{"id":"https://openalex.org/W154339036","doi":"https://doi.org/10.1016/s0021-9258(18)37908-0","title":"Insulin receptor signaling. Activation of multiple serine kinases.","display_name":"Insulin receptor signaling. Activation of multiple serine kinases.","publication_year":1988,"publication_date":"1988-08-01","ids":{"openalex":"https://openalex.org/W154339036","doi":"https://doi.org/10.1016/s0021-9258(18)37908-0","mag":"154339036","pmid":"https://pubmed.ncbi.nlm.nih.gov/2969888"},"language":"en","primary_location":{"id":"doi:10.1016/s0021-9258(18)37908-0","doi":"https://doi.org/10.1016/s0021-9258(18)37908-0","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(18)37908-0","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/s0021-9258(18)37908-0","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111451304","display_name":"Michael P. Czech","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M P Czech","raw_affiliation_strings":["Department of Biochemistry, University of Massachusetts Medical Center, Worcester 01655"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Massachusetts Medical Center, Worcester 01655","institution_ids":["https://openalex.org/I166722992"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014717748","display_name":"Jes K. Klarlund","orcid":"https://orcid.org/0000-0003-1838-1721","observed_orcids":["https://orcid.org/0000-0003-1838-1721"]},"institutions":[{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J K Klarlund","raw_affiliation_strings":["University of Massachusetts Medical School"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Massachusetts Medical School","institution_ids":["https://openalex.org/I166722992"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031148524","display_name":"Keith A. Yagaloff","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K A Yagaloff","raw_affiliation_strings":["University of Massachusetts Medical School"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Massachusetts Medical School","institution_ids":["https://openalex.org/I166722992"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017784878","display_name":"Andrew P. Bradford","orcid":"https://orcid.org/0000-0002-8728-571X","observed_orcids":["https://orcid.org/0000-0002-8728-571X"]},"institutions":[{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A P Bradford","raw_affiliation_strings":["University of Massachusetts Medical School"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Massachusetts Medical School","institution_ids":["https://openalex.org/I166722992"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072416990","display_name":"Robert E. Lewis","orcid":"https://orcid.org/0000-0002-3616-2971","observed_orcids":["https://orcid.org/0000-0002-3616-2971","https://orcid.org/0009-0005-0177-220X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R E Lewis","raw_affiliation_strings":["Eppley Institute for Cancer Research"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eppley Institute for Cancer Research","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":13.1815,"has_fulltext":false,"cited_by_count":196,"citation_normalized_percentile":{"value":0.99309802,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"263","issue":"23","first_page":"11017","last_page":"11020"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.9613999724388123,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.9613999724388123,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.020400000736117363,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.007199999876320362,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/insulin-receptor-signaling","display_name":"insulin receptor signaling","score":0.9150000214576721},{"id":"https://openalex.org/keywords/insulin-receptor","display_name":"insulin receptor","score":0.5799999833106995},{"id":"https://openalex.org/keywords/serine-kinase","display_name":"serine kinase","score":0.8840000033378601},{"id":"https://openalex.org/keywords/protein-phosphorylation","display_name":"protein phosphorylation","score":0.8500000238418579},{"id":"https://openalex.org/keywords/enzyme-dephosphorylation","display_name":"enzyme dephosphorylation","score":0.8420000076293945}],"concepts":[{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.6386194229125977},{"id":"https://openalex.org/C2910050888","wikidata":"https://www.wikidata.org/wiki/Q4857068","display_name":"Protein-Serine-Threonine Kinases","level":4,"score":0.6371258497238159},{"id":"https://openalex.org/C112446052","wikidata":"https://www.wikidata.org/wiki/Q422579","display_name":"Insulin receptor","level":4,"score":0.6354420185089111},{"id":"https://openalex.org/C2776414213","wikidata":"https://www.wikidata.org/wiki/Q183290","display_name":"Serine","level":3,"score":0.6301863193511963},{"id":"https://openalex.org/C82183700","wikidata":"https://www.wikidata.org/wiki/Q14914347","display_name":"GRB10","level":5,"score":0.45217612385749817},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.45003741979599},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.42564696073532104},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.41333308815956116},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.3844970166683197},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.3594278395175934},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.313924640417099},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2768564224243164},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.24204829335212708},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.1765444278717041},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.14720940589904785}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011972","descriptor_name":"Receptor, Insulin","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1016/s0021-9258(18)37908-0","doi":"https://doi.org/10.1016/s0021-9258(18)37908-0","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(18)37908-0","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:2969888","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2969888","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:escholarship.umassmed.edu:oapubs-1890","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.umassmed.edu/oapubs/891","pdf_url":null,"source":{"id":"https://openalex.org/S7407064370","display_name":"eScholarship@UMassChan","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Open Access Publications by UMass Chan Authors","raw_type":"text"},{"id":"mag:2184515112","doi":null,"is_oa":false,"landing_page_url":"http://www.jbc.org/content/263/23/11017.full.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.1016/s0021-9258(18)37908-0","doi":"https://doi.org/10.1016/s0021-9258(18)37908-0","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(18)37908-0","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3696651055","display_name":null,"funder_award_id":"DK 30648","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G558153072","display_name":null,"funder_award_id":"DK30898","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G657174647","display_name":null,"funder_award_id":"CA 39240","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":90,"referenced_works":["https://openalex.org/W174436376","https://openalex.org/W174752440","https://openalex.org/W983821859","https://openalex.org/W1488023480","https://openalex.org/W1492465703","https://openalex.org/W1497588826","https://openalex.org/W1501439526","https://openalex.org/W1505075493","https://openalex.org/W1508045395","https://openalex.org/W1514538091","https://openalex.org/W1515345850","https://openalex.org/W1521894706","https://openalex.org/W1533778697","https://openalex.org/W1533957803","https://openalex.org/W1538276446","https://openalex.org/W1548708480","https://openalex.org/W1554118571","https://openalex.org/W1554600107","https://openalex.org/W1556948298","https://openalex.org/W1562004079","https://openalex.org/W1563354863","https://openalex.org/W1564828769","https://openalex.org/W1566077296","https://openalex.org/W1572589552","https://openalex.org/W1573034460","https://openalex.org/W1578435464","https://openalex.org/W1578488932","https://openalex.org/W1578617720","https://openalex.org/W1579659728","https://openalex.org/W1593717444","https://openalex.org/W1604279237","https://openalex.org/W1607323359","https://openalex.org/W1607978009","https://openalex.org/W1608814723","https://openalex.org/W1610735267","https://openalex.org/W1622031496","https://openalex.org/W1678115372","https://openalex.org/W1742701470","https://openalex.org/W1963887390","https://openalex.org/W1970148057","https://openalex.org/W1977193553","https://openalex.org/W1982879218","https://openalex.org/W1983854256","https://openalex.org/W1983877797","https://openalex.org/W1984159784","https://openalex.org/W1991616039","https://openalex.org/W1996223471","https://openalex.org/W2004917770","https://openalex.org/W2005740284","https://openalex.org/W2014459225","https://openalex.org/W2015915885","https://openalex.org/W2017300333","https://openalex.org/W2018450485","https://openalex.org/W2018751358","https://openalex.org/W2027766814","https://openalex.org/W2030156849","https://openalex.org/W2031894298","https://openalex.org/W2036061004","https://openalex.org/W2037394821","https://openalex.org/W2039140238","https://openalex.org/W2039372097","https://openalex.org/W2052701716","https://openalex.org/W2053500972","https://openalex.org/W2055042914","https://openalex.org/W2058391196","https://openalex.org/W2058793161","https://openalex.org/W2061113199","https://openalex.org/W2065129741","https://openalex.org/W2067015505","https://openalex.org/W2070202191","https://openalex.org/W2082176730","https://openalex.org/W2085341573","https://openalex.org/W2088056954","https://openalex.org/W2089048778","https://openalex.org/W2090030460","https://openalex.org/W2094212789","https://openalex.org/W2105716780","https://openalex.org/W2111295274","https://openalex.org/W2114514865","https://openalex.org/W2120261738","https://openalex.org/W2144793688","https://openalex.org/W2165022312","https://openalex.org/W2180553270","https://openalex.org/W2230397109","https://openalex.org/W2328199804","https://openalex.org/W2343637328","https://openalex.org/W2345105332","https://openalex.org/W2809381039","https://openalex.org/W4300941830","https://openalex.org/W4323913119"],"related_works":["https://openalex.org/W1995995486","https://openalex.org/W75241094","https://openalex.org/W2026140809","https://openalex.org/W4238959582","https://openalex.org/W2066065294","https://openalex.org/W2328199804","https://openalex.org/W2070328434","https://openalex.org/W376381416","https://openalex.org/W6823376","https://openalex.org/W1507117319"],"abstract_inverted_index":{"Le":[0],"role":[1],"de":[2,22,46,58],"l'insuline":[3,47],"dans":[4],"la":[5,20,35,59],"cellule":[6],"normale":[7],"est":[8],"discute.":[9],"Au":[10],"fait":[11],"l'insuline,":[12,63],"en":[13],"se":[14],"fixant":[15],"sur":[16],"son":[17],"recepteur,":[18],"induit":[19,34],"dephosphorylation":[21],"certaines":[23],"enzymes":[24],"pour":[25],"les":[26,29],"activer":[27],"ou":[28],"inhiber.":[30],"D'autre":[31],"part,":[32],"elle":[33],"phosphorylation":[36],"d'autres":[37],"proteines":[38,44],"sans":[39],"influencer":[40],"leurs":[41,52],"activites.":[42],"Differentes":[43],"cibles":[45],"sont":[48,64],"discutees":[49],"ainsi":[50],"que":[51],"substrats":[53],"potentiels.":[54],"Deux":[55],"mecanismes":[56],"hypothetiques":[57],"phosphorylation,":[60],"mediee":[61],"par":[62],"discutes":[65]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}