{"id":"https://openalex.org/W1542960186","doi":"https://doi.org/10.1158/1538-7445.am2014-1953","title":"Abstract 1953: The role of NR5a2 in pancreas development and carcinogenesis","display_name":"Abstract 1953: The role of NR5a2 in pancreas development and carcinogenesis","publication_year":2014,"publication_date":"2014-10-01","ids":{"openalex":"https://openalex.org/W1542960186","doi":"https://doi.org/10.1158/1538-7445.am2014-1953","mag":"1542960186"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2014-1953","doi":"https://doi.org/10.1158/1538-7445.am2014-1953","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2014-1953","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087249271","display_name":"Sahar Nissim","orcid":"https://orcid.org/0000-0002-2303-6415","observed_orcids":["https://orcid.org/0000-0002-2303-6415"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sahar Nissim","raw_affiliation_strings":["1Brigham and Women's Hospital, Boston, MA;","#N#1Brigham and Women's Hospital, Boston, MA#N#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Brigham and Women's Hospital, Boston, MA;","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"#N#1Brigham and Women's Hospital, Boston, MA#N#","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086691580","display_name":"Julia I. Wucherpfennig","orcid":"https://orcid.org/0000-0003-3471-6624","observed_orcids":["https://orcid.org/0000-0003-3471-6624"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julia Wucherpfennig","raw_affiliation_strings":["1Brigham and Women's Hospital, Boston, MA;","#N#1Brigham and Women's Hospital, Boston, MA#N#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Brigham and Women's Hospital, Boston, MA;","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"#N#1Brigham and Women's Hospital, Boston, MA#N#","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100626420","display_name":"Xiaoxu Wang","orcid":"https://orcid.org/0000-0002-8364-9467","observed_orcids":["https://orcid.org/0000-0002-8364-9467"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiao-Xu Wang","raw_affiliation_strings":["2Dana Farber Cancer Institute, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Dana Farber Cancer Institute, Boston, MA","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011348783","display_name":"Alec C. Kimmelman","orcid":"https://orcid.org/0009-0002-9465-8411","observed_orcids":["https://orcid.org/0009-0002-9465-8411"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alec Kimmelman","raw_affiliation_strings":["2Dana Farber Cancer Institute, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Dana Farber Cancer Institute, Boston, MA","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007257334","display_name":"Wolfram Goessling","orcid":"https://orcid.org/0000-0001-9972-1569","observed_orcids":["https://orcid.org/0000-0001-9972-1569"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]},{"id":"https://openalex.org/I4210157861","display_name":"Harvard Stem Cell Institute","ror":"https://ror.org/04kj1hn59","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210157861"]},{"id":"https://openalex.org/I4210161994","display_name":"Dana-Farber Brigham Cancer Center","ror":"https://ror.org/05rgrbr06","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I4210117453","https://openalex.org/I4210161994","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wolfram Goessling","raw_affiliation_strings":["3Brigham and Women's Hospital, Dana-Farber Cancer Institute, Harvard Stem Cell Institute, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Brigham and Women's Hospital, Dana-Farber Cancer Institute, Harvard Stem Cell Institute, Boston, MA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984","https://openalex.org/I4210117453","https://openalex.org/I4210157861","https://openalex.org/I4210161994"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"74","issue":"19_Supplement","first_page":"1953","last_page":"1953"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9053000211715698,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9053000211715698,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.05649999901652336,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.013500000350177288,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nr5a2","display_name":"NR5A2","score":0.9890000224113464},{"id":"https://openalex.org/keywords/pancreatic-ductal-adenocarcinoma","display_name":"pancreatic ductal adenocarcinoma","score":0.9390000104904175},{"id":"https://openalex.org/keywords/pancreas-development","display_name":"pancreatic development","score":0.9490000009536743},{"id":"https://openalex.org/keywords/exocrine-pancreas","display_name":"exocrine pancreas","score":0.8109999895095825},{"id":"https://openalex.org/keywords/pancreatic-progenitor-cells","display_name":"pancreatic progenitor cells","score":0.7960000038146973},{"id":"https://openalex.org/keywords/pancreatic-carcinogenesis","display_name":"pancreatic carcinogenesis","score":0.7839999794960022},{"id":"https://openalex.org/keywords/zebrafish","display_name":"zebrafish","score":0.7990000247955322},{"id":"https://openalex.org/keywords/notch-signaling","display_name":"Notch signaling","score":0.8450000286102295},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.5820000171661377},{"id":"https://openalex.org/keywords/genome-wide-association-study","display_name":"genome-wide association study","score":0.6299999952316284}],"concepts":[{"id":"https://openalex.org/C201716435","wikidata":"https://www.wikidata.org/wiki/Q15312697","display_name":"Liver receptor homolog-1","level":5,"score":0.7445425987243652},{"id":"https://openalex.org/C2778764654","wikidata":"https://www.wikidata.org/wiki/Q9618","display_name":"Pancreas","level":2,"score":0.6423341035842896},{"id":"https://openalex.org/C2778148616","wikidata":"https://www.wikidata.org/wiki/Q5311600","display_name":"Ductal cells","level":3,"score":0.6336746215820312},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.6335909366607666},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6119489669799805},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.5681331753730774},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5046485662460327},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.4943366050720215},{"id":"https://openalex.org/C15729860","wikidata":"https://www.wikidata.org/wiki/Q2329919","display_name":"Progenitor","level":4,"score":0.4405834972858429},{"id":"https://openalex.org/C63932345","wikidata":"https://www.wikidata.org/wiki/Q422500","display_name":"Nuclear receptor","level":4,"score":0.4175361096858978},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3257383704185486},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.3113919198513031},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2950860857963562},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.27390506863594055},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.27372848987579346},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12742283940315247},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09361720085144043}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2014-1953","doi":"https://doi.org/10.1158/1538-7445.am2014-1953","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2014-1953","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2566023970","https://openalex.org/W2317667975","https://openalex.org/W3121247185","https://openalex.org/W2169837598","https://openalex.org/W1983959103","https://openalex.org/W7214360398","https://openalex.org/W2608246637","https://openalex.org/W2495712628","https://openalex.org/W2156950220","https://openalex.org/W3144008872"],"abstract_inverted_index":{"Abstract":[0],"Pancreatic":[1],"ductal":[2,138,214],"adenocarcinoma":[3],"(PDAC)":[4],"remains":[5],"one":[6],"of":[7,68,73,93,115,143,148,174,200,205,220,255,265,270],"the":[8,21,60,96,103,153,170,209,239,266,271],"most":[9],"lethal":[10],"cancers":[11],"today.":[12],"A":[13],"recent":[14],"genome-wide":[15],"association":[16],"study":[17],"(GWAS)":[18],"has":[19,40],"implicated":[20],"nuclear":[22],"receptor":[23],"NR5A2":[24,131,144,156],"in":[25,37,53,71,85,112,124,159,203,208,229,257],"modulating":[26],"risk":[27],"for":[28,34,110,274],"pancreatic":[29,38,160],"cancer.":[30],"While":[31],"a":[32,108,165],"role":[33,52,84,109,254],"this":[35,183],"gene":[36],"cancer":[39],"not":[41,236],"been":[42],"previously":[43],"recognized,":[44],"it":[45],"is":[46,133,157,225],"known":[47],"to":[48,95,102,136,217],"have":[49],"an":[50,82,226],"important":[51,227],"stem":[54],"cell":[55,126,150],"pluripotency":[56],"and":[57,123,172,223,260],"metabolism.":[58],"Using":[59],"zebrafish":[61],"model":[62,166],"organism,":[63],"we":[64,90,128,185],"demonstrate":[65],"that":[66,99,130,155,167,187,197],"knockdown":[67,142],"nr5a2":[69,94,111,190],"results":[70,202],"absence":[72],"exocrine":[74,104,175],"pancreas,":[75,105],"while":[76],"leaving":[77],"endocrine":[78],"pancreas":[79,86,116,176,211,230,258],"unaffected,":[80],"indicating":[81],"essential":[83],"organ":[87],"formation.":[88],"Further,":[89],"localize":[91],"expression":[92,132,199],"endodermal":[97],"bud":[98],"gives":[100],"rise":[101],"consistent":[106],"with":[107,182,192],"regulating":[113],"differentiation":[114,173],"progenitors.":[117],"In":[118],"resected":[119],"human":[120],"PDAC":[121,149],"specimens":[122],"vitro":[125],"lines,":[127,151],"find":[129,186],"altered":[134],"compared":[135],"normal":[137],"epithelium.":[139],"Moreover,":[140],"shRNA":[141],"dramatically":[145],"alters":[146],"proliferation":[147,171],"supporting":[152],"hypothesis":[154],"involved":[158],"carcinogenesis.":[161,261],"These":[162],"data":[163],"support":[164],"NR5a2":[168,201,256],"regulates":[169],"progenitor":[177,221],"cells":[178,216],"during":[179],"development.":[180],"Consistent":[181],"model,":[184],"signaling":[188],"through":[189],"interacts":[191],"notch":[193],"activity.":[194],"We":[195],"postulate":[196],"aberrant":[198],"dysregulation":[204],"these":[206],"processes":[207],"adult":[210],"by":[212],"driving":[213],"epithelial":[215],"acquire":[218],"properties":[219],"cells,":[222],"therefore":[224],"step":[228],"oncogenesis.":[231],"Note:":[232],"This":[233],"abstract":[234],"was":[235],"presented":[237],"at":[238],"meeting.":[240],"Citation":[241],"Format:":[242],"Sahar":[243],"Nissim,":[244],"Julia":[245],"Wucherpfennig,":[246],"Xiao-Xu":[247],"Wang,":[248],"Alec":[249],"Kimmelman,":[250],"Wolfram":[251],"Goessling.":[252],"The":[253],"development":[259],"[abstract].":[262],"In:":[263],"Proceedings":[264],"105th":[267],"Annual":[268],"Meeting":[269],"American":[272],"Association":[273],"Cancer":[275,286],"Research;":[276],"2014":[277],"Apr":[278],"5-9;":[279],"San":[280],"Diego,":[281],"CA.":[282],"Philadelphia":[283],"(PA):":[284],"AACR;":[285],"Res":[287],"2014;74(19":[288],"Suppl):Abstract":[289],"nr":[290],"1953.":[291],"doi:10.1158/1538-7445.AM2014-1953":[292]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}
