{"id":"https://openalex.org/W1544106935","doi":"https://doi.org/10.1016/s0021-9258(19)83652-9","title":"Reaction rates of creatine kinase and ATP synthesis in the isolated rat heart. A 31P NMR magnetization transfer study.","display_name":"Reaction rates of creatine kinase and ATP synthesis in the isolated rat heart. A 31P NMR magnetization transfer study.","publication_year":1985,"publication_date":"1985-03-01","ids":{"openalex":"https://openalex.org/W1544106935","doi":"https://doi.org/10.1016/s0021-9258(19)83652-9","mag":"1544106935","pmid":"https://pubmed.ncbi.nlm.nih.gov/3972835"},"language":"en","primary_location":{"id":"doi:10.1016/s0021-9258(19)83652-9","doi":"https://doi.org/10.1016/s0021-9258(19)83652-9","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(19)83652-9","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W1544106935"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/s0021-9258(19)83652-9","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086611754","display_name":"John A. Bittl","orcid":"https://orcid.org/0000-0003-3254-5198","observed_orcids":["https://orcid.org/0000-0003-3254-5198"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J A Bittl","raw_affiliation_strings":["From the Haruard Medical School NMR Laboratory and the Departments of Medicine, Brighum and Women's Hospital and","Harvard Medical School, Boston, Massachusetts 021 15"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Haruard Medical School NMR Laboratory and the Departments of Medicine, Brighum and Women's Hospital and","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"Harvard Medical School, Boston, Massachusetts 021 15","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057568972","display_name":"Joanne S. Ingwall","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J S Ingwall","raw_affiliation_strings":["From the Haruard Medical School NMR Laboratory and the Departments of Medicine, Brighum and Women's Hospital and","Harvard Medical School, Boston, Massachusetts 021 15"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Haruard Medical School NMR Laboratory and the Departments of Medicine, Brighum and Women's Hospital and","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"Harvard Medical School, Boston, Massachusetts 021 15","institution_ids":["https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":10.8643,"has_fulltext":false,"cited_by_count":294,"citation_normalized_percentile":{"value":0.99593838,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"260","issue":"6","first_page":"3512","last_page":"3517"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11809","display_name":"Advanced NMR Techniques and Applications","score":0.6826000213623047,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11809","display_name":"Advanced NMR Techniques and Applications","score":0.6826000213623047,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.08560000360012054,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.07919999957084656,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/creatine-kinase","display_name":"creatine kinase","score":0.9909999966621399},{"id":"https://openalex.org/keywords/atp-production","display_name":"ATP production","score":0.9819999933242798},{"id":"https://openalex.org/keywords/magnetization-transfer","display_name":"magnetization transfer","score":0.7310000061988831},{"id":"https://openalex.org/keywords/31p-nmr-spectroscopy","display_name":"31P NMR","score":0.8330000042915344},{"id":"https://openalex.org/keywords/myocardial-energy-metabolism","display_name":"myocardial energy metabolism","score":0.7870000004768372},{"id":"https://openalex.org/keywords/oxygen-consumption","display_name":"oxygen consumption","score":0.7129999995231628},{"id":"https://openalex.org/keywords/rate-pressure-product","display_name":"rate-pressure product","score":0.7839999794960022},{"id":"https://openalex.org/keywords/michaelis-menten-kinetics","display_name":"Michaelis-Menten kinetics","score":0.9160000085830688},{"id":"https://openalex.org/keywords/phosphocreatine","display_name":"phosphocreatine","score":0.8830000162124634},{"id":"https://openalex.org/keywords/inorganic-phosphate","display_name":"inorganic phosphate","score":0.7310000061988831},{"id":"https://openalex.org/keywords/longitudinal-relaxation-time","display_name":"longitudinal relaxation time","score":0.5860000252723694},{"id":"https://openalex.org/keywords/isolated-rat-heart","display_name":"isolated rat heart","score":0.492000013589859}],"concepts":[{"id":"https://openalex.org/C36880943","wikidata":"https://www.wikidata.org/wiki/Q409458","display_name":"Creatine kinase","level":2,"score":0.7045564651489258},{"id":"https://openalex.org/C27826641","wikidata":"https://www.wikidata.org/wiki/Q6731637","display_name":"Magnetization transfer","level":3,"score":0.6956969499588013},{"id":"https://openalex.org/C32546565","wikidata":"https://www.wikidata.org/wiki/Q856711","display_name":"Magnetization","level":3,"score":0.5506222248077393},{"id":"https://openalex.org/C2779896295","wikidata":"https://www.wikidata.org/wiki/Q223600","display_name":"Creatine","level":2,"score":0.5371111035346985},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.44607216119766235},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2988143563270569},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22087734937667847},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.15949732065200806},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.07715174555778503},{"id":"https://openalex.org/C115260700","wikidata":"https://www.wikidata.org/wiki/Q11408","display_name":"Magnetic field","level":2,"score":0.05842715501785278},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003402","descriptor_name":"Creatine Kinase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008433","descriptor_name":"Mathematics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009682","descriptor_name":"Magnetic Resonance Spectroscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010477","descriptor_name":"Perfusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011189","descriptor_name":"Potassium Chloride","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0021-9258(19)83652-9","doi":"https://doi.org/10.1016/s0021-9258(19)83652-9","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(19)83652-9","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:3972835","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3972835","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/s0021-9258(19)83652-9","doi":"https://doi.org/10.1016/s0021-9258(19)83652-9","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(19)83652-9","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2001104672","display_name":null,"funder_award_id":"HL-07049","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G7418121332","display_name":null,"funder_award_id":"HL28012","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G8602371110","display_name":"SPECIALIZED CENTER OF RESEARCH IN ISCHEMIC HEART DISEASE","funder_award_id":"P50HL026215","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W1580463159","https://openalex.org/W1661549035","https://openalex.org/W1954126887","https://openalex.org/W1968760557","https://openalex.org/W2006422542","https://openalex.org/W2029621593","https://openalex.org/W2050136739","https://openalex.org/W2075167762","https://openalex.org/W2079699518","https://openalex.org/W2083741754","https://openalex.org/W2087232199","https://openalex.org/W2158330490","https://openalex.org/W2285739291","https://openalex.org/W2410892011"],"related_works":["https://openalex.org/W2085573744","https://openalex.org/W171939927","https://openalex.org/W2416035679","https://openalex.org/W1982666047","https://openalex.org/W1596258111","https://openalex.org/W1970330964","https://openalex.org/W2040704590","https://openalex.org/W2424657075","https://openalex.org/W99943510","https://openalex.org/W2025635154"],"abstract_inverted_index":{"The":[0,61,128,164],"NMR":[1],"technique":[2,37],"of":[3,55,111,144,149,168,176],"magnetization":[4,154],"transfer":[5,155,197],"can":[6],"be":[7],"used":[8,35],"to":[9,16,38,96,108,119,126,158,206],"define":[10],"intracellular":[11],"reaction":[12,29,45,63,202],"kinetics.":[13],"In":[14],"order":[15],"determine":[17],"the":[18,26,31,42,47,75,90,142,145,173,199],"relationship":[19,129],"between":[20,130],"ATP":[21,139,150,177],"synthesis":[22,151],"and":[23,58,77,86,102,121,134,137,180],"flux":[24,40,133],"through":[25,41],"creatine":[27,43,79,131,169,200],"kinase":[28,44,80,132,201],"in":[30,46],"intact":[32],"heart,":[33],"we":[34],"this":[36],"measure":[39],"isolated,":[48],"isovolumic":[49],"rat":[50],"heart":[51],"at":[52],"five":[53],"levels":[54],"cardiac":[56,84,189],"performance":[57,85],"oxygen":[59,87,103,135,162],"consumption.":[60,88,163],"unidirectional":[62],"rate":[64],"constants":[65],"(s-1)":[66],"calculated":[67,160],"from":[68,94,106,117,124,153,161],"a":[69],"two-site":[70],"exchange":[71],"model":[72],"for":[73],"both":[74],"forward":[76],"reverse":[78],"reactions":[81],"increased":[82,116,123],"with":[83,188],"As":[89],"rate-pressure":[91],"product":[92],"varied":[93],"0":[95],"44.7":[97],"X":[98],"10(3)":[99],"mm":[100],"Hg/min":[101],"consumption":[104],"rose":[105],"5.9":[107],"45.8":[109],"mumol":[110],"O2/g":[112],"dry":[113],"weight/min,":[114],"kforward":[115],"0.27":[118],"1.30":[120],"kreverse":[122],"0.31":[125],"1.14.":[127],"consumption,":[136],"thus":[138],"synthesis,":[140],"took":[141],"form":[143],"Michaelis-Menten":[146],"equation.":[147],"Rates":[148],"estimated":[152],"were":[156],"similar":[157],"values":[159],"longitudinal":[165],"relaxation":[166],"time":[167],"phosphate":[170,182],"(2.06":[171],"s),":[172,179],"gamma-phosphorus":[174],"atom":[175],"(0.75":[178],"inorganic":[181],"(0.81":[183],"s)":[184],"did":[185],"not":[186],"change":[187],"performance.":[190],"These":[191],"results":[192],"show":[193],"that":[194],"myocardial":[195],"energy":[196,207],"via":[198],"is":[203],"closely":[204],"coupled":[205],"production.":[208]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":10},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2016-06-24T00:00:00"}