{"id":"https://openalex.org/W1543558296","doi":"https://doi.org/10.1002/ar.a.10079","title":"Effect of lacunocanalicular architecture on hydraulic conductance in bone tissue: Implications for bone health and evolution","display_name":"Effect of lacunocanalicular architecture on hydraulic conductance in bone tissue: Implications for bone health and evolution","publication_year":2003,"publication_date":"2003-07-01","ids":{"openalex":"https://openalex.org/W1543558296","doi":"https://doi.org/10.1002/ar.a.10079","mag":"1543558296","pmid":"https://pubmed.ncbi.nlm.nih.gov/12845711"},"language":"en","primary_location":{"id":"doi:10.1002/ar.a.10079","doi":"https://doi.org/10.1002/ar.a.10079","is_oa":true,"landing_page_url":"https://doi.org/10.1002/ar.a.10079","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ar.a.10079","source":{"id":"https://openalex.org/S4210227131","display_name":"The Anatomical Record Part A Discoveries in Molecular Cellular and Evolutionary Biology","issn_l":"1552-4884","issn":["1552-4884","1552-4892"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Anatomical Record Part A: Discoveries in Molecular, Cellular, and Evolutionary Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ar.a.10079","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050399895","display_name":"Sanjay Kumar Mishra","orcid":"https://orcid.org/0000-0002-6037-7972","observed_orcids":["https://orcid.org/0000-0002-6037-7972"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I4405287411","display_name":"Cleveland Clinic Research","ror":"https://ror.org/053229s83","country_code":"US","type":"facility","lineage":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sanjay Mishra","raw_affiliation_strings":["Departments of Biomedical Engineering and Orthopaedic Surgery, Orthopaedic Research Center, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio44195, USA","Departments of Biomedical Engineering and Orthopaedic Surgery, Orthopaedic Research Center, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Biomedical Engineering and Orthopaedic Surgery, Orthopaedic Research Center, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio44195, USA","institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]},{"raw_affiliation_string":"Departments of Biomedical Engineering and Orthopaedic Surgery, Orthopaedic Research Center, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio","institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004319969","display_name":"Melissa L. Knothe Tate","orcid":"https://orcid.org/0000-0002-3552-2525","observed_orcids":["https://orcid.org/0000-0002-3552-2525"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I4405287411","display_name":"Cleveland Clinic Research","ror":"https://ror.org/053229s83","country_code":"US","type":"facility","lineage":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Melissa L. Knothe Tate","raw_affiliation_strings":["","Departments of Biomedical Engineering and Orthopaedic Surgery, Orthopaedic Research Center, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Departments of Biomedical Engineering and Orthopaedic Surgery, Orthopaedic Research Center, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio","institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5004319969"],"corresponding_institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"],"apc_list":null,"apc_paid":null,"fwci":3.5874,"has_fulltext":true,"cited_by_count":75,"citation_normalized_percentile":{"value":0.91148508,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"273A","issue":"2","first_page":"752","last_page":"762"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.8012999892234802,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.8012999892234802,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.06430000066757202,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.05169999971985817,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hydraulic-conductance","display_name":"hydraulic conductance","score":0.7250000238418579},{"id":"https://openalex.org/keywords/bone","display_name":"bone","score":0.4740000069141388},{"id":"https://openalex.org/keywords/haversian-canals","display_name":"Haversian canals","score":0.8899999856948853},{"id":"https://openalex.org/keywords/fluid-transport","display_name":"fluid transport","score":0.6019999980926514},{"id":"https://openalex.org/keywords/solute-transport","display_name":"solute transport","score":0.8510000109672546},{"id":"https://openalex.org/keywords/bone-blood-supply","display_name":"bone blood supply","score":0.6460000276565552},{"id":"https://openalex.org/keywords/energy-expenditure","display_name":"energy expenditure","score":0.550000011920929},{"id":"https://openalex.org/keywords/bone-tissue-engineering","display_name":"bone tissue engineering","score":0.7680000066757202}],"concepts":[{"id":"https://openalex.org/C2777909254","wikidata":"https://www.wikidata.org/wiki/Q1424568","display_name":"Osteon","level":3,"score":0.8187533617019653},{"id":"https://openalex.org/C136301237","wikidata":"https://www.wikidata.org/wiki/Q3247568","display_name":"Lamella (surface anatomy)","level":2,"score":0.5884496569633484},{"id":"https://openalex.org/C63184880","wikidata":"https://www.wikidata.org/wiki/Q2783041","display_name":"Hydraulic conductivity","level":3,"score":0.5843214392662048},{"id":"https://openalex.org/C77851909","wikidata":"https://www.wikidata.org/wiki/Q6481705","display_name":"Lamellar structure","level":2,"score":0.5565690398216248},{"id":"https://openalex.org/C94033540","wikidata":"https://www.wikidata.org/wiki/Q5746981","display_name":"Bone canaliculus","level":2,"score":0.4619453549385071},{"id":"https://openalex.org/C72921944","wikidata":"https://www.wikidata.org/wiki/Q206621","display_name":"Drag","level":2,"score":0.4399125277996063},{"id":"https://openalex.org/C2778606738","wikidata":"https://www.wikidata.org/wiki/Q265868","display_name":"Bone tissue","level":2,"score":0.43760567903518677},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.424543172121048},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3685048818588257},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.35774412751197815},{"id":"https://openalex.org/C57879066","wikidata":"https://www.wikidata.org/wiki/Q41217","display_name":"Mechanics","level":1,"score":0.3539876341819763},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.3419734239578247},{"id":"https://openalex.org/C127313418","wikidata":"https://www.wikidata.org/wiki/Q1069","display_name":"Geology","level":0,"score":0.22077429294586182},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.1766032576560974},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.16196948289871216},{"id":"https://openalex.org/C159390177","wikidata":"https://www.wikidata.org/wiki/Q9161265","display_name":"Soil science","level":1,"score":0.13683846592903137},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.11275157332420349},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.09093132615089417},{"id":"https://openalex.org/C2781451080","wikidata":"https://www.wikidata.org/wiki/Q265868","display_name":"Cortical bone","level":2,"score":0.0},{"id":"https://openalex.org/C159750122","wikidata":"https://www.wikidata.org/wiki/Q96621023","display_name":"Soil water","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004058","descriptor_name":"Diffusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005075","descriptor_name":"Biological Evolution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006253","descriptor_name":"Haversian System","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D006253","descriptor_name":"Haversian System","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D006253","descriptor_name":"Haversian System","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006874","descriptor_name":"Hydrostatic Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008833","descriptor_name":"Microcirculation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010011","descriptor_name":"Osteocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D010011","descriptor_name":"Osteocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D045604","descriptor_name":"Extracellular Fluid","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1002/ar.a.10079","doi":"https://doi.org/10.1002/ar.a.10079","is_oa":true,"landing_page_url":"https://doi.org/10.1002/ar.a.10079","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ar.a.10079","source":{"id":"https://openalex.org/S4210227131","display_name":"The Anatomical Record Part A Discoveries in Molecular Cellular and Evolutionary Biology","issn_l":"1552-4884","issn":["1552-4884","1552-4892"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Anatomical Record Part A: Discoveries in Molecular, Cellular, and Evolutionary Biology","raw_type":"journal-article"},{"id":"pmid:12845711","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12845711","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology","raw_type":"Journal Article"},{"id":"pmh:oai:eprints.qut.edu.au:225311","doi":null,"is_oa":false,"landing_page_url":"https://eprints.qut.edu.au/225311/1/6760.pdf","pdf_url":"https://eprints.qut.edu.au/225311/1/6760.pdf","source":{"id":"https://openalex.org/S4306402607","display_name":"QUT ePrints (Queensland University of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I160993911","host_organization_name":"Queensland University of Technology","host_organization_lineage":["https://openalex.org/I160993911"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Anatomical Record - Part A Discoveries in Molecular, Cellular, and Evolutionary Biology","raw_type":"Contribution to Journal"},{"id":"pmh:oai:eprints.qut.edu.au:6760","doi":null,"is_oa":true,"landing_page_url":"https://eprints.qut.edu.au/6760/1/6760.pdf","pdf_url":"https://eprints.qut.edu.au/6760/1/6760.pdf","source":{"id":"https://openalex.org/S4306402607","display_name":"QUT ePrints (Queensland University of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I160993911","host_organization_name":"Queensland University of Technology","host_organization_lineage":["https://openalex.org/I160993911"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Anatomical Record - Part A Discoveries in Molecular, Cellular, and Evolutionary Biology","raw_type":"Contribution to Journal"}],"best_oa_location":{"id":"doi:10.1002/ar.a.10079","doi":"https://doi.org/10.1002/ar.a.10079","is_oa":true,"landing_page_url":"https://doi.org/10.1002/ar.a.10079","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ar.a.10079","source":{"id":"https://openalex.org/S4210227131","display_name":"The Anatomical Record Part A Discoveries in Molecular Cellular and Evolutionary Biology","issn_l":"1552-4884","issn":["1552-4884","1552-4892"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Anatomical Record Part A: Discoveries in Molecular, Cellular, and Evolutionary Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1543558296.pdf","grobid_xml":"https://content.openalex.org/works/W1543558296.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W76298574","https://openalex.org/W118271503","https://openalex.org/W140613287","https://openalex.org/W1639537743","https://openalex.org/W1982701868","https://openalex.org/W1989919731","https://openalex.org/W2005400889","https://openalex.org/W2006159519","https://openalex.org/W2006623704","https://openalex.org/W2014684811","https://openalex.org/W2021659915","https://openalex.org/W2030040484","https://openalex.org/W2031811016","https://openalex.org/W2037650463","https://openalex.org/W2051876520","https://openalex.org/W2063773406","https://openalex.org/W2066044668","https://openalex.org/W2077439666","https://openalex.org/W2092266930","https://openalex.org/W2096670808","https://openalex.org/W2104192993","https://openalex.org/W2108670067","https://openalex.org/W2109228661","https://openalex.org/W2111601530","https://openalex.org/W2163208284","https://openalex.org/W2231050432","https://openalex.org/W2411441364","https://openalex.org/W2476526439","https://openalex.org/W4230551183","https://openalex.org/W4297929813"],"related_works":["https://openalex.org/W7096119604","https://openalex.org/W2991187435","https://openalex.org/W2099688894","https://openalex.org/W2331541276","https://openalex.org/W4414065869","https://openalex.org/W4200515860","https://openalex.org/W4321596595","https://openalex.org/W2051876520","https://openalex.org/W2009055676","https://openalex.org/W2744021351"],"abstract_inverted_index":{"Bone":[0],"tissue":[1,281],"health":[2,286],"depends":[3],"largely":[4],"on":[5,90],"efficient":[6],"fluid":[7,38,51,91,118,219],"and":[8,15,52,58,83,85,97,119,129,149,220,227,238,271,287,289],"solute":[9,221],"transport":[10,50,92,222,250],"between":[11,54,93,125,223],"the":[12,19,23,28,36,55,69,75,94,101,114,126,145,155,162,173,176,182,187,191,195,205,224,235],"blood":[13,56,95,127,156,225],"supply":[14,57,96,128,226],"cells":[16],"that":[17,27,40,108,135,249],"are":[18],"living":[20],"component":[21],"of":[22,71,79,87,103,175,184,197,200,262,278],"tissue.":[24],"We":[25],"hypothesized":[26],"lacunocanalicular":[29,192],"hydraulic":[30,136,188,232],"network,":[31],"which":[32,117],"is":[33,41,47,111,138,242,251],"defined":[34],"by":[35],"pericellular":[37],"space":[39],"common":[42],"to":[43,49,67,113,144,202,253],"all":[44],"bone":[45,59,98,269,283],"tissue,":[46],"optimized":[48,252],"solutes":[53,120],"cells.":[60,99,130],"An":[61],"analytical":[62],"study":[63],"was":[64],"carried":[65],"out":[66],"evaluate":[68],"effect":[70],"osteonal":[72],"architecture,":[73],"including":[74],"osteon":[76,109],"diameter,":[77],"number":[78,84],"annular":[80],"lamellar":[81,141,212],"regions,":[82],"length":[86,183],"canalicular":[88],"channels,":[89],"On":[100],"basis":[102,277],"this":[104,203,230],"analysis,":[105,204],"we":[106],"conclude":[107],"size":[110],"limited":[112],"distance":[115,153,207],"over":[116],"can":[121],"be":[122],"transported":[123],"efficiently":[124],"This":[131,247,264],"analytic":[132],"model":[133],"suggests":[134,248],"conductivity":[137,189],"highest":[139],"in":[140,172,181,234,285],"regions":[142,213],"closest":[143],"Haversian":[146],"canal":[147],"(HC)":[148],"decreases":[150],"with":[151,258],"increasing":[152],"from":[154],"supply,":[157],"reaching":[158],"a":[159,179,259,275],"plateau":[160],"after":[161],"fifth":[163],"lamella":[164],"(169":[165],"micro":[166],"m":[167],"radius).":[168],"Furthermore,":[169],"an":[170,215],"increase":[171],"diameter":[174],"HC,":[177],"or":[178,210],"decrease":[180],"canaliculi,":[185],"reduces":[186],"within":[190],"network.":[193],"Applying":[194],"principle":[196],"minimal":[198,260],"expenditure":[199,241,261],"energy":[201,240],"path":[206],"comprising":[208],"five":[209],"six":[211],"represents":[214],"effective":[216],"limit":[217],"for":[218,244,280],"cells;":[228],"beyond":[229],"threshold,":[231],"resistance":[233],"network":[236],"increases":[237],"additional":[239],"necessary":[243],"further":[245],"transportation.":[246],"meet":[254],"metabolic":[255],"demands":[256],"concomitant":[257],"energy.":[263],"fundamental":[265],"new":[266,276],"insight":[267],"into":[268],"structure":[270],"physiology":[272,284],"may":[273],"provide":[274],"understanding":[279],"engineering,":[282],"disease,":[288],"evolutionary":[290],"biology.":[291]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":7}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}