{"id":"https://openalex.org/W154303479","doi":"https://doi.org/10.1007/978-1-4757-9637-7_3","title":"An Enzyme-Targeted Herbicide Design Program Based on EPSP Synthase: Chemical Mechanism and Glyphosate Inhibition Studies","display_name":"An Enzyme-Targeted Herbicide Design Program Based on EPSP Synthase: Chemical Mechanism and Glyphosate Inhibition Studies","publication_year":1990,"publication_date":"1990-01-01","ids":{"openalex":"https://openalex.org/W154303479","doi":"https://doi.org/10.1007/978-1-4757-9637-7_3","mag":"154303479"},"language":"en","primary_location":{"id":"doi:10.1007/978-1-4757-9637-7_3","doi":"https://doi.org/10.1007/978-1-4757-9637-7_3","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-4757-9637-7_3","pdf_url":null,"source":{"id":"https://openalex.org/S4306463937","display_name":"Springer eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical Aspects of Enzyme Biotechnology","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W2490422649","display_name":"Chemical Aspects of Enzyme Biotechnology"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016054923","display_name":"James A. Sikorski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1295346377","display_name":"Monsanto (United States)","ror":"https://ror.org/00j83wy46","country_code":"US","type":"company","lineage":["https://openalex.org/I1295346377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James A. Sikorski","raw_affiliation_strings":["Technology Division, Monsanto Agricultural Company, A Unit of Monsanto Company, 800 N. Lindbergh Blvd., St. Louis, MO, 63167, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Technology Division, Monsanto Agricultural Company, A Unit of Monsanto Company, 800 N. Lindbergh Blvd., St. Louis, MO, 63167, USA","institution_ids":["https://openalex.org/I1295346377"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048319542","display_name":"Karen S. Anderson","orcid":"https://orcid.org/0000-0003-3433-0780","observed_orcids":["https://orcid.org/0000-0003-3433-0780","https://orcid.org/0000-0002-3870-5730"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karen S. Anderson","raw_affiliation_strings":["Departments of Molecular & Cell Biology and Chemistry, The Pennsylvania State Univ., 301 Althouse Laboratory, University Park, PA, 16802, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Molecular & Cell Biology and Chemistry, The Pennsylvania State Univ., 301 Althouse Laboratory, University Park, PA, 16802, USA","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026985407","display_name":"Darryl G. Cleary","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1295346377","display_name":"Monsanto (United States)","ror":"https://ror.org/00j83wy46","country_code":"US","type":"company","lineage":["https://openalex.org/I1295346377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Darryl G. Cleary","raw_affiliation_strings":["Technology Division, Monsanto Agricultural Company, A Unit of Monsanto Company, 800 N. Lindbergh Blvd., St. Louis, MO, 63167, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Technology Division, Monsanto Agricultural Company, A Unit of Monsanto Company, 800 N. Lindbergh Blvd., St. Louis, MO, 63167, USA","institution_ids":["https://openalex.org/I1295346377"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Michael J. Miller","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1295346377","display_name":"Monsanto (United States)","ror":"https://ror.org/00j83wy46","country_code":"US","type":"company","lineage":["https://openalex.org/I1295346377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael J. Miller","raw_affiliation_strings":["Technology Division, Monsanto Agricultural Company, A Unit of Monsanto Company, 800 N. Lindbergh Blvd., St. Louis, MO, 63167, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Technology Division, Monsanto Agricultural Company, A Unit of Monsanto Company, 800 N. Lindbergh Blvd., St. Louis, MO, 63167, USA","institution_ids":["https://openalex.org/I1295346377"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010377091","display_name":"Paul D. Pansegrau","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1295346377","display_name":"Monsanto (United States)","ror":"https://ror.org/00j83wy46","country_code":"US","type":"company","lineage":["https://openalex.org/I1295346377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul D. Pansegrau","raw_affiliation_strings":["Technology Division, Monsanto Agricultural Company, A Unit of Monsanto Company, 800 N. Lindbergh Blvd., St. Louis, MO, 63167, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Technology Division, Monsanto Agricultural Company, A Unit of Monsanto Company, 800 N. Lindbergh Blvd., St. Louis, MO, 63167, USA","institution_ids":["https://openalex.org/I1295346377"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045197208","display_name":"Joel E. Ream","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1295346377","display_name":"Monsanto (United States)","ror":"https://ror.org/00j83wy46","country_code":"US","type":"company","lineage":["https://openalex.org/I1295346377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joel E. Ream","raw_affiliation_strings":["Technology Division, Monsanto Agricultural Company, A Unit of Monsanto Company, 800 N. Lindbergh Blvd., St. Louis, MO, 63167, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Technology Division, Monsanto Agricultural Company, A Unit of Monsanto Company, 800 N. Lindbergh Blvd., St. Louis, MO, 63167, USA","institution_ids":["https://openalex.org/I1295346377"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080533862","display_name":"Robert Douglas Sammons","orcid":"https://orcid.org/0000-0002-0956-481X","observed_orcids":["https://orcid.org/0000-0002-0956-481X"]},"institutions":[{"id":"https://openalex.org/I1295346377","display_name":"Monsanto (United States)","ror":"https://ror.org/00j83wy46","country_code":"US","type":"company","lineage":["https://openalex.org/I1295346377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. Douglas Sammons","raw_affiliation_strings":["Technology Division, Monsanto Agricultural Company, A Unit of Monsanto Company, 800 N. Lindbergh Blvd., St. Louis, MO, 63167, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Technology Division, Monsanto Agricultural Company, A Unit of Monsanto Company, 800 N. Lindbergh Blvd., St. Louis, MO, 63167, USA","institution_ids":["https://openalex.org/I1295346377"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054934658","display_name":"Kenneth Allen Johnson","orcid":"https://orcid.org/0000-0002-6575-2823","observed_orcids":["https://orcid.org/0000-0002-6575-2823"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kenneth A. Johnson","raw_affiliation_strings":["Departments of Molecular & Cell Biology and Chemistry, The Pennsylvania State Univ., 301 Althouse Laboratory, University Park, PA, 16802, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Molecular & Cell Biology and Chemistry, The Pennsylvania State Univ., 301 Althouse Laboratory, University Park, PA, 16802, USA","institution_ids":["https://openalex.org/I130769515"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.3227,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.74984127,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"23","last_page":"39"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10774","display_name":"Weed Control and Herbicide Applications","score":0.9692000150680542,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10774","display_name":"Weed Control and Herbicide Applications","score":0.9692000150680542,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11180","display_name":"Pesticide and Herbicide Environmental Studies","score":0.007000000216066837,"subfield":{"id":"https://openalex.org/subfields/2310","display_name":"Pollution"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12191","display_name":"Chemical Reaction Mechanisms","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epsp-synthase","display_name":"EPSP synthase","score":0.8820000290870667},{"id":"https://openalex.org/keywords/glyphosate","display_name":"glyphosate","score":0.7879999876022339},{"id":"https://openalex.org/keywords/herbicide-design","display_name":"herbicide design","score":0.6990000009536743},{"id":"https://openalex.org/keywords/enzyme-inhibition-mechanism","display_name":"enzyme inhibition mechanism","score":0.843999981880188},{"id":"https://openalex.org/keywords/selective-herbicides","display_name":"selective herbicides","score":0.5009999871253967},{"id":"https://openalex.org/keywords/mammalian-toxicity","display_name":"mammalian toxicity","score":0.8510000109672546},{"id":"https://openalex.org/keywords/structural-biology","display_name":"structural biology","score":0.5709999799728394},{"id":"https://openalex.org/keywords/herbicide-discovery","display_name":"herbicide discovery","score":0.5609999895095825}],"concepts":[{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.6473363637924194},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.5897825956344604},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.46513456106185913},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4264974594116211},{"id":"https://openalex.org/C2779715943","wikidata":"https://www.wikidata.org/wiki/Q427492","display_name":"Enzyme inhibition","level":3,"score":0.4199720025062561},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3984375596046448},{"id":"https://openalex.org/C183696295","wikidata":"https://www.wikidata.org/wiki/Q2487696","display_name":"Biochemical engineering","level":1,"score":0.39761584997177124},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.3676072061061859},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3200984001159668},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.23156416416168213},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/978-1-4757-9637-7_3","doi":"https://doi.org/10.1007/978-1-4757-9637-7_3","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-4757-9637-7_3","pdf_url":null,"source":{"id":"https://openalex.org/S4306463937","display_name":"Springer eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical Aspects of Enzyme Biotechnology","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"display_name":"Zero hunger","id":"https://metadata.un.org/sdg/2","score":0.6000000238418579}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W250215297","https://openalex.org/W254572893","https://openalex.org/W349644444","https://openalex.org/W616005241","https://openalex.org/W617331918","https://openalex.org/W1485233340","https://openalex.org/W1486037411","https://openalex.org/W1504079901","https://openalex.org/W1533205371","https://openalex.org/W1557206549","https://openalex.org/W1561096771","https://openalex.org/W1564639022","https://openalex.org/W1571909580","https://openalex.org/W1602374426","https://openalex.org/W1670762346","https://openalex.org/W1889077695","https://openalex.org/W1972047447","https://openalex.org/W1976785957","https://openalex.org/W1977762547","https://openalex.org/W1986456092","https://openalex.org/W1988611873","https://openalex.org/W1990619974","https://openalex.org/W1994333867","https://openalex.org/W1998929301","https://openalex.org/W2004533078","https://openalex.org/W2008687945","https://openalex.org/W2011920569","https://openalex.org/W2021636407","https://openalex.org/W2026937656","https://openalex.org/W2030088094","https://openalex.org/W2035472615","https://openalex.org/W2035707277","https://openalex.org/W2041593035","https://openalex.org/W2058067700","https://openalex.org/W2066490611","https://openalex.org/W2077542581","https://openalex.org/W2091943628","https://openalex.org/W2116980379","https://openalex.org/W2121749642","https://openalex.org/W2202507062","https://openalex.org/W2218032941","https://openalex.org/W2314623463","https://openalex.org/W2417309992","https://openalex.org/W2909107085","https://openalex.org/W3004507292","https://openalex.org/W3004623196"],"related_works":["https://openalex.org/W2024684631","https://openalex.org/W4252440075","https://openalex.org/W7098914523","https://openalex.org/W1557041845","https://openalex.org/W2026683275","https://openalex.org/W2127972744","https://openalex.org/W316656207","https://openalex.org/W1999550637","https://openalex.org/W4220899616","https://openalex.org/W2949999957"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2016-06-24T00:00:00"}