{"id":"https://openalex.org/W1544668985","doi":null,"title":"Confirmation of the identity of the major phospholipid in human lens membranes.","display_name":"Confirmation of the identity of the major phospholipid in human lens membranes.","publication_year":1996,"publication_date":"1996-07-01","ids":{"openalex":"https://openalex.org/W1544668985","mag":"1544668985","pmid":"https://pubmed.ncbi.nlm.nih.gov/8675415"},"language":"en","primary_location":{"id":"pmid:8675415","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8675415","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Comparative Study"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061753231","display_name":"S R Ferguson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S R Ferguson","raw_affiliation_strings":["Department of Chemistry, Kentucky Lions Eye Research Institute, University of Louisville 40292, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Kentucky Lions Eye Research Institute, University of Louisville 40292, USA","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031315736","display_name":"Douglas Borchman","orcid":"https://orcid.org/0000-0003-4241-591X","observed_orcids":["https://orcid.org/0000-0003-4241-591X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D Borchman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5109848112","display_name":"Marta Cecilia Yappert","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M C Yappert","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5276,"has_fulltext":false,"cited_by_count":32,"citation_normalized_percentile":{"value":0.57768423,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"37","issue":"8","first_page":"1703","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":0.7172999978065491,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":0.7172999978065491,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.2660999894142151,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.0038999998942017555,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dihydrosphingomyelin","display_name":"dihydrosphingomyelin","score":0.9800000190734863},{"id":"https://openalex.org/keywords/sphingolipids","display_name":"sphingolipids","score":0.9110000133514404},{"id":"https://openalex.org/keywords/31p-nmr-spectroscopy","display_name":"31P NMR","score":0.8050000071525574},{"id":"https://openalex.org/keywords/1h-nmr-spectroscopy","display_name":"1H NMR","score":0.9760000109672546}],"concepts":[{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.7914950251579285},{"id":"https://openalex.org/C2778918659","wikidata":"https://www.wikidata.org/wiki/Q186915","display_name":"Phospholipid","level":3,"score":0.7030459642410278},{"id":"https://openalex.org/C15336307","wikidata":"https://www.wikidata.org/wiki/Q1766051","display_name":"Lens (geology)","level":2,"score":0.6858571767807007},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5617647171020508},{"id":"https://openalex.org/C66974803","wikidata":"https://www.wikidata.org/wiki/Q10359898","display_name":"Nuclear magnetic resonance spectroscopy","level":2,"score":0.5428973436355591},{"id":"https://openalex.org/C61322309","wikidata":"https://www.wikidata.org/wiki/Q423143","display_name":"Sphingomyelin","level":3,"score":0.4887545108795166},{"id":"https://openalex.org/C103319777","wikidata":"https://www.wikidata.org/wiki/Q1979695","display_name":"Proton NMR","level":2,"score":0.4661511182785034},{"id":"https://openalex.org/C46141821","wikidata":"https://www.wikidata.org/wiki/Q209402","display_name":"Nuclear magnetic resonance","level":1,"score":0.33573251962661743},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.21373134851455688},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10878312587738037},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.07123559713363647},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0712079405784607}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001923","descriptor_name":"Brain Chemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006865","descriptor_name":"Hydrogenation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007908","descriptor_name":"Lens, Crystalline","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008563","descriptor_name":"Membrane Lipids","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D008563","descriptor_name":"Membrane Lipids","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D009682","descriptor_name":"Magnetic Resonance Spectroscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010743","descriptor_name":"Phospholipids","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D010743","descriptor_name":"Phospholipids","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D013109","descriptor_name":"Sphingomyelins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D013109","descriptor_name":"Sphingomyelins","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:8675415","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8675415","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Comparative Study"},{"id":"mag:1544668985","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8675415","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G8247648612","display_name":"SPECTROSCOPIC AND RELATED STUDIES ON LENS MEMBRANE LIPID","funder_award_id":"R01EY007975","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"}],"funders":[{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":8,"referenced_works":["https://openalex.org/W100744059","https://openalex.org/W110513267","https://openalex.org/W193913756","https://openalex.org/W1931677656","https://openalex.org/W1991559715","https://openalex.org/W2004718107","https://openalex.org/W2007062410","https://openalex.org/W4300545919"],"related_works":["https://openalex.org/W100744059","https://openalex.org/W2009937162","https://openalex.org/W2093679003","https://openalex.org/W1970785194","https://openalex.org/W4233638431","https://openalex.org/W2080093415","https://openalex.org/W1594157888","https://openalex.org/W2032444757","https://openalex.org/W2009624325","https://openalex.org/W2088676262"],"abstract_inverted_index":{"PURPOSE:":[0],"To":[1],"confirm":[2],"the":[3,6,10,29,66,76,80,86,92,100,108,114,124,129,134],"identity":[4,135],"of":[5,9,28,37,65,85,107,119,136],"major":[7,67,125],"component":[8,68],"human":[11,71,101,130],"lens":[12,72,102,131],"membranes":[13,132],"proposed":[14],"in":[15],"1994":[16],"to":[17,63],"be":[18],"dihydrosphingomyelin":[19],"(DH-SPH).":[20],"METHODS:":[21],"DH-SPH":[22,40,88,115],"was":[23,41],"prepared":[24,87,116],"by":[25,43,117],"catalytic":[26],"hydrogenation":[27,118],"double":[30],"bond":[31],"between":[32],"carbons":[33],"4":[34],"and":[35,46,79,121],"5":[36],"sphingomyelin":[38],"(SPH).":[39],"characterized":[42],"phosphorus-31":[44],"(31P)":[45],"proton":[47],"(1H)":[48],"nuclear":[49],"magnetic":[50],"resonance":[51],"(NMR)":[52],"spectroscopy":[53],"at":[54],"different":[55],"reaction":[56],"times.":[57],"The":[58,105],"spectroscopic":[59,109],"data":[60,111],"were":[61],"compared":[62],"those":[64,90,122],"extracted":[69],"from":[70,128],"membranes.":[73],"RESULTS:":[74],"Both":[75],"1H":[77],"NMR":[78,82,110],"31P":[81],"spectral":[83],"resonances":[84],"matched":[89],"for":[91,113,123],"once":[93],"\"unknown":[94],"phospholipid\"":[95],"that":[96],"constitutes":[97],"approximately":[98],"half":[99],"phospholipids.":[103],"CONCLUSIONS:":[104],"match":[106],"obtained":[112],"SPH":[120],"phospholipid":[126],"isolated":[127],"confirms":[133],"this":[137],"sphingolipid":[138],"as":[139],"D-erythro-4,5-dihydrosphingomyelin.":[140]},"counts_by_year":[{"year":2022,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}