{"id":"https://openalex.org/W1543801042","doi":null,"title":"V\u00eda de se\u00f1alizaci\u00f3n del receptor apopt\u00f3tico Fas en la adicci\u00f3n a opi\u00e1ceos, La","display_name":"V\u00eda de se\u00f1alizaci\u00f3n del receptor apopt\u00f3tico Fas en la adicci\u00f3n a opi\u00e1ceos, La","publication_year":2005,"publication_date":"2005-10-07","ids":{"openalex":"https://openalex.org/W1543801042","mag":"1543801042"},"language":"es","primary_location":{"id":"pmh:oai:diposit.ub.edu:2445/36146","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10803/984","pdf_url":"http://hdl.handle.net/2445/36146","source":{"id":"https://openalex.org/S4306401653","display_name":"Dip\u00f2sit Digital de la Universitat de Barcelona (Universitat de Barcelona)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I71999127","host_organization_name":"Universitat de Barcelona","host_organization_lineage":["https://openalex.org/I71999127"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Tesis Doctorals - Departament - Bioqu\u00edmica i Biologia Molecular (Biologia)","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/2445/36146","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077320673","display_name":"Garc\u00eda Fuster","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Garc\u00eda Fuster","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5110410594","display_name":"Marta Juli\u00e0","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marta Juli\u00e0","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.4666000008583069,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.4666000008583069,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.4293999969959259,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10576","display_name":"Opioid Use Disorder Treatment","score":0.02850000001490116,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/opioid-use-disorder","display_name":"opioid use disorder","score":0.734000027179718},{"id":"https://openalex.org/keywords/fas","display_name":"Fas","score":0.8640000224113464},{"id":"https://openalex.org/keywords/fadd","display_name":"FADD","score":0.8880000114440918},{"id":"https://openalex.org/keywords/caspases","display_name":"caspases","score":0.8669999837875366},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.7300000190734863},{"id":"https://openalex.org/keywords/mu-opioid-receptor","display_name":"mu-opioid receptor","score":0.8700000047683716},{"id":"https://openalex.org/keywords/delta-opioid-receptor","display_name":"delta opioid receptor","score":0.9620000123977661},{"id":"https://openalex.org/keywords/kappa-opioid-receptor","display_name":"kappa opioid receptor","score":1.0},{"id":"https://openalex.org/keywords/opioid-tolerance-and-dependence","display_name":"opioid tolerance and dependence","score":0.6850000023841858},{"id":"https://openalex.org/keywords/opioid-withdrawal","display_name":"opioid withdrawal","score":0.859000027179718},{"id":"https://openalex.org/keywords/mek1-2-inhibition","display_name":"MEK1/2 inhibition","score":0.8450000286102295},{"id":"https://openalex.org/keywords/erk-signaling","display_name":"ERK signaling","score":0.8980000019073486},{"id":"https://openalex.org/keywords/creb","display_name":"CREB","score":0.7940000295639038},{"id":"https://openalex.org/keywords/prefrontal-cortex","display_name":"prefrontal cortex","score":0.8669999837875366},{"id":"https://openalex.org/keywords/postmortem-brain","display_name":"postmortem brain","score":0.7129999995231628}],"concepts":[{"id":"https://openalex.org/C2776055636","wikidata":"https://www.wikidata.org/wiki/Q14907137","display_name":"FADD","level":5,"score":0.8826410174369812},{"id":"https://openalex.org/C3031857","wikidata":"https://www.wikidata.org/wiki/Q1649375","display_name":"Fas receptor","level":4,"score":0.5699975490570068},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5631142854690552},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5476197600364685},{"id":"https://openalex.org/C2779004061","wikidata":"https://www.wikidata.org/wiki/Q5247322","display_name":"Death domain","level":4,"score":0.4577021598815918},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.43634453415870667},{"id":"https://openalex.org/C98424977","wikidata":"https://www.wikidata.org/wiki/Q25805","display_name":"Caspase","level":4,"score":0.4299173355102539},{"id":"https://openalex.org/C66008609","wikidata":"https://www.wikidata.org/wiki/Q14866113","display_name":"Fas ligand","level":4,"score":0.4258691668510437},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4170264005661011},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35102009773254395},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.29878342151641846},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.24749919772148132},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15551093220710754}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:diposit.ub.edu:2445/36146","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10803/984","pdf_url":"http://hdl.handle.net/2445/36146","source":{"id":"https://openalex.org/S4306401653","display_name":"Dip\u00f2sit Digital de la Universitat de Barcelona (Universitat de Barcelona)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I71999127","host_organization_name":"Universitat de Barcelona","host_organization_lineage":["https://openalex.org/I71999127"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Tesis Doctorals - Departament - Bioqu\u00edmica i Biologia Molecular (Biologia)","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"pmh:oai:dnet:tdr_________::41ee1a0846e8830f9f9ca8e70dc6f423","doi":null,"is_oa":true,"landing_page_url":"http://www.tdx.cat/TDX-0117106-113815","pdf_url":"http://www.tdx.cat/TDX-0117106-113815","source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"TDX (Tesis Doctorals en Xarxa)","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"pmh:oai:www.tdx.cat:10803/984","doi":null,"is_oa":true,"landing_page_url":"http://www.tdx.cat/TDX-0117106-113815","pdf_url":"http://hdl.handle.net/10803/984","source":{"id":"https://openalex.org/S4306401111","display_name":"Tesis Doctorals en Xarxa (Consorci de Serveis Universitaris de Catalunya)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210090028","host_organization_name":"Consorci de Serveis Universitaris de Catalunya","host_organization_lineage":["https://openalex.org/I4210090028"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"TDX (Tesis Doctorals en Xarxa)","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:1543801042","doi":null,"is_oa":false,"landing_page_url":"http://diposit.ub.edu/dspace/bitstream/2445/36146/1/TESIS_Julia_Garcia_Fuster.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S4306531624","display_name":"TDX (Tesis Doctorals en Xarxa)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"TDX (Tesis Doctorals en Xarxa)","raw_type":null}],"best_oa_location":{"id":"pmh:oai:diposit.ub.edu:2445/36146","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10803/984","pdf_url":"http://hdl.handle.net/2445/36146","source":{"id":"https://openalex.org/S4306401653","display_name":"Dip\u00f2sit Digital de la Universitat de Barcelona (Universitat de Barcelona)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I71999127","host_organization_name":"Universitat de Barcelona","host_organization_lineage":["https://openalex.org/I71999127"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Tesis Doctorals - Departament - Bioqu\u00edmica i Biologia Molecular (Biologia)","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8371999859809875}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8888648735","display_name":"RegulationofNeurofilament Proteins Through Mitogen-Activated Protein Kinase Cascade in Opioid Addiction.","funder_award_id":"57066","funder_id":"https://openalex.org/F4320320924","funder_display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung"}],"funders":[{"id":"https://openalex.org/F4320320924","display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","ror":"https://ror.org/00yjd3n13"},{"id":"https://openalex.org/F4320321764","display_name":"Ministerio de Educaci\u00f3n, Cultura y Deporte","ror":"https://ror.org/03nc27g21"},{"id":"https://openalex.org/F4320321837","display_name":"Ministerio de Econom\u00eda y Competitividad","ror":"https://ror.org/034900433"},{"id":"https://openalex.org/F4320326634","display_name":"Institut d'Estudis Catalans","ror":"https://ror.org/04b27tr16"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1543801042.pdf","grobid_xml":"https://content.openalex.org/works/W1543801042.grobid-xml"},"referenced_works_count":202,"referenced_works":["https://openalex.org/W137308408","https://openalex.org/W1484896659","https://openalex.org/W1490481380","https://openalex.org/W1494856442","https://openalex.org/W1495996409","https://openalex.org/W1497432777","https://openalex.org/W1505495051","https://openalex.org/W1530982587","https://openalex.org/W1531431930","https://openalex.org/W1534583164","https://openalex.org/W1535722786","https://openalex.org/W1540436551","https://openalex.org/W1558473055","https://openalex.org/W1565566868","https://openalex.org/W1570717867","https://openalex.org/W1574633507","https://openalex.org/W1607902351","https://openalex.org/W1642763135","https://openalex.org/W1646063119","https://openalex.org/W1661967651","https://openalex.org/W1671694443","https://openalex.org/W1737683501","https://openalex.org/W1775749144","https://openalex.org/W1794170884","https://openalex.org/W1836073275","https://openalex.org/W1851307228","https://openalex.org/W1860841401","https://openalex.org/W1880073789","https://openalex.org/W1909195053","https://openalex.org/W1909273809","https://openalex.org/W1934898652","https://openalex.org/W1942214720","https://openalex.org/W1961046454","https://openalex.org/W1961715910","https://openalex.org/W1962507920","https://openalex.org/W1964617786","https://openalex.org/W1966539065","https://openalex.org/W1967318257","https://openalex.org/W1967493826","https://openalex.org/W1968901954","https://openalex.org/W1970807381","https://openalex.org/W1971860637","https://openalex.org/W1973792489","https://openalex.org/W1974999182","https://openalex.org/W1975513971","https://openalex.org/W1976226379","https://openalex.org/W1976637929","https://openalex.org/W1978992470","https://openalex.org/W1981404696","https://openalex.org/W1981891173","https://openalex.org/W1984633191","https://openalex.org/W1987675396","https://openalex.org/W1988925814","https://openalex.org/W1990065094","https://openalex.org/W1990996190","https://openalex.org/W1991915145","https://openalex.org/W1992361007","https://openalex.org/W1992768650","https://openalex.org/W1993258945","https://openalex.org/W1993756643","https://openalex.org/W1993902481","https://openalex.org/W1994672187","https://openalex.org/W1995651798","https://openalex.org/W1997350849","https://openalex.org/W1997802449","https://openalex.org/W1998602106","https://openalex.org/W2000514139","https://openalex.org/W2002673255","https://openalex.org/W2004150120","https://openalex.org/W2004992894","https://openalex.org/W2007611402","https://openalex.org/W2008439876","https://openalex.org/W2010489503","https://openalex.org/W2011843754","https://openalex.org/W2012173926","https://openalex.org/W2013350164","https://openalex.org/W2016198585","https://openalex.org/W2017092598","https://openalex.org/W2019607920","https://openalex.org/W2020337294","https://openalex.org/W2021259746","https://openalex.org/W2023079553","https://openalex.org/W2023735231","https://openalex.org/W2025128734","https://openalex.org/W2025267218","https://openalex.org/W2027105757","https://openalex.org/W2031133522","https://openalex.org/W2031665124","https://openalex.org/W2032425419","https://openalex.org/W2033260606","https://openalex.org/W2033447249","https://openalex.org/W2033785744","https://openalex.org/W2034265562","https://openalex.org/W2034475021","https://openalex.org/W2035936653","https://openalex.org/W2041466047","https://openalex.org/W2041627937","https://openalex.org/W2042838999","https://openalex.org/W2044479377","https://openalex.org/W2045112376","https://openalex.org/W2047229615","https://openalex.org/W2048595114","https://openalex.org/W2048658872","https://openalex.org/W2049277966","https://openalex.org/W2049796382","https://openalex.org/W2051614379","https://openalex.org/W2051746492","https://openalex.org/W2052116338","https://openalex.org/W2052853635","https://openalex.org/W2053763819","https://openalex.org/W2053870616","https://openalex.org/W2054370211","https://openalex.org/W2056066002","https://openalex.org/W2057257609","https://openalex.org/W2057518805","https://openalex.org/W2057694016","https://openalex.org/W2058905596","https://openalex.org/W2061497413","https://openalex.org/W2062853648","https://openalex.org/W2063010307","https://openalex.org/W2063495408","https://openalex.org/W2063968553","https://openalex.org/W2066427004","https://openalex.org/W2067441158","https://openalex.org/W2067477282","https://openalex.org/W2071142713","https://openalex.org/W2074815848","https://openalex.org/W2075811628","https://openalex.org/W2077129682","https://openalex.org/W2078245438","https://openalex.org/W2079688483","https://openalex.org/W2080815758","https://openalex.org/W2082013220","https://openalex.org/W2083909523","https://openalex.org/W2086139880","https://openalex.org/W2086217382","https://openalex.org/W2087339935","https://openalex.org/W2088359192","https://openalex.org/W2089555312","https://openalex.org/W2090181211","https://openalex.org/W2091055258","https://openalex.org/W2092061953","https://openalex.org/W2093472094","https://openalex.org/W2093628776","https://openalex.org/W2093685285","https://openalex.org/W2093888902","https://openalex.org/W2094093890","https://openalex.org/W2100837269","https://openalex.org/W2101108802","https://openalex.org/W2101685247","https://openalex.org/W2102870521","https://openalex.org/W2104690453","https://openalex.org/W2105080299","https://openalex.org/W2109994778","https://openalex.org/W2110636497","https://openalex.org/W2117862683","https://openalex.org/W2118977349","https://openalex.org/W2119171367","https://openalex.org/W2119682716","https://openalex.org/W2119800239","https://openalex.org/W2120057014","https://openalex.org/W2121802881","https://openalex.org/W2122530393","https://openalex.org/W2125834587","https://openalex.org/W2127993518","https://openalex.org/W2128635872","https://openalex.org/W2129228558","https://openalex.org/W2130135920","https://openalex.org/W2130866079","https://openalex.org/W2133958296","https://openalex.org/W2134872883","https://openalex.org/W2134878535","https://openalex.org/W2136108338","https://openalex.org/W2136637141","https://openalex.org/W2137577469","https://openalex.org/W2137871903","https://openalex.org/W2139606807","https://openalex.org/W2144475886","https://openalex.org/W2144701362","https://openalex.org/W2145626047","https://openalex.org/W2146702633","https://openalex.org/W2151477904","https://openalex.org/W2152646879","https://openalex.org/W2154458783","https://openalex.org/W2154745705","https://openalex.org/W2157230982","https://openalex.org/W2157935840","https://openalex.org/W2160112211","https://openalex.org/W2163037006","https://openalex.org/W2165005697","https://openalex.org/W2165590312","https://openalex.org/W2165721689","https://openalex.org/W2166320770","https://openalex.org/W2170807563","https://openalex.org/W2172734677","https://openalex.org/W2268369589","https://openalex.org/W2289465026","https://openalex.org/W2323356395","https://openalex.org/W2399045151","https://openalex.org/W2436697492","https://openalex.org/W4313341495","https://openalex.org/W4406054880"],"related_works":["https://openalex.org/W7048523431","https://openalex.org/W2030135315","https://openalex.org/W2017338360","https://openalex.org/W1964237484","https://openalex.org/W7020768775","https://openalex.org/W1994476517","https://openalex.org/W1605581154","https://openalex.org/W1993669757","https://openalex.org/W1973835509","https://openalex.org/W2406685735"],"abstract_inverted_index":{"Los":[0,233],"objetivos":[1],"principales":[2,234],"de":[3,15,30,33,40,46,48,51,59,65,74,80,95,103,128,134,141,159,169,180,183,189,197,208,216,227,239,242,253,269,274,277,296,307,317,331,340,346,360,363,379,388,392,395,401,413,433,461,468,472,478,501,504,507,522,525,530,533,540,542,554,573,576,585,590,601],"esta":[4,104,312,364,469,555],"Tesis":[5,243,556],"doctoral":[6,244],"fueron:":[7],"1)":[8],"cuantificar":[9,162],"los":[10,24,28,142,178,294,361,502,552,571,591],"efectos":[11,596],"agudos":[12],"y":[13,20,35,54,88,173,188,236,266,288,328,442,455,515,517,532],"cr\u00f3nicos":[14],"f\u00e1rmacos":[16,120,300],"opi\u00e1ceos":[17,121,250,322,421,486],"(mi-,":[18,86],"delta-":[19,87],"kappa-selectivos)":[21],"as\u00ed":[22,176,343],"como":[23,152,177,201,344,575],"cambios":[25],"inducidos":[26],"durante":[27],"estados":[29],"abstinencia":[31],"(procesos":[32],"tolerancia":[34,574],"dependencia)":[36],"sobre":[37],"la":[38,70,78,92,112,126,132,170,181,194,209,260,270,275,305,329,341,345,393,411,431,436,505,523,538,558,565,588],"v\u00eda":[39,105,171,182,365,400,506,524],"se\u00f1alizaci\u00f3n":[41,75,184,402,508,589],"del":[42,72,114,185,262,325,452,509,561],"receptor":[43,66,263,326,352,453],"Fas":[44,116,265,318,454,473],"(formas":[45,528],"expresi\u00f3n":[47],"Fas,":[49],"prote\u00edna":[50,271,470],"acople":[52],"FADD":[53,118,347,380,434],"caspasas":[55,174,285,457],"efectoras)":[56],"en":[57,69,83,106,149,157,163,193,211,251,259,337,422,430,435,474,487,545,564,570],"cerebro":[58,158,164,252,423,488],"rata;":[60,160],"2)":[61],"identificar":[62],"el":[63,107,167,338,351,367],"tipo":[64],"opioide":[67,98,137,369],"involucrado":[68],"modulaci\u00f3n":[71,113,316,358,377],"complejo":[73,115,562],"Fas/FADD":[76,172,563],"mediante":[77,220],"utilizaci\u00f3n":[79],"ratones":[81],"deficientes":[82],"receptores":[84,592],"opioides":[85],"kappa-KO),":[89],"e":[90],"investigar":[91],"posible":[93],"existencia":[94],"un":[96,135,389,582],"tono":[97],"end\u00f3geno":[99],"regulando":[100],"las":[101,190,284,396,449,526],"prote\u00ednas":[102,215],"cerebro;":[108],"3)":[109],"averiguar":[110],"si":[111],"y/o":[117],"por":[119,311,321,366,381],"implica":[122],"(como":[123],"mecanismo":[124,390],"molecular)":[125],"participaci\u00f3n":[127,560],"MAPK":[129,191,398,527],"ERK1/2,":[130,399],"analizando":[131],"reversi\u00f3n":[133],"efecto":[136],"tras":[138],"inhibici\u00f3n":[139,521],"selectiva":[140],"enzimas":[143],"MEK1/2,":[144],"tanto":[145,569],"\"in":[146,153],"vitro\"":[147],"(PD98059)":[148],"c\u00e9lulas":[150],"SH-SY5Y,":[151],"vivo\"":[154],"(SL":[155],"327)":[156],"4)":[161],"humano":[165,424,477,489],"\"postmortem\"":[166],"estatus":[168],"efectoras,":[175,458],"componentes":[179,362,503],"AMPc":[186,510],"(AC/PKA/CREB)":[187],"(Ras/Raf/MEK/ERK)":[192],"corteza":[195,437],"prefrontal":[196,438],"adictos":[198],"a":[199,249,298,386,404,420,440,480,485,491,567,587],"opi\u00e1ceos,":[200,568],"modelo":[202,476],"experimental":[203],"m\u00e1s":[204],"directo":[205],"al":[206],"problema":[207],"adicci\u00f3n":[210,248,297,419,479,484,566],"humanos.":[212,548],"Las":[213],"diversas":[214,450],"estudio":[217],"se":[218,255,282,348,407,425,447,495],"cuantificaron":[219],"t\u00e9cnicas":[221],"inmunol\u00f3gicas":[222],"cuantitativas":[223],"(separaci\u00f3n":[224],"electrofor\u00e9tica":[225],"seguida":[226],"Western":[228],"blot)":[229],"empleando":[230],"anticuerpos":[231],"espec\u00edficos.":[232],"resultados":[235,553],"conclusiones":[237],"mayores":[238],"este":[240,475],"trabajo":[241],"son:":[245],"1.":[246],"La":[247,315,376,418,483],"rata":[254],"asocia":[256,349,426,496],"con":[257,267,304,350,410,427,497,518,599],"incrementos":[258],"densidad":[261,432],"apopt\u00f3tico":[264],"decrementos":[268],"FADD,":[272],"transductora":[273],"se\u00f1al":[276],"muerte,":[278],"sin":[279,445],"que":[280,291,293,355,370,403,446,460,536,580],"adem\u00e1s":[281],"alteren":[283,448],"efectoras":[286],"8":[287],"3,":[289],"lo":[290,354,459,535,579],"sugiere":[292,537],"procesos":[295,572],"estos":[299,546],"no":[301],"est\u00e1n":[302],"asociados":[303],"inducci\u00f3n":[306,539],"apoptosis":[308],"cerebral":[309],"mediados":[310],"v\u00eda.":[313],"2.":[314],"(receptor":[319],"nativo)":[320],"depende":[323],"mayormente":[324],"mi-opioide,":[327],"regulaci\u00f3n":[330,412],"sus":[332],"formas":[333,451],"agregadas":[334],"(tr\u00edmeros":[335],"relevantes":[336],"inicio":[339],"se\u00f1alizaci\u00f3n)":[342],"delta-opioide,":[353],"demuestra":[356,463],"una":[357,428,464,498,519],"diferencial":[359],"sistema":[368],"podr\u00eda":[371],"tener":[372],"repercusiones":[373],"terap\u00e9uticas.":[374],"3.":[375],"inhibitoria":[378],"agonistas":[382],"delta-opi\u00e1ceos":[383],"es":[384],"dependiente,":[385],"trav\u00e9s":[387],"indirecto,":[391],"activaci\u00f3n":[394],"quinasas":[397],"su":[405,550],"vez":[406],"ha":[408],"relacionado":[409],"varios":[414],"mecanismos":[415],"anti-apopt\u00f3ticos.":[416],"4.":[417],"disminuci\u00f3n":[429],"(efectos":[439,490],"corto":[441],"largo":[443,492],"plazo)":[444,493],"ciertas":[456],"nuevo":[462,583],"probable":[465],"menor":[466],"actividad":[467],"acopladora":[471],"opi\u00e1ceos.":[481],"5.":[482],"tambi\u00e9n":[494],"aparente":[499],"normalizaci\u00f3n":[500],"(AC":[511],"I,":[512],"PKA,":[513],"CREB":[514],"pCREB)":[516],"marcada":[520],"fosforiladas":[529],"MEK":[531],"ERK1/2),":[534],"alteraciones":[541],"plasticidad":[543,602],"neuronal":[544],"cerebros":[547],"En":[549],"conjunto,":[551],"demuestran":[557],"clara":[559],"dependencia":[577],"f\u00edsica,":[578],"a\u00f1ade":[581],"nivel":[584],"complejidad":[586],"opioides,":[593],"probablemente":[594],"mediatizando":[595],"no-apopt\u00f3ticos":[597],"relacionados":[598],"fen\u00f3menos":[600],"neuronal.":[603]},"counts_by_year":[{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}