{"id":"https://openalex.org/W1543219913","doi":null,"title":"Appearance of New Vemurafenib-associated Melanocytic Nevi on Normal-appearing Skin: Case Series and a Review of Changing or New Pigmented Lesions in Patients with Metastatic Malignant Melanoma After Initiating Treatment with Vemurafenib.","display_name":"Appearance of New Vemurafenib-associated Melanocytic Nevi on Normal-appearing Skin: Case Series and a Review of Changing or New Pigmented Lesions in Patients with Metastatic Malignant Melanoma After Initiating Treatment with Vemurafenib.","publication_year":2013,"publication_date":"2013-05-01","ids":{"openalex":"https://openalex.org/W1543219913","mag":"1543219913","pmid":"https://pubmed.ncbi.nlm.nih.gov/23710269","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3662681"},"language":"en","primary_location":{"id":"pmid:23710269","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23710269","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical and aesthetic dermatology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3662681/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075508013","display_name":"Philip R. Cohen","orcid":"https://orcid.org/0000-0003-1303-064X","observed_orcids":["https://orcid.org/0000-0003-1303-064X"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Philip R Cohen","raw_affiliation_strings":["Department of Dermatology, University of California San Diego, San Diego, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, University of California San Diego, San Diego, California","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060563693","display_name":"Agop Y. Bedikian","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Agop Y Bedikian","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5015498468","display_name":"Kevin B. Kim","orcid":"https://orcid.org/0000-0003-0694-0530","observed_orcids":["https://orcid.org/0000-0003-0694-0530"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kevin B Kim","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.1995,"has_fulltext":false,"cited_by_count":38,"citation_normalized_percentile":{"value":0.8831647,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"6","issue":"5","first_page":"27","last_page":"37"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.49219998717308044,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.49219998717308044,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10392","display_name":"Cutaneous Melanoma Detection and Management","score":0.30469998717308044,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12937","display_name":"Chemotherapy-related skin toxicity","score":0.16050000488758087,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vemurafenib","display_name":"vemurafenib","score":0.9990000128746033},{"id":"https://openalex.org/keywords/braf-v600e-mutation","display_name":"BRAF V600E mutation","score":0.8479999899864197},{"id":"https://openalex.org/keywords/metastatic-melanoma","display_name":"metastatic melanoma","score":0.878000020980835},{"id":"https://openalex.org/keywords/melanocytic-nevi","display_name":"melanocytic nevi","score":0.8930000066757202},{"id":"https://openalex.org/keywords/drug-induced-skin-reaction","display_name":"drug-induced skin reaction","score":0.7089999914169312},{"id":"https://openalex.org/keywords/dysplastic-nevi","display_name":"dysplastic nevi","score":0.9229999780654907},{"id":"https://openalex.org/keywords/pigmented-skin-lesions","display_name":"pigmented skin lesions","score":0.5910000205039978},{"id":"https://openalex.org/keywords/dermoscopy","display_name":"dermoscopy","score":0.8569999933242798},{"id":"https://openalex.org/keywords/reflectance-confocal-microscopy","display_name":"reflectance confocal microscopy","score":0.9890000224113464},{"id":"https://openalex.org/keywords/skin-assessment","display_name":"skin assessment","score":0.6050000190734863},{"id":"https://openalex.org/keywords/braf-inhibitor-therapy","display_name":"BRAF inhibitor therapy","score":0.6100000143051147},{"id":"https://openalex.org/keywords/melanoma-progression","display_name":"melanoma progression","score":0.3540000021457672}],"concepts":[{"id":"https://openalex.org/C2776131300","wikidata":"https://www.wikidata.org/wiki/Q423111","display_name":"Vemurafenib","level":4,"score":0.9519131183624268},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8198592662811279},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.8140146732330322},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.6424033045768738},{"id":"https://openalex.org/C2779323059","wikidata":"https://www.wikidata.org/wiki/Q692077","display_name":"Nevus","level":3,"score":0.525739312171936},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4722159206867218},{"id":"https://openalex.org/C2776470698","wikidata":"https://www.wikidata.org/wiki/Q21851559","display_name":"V600E","level":4,"score":0.41815248131752014},{"id":"https://openalex.org/C2780667408","wikidata":"https://www.wikidata.org/wiki/Q7643331","display_name":"Superficial spreading melanoma","level":3,"score":0.4138287305831909},{"id":"https://openalex.org/C2994587330","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Metastatic melanoma","level":3,"score":0.3171401619911194},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.21346908807754517},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.08931246399879456},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.05372118949890137},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmid:23710269","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23710269","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical and aesthetic dermatology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3662681","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3662681/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Aesthet Dermatol","raw_type":"Text"},{"id":"mag:1543219913","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23710269","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3662681","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3662681/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Aesthet Dermatol","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000878657","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA016672","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W1507247257","https://openalex.org/W1536384241","https://openalex.org/W1537628045","https://openalex.org/W1564434617","https://openalex.org/W1576725879","https://openalex.org/W1693873467","https://openalex.org/W1947952562","https://openalex.org/W1968022619","https://openalex.org/W1973801985","https://openalex.org/W1992999500","https://openalex.org/W2002812414","https://openalex.org/W2003457431","https://openalex.org/W2004181803","https://openalex.org/W2012799860","https://openalex.org/W2041851693","https://openalex.org/W2047517999","https://openalex.org/W2049979602","https://openalex.org/W2053506722","https://openalex.org/W2054322080","https://openalex.org/W2069329981","https://openalex.org/W2087219825","https://openalex.org/W2089131417","https://openalex.org/W2090648624","https://openalex.org/W2096645965","https://openalex.org/W2098839625","https://openalex.org/W2109993542","https://openalex.org/W2112967018","https://openalex.org/W2116830177","https://openalex.org/W2128542677","https://openalex.org/W2129395110","https://openalex.org/W2132786409","https://openalex.org/W2144770054","https://openalex.org/W2157210705","https://openalex.org/W2168143310","https://openalex.org/W2288959377","https://openalex.org/W2332359619"],"related_works":["https://openalex.org/W2003457431","https://openalex.org/W7097199511","https://openalex.org/W1949008155","https://openalex.org/W2125403686","https://openalex.org/W2966023692","https://openalex.org/W2154589173","https://openalex.org/W2412210967","https://openalex.org/W2064294486","https://openalex.org/W2604898693","https://openalex.org/W1576725879"],"abstract_inverted_index":{"BACKGROUND:":[0],"Vemurafenib,":[1],"a":[2,21,34,82],"selective":[3],"BRAF":[4,22,83],"inhibitor":[5],"that":[6,252],"has":[7,25,200],"antineoplastic":[8],"activity":[9],"in":[10,46,72,140,186,228,237,262,346],"patients":[11,48,216,289,299,332],"with":[12,53,68,75,131,137,196,278,304],"unresectable":[13],"or":[14,42,124,188,210,239,260,308,310,319,338,348],"metastatic":[15,76],"malignant":[16,77,250],"melanoma":[17,78],"whose":[18,79,339],"tumor":[19],"harbors":[20],"V600E":[23,84],"mutation,":[24],"multiple":[26],"drug-associated":[27],"cutaneous":[28],"adverse":[29,107],"effects.":[30],"PURPOSE:":[31],"To":[32],"provide":[33],"detailed":[35],"and":[36,149,151,155,165,175],"comprehensive":[37],"review":[38],"of":[39,59,113,122,147,158,241],"reported":[40],"changing":[41,125,320],"new":[43,57,123,159,189,211,219,248,318,335],"pigmented":[44,104,126,142,220,321,336],"lesions":[45,127,143,191,203,221,232,337,342],"oncology":[47],"who":[49,300,333],"have":[50,179,343],"been":[51,180],"treated":[52,303],"vemurafenib.":[54,132,279],"METHODS:":[55],"The":[56,111],"appearance":[58],"melanocytic":[60,160,190,231,264,341],"nevi":[61,209],"on":[62,257],"normal-appearing":[63,258],"skin":[64,259,269,283],"after":[65,128],"initiating":[66,129,194,276],"treatment":[67,130,195,277],"vemurafenib":[69],"is":[70,135],"described":[71],"two":[73],"men":[74],"tumors":[80],"demonstrated":[81],"mutation.":[85],"Using":[86],"the":[87,97,114,156,184],"PubMed":[88],"database,":[89],"an":[90],"extensive":[91],"literature":[92],"search":[93,115],"was":[94],"performed":[95],"for":[96,288,298,325,330],"following":[98],"topics:":[99],"vermurafenib,":[100],"nevus,":[101],"nevi,":[102],"melanoma,":[103],"lesion,":[105],"cutaneous,":[106],"effect,":[108],"side":[109],"effect.":[110],"results":[112],"were":[116],"used":[117,181,315],"to":[118,153,182,193,204,275,316],"secure":[119],"all":[120],"reports":[121],"RESULTS:":[133],"Vemurafenib":[134],"associated":[136],"both":[138],"changes":[139,185,227,345],"existing":[141,187,230,340],"(including":[144],"involution,":[145,235],"alteration":[146],"color":[148],"size,":[150,238],"progression":[152],"melanoma)":[154],"onset":[157],"lesions-nevi":[161],"(in":[162,168],"5":[163],"patients)":[164],"primary":[166,212,249],"melanomas":[167,251],"2":[169],"patients).":[170],"Visual":[171],"examination,":[172],"dermoscopic":[173,307],"evaluation,":[174],"reflectance":[176],"confocal":[177],"microscopy":[178],"document":[183],"subsequent":[192],"vermurafenib.":[197],"Histopathology":[198],"analysis":[199],"shown":[201],"these":[202],"usually":[205],"be":[206,272,314,328],"either":[207,253,306],"dysplastic":[208],"melanomas.":[213],"CONCLUSION:":[214],"Vemurafenib-treated":[215],"can":[217,246],"develop":[218,247,261,334],"(such":[222,233],"as":[223,234],"nevi)":[224],"and/or":[225],"morphological":[226,344],"their":[229],"increase":[236],"alternation":[240],"color).":[242],"In":[243,296],"addition,":[244,297],"they":[245,291],"occur":[254],"de":[255],"novo":[256],"pre-existing":[263],"lesions.":[265,322],"Therefore,":[266],"total":[267],"body":[268],"examination":[270],"should":[271,313,327],"considered":[273,329],"prior":[274],"Regularly":[280],"scheduled":[281],"follow-up":[282],"examinations":[284],"are":[285,292,301],"also":[286],"recommended":[287],"while":[290],"receiving":[293],"this":[294],"drug.":[295],"being":[302],"vemurafenib,":[305],"photographic":[309],"visual":[311],"modalities":[312],"evaluate":[317],"Also,":[323],"biopsy":[324],"histopathology":[326],"vemurafenib-treated":[331],"size":[347],"color.":[349]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}