{"id":"https://openalex.org/W1545115486","doi":null,"title":"Measuring human salivary amylase copy number variation","display_name":"Measuring human salivary amylase copy number variation","publication_year":2010,"publication_date":"2010-12-10","ids":{"openalex":"https://openalex.org/W1545115486","mag":"1545115486"},"language":"en","primary_location":{"id":"pmh:oai:eprints.nottingham.ac.uk:11691","doi":null,"is_oa":false,"landing_page_url":"https://eprints.nottingham.ac.uk/11691/1/ThesisFiNaL.pdf","pdf_url":"https://eprints.nottingham.ac.uk/11691/1/ThesisFiNaL.pdf","source":{"id":"https://openalex.org/S4306402014","display_name":"Nottingham ePrints (University of Nottingham)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I142263535","host_organization_name":"University of Nottingham","host_organization_lineage":["https://openalex.org/I142263535"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Thesis (University of Nottingham only)"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://repository.nottingham.ac.uk/bitstreams/65fbe6c2-4e31-45c1-86bb-fcc71449cd04/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038539722","display_name":"Sugandha Dhar","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Sugandha Dhar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5038539722"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":0.9009000062942505,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":0.9009000062942505,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10012","display_name":"Genetic diversity and population structure","score":0.022600000724196434,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10434","display_name":"Chromosomal and Genetic Variations","score":0.015399999916553497,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/salivary-amylase","display_name":"salivary amylase","score":0.9300000071525574},{"id":"https://openalex.org/keywords/amy1","display_name":"AMY1","score":0.9139999747276306},{"id":"https://openalex.org/keywords/copy-number-variation","display_name":"copy number variation","score":0.9950000047683716},{"id":"https://openalex.org/keywords/retroviral-elements","display_name":"retroviral elements","score":0.828000009059906},{"id":"https://openalex.org/keywords/paralogs","display_name":"paralogs","score":0.5299999713897705},{"id":"https://openalex.org/keywords/pancreatic-amylase","display_name":"pancreatic amylase","score":0.8119999766349792},{"id":"https://openalex.org/keywords/starch-digestion","display_name":"starch hydrolysis","score":0.6340000033378601},{"id":"https://openalex.org/keywords/adaptive-evolution","display_name":"adaptive evolution","score":0.6800000071525574},{"id":"https://openalex.org/keywords/primer-design","display_name":"primer design","score":0.5299999713897705},{"id":"https://openalex.org/keywords/annealing-temperature","display_name":"annealing temperature","score":0.5519999861717224},{"id":"https://openalex.org/keywords/human-genome-evolution","display_name":"human genome evolution","score":0.38100001215934753}],"concepts":[{"id":"https://openalex.org/C170835558","wikidata":"https://www.wikidata.org/wiki/Q17153","display_name":"Amylase","level":3,"score":0.7925094366073608},{"id":"https://openalex.org/C120821319","wikidata":"https://www.wikidata.org/wiki/Q1501491","display_name":"Copy-number variation","level":4,"score":0.7549231052398682},{"id":"https://openalex.org/C166608930","wikidata":"https://www.wikidata.org/wiki/Q5169175","display_name":"Copy number analysis","level":5,"score":0.7196601629257202},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6411224603652954},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5969359874725342},{"id":"https://openalex.org/C84597430","wikidata":"https://www.wikidata.org/wiki/Q106227","display_name":"Locus (genetics)","level":3,"score":0.5675553679466248},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.5537346005439758},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.546812117099762},{"id":"https://openalex.org/C197077220","wikidata":"https://www.wikidata.org/wiki/Q720988","display_name":"Human genome","level":4,"score":0.5203206539154053},{"id":"https://openalex.org/C7602840","wikidata":"https://www.wikidata.org/wiki/Q746284","display_name":"Gene duplication","level":3,"score":0.49817466735839844},{"id":"https://openalex.org/C55548728","wikidata":"https://www.wikidata.org/wiki/Q1465102","display_name":"Gene dosage","level":4,"score":0.4270109534263611},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.37357068061828613},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.13300493359565735},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.11984533071517944},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"pmh:oai:eprints.nottingham.ac.uk:11691","doi":null,"is_oa":false,"landing_page_url":"https://eprints.nottingham.ac.uk/11691/1/ThesisFiNaL.pdf","pdf_url":"https://eprints.nottingham.ac.uk/11691/1/ThesisFiNaL.pdf","source":{"id":"https://openalex.org/S4306402014","display_name":"Nottingham ePrints (University of Nottingham)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I142263535","host_organization_name":"University of Nottingham","host_organization_lineage":["https://openalex.org/I142263535"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Thesis (University of Nottingham only)"},{"id":"pmh:oai:repository.nottingham.ac.uk:123456789/48060","doi":null,"is_oa":true,"landing_page_url":"https://repository.nottingham.ac.uk/handle/123456789/48060","pdf_url":"https://repository.nottingham.ac.uk/bitstreams/65fbe6c2-4e31-45c1-86bb-fcc71449cd04/download","source":{"id":"https://openalex.org/S4306402014","display_name":"Nottingham ePrints (University of Nottingham)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I142263535","host_organization_name":"University of Nottingham","host_organization_lineage":["https://openalex.org/I142263535"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"ethesis"},{"id":"pmh:oai:uilis.unsyiah.ac.id:4008","doi":null,"is_oa":true,"landing_page_url":"http://uilis.unsyiah.ac.id/opentheses/items/show/4008","pdf_url":"http://uilis.unsyiah.ac.id/opentheses/items/show/4008","source":{"id":"https://openalex.org/S4377196378","display_name":"UPT. Syiah Kuala University Library (Syiah Kuala University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I187494767","host_organization_name":"Universitas Syiah Kuala","host_organization_lineage":["https://openalex.org/I187494767"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis (University of Nottingham only)"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.460.7848","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.460.7848","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://etheses.nottingham.ac.uk/1691/1/ThesisFiNaL.pdf","raw_type":"text"},{"id":"mag:1545115486","doi":null,"is_oa":false,"landing_page_url":"http://eprints.nottingham.ac.uk/11691/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:repository.nottingham.ac.uk:123456789/48060","doi":null,"is_oa":true,"landing_page_url":"https://repository.nottingham.ac.uk/handle/123456789/48060","pdf_url":"https://repository.nottingham.ac.uk/bitstreams/65fbe6c2-4e31-45c1-86bb-fcc71449cd04/download","source":{"id":"https://openalex.org/S4306402014","display_name":"Nottingham ePrints (University of Nottingham)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I142263535","host_organization_name":"University of Nottingham","host_organization_lineage":["https://openalex.org/I142263535"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"ethesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.46810001134872437}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1545115486.pdf","grobid_xml":"https://content.openalex.org/works/W1545115486.grobid-xml"},"referenced_works_count":88,"referenced_works":["https://openalex.org/W206265255","https://openalex.org/W623140833","https://openalex.org/W1484187172","https://openalex.org/W1547015482","https://openalex.org/W1551836412","https://openalex.org/W1560614145","https://openalex.org/W1765150621","https://openalex.org/W1817110620","https://openalex.org/W1861378058","https://openalex.org/W1871124929","https://openalex.org/W1903835881","https://openalex.org/W1911309901","https://openalex.org/W1947892967","https://openalex.org/W1965141089","https://openalex.org/W1966938977","https://openalex.org/W1967134681","https://openalex.org/W1968002146","https://openalex.org/W1968046362","https://openalex.org/W1968472660","https://openalex.org/W1969892080","https://openalex.org/W1978308076","https://openalex.org/W1979175247","https://openalex.org/W1983249117","https://openalex.org/W2001526641","https://openalex.org/W2003595434","https://openalex.org/W2007589425","https://openalex.org/W2017253520","https://openalex.org/W2022227920","https://openalex.org/W2023865653","https://openalex.org/W2024984404","https://openalex.org/W2026502449","https://openalex.org/W2027867510","https://openalex.org/W2029203450","https://openalex.org/W2035244253","https://openalex.org/W2035380874","https://openalex.org/W2036488627","https://openalex.org/W2039608769","https://openalex.org/W2039858518","https://openalex.org/W2044733613","https://openalex.org/W2045757225","https://openalex.org/W2050345568","https://openalex.org/W2055821541","https://openalex.org/W2058442049","https://openalex.org/W2060453248","https://openalex.org/W2060842475","https://openalex.org/W2061921541","https://openalex.org/W2063873651","https://openalex.org/W2065684972","https://openalex.org/W2065723155","https://openalex.org/W2078411483","https://openalex.org/W2080037603","https://openalex.org/W2081508278","https://openalex.org/W2084115758","https://openalex.org/W2085755265","https://openalex.org/W2086374466","https://openalex.org/W2090738704","https://openalex.org/W2091279754","https://openalex.org/W2094389660","https://openalex.org/W2102773855","https://openalex.org/W2103145701","https://openalex.org/W2106425356","https://openalex.org/W2106982327","https://openalex.org/W2109291482","https://openalex.org/W2109352113","https://openalex.org/W2110227850","https://openalex.org/W2110359348","https://openalex.org/W2112441302","https://openalex.org/W2113926943","https://openalex.org/W2114857255","https://openalex.org/W2124896761","https://openalex.org/W2135891884","https://openalex.org/W2139496296","https://openalex.org/W2140481050","https://openalex.org/W2142805668","https://openalex.org/W2144644150","https://openalex.org/W2144690533","https://openalex.org/W2147429782","https://openalex.org/W2151464048","https://openalex.org/W2155707112","https://openalex.org/W2161123406","https://openalex.org/W2163065744","https://openalex.org/W2164578725","https://openalex.org/W2166512140","https://openalex.org/W2168909179","https://openalex.org/W2170179136","https://openalex.org/W2182452189","https://openalex.org/W2266088244","https://openalex.org/W2412557436"],"related_works":["https://openalex.org/W2800779458","https://openalex.org/W2155319238","https://openalex.org/W1780686765","https://openalex.org/W2590735158","https://openalex.org/W4406155680","https://openalex.org/W2076932555","https://openalex.org/W7136067600","https://openalex.org/W2577266753","https://openalex.org/W4403510091","https://openalex.org/W2944958548"],"abstract_inverted_index":{"Copy":[0],"number":[1,30,99,252,267,283,302],"variations":[2],"represent":[3],"large":[4],"scale":[5],"genomic":[6],"alterations":[7],"varying":[8],"from":[9,184,192,272],"1kb":[10],"to":[11,72,151,249],"3Mb":[12],"and":[13,23,32,69,143,187,217,236,242,257,298,315],"are":[14,63,176],"proposed":[15],"as":[16,291],"a":[17,81,156,196],"driving":[18],"force":[19],"for":[20,41,95,130],"genome":[21,33,180],"evolution":[22,34],"variation.":[24],"One":[25],"such":[26,165],"locus":[27],"exhibiting":[28],"copy":[29,61,78,98,134,251,266,282,289,301],"variation":[31],"is":[35,39],"salivary":[36,57,141,161,168],"amylase,":[37],"which":[38,109],"responsible":[40],"the":[42,47,73,101,106,121,152,160,179,208,215,264,270,288,307,313,318],"digestion":[43],"of":[44,75,97,117,123,155,204,225,234,253,281,300,310,317],"starch":[45,82],"in":[46,100,199,231,255,269],"human":[48,56,102,132],"parotid":[49],"glands.":[50],"It":[51],"was":[52,92,120,148,195,263],"reported":[53],"that":[54,166,213],"since":[55],"amylase":[58,133,142,145,162,169],"gene":[59,77,163],"(AMY1)":[60],"numbers":[62,79,290],"correlated":[64],"positively":[65],"with":[66,80,105,159,287],"protein":[67],"levels,":[68],"also":[70,229],"due":[71,150],"correlation":[74],"high":[76],"rich":[83],"diet,":[84],"AMY1":[85,254],"had":[86],"undergone":[87],"adaptive":[88],"evolution.":[89],"Moreover":[90],"there":[91],"recent":[93],"evidence":[94],"gain":[96],"lineage":[103],"concordant":[104],"dietary":[107],"shift":[108],"occurred":[110],"during":[111],"Neolithic":[112],"times.":[113],"The":[114],"main":[115],"focus":[116],"this":[118,200],"study":[119],"development":[122],"multiplex":[124],"Paralogue":[125],"Ratio":[126],"Test":[127],"(PRT)":[128],"systems":[129,309],"measuring":[131],"number.":[135],"Despite":[136],"having":[137],"considerable":[138],"identity":[139],"between":[140],"pancreatic":[144],"copies,":[146,164],"PRT":[147,274],"designed":[149,248],"exclusive":[153,232],"association":[154],"retroviral":[157,174],"element":[158],"only":[167,214],"copies":[170,262],"were":[171,220,246],"quantified.":[172],"As":[173],"elements":[175],"scattered":[177],"throughout":[178],"therefore":[181],"eliciting":[182],"amplification":[183,233],"just":[185],"test":[186,216,235],"reference":[188,218,237],"without":[189],"any":[190],"contribution":[191],"alternative":[193],"loci":[194],"technical":[197],"challenge":[198],"project.":[201],"However,":[202],"creation":[203],"enough":[205],"mismatches":[206],"within":[207],"primer":[209],"binding":[210],"sites":[211],"ensured":[212],"sequences":[219],"amplified.":[221],"Discrimination":[222],"by":[223,293,305],"means":[224],"increasing":[226],"annealing":[227],"temperature":[228],"aided":[230],"sequences.":[238],"Consequently,":[239],"two":[240],"PRTs":[241],"1":[243],"microsatellite":[244],"assay":[245],"successfully":[247],"measure":[250],"Japanese":[256],"UK":[258],"DNA":[259],"samples.":[260],"14":[261],"highest":[265],"seen":[268],"samples":[271,277],"both":[273,306],"systems.":[275],"Reference":[276],"specifying":[278],"individual":[279,308],"classes":[280],"exhibited":[284],"strong":[285],"relationship":[286],"determined":[292],"previous":[294],"work.":[295],"Repeat":[296],"testing":[297],"clustering":[299],"data":[303],"points":[304],"measurement":[311],"ascertained":[312],"accuracy":[314],"reproducibility":[316],"developed":[319],"assays.":[320]},"counts_by_year":[{"year":2015,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-05T09:50:58.205359","created_date":"2016-06-24T00:00:00"}