{"id":"https://openalex.org/W1543579489","doi":null,"title":"HLA association with response and toxicity in melanoma patients treated with interleukin 2-based immunotherapy.","display_name":"HLA association with response and toxicity in melanoma patients treated with interleukin 2-based immunotherapy.","publication_year":1992,"publication_date":"1992-12-01","ids":{"openalex":"https://openalex.org/W1543579489","mag":"1543579489","pmid":"https://pubmed.ncbi.nlm.nih.gov/1423301"},"language":"en","primary_location":{"id":"pmid:1423301","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1423301","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059941996","display_name":"Francesco Maria Marincola","orcid":"https://orcid.org/0000-0001-6423-391X","observed_orcids":["https://orcid.org/0000-0001-6423-391X"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"F M Marincola","raw_affiliation_strings":["Surgery Branch, National Cancer Institute, NIH, Bethesda, Maryland 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Surgery Branch, National Cancer Institute, NIH, Bethesda, Maryland 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024024043","display_name":"David J. Venzon","orcid":"https://orcid.org/0000-0002-8990-158X","observed_orcids":["https://orcid.org/0000-0002-8990-158X"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D Venzon","raw_affiliation_strings":["National Institutes of Health, Bethesda"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institutes of Health, Bethesda","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":null,"display_name":"D White","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D White","raw_affiliation_strings":["National Institutes of Health, Bethesda"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institutes of Health, Bethesda","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035662199","display_name":"Joshua T. Rubin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J T Rubin","raw_affiliation_strings":["University of Pittsburgh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pittsburgh","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024528047","display_name":"Michael T. Lotze","orcid":"https://orcid.org/0000-0003-3988-5419","observed_orcids":["https://orcid.org/0000-0003-3988-5419"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M T Lotze","raw_affiliation_strings":["University of Pittsburgh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pittsburgh","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029944663","display_name":"Toni B. Simonis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T B Simonis","raw_affiliation_strings":["National Institutes of Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institutes of Health","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110967222","display_name":"Jaikrishna Balkissoon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J Balkissoon","raw_affiliation_strings":["National Institutes of Health, Bethesda"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institutes of Health, Bethesda","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072133376","display_name":"Steven A. Rosenberg","orcid":"https://orcid.org/0000-0002-8939-8910","observed_orcids":["https://orcid.org/0000-0002-8939-8910"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S A Rosenberg","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"D R Parkinson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D R Parkinson","raw_affiliation_strings":["National Institutes of Health, Bethesda"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institutes of Health, Bethesda","institution_ids":["https://openalex.org/I1299303238"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.6587,"has_fulltext":false,"cited_by_count":51,"citation_normalized_percentile":{"value":0.85728028,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"52","issue":"23","first_page":"6561","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.5990999937057495,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.5990999937057495,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.22679999470710754,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10392","display_name":"Cutaneous Melanoma Detection and Management","score":0.14180000126361847,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hla","display_name":"HLA","score":0.6610000133514404},{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.6959999799728394},{"id":"https://openalex.org/keywords/interleukin-2","display_name":"interleukin-2","score":0.8889999985694885},{"id":"https://openalex.org/keywords/tumor-infiltrating-lymphocytes","display_name":"tumor-infiltrating lymphocytes","score":0.9100000262260437},{"id":"https://openalex.org/keywords/immunotherapy-response","display_name":"immunotherapy response","score":0.7229999899864197},{"id":"https://openalex.org/keywords/il-2-toxicity","display_name":"IL-2 toxicity","score":0.781000018119812},{"id":"https://openalex.org/keywords/hla-a11","display_name":"HLA-A11","score":0.8420000076293945},{"id":"https://openalex.org/keywords/hla-class-i","display_name":"HLA class I","score":0.9010000228881836},{"id":"https://openalex.org/keywords/hla-class-ii","display_name":"HLA class II","score":0.9980000257492065},{"id":"https://openalex.org/keywords/predictive-biomarkers","display_name":"predictive biomarkers","score":0.5410000085830688},{"id":"https://openalex.org/keywords/interferon-alpha","display_name":"interferon-alpha","score":0.7419999837875366},{"id":"https://openalex.org/keywords/lymphokine-activated-killer-cells","display_name":"lymphokine-activated killer cells","score":0.972000002861023}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7420737743377686},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.6636178493499756},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.6452393531799316},{"id":"https://openalex.org/C2778326572","wikidata":"https://www.wikidata.org/wiki/Q7852668","display_name":"Tumor-infiltrating lymphocytes","level":4,"score":0.5673397779464722},{"id":"https://openalex.org/C2777371288","wikidata":"https://www.wikidata.org/wiki/Q410130","display_name":"Interleukin 2","level":3,"score":0.5274213552474976},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5076092481613159},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5017788410186768},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5002715587615967},{"id":"https://openalex.org/C188280979","wikidata":"https://www.wikidata.org/wiki/Q911125","display_name":"Human leukocyte antigen","level":3,"score":0.4518435001373291},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4063762426376343},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3506532609462738},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.301125168800354},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.2832348942756653},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.22121018171310425},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.15992578864097595},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006680","descriptor_name":"HLA Antigens","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007376","descriptor_name":"Interleukin-2","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D007376","descriptor_name":"Interleukin-2","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012074","descriptor_name":"Remission Induction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016246","descriptor_name":"Lymphocytes, Tumor-Infiltrating","qualifier_ui":"Q000637","qualifier_name":"transplantation","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:1423301","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1423301","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"mag:1543579489","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1423301","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.8199999928474426,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W124701862","https://openalex.org/W1529308054","https://openalex.org/W1575119798","https://openalex.org/W1576953154","https://openalex.org/W1582239924","https://openalex.org/W1621456877","https://openalex.org/W1721689128","https://openalex.org/W1896821329","https://openalex.org/W1975114933","https://openalex.org/W1975568557","https://openalex.org/W1977912601","https://openalex.org/W1985426707","https://openalex.org/W1991016287","https://openalex.org/W1996199225","https://openalex.org/W2021985978","https://openalex.org/W2023892034","https://openalex.org/W2028156913","https://openalex.org/W2030620897","https://openalex.org/W2033165805","https://openalex.org/W2041742567","https://openalex.org/W2050689467","https://openalex.org/W2073781701","https://openalex.org/W2073901764","https://openalex.org/W2093523286","https://openalex.org/W2105998729","https://openalex.org/W2126843316","https://openalex.org/W2151190093","https://openalex.org/W2152125028","https://openalex.org/W2167447755","https://openalex.org/W2167917532","https://openalex.org/W2325343629","https://openalex.org/W2336770414","https://openalex.org/W2406901734","https://openalex.org/W2474182291"],"related_works":["https://openalex.org/W2094665318","https://openalex.org/W2069091537","https://openalex.org/W2090865938","https://openalex.org/W2473101076","https://openalex.org/W1831933605","https://openalex.org/W2065367621","https://openalex.org/W2257968979","https://openalex.org/W2417025735","https://openalex.org/W1971516092","https://openalex.org/W1524252995"],"abstract_inverted_index":{"Peripheral":[0],"blood":[1],"lymphocytes":[2,44],"from":[3],"146":[4],"patients":[5,106,140,197],"with":[6,34,42,79,232],"metastatic":[7],"melanoma":[8,105,127,208],"undergoing":[9],"interleukin":[10,63],"2":[11],"(IL-2)-based":[12],"immunotherapy":[13],"were":[14],"characterized":[15],"for":[16,66,217],"HLA":[17,74,211,227],"A,":[18],"B,":[19],"Cw,":[20],"DR,":[21],"DQw,":[22],"and":[23,62,82,107,177,183,190,239],"DRw":[24],"specificities.":[25],"Patients":[26],"had":[27,156],"been":[28],"enrolled":[29],"into":[30],"sequential":[31],"treatment":[32],"protocols":[33],"either":[35],"IL-2":[36,194,240],"alone":[37],"(28)":[38],"or":[39],"in":[40,92,125,207],"combination":[41,236],"tumor-infiltrating":[43],"(TILs)":[45],"(86),":[46],"alpha-interferon":[47],"(26),":[48],"lymphokine-activated":[49],"killer":[50],"cells":[51],"(16),":[52],"radiation":[53],"therapy":[54,144],"(7),":[55],"cyclophosphamide":[56],"(3),":[57],"tumor":[58],"necrosis":[59],"factor":[60],"(1),":[61],"4":[64],"(1)":[65],"a":[67,89,114,169,218],"total":[68],"of":[69,72,95,118,160,174,221,237],"168":[70],"courses":[71],"therapy.":[73,241],"phenotype":[75,120,230],"was":[76,135],"then":[77],"correlated":[78],"response":[80,178,222],"rate":[81,179],"toxicity":[83],"to":[84,142,193,223,234],"IL-2.":[85],"We":[86],"noted:":[87],"(a)":[88],"significant":[90],"difference":[91],"the":[93,108,126,172,196,235],"frequency":[94,117,159],"A11":[96,119],"(20.5%":[97],"versus":[98,146,163],"10.2%;":[99],"P":[100,131,148,165],"<":[101,132,149,166,181],"0.05)":[102],"allele":[103],"between":[104,171,187],"North":[109],"American":[110],"Caucasian":[111],"population;":[112],"(b)":[113],"significantly":[115],"higher":[116],"among":[121,139,195],"responders":[122,154],"(40.5%)":[123],"than":[124],"patient":[128],"population":[129],"(20.5%;":[130],"0.01),":[133],"which":[134],"even":[136],"more":[137],"obvious":[138],"responding":[141],"TIL":[143,152,238],"(47.4%":[145],"22.1%;":[147],"0.05);":[150,167],"within":[151],"patients,":[153,209],"also":[155],"an":[157,185],"increased":[158],"A19":[161],"(42.1%":[162],"25.6%;":[164],"(c)":[168],"correlation":[170],"number":[173],"TILs":[175,199],"received":[176],"(P":[180,200],"0.005);":[182],"(d)":[184],"association":[186],"DR4":[188],"haplotype":[189],"decreased":[191],"tolerance":[192,233],"receiving":[198],"=":[201],"0.01).":[202],"These":[203],"results":[204],"suggest":[205],"that,":[206],"some":[210],"Class":[212,228],"I":[213],"specificities":[214],"may":[215],"predict":[216],"greater":[219],"likelihood":[220],"IL-2-based":[224],"therapy,":[225],"while":[226],"II":[229],"correlates":[231]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
