{"id":"https://openalex.org/W154389137","doi":null,"title":"INJURY ESTABLISHES CONSTITUTIVE \u00b5-OPIOID RECEPTOR ACTIVITY LEADING TO LASTING ENDOGENOUS ANALGESIA AND DEPENDENCE","display_name":"INJURY ESTABLISHES CONSTITUTIVE \u00b5-OPIOID RECEPTOR ACTIVITY LEADING TO LASTING ENDOGENOUS ANALGESIA AND DEPENDENCE","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W154389137","mag":"154389137"},"language":"en","primary_location":{"id":"pmh:oai:uknowledge.uky.edu:physiology_etds-1009","doi":null,"is_oa":true,"landing_page_url":"https://uknowledge.uky.edu/physiology_etds/10","pdf_url":"https://uknowledge.uky.edu/cgi/viewcontent.cgi?article=1009&context=physiology_etds","source":{"id":"https://openalex.org/S4306402623","display_name":"UKnowledge (University of Kentucky)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I143302722","host_organization_name":"University of Kentucky","host_organization_lineage":["https://openalex.org/I143302722"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Theses and Dissertations--Physiology","raw_type":"text"},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://uknowledge.uky.edu/cgi/viewcontent.cgi?article=1009&context=physiology_etds","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082491541","display_name":"Gregory F. Corder","orcid":"https://orcid.org/0000-0003-0031-0773","observed_orcids":["https://orcid.org/0000-0003-0031-0773"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Gregory Corder","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0031-0773","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5082491541"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.207,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.57108497,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.003700000001117587,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mu-opioid-receptor","display_name":"mu-opioid receptor","score":0.9629999995231628},{"id":"https://openalex.org/keywords/constitutive-receptor-activity","display_name":"constitutive receptor activity","score":0.9559999704360962},{"id":"https://openalex.org/keywords/endogenous-analgesia","display_name":"endogenous analgesia","score":0.7749999761581421},{"id":"https://openalex.org/keywords/opioid-use-disorder","display_name":"opioid use disorder","score":0.9100000262260437},{"id":"https://openalex.org/keywords/chronic-pain","display_name":"chronic pain","score":0.8759999871253967},{"id":"https://openalex.org/keywords/pathological-pain","display_name":"pathological pain","score":0.6209999918937683},{"id":"https://openalex.org/keywords/spinal-cord-dorsal-horn","display_name":"dorsal horn","score":0.8130000233650208},{"id":"https://openalex.org/keywords/nmda-receptor","display_name":"NMDA receptor","score":0.9179999828338623},{"id":"https://openalex.org/keywords/calcium-signaling","display_name":"calcium signaling","score":0.5},{"id":"https://openalex.org/keywords/tissue-inflammation","display_name":"tissue inflammation","score":0.6809999942779541},{"id":"https://openalex.org/keywords/hyperalgesia","display_name":"hyperalgesia","score":0.8180000185966492},{"id":"https://openalex.org/keywords/opioid-withdrawal","display_name":"opioid withdrawal","score":0.5920000076293945},{"id":"https://openalex.org/keywords/acute-to-chronic-pain-transition","display_name":"acute to chronic pain transition","score":0.6819999814033508}],"concepts":[{"id":"https://openalex.org/C2781063702","wikidata":"https://www.wikidata.org/wiki/Q427523","display_name":"Opioid","level":3,"score":0.5656806826591492},{"id":"https://openalex.org/C3017995582","wikidata":"https://www.wikidata.org/wiki/Q417189","display_name":"Endogenous opioid","level":4,"score":0.5183244943618774},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.33617928624153137},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.283671498298645},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.11900827288627625}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:uknowledge.uky.edu:physiology_etds-1009","doi":null,"is_oa":true,"landing_page_url":"https://uknowledge.uky.edu/physiology_etds/10","pdf_url":"https://uknowledge.uky.edu/cgi/viewcontent.cgi?article=1009&context=physiology_etds","source":{"id":"https://openalex.org/S4306402623","display_name":"UKnowledge (University of Kentucky)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I143302722","host_organization_name":"University of Kentucky","host_organization_lineage":["https://openalex.org/I143302722"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Theses and Dissertations--Physiology","raw_type":"text"},{"id":"mag:154389137","doi":null,"is_oa":false,"landing_page_url":"https://uknowledge.uky.edu/cgi/viewcontent.cgi?article=1009&context=physiology_etds","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:uknowledge.uky.edu:physiology_etds-1009","doi":null,"is_oa":true,"landing_page_url":"https://uknowledge.uky.edu/physiology_etds/10","pdf_url":"https://uknowledge.uky.edu/cgi/viewcontent.cgi?article=1009&context=physiology_etds","source":{"id":"https://openalex.org/S4306402623","display_name":"UKnowledge (University of Kentucky)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I143302722","host_organization_name":"University of Kentucky","host_organization_lineage":["https://openalex.org/I143302722"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Theses and Dissertations--Physiology","raw_type":"text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W154389137.pdf","grobid_xml":"https://content.openalex.org/works/W154389137.grobid-xml"},"referenced_works_count":192,"referenced_works":["https://openalex.org/W117389605","https://openalex.org/W156060791","https://openalex.org/W207549754","https://openalex.org/W935051666","https://openalex.org/W1492294380","https://openalex.org/W1530030261","https://openalex.org/W1590321390","https://openalex.org/W1619516058","https://openalex.org/W1646063119","https://openalex.org/W1709837271","https://openalex.org/W1722020637","https://openalex.org/W1759725395","https://openalex.org/W1869612810","https://openalex.org/W1918820105","https://openalex.org/W1946662971","https://openalex.org/W1963501419","https://openalex.org/W1964191104","https://openalex.org/W1964516837","https://openalex.org/W1964916807","https://openalex.org/W1965066118","https://openalex.org/W1965693682","https://openalex.org/W1965866432","https://openalex.org/W1966101832","https://openalex.org/W1966351672","https://openalex.org/W1966563439","https://openalex.org/W1968107218","https://openalex.org/W1969138450","https://openalex.org/W1969845682","https://openalex.org/W1970854097","https://openalex.org/W1974057366","https://openalex.org/W1974364089","https://openalex.org/W1975399276","https://openalex.org/W1975695406","https://openalex.org/W1976201689","https://openalex.org/W1977919560","https://openalex.org/W1979691582","https://openalex.org/W1981291046","https://openalex.org/W1981891173","https://openalex.org/W1982326881","https://openalex.org/W1982922085","https://openalex.org/W1983628593","https://openalex.org/W1983682905","https://openalex.org/W1983753498","https://openalex.org/W1984930321","https://openalex.org/W1985688040","https://openalex.org/W1986687702","https://openalex.org/W1986726112","https://openalex.org/W1986741831","https://openalex.org/W1988116741","https://openalex.org/W1988165457","https://openalex.org/W1989416066","https://openalex.org/W1990512833","https://openalex.org/W1990691243","https://openalex.org/W1993444360","https://openalex.org/W1993970124","https://openalex.org/W1995796629","https://openalex.org/W1996971845","https://openalex.org/W1997185941","https://openalex.org/W2001271898","https://openalex.org/W2002747090","https://openalex.org/W2004343753","https://openalex.org/W2004551214","https://openalex.org/W2005703418","https://openalex.org/W2006586956","https://openalex.org/W2006767554","https://openalex.org/W2007028896","https://openalex.org/W2009182920","https://openalex.org/W2010103767","https://openalex.org/W2010271493","https://openalex.org/W2011244997","https://openalex.org/W2011645297","https://openalex.org/W2012199594","https://openalex.org/W2012659957","https://openalex.org/W2012855349","https://openalex.org/W2014408809","https://openalex.org/W2014779151","https://openalex.org/W2015207684","https://openalex.org/W2015592781","https://openalex.org/W2016315625","https://openalex.org/W2016671793","https://openalex.org/W2020348231","https://openalex.org/W2022957057","https://openalex.org/W2023724239","https://openalex.org/W2026168925","https://openalex.org/W2027449956","https://openalex.org/W2027623266","https://openalex.org/W2028351745","https://openalex.org/W2030751218","https://openalex.org/W2033001509","https://openalex.org/W2033059080","https://openalex.org/W2035229537","https://openalex.org/W2037468933","https://openalex.org/W2038905876","https://openalex.org/W2038990149","https://openalex.org/W2039043164","https://openalex.org/W2039539746","https://openalex.org/W2039891360","https://openalex.org/W2040642697","https://openalex.org/W2040742820","https://openalex.org/W2041018266","https://openalex.org/W2042032362","https://openalex.org/W2044496525","https://openalex.org/W2045965401","https://openalex.org/W2047615113","https://openalex.org/W2047866642","https://openalex.org/W2048166104","https://openalex.org/W2049153510","https://openalex.org/W2049275111","https://openalex.org/W2049356398","https://openalex.org/W2053855385","https://openalex.org/W2054484884","https://openalex.org/W2059792931","https://openalex.org/W2063056648","https://openalex.org/W2063223361","https://openalex.org/W2064765332","https://openalex.org/W2065151661","https://openalex.org/W2065229769","https://openalex.org/W2066753814","https://openalex.org/W2067924690","https://openalex.org/W2068007833","https://openalex.org/W2070034006","https://openalex.org/W2070357349","https://openalex.org/W2070466512","https://openalex.org/W2070479232","https://openalex.org/W2071587854","https://openalex.org/W2071801806","https://openalex.org/W2074728653","https://openalex.org/W2075147858","https://openalex.org/W2075715972","https://openalex.org/W2076843003","https://openalex.org/W2077358692","https://openalex.org/W2078972659","https://openalex.org/W2080495978","https://openalex.org/W2081577163","https://openalex.org/W2081608455","https://openalex.org/W2083698627","https://openalex.org/W2083910964","https://openalex.org/W2084455886","https://openalex.org/W2084487340","https://openalex.org/W2085973610","https://openalex.org/W2087135060","https://openalex.org/W2088104404","https://openalex.org/W2088366788","https://openalex.org/W2090521351","https://openalex.org/W2093187769","https://openalex.org/W2094713497","https://openalex.org/W2097088407","https://openalex.org/W2101762698","https://openalex.org/W2108114952","https://openalex.org/W2109568827","https://openalex.org/W2109991720","https://openalex.org/W2110133277","https://openalex.org/W2110645568","https://openalex.org/W2114214434","https://openalex.org/W2116430856","https://openalex.org/W2119970606","https://openalex.org/W2121899752","https://openalex.org/W2122778405","https://openalex.org/W2129360860","https://openalex.org/W2132829674","https://openalex.org/W2135934730","https://openalex.org/W2137138688","https://openalex.org/W2137853291","https://openalex.org/W2138512124","https://openalex.org/W2139129258","https://openalex.org/W2139833086","https://openalex.org/W2142977624","https://openalex.org/W2143387733","https://openalex.org/W2145947130","https://openalex.org/W2147165853","https://openalex.org/W2148300669","https://openalex.org/W2148636523","https://openalex.org/W2149290144","https://openalex.org/W2151517894","https://openalex.org/W2153323638","https://openalex.org/W2153722042","https://openalex.org/W2155524482","https://openalex.org/W2158056917","https://openalex.org/W2165542532","https://openalex.org/W2166367851","https://openalex.org/W2214956132","https://openalex.org/W2257171576","https://openalex.org/W2263212457","https://openalex.org/W2272624151","https://openalex.org/W2273924248","https://openalex.org/W2314614866","https://openalex.org/W2326190919","https://openalex.org/W2403431457","https://openalex.org/W2416302782","https://openalex.org/W2417383763","https://openalex.org/W2421680897","https://openalex.org/W4322703287"],"related_works":["https://openalex.org/W1973966533","https://openalex.org/W6999439822","https://openalex.org/W96392281","https://openalex.org/W2087610059","https://openalex.org/W3159889134","https://openalex.org/W2160567108","https://openalex.org/W2975893901","https://openalex.org/W7167595289","https://openalex.org/W7159820016","https://openalex.org/W3172632867"],"abstract_inverted_index":{"Injury":[0],"causes":[1],"increased":[2],"pain":[3,18,39,60,89,127,139,180,196],"sensation":[4],"in":[5,22,91,104,182,203],"humans":[6],"and":[7,124,140,144,209],"animals":[8],"but":[9,61],"the":[10,13,23,33,62,76,79,92,105,109,174,192],"mechanisms":[11,81],"underlying":[12],"emergence":[14],"of":[15,25,36,41,52,64,82,88,108,130,147,156,168,194,206,212],"persistent":[16],"pathological":[17,86],"states,":[19],"which":[20,112],"arise":[21],"absence":[24],"on-going":[26],"physical":[27,148,185],"damage,":[28],"are":[29],"unclear.":[30],"Therefore,":[31],"elucidating":[32],"physiological":[34],"regulation":[35],"such":[37],"intractable":[38],"is":[40,46],"exceptional":[42],"biomedical":[43],"importance.":[44],"It":[45],"well":[47],"known":[48],"that":[49,78,97,172,191],"endogenous":[50,66,213],"activation":[51,155],"\u00b5-opioid":[53],"receptors":[54],"(MORs)":[55],"provides":[56],"relief":[57],"from":[58,122,176,200],"acute":[59,177],"consequences":[63],"prolonged":[65],"opioidergic":[67],"signaling":[68,84,103,205],"have":[69],"not":[70],"been":[71],"considered.":[72],"Here":[73],"we":[74,163,189],"test":[75],"hypothesis":[77],"intrinsic":[80],"MOR":[83,102,135],"promote":[85],"sensitization":[87],"circuits":[90],"spinal":[93,110,207],"cord.":[94],"We":[95],"found":[96],"tissue":[98],"inflammation":[99],"produces":[100],"agonist-independent":[101],"dorsal":[106],"horn":[107],"cord,":[111],"tonically":[113],"represses":[114],"hyperalgesia":[115],"for":[116],"months,":[117],"even":[118],"after":[119],"complete":[120],"recovery":[121],"injury":[123],"re-established":[125],"normal":[126],"thresholds.":[128],"Disruption":[129],"this":[131],"constitutive":[132,204],"activity":[133],"with":[134],"inverse":[136],"agonists":[137],"reinstated":[138],"precipitated":[141],"cellular,":[142],"somatic":[143],"aversive":[145],"signs":[146],"withdrawal.":[149],"This":[150],"phenomenon":[151],"required":[152],"N-methyl-D-aspartate":[153],"receptor":[154],"calcium-sensitive":[157],"adenylyl":[158],"cyclase":[159],"type":[160],"1.":[161],"Thus,":[162],"present":[164],"a":[165,201,210],"novel":[166],"mechanism":[167],"long-lasting":[169],"opioid":[170],"analgesia":[171],"regulates":[173],"transition":[175],"to":[178],"chronic":[179,195],"while,":[181],"parallel,":[183],"generates":[184],"dependence.":[186],"In":[187],"conclusion":[188],"propose":[190],"prevalence":[193],"syndromes":[197],"may":[198],"result":[199],"failure":[202],"MORs":[208],"loss":[211],"analgesic":[214],"control.":[215]},"counts_by_year":[{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
