":[4],"(cPLA2)":[5],"is":[6],"the":[7,32,35,125,131,160,171,184],"major":[8],"hormone":[9],"and":[10,31,61,66,76,104,119,176,190],"growth":[11],"factor-regulated":[12],"enzyme":[13,37],"that":[14,71],"catalyzes":[15],"release":[16,111,180],"of":[17,24,28,34,44,56,85,108,113,124,150,159,173,186],"arachidonic":[18,67,86,109,151,178],"acid":[19,68,87,110,152,179],"in":[20,170,181],"mammalian":[21],"cells.":[22],"Activation":[23],"cPLA2":[25,36,174],"requires":[26],"elevation":[27],"intracellular":[29,187],"Ca2+":[30,117,188],"phosphorylation":[33],"by":[38,48],"mitogen-activated":[39],"protein":[40,45,73,83],"(MAP)":[41],"kinase.":[42],"Down-regulation":[43],"kinase":[46,65,74,121,192],"C":[47,75],"phorbol":[49],"esters":[50],"or":[51,130,146],"pertussis":[52],"toxin":[53],"catalyzed":[54],"ADP-ribosylation":[55],"Gi":[57,77],"proteins":[58,78],"inhibits":[59],"thrombin":[60,103,145],"ATP":[62,105,147],"receptor-stimulated":[63],"MAP":[64,120,191],"release,":[69],"indicating":[70],"functional":[72],"are":[79],"required":[80],"for":[81,168],"G":[82,91],"regulation":[84,185],"release.":[88,153],"A":[89],"mutant":[90,133,161],"alpha":[92,127,134,162],"i2":[93,128],"subunit":[94],"having":[95],"Gly203":[96],"mutated":[97,137],"to":[98,138,183],"Thr":[99],"(alpha":[100],"i2G203T)":[101],"inhibited":[102],"receptor":[106,148],"stimulation":[107,149],"independent":[112],"adenylyl":[114],"cyclase":[115],"inhibition,":[116],"mobilization,":[118],"activation.":[122],"Overexpression":[123],"wild-type":[126],"polypeptide":[129,140,164],"inactive":[132],"i2G204A":[135],"(Gly204":[136],"Ala)":[139],"had":[141],"no":[142],"effect":[143],"on":[144],"phenotype":[155],"observed":[156],"with":[157],"expression":[158],"i2G203T":[163],"defines":[165],"a":[166],"role":[167],"Gi2":[169],"control":[172],"activity":[175],"subsequent":[177],"addition":[182],"levels":[189],"activity.":[193]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
