{"id":"https://openalex.org/W1542785340","doi":null,"title":"Computational Gene Structure Prediction","display_name":"Computational Gene Structure Prediction","publication_year":2013,"publication_date":"2013-07-04","ids":{"openalex":"https://openalex.org/W1542785340","mag":"1542785340"},"language":"en","primary_location":{"id":"mag:1542785340","doi":null,"is_oa":false,"landing_page_url":"https://ediss.sub.uni-hamburg.de/volltexte/2013/6237/pdf/Dissertation.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003416136","display_name":"Gordon Gremme","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Gordon Gremme","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5003416136"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12946","display_name":"Fractal and DNA sequence analysis","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13937","display_name":"Genetics, Bioinformatics, and Biomedical Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/spliced-alignment","display_name":"spliced alignment","score":0.7229999899864197},{"id":"https://openalex.org/keywords/genome-annotation","display_name":"genome annotation","score":0.847000002861023},{"id":"https://openalex.org/keywords/cdna","display_name":"cDNA","score":0.5429999828338623},{"id":"https://openalex.org/keywords/expressed-sequence-tags","display_name":"expressed sequence tags","score":0.9700000286102295},{"id":"https://openalex.org/keywords/protein-sequences","display_name":"protein sequences","score":0.6970000267028809},{"id":"https://openalex.org/keywords/open-source-bioinformatics","display_name":"open source bioinformatics","score":0.6489999890327454}],"concepts":[{"id":"https://openalex.org/C105565629","wikidata":"https://www.wikidata.org/wiki/Q1248292","display_name":"Gene prediction","level":4,"score":0.6678181886672974},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6357899308204651},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.5925178527832031},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.5875648260116577},{"id":"https://openalex.org/C2777904410","wikidata":"https://www.wikidata.org/wiki/Q7397","display_name":"Software","level":2,"score":0.5829175114631653},{"id":"https://openalex.org/C2776321320","wikidata":"https://www.wikidata.org/wiki/Q857525","display_name":"Annotation","level":2,"score":0.522499144077301},{"id":"https://openalex.org/C89566754","wikidata":"https://www.wikidata.org/wiki/Q2273828","display_name":"Genome project","level":4,"score":0.4797307550907135},{"id":"https://openalex.org/C201797286","wikidata":"https://www.wikidata.org/wiki/Q4914986","display_name":"Biological data","level":2,"score":0.4771670401096344},{"id":"https://openalex.org/C98045186","wikidata":"https://www.wikidata.org/wiki/Q205663","display_name":"Process (computing)","level":2,"score":0.47379443049430847},{"id":"https://openalex.org/C180384323","wikidata":"https://www.wikidata.org/wiki/Q16335137","display_name":"Alignment-free sequence analysis","level":5,"score":0.4420276880264282},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4399799704551697},{"id":"https://openalex.org/C2908923196","wikidata":"https://www.wikidata.org/wiki/Q5205742","display_name":"Gene Annotation","level":4,"score":0.4155053198337555},{"id":"https://openalex.org/C136197465","wikidata":"https://www.wikidata.org/wiki/Q1729295","display_name":"Variety (cybernetics)","level":2,"score":0.41313236951828003},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3788600564002991},{"id":"https://openalex.org/C45484198","wikidata":"https://www.wikidata.org/wiki/Q827246","display_name":"Sequence alignment","level":4,"score":0.346770703792572},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.30914753675460815},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.28174516558647156},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21855244040489197},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.17976737022399902},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:1542785340","doi":null,"is_oa":false,"landing_page_url":"https://ediss.sub.uni-hamburg.de/volltexte/2013/6237/pdf/Dissertation.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":120,"referenced_works":["https://openalex.org/W53898165","https://openalex.org/W266528716","https://openalex.org/W1490430289","https://openalex.org/W1508225465","https://openalex.org/W1511730061","https://openalex.org/W1520134085","https://openalex.org/W1544282843","https://openalex.org/W1557880001","https://openalex.org/W1558096929","https://openalex.org/W1630069591","https://openalex.org/W1649645444","https://openalex.org/W1749816123","https://openalex.org/W1895714488","https://openalex.org/W1966833356","https://openalex.org/W1967465227","https://openalex.org/W1971403296","https://openalex.org/W1973738093","https://openalex.org/W1979083306","https://openalex.org/W1980052495","https://openalex.org/W1981509058","https://openalex.org/W1981831747","https://openalex.org/W1983477307","https://openalex.org/W1984966768","https://openalex.org/W1985471440","https://openalex.org/W1987423713","https://openalex.org/W1988037647","https://openalex.org/W1994017531","https://openalex.org/W1994356024","https://openalex.org/W1996116897","https://openalex.org/W1996181407","https://openalex.org/W1996948250","https://openalex.org/W2000484009","https://openalex.org/W2006561388","https://openalex.org/W2012128982","https://openalex.org/W2014840769","https://openalex.org/W2020240988","https://openalex.org/W2028709282","https://openalex.org/W2030175533","https://openalex.org/W2033715651","https://openalex.org/W2034027620","https://openalex.org/W2037444377","https://openalex.org/W2038395276","https://openalex.org/W2045110824","https://openalex.org/W2045510682","https://openalex.org/W2050902903","https://openalex.org/W2053833990","https://openalex.org/W2054254276","https://openalex.org/W2055043387","https://openalex.org/W2060612359","https://openalex.org/W2061085499","https://openalex.org/W2061680337","https://openalex.org/W2061918857","https://openalex.org/W2065262709","https://openalex.org/W2067911767","https://openalex.org/W2068702161","https://openalex.org/W2077132193","https://openalex.org/W2080667183","https://openalex.org/W2081774262","https://openalex.org/W2096525273","https://openalex.org/W2102304447","https://openalex.org/W2103903744","https://openalex.org/W2104139298","https://openalex.org/W2107499729","https://openalex.org/W2107694985","https://openalex.org/W2108775112","https://openalex.org/W2108787198","https://openalex.org/W2108895516","https://openalex.org/W2109823109","https://openalex.org/W2110041134","https://openalex.org/W2116398954","https://openalex.org/W2117489991","https://openalex.org/W2118526609","https://openalex.org/W2118784262","https://openalex.org/W2120815702","https://openalex.org/W2120935357","https://openalex.org/W2121857350","https://openalex.org/W2122634343","https://openalex.org/W2126598626","https://openalex.org/W2127230663","https://openalex.org/W2128016314","https://openalex.org/W2130395351","https://openalex.org/W2136145671","https://openalex.org/W2136725005","https://openalex.org/W2138270253","https://openalex.org/W2139133899","https://openalex.org/W2141165178","https://openalex.org/W2141572089","https://openalex.org/W2142009178","https://openalex.org/W2142418779","https://openalex.org/W2143210482","https://openalex.org/W2145477956","https://openalex.org/W2145697506","https://openalex.org/W2148237482","https://openalex.org/W2150934173","https://openalex.org/W2152399502","https://openalex.org/W2153993827","https://openalex.org/W2156095709","https://openalex.org/W2156782749","https://openalex.org/W2156858199","https://openalex.org/W2157160484","https://openalex.org/W2157537758","https://openalex.org/W2158386692","https://openalex.org/W2158714788","https://openalex.org/W2159512882","https://openalex.org/W2164085656","https://openalex.org/W2164686527","https://openalex.org/W2168909179","https://openalex.org/W2169123200","https://openalex.org/W2170643036","https://openalex.org/W2221571340","https://openalex.org/W2341171179","https://openalex.org/W2420301231","https://openalex.org/W2741340870","https://openalex.org/W2764167475","https://openalex.org/W3145128584","https://openalex.org/W4255654930","https://openalex.org/W7000558737","https://openalex.org/W7036408870","https://openalex.org/W7071999509","https://openalex.org/W7096590985"],"related_works":["https://openalex.org/W148859436","https://openalex.org/W213172185","https://openalex.org/W1987423713","https://openalex.org/W2107694985","https://openalex.org/W1993826818","https://openalex.org/W2037626481","https://openalex.org/W2147489306","https://openalex.org/W2164165130","https://openalex.org/W3189960879","https://openalex.org/W1819041927"],"abstract_inverted_index":{"Modern":[0],"molecular":[1],"biology":[2],"research":[3],"is":[4,17,55,82,182,220,235,240],"characterized":[5],"by":[6,111,140],"the":[7,22,25,40,49,83,90,121,173,200,204,218,223,226,264,278,287],"availability":[8],"of":[9,13,24,35,45,53,70,85,150,190,197,217,225,286],"an":[10,283],"increasing":[11],"amount":[12],"biological":[14,100],"data":[15,126],"which":[16,97,136,181,252,281],"often":[18],"fuzzy":[19],"due":[20,245],"to":[21,29,64,107,131,163,243,246],"nature":[23],"experimental":[26],"methods":[27],"used":[28,295],"derive":[30],"it.":[31],"Bioinformatics,":[32],"a":[33,75,117,195,250,297],"branch":[34],"computer":[36],"science,":[37],"deals":[38],"with":[39,167,222],"storage,":[41],"retrieval,":[42],"and":[43,62,161,171,199,230,273,303],"analysis":[44,176],"this":[46,86,151,186],"data.":[47],"DNA,":[48,348],"basic":[50],"information":[51],"carrier":[52],"life,":[54],"now":[56],"sequenced":[57],"industrially":[58],"in":[59,72,128,145,185,231,263,375,432,441,482,551],"large":[60,124,160],"quantities":[61],"assembled":[63],"complete":[65],"genomes.":[66],"The":[67,148,215,238,289],"automatic":[68],"annotation":[69,304],"genes":[71],"these":[73],"genomes,":[74],"process":[76],"called":[77],"computational":[78,91],"gene":[79,92,109,134,152,211],"structure":[80,93,153,212],"prediction,":[81],"scope":[84],"thesis.\r\nThis":[87],"dissertation":[88],"describes":[89,282],"prediction":[94,188,213],"software":[95,205,239],"GenomeThreader":[96,115,191,258,397,399,489,499,547],"uses":[98,116],"homologous":[99],"sequences":[101],"(so-called":[102],"cDNAs/ESTs":[103],"and/or":[104],"protein":[105],"sequences)":[106],"predict":[108],"structures":[110],"computing":[112],"spliced":[113],"alignments.":[114],"multi-phase":[118],"approach,":[119],"filtering":[120],"possibly":[122],"very":[123,207,241],"sequence":[125,302],"sets":[127],"early":[129],"phases":[130],"obtain":[132],"promising":[133],"candidates":[135],"are":[137],"then":[138],"refined":[139],"more":[141],"computationally":[142],"expensive":[143],"algorithms":[144],"later":[146],"phases.":[147],"results":[149,201,219,224],"predictions,":[154],"genome":[155,175],"annotations,":[156],"can":[157],"become":[158],"quite":[159],"cumbersome":[162],"process.":[164],"To":[165],"deal":[166],"such":[168],"annotations":[169],"easily":[170],"efficiently,":[172],"GenomeTools":[174,293,477,578],"system":[177],"has":[178,259,268],"been":[179,260],"developed,":[180],"also":[183],"described":[184],"thesis.\r\nThe":[187],"quality":[189,216],"was":[192,294],"evaluated":[193],"on":[194,209],"variety":[196],"datasets":[198],"show":[202],"that":[203],"performs":[206],"well":[208],"common":[210],"tasks.":[214],"comparable":[221],"best":[227],"other":[228],"programs":[229],"some":[232],"cases":[233],"it":[234,254,267],"even":[236],"better.":[237],"easy":[242],"use":[244],"its":[247,256],"integrated":[248],"nature,":[249],"feature":[251],"distinguishes":[253],"from":[255],"competitors.":[257],"adopted":[261],"widely":[262],"scientific":[265,279],"community,":[266],"approx.":[269],"150":[270,558],"users":[271],"world-wide":[272],"over":[274],"30":[275,562],"publications":[276],"cite":[277],"article":[280],"earlier":[284],"version":[285],"software.":[288],"open":[290],"source":[291],"package":[292],"as":[296],"foundation":[298],"for":[299],"10":[300,583],"published":[301],"processing":[305],"tools.":[306],"\nModerne":[307],"molekularbiologische":[308,340],"Forschung":[309],"ist":[310,512,532],"durch":[311,444],"die":[312,326,388,392,393,412,426,439,453,501,526,533,541],"Verfugbarkeit":[313],"stetig":[314],"wachsender":[315],"Datenmengen":[316],"charakterisiert.":[317],"Diese":[318,365],"Daten":[319,341],"sind":[320],"auf":[321,435,491],"Grund":[322],"der":[323,335,349,370,381,395,417,462,510,517,529,552,568,572],"experimentellen":[324],"Methoden,":[325],"sie":[327,542],"erzeugen,":[328],"oftmals":[329],"fehlerbehaftet.":[330],"Die":[331,449,508],"Bioinformatik,":[332],"ein":[333,379,420],"Teilbereich":[334],"Informatik,":[336],"beschaftigt":[337],"sich":[338,368],"damit":[339],"zu":[342,346,361,473,537],"speichern,":[343],"abzurufen":[344],"und":[345,360,390,408,459,470,521,561,589],"analysieren.":[347],"grundlegende":[350],"Informationstrager":[351],"des":[352],"Lebens,":[353],"wird":[354,419],"heutzutage":[355],"im":[356],"industriellen":[357],"Masstab":[358],"sequenziert":[359],"kompletten":[362],"Genomen":[363],"zusammengefugt.":[364],"Disseration":[366],"befasst":[367],"mit":[369,466,514],"automatische":[371],"Annotation":[372],"von":[373,488,543],"Genen":[374],"vollstandig":[376],"sequenzierten":[377],"Genomen,":[378],"Prozess":[380],"rechnergestutzte":[382],"Genstrukturvorhersage":[383],"genannt":[384],"wird.\r\nDiese":[385],"Dissertation":[386],"beschreibt":[387],"Methoden":[389],"Techniken,":[391],"Grundlage":[394,581],"Genstrukturvorhersagesoftware":[396],"bilden.":[398],"benutzt":[400],"homologe":[401],"biologische":[402],"Sequenzen":[403],"(sogenannte":[404],"cDNA/EST":[405],"und/oder":[406],"Proteinsequenzen)":[407],"berechnet":[409],"Spliced":[410],"Alignments,":[411],"Genstrukturen":[413,418],"beschreiben.":[414],"Zur":[415],"Vorhersage":[416],"mehrphasiger":[421],"Ansatz":[422],"benutzt.":[423],"Dabei":[424],"werden":[425,458],"unter":[427],"Umstanden":[428],"sehr":[429,456,504,535],"grosen":[430],"Sequenzdatenmengen":[431],"fruhen":[433],"Phasen":[434,443,531],"vielversprechende":[436],"Genkandidaten":[437],"reduziert,":[438],"dann":[440],"spateren":[442],"rechenaufwendigere":[445],"Algorithmen":[446],"verfeinert":[447],"werden.":[448],"Resultate":[450],"dieser":[451,483],"Genstrukturvorhersagen,":[452],"Genomannotationen,":[454],"konnen":[455],"umfangreich":[457],"aufwendige":[460],"Schritte":[461],"Weiterverarbeitung":[463],"erfordern.":[464],"Um":[465],"solchen":[467],"Annotationen":[468],"einfach":[469,536],"effizient":[471],"umgehen":[472],"konnen,":[474],"wurde":[475,490],"das":[476,480],"Genomanalysesystem":[478],"entwickelt,":[479],"ebenfalls":[481],"Arbeit":[484],"beschrieben":[485],"wird.\r\nDie":[486],"Vorhersagequalitat":[487],"verschiedenen":[492],"Datensatzen":[493],"evaluiert.":[494],"Es":[495,555],"zeigt":[496],"sich,":[497],"dass":[498],"fur":[500,582],"ublichen":[502],"Genvorhersageaufgaben":[503],"gute":[505],"Ergebnisse":[506,511],"liefert.":[507],"Qualitat":[509],"vergleichbar":[513],"den":[515,565],"Ergebnissen":[516],"besten":[518],"anderen":[519],"Programme":[520],"teilweise":[522],"sogar":[523],"besser.":[524],"Durch":[525],"gelungene":[527],"Integration":[528],"einzelnen":[530],"Software":[534,573],"benutzen,":[538],"eine":[539,569],"Eigenschaft,":[540],"ihren":[544],"Wettbewerbern":[545],"unterscheidet.":[546],"hat":[548],"weite":[549],"Verbreitung":[550],"Wissenschaftsgemeinde":[553],"gefunden.":[554],"gibt":[556],"ca.":[557],"Nutzer":[559],"weltweit":[560],"Publikationen":[563],"zitieren":[564],"wissenschaftlichen":[566],"Artikel,":[567],"fruhe":[570],"Version":[571],"beschreibt.":[574],"Das":[575],"quelloffene":[576],"Softwarepaket":[577],"diente":[579],"als":[580],"weitere":[584],"publizierte":[585],"Werkzeuge":[586],"zur":[587],"Sequenz-":[588],"Annotationsverarbeitung.":[590]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}