{"id":"https://openalex.org/W1543428015","doi":"https://doi.org/10.1542/peds.86.4.564","title":"Single- Versus Multiple-Dose Surfactant Replacement Therapy in Neonates of 30 to 36 Weeks' Gestation With Respiratory Distress Syndrome","display_name":"Single- Versus Multiple-Dose Surfactant Replacement Therapy in Neonates of 30 to 36 Weeks' Gestation With Respiratory Distress Syndrome","publication_year":1990,"publication_date":"1990-10-01","ids":{"openalex":"https://openalex.org/W1543428015","doi":"https://doi.org/10.1542/peds.86.4.564","mag":"1543428015","pmid":"https://pubmed.ncbi.nlm.nih.gov/2216622"},"language":"en","primary_location":{"id":"doi:10.1542/peds.86.4.564","doi":"https://doi.org/10.1542/peds.86.4.564","is_oa":false,"landing_page_url":"https://doi.org/10.1542/peds.86.4.564","pdf_url":null,"source":{"id":"https://openalex.org/S77494981","display_name":"PEDIATRICS","issn_l":"0031-4005","issn":["0031-4005","1098-4275"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315734","host_organization_name":"American Academy of Pediatrics","host_organization_lineage":["https://openalex.org/P4310315734"],"host_organization_lineage_names":["American Academy of Pediatrics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatrics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023008796","display_name":"Michael Dunn","orcid":"https://orcid.org/0000-0002-3908-4147","observed_orcids":["https://orcid.org/0000-0002-3908-4147"]},"institutions":[{"id":"https://openalex.org/I125749732","display_name":"Western University","ror":"https://ror.org/02grkyz14","country_code":"CA","type":"education","lineage":["https://openalex.org/I125749732"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I2801816099","display_name":"Women's College Hospital","ror":"https://ror.org/03cw63y62","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801816099"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Michael S. Dunn","raw_affiliation_strings":["From the Regional Perinatal Unit, University of Toronto Perinatal Complex, Women's College Hospital, Toronto, and University of Western Ontario, London, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Regional Perinatal Unit, University of Toronto Perinatal Complex, Women's College Hospital, Toronto, and University of Western Ontario, London, Ontario, Canada","institution_ids":["https://openalex.org/I125749732","https://openalex.org/I185261750","https://openalex.org/I2801816099"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110018156","display_name":"Andrew T. Shennan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I125749732","display_name":"Western University","ror":"https://ror.org/02grkyz14","country_code":"CA","type":"education","lineage":["https://openalex.org/I125749732"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I2801816099","display_name":"Women's College Hospital","ror":"https://ror.org/03cw63y62","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801816099"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Andrew T. Shennan","raw_affiliation_strings":["From the Regional Perinatal Unit, University of Toronto Perinatal Complex, Women's College Hospital, Toronto, and University of Western Ontario, London, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Regional Perinatal Unit, University of Toronto Perinatal Complex, Women's College Hospital, Toronto, and University of Western Ontario, London, Ontario, Canada","institution_ids":["https://openalex.org/I125749732","https://openalex.org/I185261750","https://openalex.org/I2801816099"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031807216","display_name":"Fred Possmayer","orcid":"https://orcid.org/0000-0002-5173-3437","observed_orcids":["https://orcid.org/0000-0002-5173-3437"]},"institutions":[{"id":"https://openalex.org/I125749732","display_name":"Western University","ror":"https://ror.org/02grkyz14","country_code":"CA","type":"education","lineage":["https://openalex.org/I125749732"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I2801816099","display_name":"Women's College Hospital","ror":"https://ror.org/03cw63y62","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801816099"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Fred Possmayer","raw_affiliation_strings":["From the Regional Perinatal Unit, University of Toronto Perinatal Complex, Women's College Hospital, Toronto, and University of Western Ontario, London, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Regional Perinatal Unit, University of Toronto Perinatal Complex, Women's College Hospital, Toronto, and University of Western Ontario, London, Ontario, Canada","institution_ids":["https://openalex.org/I125749732","https://openalex.org/I185261750","https://openalex.org/I2801816099"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":11.6659,"has_fulltext":false,"cited_by_count":111,"citation_normalized_percentile":{"value":0.98766644,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"86","issue":"4","first_page":"564","last_page":"571"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10549","display_name":"Neonatal Respiratory Health Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10549","display_name":"Neonatal Respiratory Health Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11586","display_name":"Congenital Diaphragmatic Hernia Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/surfactant-replacement-therapy","display_name":"surfactant therapy","score":0.9990000128746033},{"id":"https://openalex.org/keywords/respiratory-distress-syndrome","display_name":"respiratory distress syndrome","score":0.8759999871253967},{"id":"https://openalex.org/keywords/preterm-infants","display_name":"preterm infants","score":0.7649999856948853},{"id":"https://openalex.org/keywords/bovine-surfactant","display_name":"bovine surfactant","score":0.7390000224113464},{"id":"https://openalex.org/keywords/oxygenation","display_name":"oxygenation","score":0.9259999990463257},{"id":"https://openalex.org/keywords/extubation-time","display_name":"extubation time","score":0.796999990940094}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9870067834854126},{"id":"https://openalex.org/C141983124","wikidata":"https://www.wikidata.org/wiki/Q188008","display_name":"Respiratory distress","level":2,"score":0.8473583459854126},{"id":"https://openalex.org/C46973012","wikidata":"https://www.wikidata.org/wiki/Q28627","display_name":"Gestation","level":3,"score":0.7365161180496216},{"id":"https://openalex.org/C2776953283","wikidata":"https://www.wikidata.org/wiki/Q17125052","display_name":"Surfactant therapy","level":4,"score":0.6583797335624695},{"id":"https://openalex.org/C534529494","wikidata":"https://www.wikidata.org/wiki/Q7891","display_name":"Respiratory system","level":2,"score":0.46636804938316345},{"id":"https://openalex.org/C2780395437","wikidata":"https://www.wikidata.org/wiki/Q754348","display_name":"Neonatal respiratory distress syndrome","level":4,"score":0.4503169059753418},{"id":"https://openalex.org/C58226133","wikidata":"https://www.wikidata.org/wiki/Q1324199","display_name":"Pulmonary surfactant","level":2,"score":0.44119730591773987},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.37038618326187134},{"id":"https://openalex.org/C2778376644","wikidata":"https://www.wikidata.org/wiki/Q2253111","display_name":"Gestational age","level":3,"score":0.2775561809539795},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.2355659306049347},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.23469310998916626},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.20898637175559998},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001034","descriptor_name":"Apgar Score","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001724","descriptor_name":"Birth Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005865","descriptor_name":"Gestational Age","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007234","descriptor_name":"Infant, Premature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010092","descriptor_name":"Oximetry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011659","descriptor_name":"Pulmonary Gas Exchange","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011663","descriptor_name":"Pulmonary Surfactants","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D012127","descriptor_name":"Respiratory Distress Syndrome, Newborn","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1542/peds.86.4.564","doi":"https://doi.org/10.1542/peds.86.4.564","is_oa":false,"landing_page_url":"https://doi.org/10.1542/peds.86.4.564","pdf_url":null,"source":{"id":"https://openalex.org/S77494981","display_name":"PEDIATRICS","issn_l":"0031-4005","issn":["0031-4005","1098-4275"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315734","host_organization_name":"American Academy of Pediatrics","host_organization_lineage":["https://openalex.org/P4310315734"],"host_organization_lineage_names":["American Academy of Pediatrics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatrics","raw_type":"journal-article"},{"id":"pmid:2216622","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2216622","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatrics","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9922999739646912,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1586153322","https://openalex.org/W2013648784","https://openalex.org/W1724529511","https://openalex.org/W1831926862","https://openalex.org/W2130628433","https://openalex.org/W2066789314","https://openalex.org/W3030500637","https://openalex.org/W2038849402","https://openalex.org/W2278165341","https://openalex.org/W4206522872"],"abstract_inverted_index":{"To":[0],"assess":[1],"the":[2,67,119,142,153],"efficacy":[3],"of":[4,8,14,39,44,59,155,183,196,211],"a":[5,42,87,214],"multiple-dose":[6,30,68],"protocol":[7],"surfactant":[9,31,61,84,106,176,212],"replacement":[10],"therapy":[11,177],"in":[12,66,82,95,125,132,147,187,194,220],"neonates":[13,21,195],"30":[15,197],"to":[16,25,54,72,75,90,138,170,198,230],"36":[17,199],"weeks'":[18,200],"gestation,":[19],"75":[20],"were":[22,48,51,70],"randomly":[23,52],"assigned":[24,53],"control,":[26],"single-dose":[27],"surfactant,":[28],"or":[29,62,168],"groups.":[32],"Neonates":[33,65,81],"at":[34,114,178],"less":[35,102,179],"than":[36,103,111,180,222],"6":[37,137,181],"hours":[38,140,182],"age":[40,184],"with":[41,92,202],"diagnosis":[43],"respiratory":[45,203],"distress":[46,204],"syndrome":[47],"eligible.":[49],"Subjects":[50],"receive":[55,73],"either":[56],"100":[57],"mg/kg":[58],"bovine":[60],"air":[63],"placebo.":[64],"group":[69],"eligible":[71],"up":[74],"three":[76],"additional":[77],"doses":[78,160,210],"as":[79],"indicated.":[80],"both":[83,133],"groups":[85,107,135],"showed":[86],"positive":[88],"response":[89],"treatment,":[91],"marked":[93],"improvement":[94],"oxygenation":[96,110,126,148,221],"by":[97,152],"10":[98],"minutes":[99],"postinstillation":[100],"(P":[101],".0001).":[104],"Both":[105],"had":[108,161],"better":[109],"control":[112],"subjects":[113],"lower":[115],"ventilatory":[116,128,166,192,224],"parameters":[117],"over":[118],"first":[120,143],"24":[121],"hours.":[122],"A":[123],"deterioration":[124,146],"and":[127,191,234],"requirements":[129,167,193],"was":[130],"seen":[131],"treatment":[134],"starting":[136],"12":[139],"after":[141],"dose.":[144],"The":[145],"could":[149],"be":[150],"minimized":[151],"use":[154],"multiple":[156,209],"doses;":[157],"however,":[158],"extra":[159],"no":[162],"effect":[163,216],"on":[164,217,223],"diminishing":[165],"time":[169],"extubation.":[171],"It":[172,206],"is":[173,185,228],"concluded":[174],"that":[175,208],"effective":[186],"acutely":[188],"reducing":[189],"oxygen":[190],"gestation":[201],"syndrome.":[205],"appears":[207],"have":[213],"greater":[215],"sustaining":[218],"improvements":[219],"requirements.":[225],"Further":[226],"study":[227],"required":[229],"determine":[231],"optimal":[232],"dosage":[233],"retreatment":[235],"strategy.":[236]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}