{"id":"https://openalex.org/W1543095225","doi":null,"title":"Studies on the manipulation of gastrointestinal tract bacteria","display_name":"Studies on the manipulation of gastrointestinal tract bacteria","publication_year":2005,"publication_date":"2005-01-01","ids":{"openalex":"https://openalex.org/W1543095225","mag":"1543095225"},"language":"en","primary_location":{"id":"pmh:oai:ro.uow.edu.au:theses-1483","doi":null,"is_oa":true,"landing_page_url":"https://ro.uow.edu.au/theses/483","pdf_url":"https://ro.uow.edu.au/theses/483","source":{"id":"https://openalex.org/S4306400510","display_name":"Research Online (University of Wollongong)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I204824540","host_organization_name":"University of Wollongong","host_organization_lineage":["https://openalex.org/I204824540"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"University of Wollongong Thesis Collection 1954-2016","raw_type":"thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://ro.uow.edu.au/theses/483","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041037362","display_name":"Peter Njuguna","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204824540","display_name":"University of Wollongong","ror":"https://ror.org/00jtmb277","country_code":"AU","type":"education","lineage":["https://openalex.org/I204824540"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Peter Njuguna","raw_affiliation_strings":["University of Wollongong"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Wollongong","institution_ids":["https://openalex.org/I204824540"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5041037362"],"corresponding_institution_ids":["https://openalex.org/I204824540"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10141","display_name":"Probiotics and Fermented Foods","score":0.8769999742507935,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10141","display_name":"Probiotics and Fermented Foods","score":0.8769999742507935,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12489","display_name":"Microbial Metabolites in Food Biotechnology","score":0.057500001043081284,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.03669999912381172,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prebiotics","display_name":"prebiotics","score":1.0},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.6420000195503235},{"id":"https://openalex.org/keywords/ganoderma-lucidum-polysaccharides","display_name":"Ganoderma lucidum polysaccharides","score":0.8769999742507935},{"id":"https://openalex.org/keywords/lactic-acid-bacteria","display_name":"lactic acid bacteria","score":0.7639999985694885},{"id":"https://openalex.org/keywords/colicins","display_name":"colicins","score":0.9070000052452087},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.972000002861023},{"id":"https://openalex.org/keywords/post-weaning-diarrhea","display_name":"post-weaning diarrhea","score":0.7839999794960022},{"id":"https://openalex.org/keywords/antimicrobial-resistance","display_name":"antimicrobial resistance","score":0.5109999775886536}],"concepts":[{"id":"https://openalex.org/C168707992","wikidata":"https://www.wikidata.org/wiki/Q15439223","display_name":"Colicin","level":4,"score":0.9413726329803467},{"id":"https://openalex.org/C115574571","wikidata":"https://www.wikidata.org/wiki/Q183119","display_name":"Bacteriocin","level":3,"score":0.6280340552330017},{"id":"https://openalex.org/C2780512811","wikidata":"https://www.wikidata.org/wiki/Q11829360","display_name":"Gastrointestinal tract","level":2,"score":0.5869321823120117},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.5726249814033508},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5127214193344116},{"id":"https://openalex.org/C22744801","wikidata":"https://www.wikidata.org/wiki/Q172778","display_name":"Plasmid","level":3,"score":0.3082638382911682},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.305542528629303},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11063817143440247},{"id":"https://openalex.org/C4937899","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Antimicrobial","level":2,"score":0.0586608350276947}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:ro.uow.edu.au:theses-1483","doi":null,"is_oa":true,"landing_page_url":"https://ro.uow.edu.au/theses/483","pdf_url":"https://ro.uow.edu.au/theses/483","source":{"id":"https://openalex.org/S4306400510","display_name":"Research Online (University of Wollongong)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I204824540","host_organization_name":"University of Wollongong","host_organization_lineage":["https://openalex.org/I204824540"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"University of Wollongong Thesis Collection 1954-2016","raw_type":"thesis"},{"id":"pmh:oai:figshare.com:article/27827856","doi":null,"is_oa":false,"landing_page_url":"https://figshare.com/articles/thesis/Studies_on_the_manipulation_of_gastrointestinal_tract_bacteria/27827856","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"mag:1543095225","doi":null,"is_oa":false,"landing_page_url":"https://ro.uow.edu.au/cgi/viewcontent.cgi?article=1483&context=theses","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:ro.uow.edu.au:theses-1483","doi":null,"is_oa":true,"landing_page_url":"https://ro.uow.edu.au/theses/483","pdf_url":"https://ro.uow.edu.au/theses/483","source":{"id":"https://openalex.org/S4306400510","display_name":"Research Online (University of Wollongong)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I204824540","host_organization_name":"University of Wollongong","host_organization_lineage":["https://openalex.org/I204824540"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"University of Wollongong Thesis Collection 1954-2016","raw_type":"thesis"},"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320969","display_name":"University of Wollongong","ror":"https://ror.org/00jtmb277"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1543095225.pdf","grobid_xml":"https://content.openalex.org/works/W1543095225.grobid-xml"},"referenced_works_count":88,"referenced_works":["https://openalex.org/W94412437","https://openalex.org/W171739003","https://openalex.org/W212311013","https://openalex.org/W1547933399","https://openalex.org/W1557544700","https://openalex.org/W1596304986","https://openalex.org/W1598237762","https://openalex.org/W1619889507","https://openalex.org/W1653594586","https://openalex.org/W1654399940","https://openalex.org/W1687165263","https://openalex.org/W1764832964","https://openalex.org/W1847879046","https://openalex.org/W1929639018","https://openalex.org/W1967278732","https://openalex.org/W1974527922","https://openalex.org/W1976275371","https://openalex.org/W1980615440","https://openalex.org/W1992841622","https://openalex.org/W2004708285","https://openalex.org/W2008924807","https://openalex.org/W2013725374","https://openalex.org/W2014298338","https://openalex.org/W2016281336","https://openalex.org/W2016786240","https://openalex.org/W2018448695","https://openalex.org/W2018846731","https://openalex.org/W2022471566","https://openalex.org/W2025458032","https://openalex.org/W2027507265","https://openalex.org/W2027802399","https://openalex.org/W2028322111","https://openalex.org/W2030960641","https://openalex.org/W2032981312","https://openalex.org/W2033691547","https://openalex.org/W2044034553","https://openalex.org/W2051108593","https://openalex.org/W2052383391","https://openalex.org/W2061071686","https://openalex.org/W2063177628","https://openalex.org/W2067651150","https://openalex.org/W2067778098","https://openalex.org/W2072084749","https://openalex.org/W2080223927","https://openalex.org/W2080230832","https://openalex.org/W2082164251","https://openalex.org/W2085871805","https://openalex.org/W2087484128","https://openalex.org/W2091997040","https://openalex.org/W2100329115","https://openalex.org/W2101132534","https://openalex.org/W2107414352","https://openalex.org/W2110007623","https://openalex.org/W2111983489","https://openalex.org/W2112111992","https://openalex.org/W2113799232","https://openalex.org/W2115014672","https://openalex.org/W2115625081","https://openalex.org/W2115767337","https://openalex.org/W2118491150","https://openalex.org/W2120510240","https://openalex.org/W2120977803","https://openalex.org/W2122210041","https://openalex.org/W2122446900","https://openalex.org/W2124389865","https://openalex.org/W2125397171","https://openalex.org/W2128679636","https://openalex.org/W2129248774","https://openalex.org/W2131823595","https://openalex.org/W2134202672","https://openalex.org/W2135894581","https://openalex.org/W2137089963","https://openalex.org/W2138139644","https://openalex.org/W2139937528","https://openalex.org/W2145584493","https://openalex.org/W2145717531","https://openalex.org/W2146122066","https://openalex.org/W2155752438","https://openalex.org/W2157124349","https://openalex.org/W2159401663","https://openalex.org/W2165958271","https://openalex.org/W2167336969","https://openalex.org/W2167608482","https://openalex.org/W2169054817","https://openalex.org/W2171288701","https://openalex.org/W2220516585","https://openalex.org/W2399887765","https://openalex.org/W4313331951"],"related_works":["https://openalex.org/W7038502074","https://openalex.org/W2799822690","https://openalex.org/W2356389881","https://openalex.org/W3217260865","https://openalex.org/W2901829955","https://openalex.org/W2363542712","https://openalex.org/W2191813228","https://openalex.org/W2956175090","https://openalex.org/W2403036402","https://openalex.org/W4288928528"],"abstract_inverted_index":{"Increasing":[0],"awareness":[1],"that":[2,46,116,284,668,727],"the":[3,22,32,49,54,67,73,89,93,96,106,118,130,147,156,172,201,218,236,245,248,314,329,382,392,421,449,469,518,527,531,541,620,633,677,698,710],"human":[4,422,576],"intestinal":[5,554],"flora":[6,23],"is":[7,105,706],"a":[8,61,185,191,299,474,488,583],"major":[9],"factor":[10],"in":[11,66,126,171,196,209,217,289,302,308,346,391,459,496,540,546,682,687,716],"health":[12],"and":[13,38,135,200,222,277,306,325,344,361,387,403,405,436,448,456,477,482,505,577,595,642,660],"disease":[14],"has":[15],"led":[16],"to":[17,20,24,31,83,137,327,537,589,604,614,646,649,679,721,733,745,748],"different":[18,379,553],"strategies":[19],"manipulate":[21,138],"promote":[25],"health.":[26],"These":[27],"approaches":[28],"include":[29],"changes":[30],"diet":[33],"by":[34,51,91,154,167,224,257,293],"inclusion":[35],"of":[36,58,64,79,95,101,103,108,120,133,178,187,193,212,227,247,252,316,331,381,420,441,463,468,493,511,517,524,543,575,601,610,619,656,664,689,700,709,713],"prebiotics":[37,134,686],"probiotics.":[39],"Prebiotics":[40],"are":[41,76],"non-digestible":[42],"polysaccharide":[43,143,670],"food":[44],"ingredients":[45],"beneficially":[47,87],"affect":[48,88,244],"host":[50,90],"selectively":[52],"stimulating":[53],"growth":[55,119],"and/or":[56],"activity":[57,569,739],"one":[59,428],"or":[60,85,628],"limited":[62],"number":[63],"bacteria":[65,214,232,305,311,705],"gastrointestinal":[68],"tract":[69],"(GIT).":[70],"Probiotics":[71],"on":[72,269,355,693],"other":[74],"hand":[75],"viable":[77],"culture":[78],"bacteria,":[80],"which":[81,241],"applied":[82,326],"animals":[84],"humans,":[86],"improving":[92],"properties":[94],"indigenous":[97],"microflora.":[98],"One":[99],"mechanism":[100],"action":[102,631],"probiotics":[104,136],"production":[107],"antimicrobial":[109],"substances":[110],"called":[111],"bacteriocins,":[112],"such":[113],"as":[114,685,703],"colicins,":[115],"inhibit":[117],"their":[121,690,737],"competitors.":[122],"The":[123,162,250,296,352,580,608,662],"experiments":[124],"described":[125],"this":[127,665],"thesis":[128,666],"examined":[129],"potential":[131,678,728],"use":[132,699],"GIT":[139,383],"bacteria.":[140,249],"A":[141,320],"crude":[142],"extract":[144,163,294],"(HW)":[145],"from":[146,313,359,364,378,552,673],"medicinal":[148],"mushroom":[149],"Ganoderma":[150,674],"lucidium":[151,675],"was":[152,164,255,286,298,323,487,612],"prepared":[153],"extracting":[155],"fruiting":[157],"body":[158],"with":[159,235,366,431,526,598,617],"boiling":[160],"water.":[161],"then":[165,203],"purified":[166,669],"ethanol":[168],"precipitation":[169],"resulting":[170],"hot":[173],"water-ethanol":[174],"(HWE)":[175,672],"extract.":[176],"Groups":[177],"mice":[179,202],"were":[180,215,233,267,389,415,453,457,479,565,644],"fed":[181],"these":[182,478,724],"extracts":[183,671],"over":[184],"period":[186],"three":[188,206,650],"weeks":[189],"at":[190,426,439],"concentration":[192],"150":[194],"\ufffd\ufffdg/ml":[195,600],"sterile":[197],"drinking":[198],"water":[199],"euthanised":[204],"after":[205],"weeks.":[207],"Changes":[208],"population":[210,290],"dynamics":[211,291],"lumen":[213,304,310],"determined":[216],"duodenum,":[219],"ileum,":[220,385],"colon":[221,315,386],"faeces":[223],"rigorous":[225],"washing":[226],"excised":[228],"segments":[229],"while":[230],"adherent":[231],"released":[234],"non-ionic":[237],"detergent":[238],"Triton":[239],"X100,":[240],"does":[242],"not":[243],"viability":[246],"prevalence":[251,330],"haemolytic":[253,303],"colonies":[254],"assessed":[256],"plating":[258],"washouts":[259],"onto":[260],"blood":[261],"agar.":[262],"Total":[263],"colony":[264],"forming":[265],"units":[266],"enumerated":[268],"bacteriological":[270],"media":[271],"selective":[272],"for":[273,508,567,736],"Enterobacteriaceae,":[274],"Streptococci,":[275],"Enterococci":[276],"Lactic":[278],"acid":[279],"Bacteria":[280],"(LAB).":[281],"Results":[282],"showed":[283],"there":[285,486,535],"little":[287,627],"change":[288],"elicited":[292],"feeding.":[295],"exception":[297],"significant":[300],"reduction":[301],"increase":[307],"LAB":[309],"recovered":[312,551],"HWE":[317],"treated":[318],"mice.":[319],"multiplex":[321],"PCR":[322,393],"optimized":[324],"survey":[328],"eight":[332],"common":[333,529],"colicin":[334,408,429,475,494,513,606,714],"genes":[335,495,514,715],"(Colicins":[336],"A,":[337],"D,":[338,433],"E1,":[339,434,503],"E2,":[340,399],"E6,":[341,400,446],"E7,":[342,401],"Ia":[343,402,447,506],"V)":[345,404],"Escherichia":[347],"coli":[348,375,549,560,574,624,654,719],"(E.":[349],"coli)":[350],"isolates.":[351],"study":[353],"focused":[354],"39":[356],"clinical":[357],"isolates":[358,363,376,424,472,550],"humans":[360],"68":[362],"pigs":[365],"post-weaning":[367],"diarrhoea.":[368],"In":[369,484,696],"addition,":[370,697],"152":[371],"porcine":[372,470,498,557,578,622,651],"commensal":[373,497,519,547,558,621,639],"E.":[374,499,548,559,573,623,653,718],"obtained":[377],"compartments":[380],"(duodenum,":[384],"faeces)":[388],"included":[390],"analysis.":[394],"Six":[395,516],"individual":[396,741],"colicins":[397,432,525,544,564],"(E1,":[398],"four":[406],"dual":[407,450],"combinations":[409],"(E1/E2,":[410],"E1/E7,":[411],"E2/E7,":[412],"&":[413],"E2/Ia)":[414],"detected.":[416,515],"Approximately":[417],"28.2":[418],"%":[419,443,462,467,510],"pathogenic":[423,471,572,635,652,717,742],"had":[425],"least":[427],"gene":[430,476],"E7":[435,504],"V":[437],"occurring":[438],"frequencies":[440],"5.1":[442],"each.":[444],"Colicins":[445],"colicin,":[451],"E2/Ia,":[452],"less":[454],"frequent":[455],"found":[458,545,613,645],"about":[460],"2.6":[461],"clones.":[464],"Only":[465],"4":[466],"possessed":[473,521],"exclusively":[480],"E1":[481],"V.":[483],"contrast,":[485],"significantly":[489],"higher":[490],"carriage":[491],"(36.2%)":[492],"coli.":[500],"Of":[501],"these,":[502],"accounted":[507],"87":[509],"all":[512],"strains":[520,561,625,655,702,731,743],"multiple":[522],"types":[523],"most":[528,618],"being":[530,746],"E2/E7":[532],"combination.":[533],"Furthermore,":[534],"appeared":[536],"be":[538,615,680,734],"differences":[539],"type":[542],"compartments.":[555],"Seven":[556],"producing":[562],"standard":[563],"evaluated":[566],"inhibitory":[568,585,630,648,738],"against":[570,632,740],"five":[571,634],"origin.":[579],"experiment":[581],"utilized":[582],"kinetic":[584],"microtitre":[586],"assay":[587],"(KIMA)":[588],"assess":[590],"inhibition":[591,611],"using":[592],"non-induced":[593],"supernatants":[594,596],"induced":[597],"0.2":[599],"mitomycin":[602],"C":[603],"stimulate":[605],"production.":[607],"level":[609],"variable":[616],"showing":[626],"no":[629],"strains.":[636],"However,":[637],"two":[638],"strains,":[640],"ILC33":[641],"CC89":[643],"highly":[647],"serotypes":[657],"O141:K85,":[658],"0141:K88":[659],"0149:K88.":[661],"findings":[663,725],"suggest":[667],"have":[676,732],"used":[681],"further":[683,749],"studies":[684],"view":[688],"positive":[691],"effects":[692],"beneficial":[694],"LAB.":[695],"colicin-bearing":[701],"probiotic":[704,729],"justifiable":[707],"because":[708],"low":[711],"incidence":[712],"compared":[720],"commensals.":[722],"Finally,":[723],"indicate":[726],"bacterial":[730],"scrutinised":[735],"prior":[744],"subjected":[747],"assessments.":[750]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
