{"id":"https://openalex.org/W1543890258","doi":"https://doi.org/10.1186/1742-4690-3-s1-s63","title":"HIV interactions with herpes viruses in human lyphoid tissues","display_name":"HIV interactions with herpes viruses in human lyphoid tissues","publication_year":2006,"publication_date":"2006-12-01","ids":{"openalex":"https://openalex.org/W1543890258","doi":"https://doi.org/10.1186/1742-4690-3-s1-s63","mag":"1543890258"},"language":"en","primary_location":{"id":"doi:10.1186/1742-4690-3-s1-s63","doi":"https://doi.org/10.1186/1742-4690-3-s1-s63","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1742-4690-3-s1-s63","pdf_url":"https://retrovirology.biomedcentral.com/counter/pdf/10.1186/1742-4690-3-S1-S63","source":{"id":"https://openalex.org/S54115554","display_name":"Retrovirology","issn_l":"1742-4690","issn":["1742-4690"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Retrovirology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://retrovirology.biomedcentral.com/counter/pdf/10.1186/1742-4690-3-S1-S63","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053982479","display_name":"Leonid B Margolis","orcid":"https://orcid.org/0000-0002-1960-1928","observed_orcids":["https://orcid.org/0000-0002-1960-1928"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210144228","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210144228"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Leonid Margolis","raw_affiliation_strings":["National Institute of Child Health and Human Development, Bethesda, Maryland, 20892, USA","National Institute of Child Health and Human Development, Bethesda, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute of Child Health and Human Development, Bethesda, Maryland, 20892, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210144228"]},{"raw_affiliation_string":"National Institute of Child Health and Human Development, Bethesda, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210144228"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5053982479"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210144228"],"apc_list":{"value":2890,"currency":"USD","value_usd":2890},"apc_paid":{"value":2890,"currency":"USD","value_usd":2890},"fwci":0.0,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.05478036,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"3","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10981","display_name":"Cytomegalovirus and herpesvirus research","score":0.005499999970197678,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10625","display_name":"Herpesvirus Infections and Treatments","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-1","display_name":"HIV-1","score":0.968999981880188},{"id":"https://openalex.org/keywords/human-herpesviruses","display_name":"human herpesviruses","score":0.8270000219345093},{"id":"https://openalex.org/keywords/r5-tropic-hiv-1","display_name":"R5-tropic HIV-1","score":0.640999972820282},{"id":"https://openalex.org/keywords/x4-hiv-1","display_name":"X4 HIV-1","score":0.9900000095367432},{"id":"https://openalex.org/keywords/human-herpesvirus-6","display_name":"human herpesvirus 6","score":0.9440000057220459},{"id":"https://openalex.org/keywords/human-herpesvirus-7","display_name":"human herpesvirus 7","score":1.0},{"id":"https://openalex.org/keywords/cytomegalovirus","display_name":"cytomegalovirus","score":0.9449999928474426},{"id":"https://openalex.org/keywords/cd4-down-modulation","display_name":"CD4 down-modulation","score":0.7739999890327454},{"id":"https://openalex.org/keywords/ccl5","display_name":"RANTES","score":0.921999990940094},{"id":"https://openalex.org/keywords/chemokine-network","display_name":"chemokine network","score":0.6000000238418579},{"id":"https://openalex.org/keywords/escape-mutants","display_name":"escape mutants","score":0.6600000262260437},{"id":"https://openalex.org/keywords/simian-immunodeficiency-virus","display_name":"simian immunodeficiency virus","score":0.6299999952316284},{"id":"https://openalex.org/keywords/macaque","display_name":"macaque","score":0.7620000243186951},{"id":"https://openalex.org/keywords/lymphoid-tissue","display_name":"lymphoid tissue","score":0.7329999804496765},{"id":"https://openalex.org/keywords/viral-coevolution","display_name":"viral coevolution","score":0.5289999842643738}],"concepts":[{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.6696212291717529},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.666896641254425},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.6623753309249878},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.6341466903686523},{"id":"https://openalex.org/C12823836","wikidata":"https://www.wikidata.org/wiki/Q24720618","display_name":"Chemokine receptor","level":4,"score":0.5812165141105652},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.5789903402328491},{"id":"https://openalex.org/C2777399126","wikidata":"https://www.wikidata.org/wiki/Q6974","display_name":"Human herpesvirus 6","level":5,"score":0.5566907525062561},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.44746384024620056},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.3962481915950775},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.3669363856315613},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.19928321242332458},{"id":"https://openalex.org/C2776409557","wikidata":"https://www.wikidata.org/wiki/Q149348","display_name":"Herpesviridae","level":4,"score":0.19350403547286987},{"id":"https://openalex.org/C2780727368","wikidata":"https://www.wikidata.org/wiki/Q1928978","display_name":"Viral disease","level":3,"score":0.17450103163719177},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.17254093289375305},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.17065519094467163}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1186/1742-4690-3-s1-s63","doi":"https://doi.org/10.1186/1742-4690-3-s1-s63","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1742-4690-3-s1-s63","pdf_url":"https://retrovirology.biomedcentral.com/counter/pdf/10.1186/1742-4690-3-S1-S63","source":{"id":"https://openalex.org/S54115554","display_name":"Retrovirology","issn_l":"1742-4690","issn":["1742-4690"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Retrovirology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:410797","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC1716975","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:1716975","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1716975","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Retrovirology","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:e735d1a385404fad9237b4cd81bcd926","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/e735d1a385404fad9237b4cd81bcd926","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Retrovirology, Vol 3, Iss Suppl 1, p S63 (2006)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/1742-4690-3-s1-s63","doi":"https://doi.org/10.1186/1742-4690-3-s1-s63","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1742-4690-3-s1-s63","pdf_url":"https://retrovirology.biomedcentral.com/counter/pdf/10.1186/1742-4690-3-S1-S63","source":{"id":"https://openalex.org/S54115554","display_name":"Retrovirology","issn_l":"1742-4690","issn":["1742-4690"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Retrovirology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1543890258.pdf","grobid_xml":"https://content.openalex.org/works/W1543890258.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2106015647","https://openalex.org/W2333984830","https://openalex.org/W2115075300","https://openalex.org/W2113272638","https://openalex.org/W1488584052","https://openalex.org/W7100383537","https://openalex.org/W2075129014","https://openalex.org/W2058340882","https://openalex.org/W69092265","https://openalex.org/W1992435886"],"abstract_inverted_index":{"Critical":[0],"events":[1],"in":[2,6,16,37,91,157,221],"HIV":[3,168,187,193,217,229],"disease":[4,194],"occur":[5],"lymphoid":[7,39,160],"tissues":[8,40,223],"that":[9,55,164,214],"are":[10,116,120],"often":[11],"coinfected":[12,41,92,108,158,222],"with":[13,18,44,109,155,218],"other":[14,219],"pathogens,":[15],"particular":[17,201],"herpesviruses,":[19],"which":[20],"may":[21,238],"affect":[22,134,189],"HIV.":[23],"Here,":[24],"we":[25],"investigated":[26,72],"infection":[27,131],"by":[28,87,101,195],"and":[29,33,51,58,71,111,146,170,176,186],"evolution":[30],"of":[31,75,81,89,104,137,144,167,192,199,216,228,232,235,244],"R5":[32,62],"X4":[34,65],"HIV-1":[35,84,100,130,150,156,198],"variants":[36],"human":[38,45,152,159],"ex":[42],"vivo":[43],"herpesviruses":[46,153,185],"(HHV)":[47],"including":[48],"HHV-6,":[49],"HHV-7":[50,59,82,147],"HCMV.":[52],"We":[53],"found":[54],"both":[56],"HHV-6":[57,95,110,138],"selectively":[60],"suppress":[61],"replication,":[63],"favoring":[64],"emergence":[66],"as":[67,203,205],"the":[68,73,135,142,173,179,190,226,233,242],"dominant":[69],"phenotype,":[70],"mechanisms":[74,163,234],"these":[76],"phenomena.":[77],"The":[78],"selective":[79],"pressure":[80],"on":[83,99,127,149],"is":[85],"mediated":[86],"down-modulation":[88],"CD4":[90],"tissues,":[93],"whereas":[94],"mediates":[96],"its":[97],"effect":[98],"dramatic":[102],"upregulation":[103],"RANTES.":[105],"In":[106],"macaques":[107],"SIV,":[112],"HHV-6-resistant":[113],"escape":[114,207],"mutants":[115,119],"selected.":[117],"These":[118,209],"resistant":[121],"to":[122,241],"RANTES,":[123],"or":[124],"even":[125],"dependent":[126],"this":[128,236],"chemokine.":[129],"does":[132],"not":[133],"replication":[136,143],"but":[139],"significantly":[140,239],"changes":[141],"CMV":[145],"depending":[148],"phenotype.\r\n\r\nThus,":[151],"interact":[154],"tissue":[161],"via":[162],"include":[165],"modulation":[166],"receptors":[169],"coreceptors,":[171],"changing":[172],"cytokine/chemokine":[174],"network,":[175],"competing":[177],"for":[178,197,206],"same":[180],"cell":[181],"targets.":[182],"Interactions":[183],"between":[184],"might":[188],"course":[191],"selecting":[196],"a":[200],"phenotype":[202],"well":[204],"mutants.":[208],"findings":[210],"support":[211],"our":[212],"hypothesis":[213],"interaction":[215],"microbes":[220],"can":[224],"determine":[225],"pattern":[227],"infection.":[230],"Decipherment":[231],"phenomenon":[237],"contribute":[240],"development":[243],"efficient":[245],"anti-HIV":[246],"therapies.":[247]},"counts_by_year":[{"year":2019,"cited_by_count":1}],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2016-06-24T00:00:00"}