{"id":"https://openalex.org/W1542647666","doi":null,"title":"A rapid and sensitive flow-based screening test for detection of HLA-B57 to avoid abacavir hypersensitivity","display_name":"A rapid and sensitive flow-based screening test for detection of HLA-B57 to avoid abacavir hypersensitivity","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W1542647666","mag":"1542647666"},"language":"en","primary_location":{"id":"pmh:oai:alma.61MUN_INST:11136460970007891","doi":null,"is_oa":false,"landing_page_url":"https://researchportal.murdoch.edu.au/esploro/outputs/conferencePresentation/A-rapid-and-sensitive-flow-based-screening/991005544704207891","pdf_url":null,"source":{"id":"https://openalex.org/S4306400274","display_name":"Murdoch University Research Portal","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I176790772","host_organization_name":"Murdoch University","host_organization_lineage":["https://openalex.org/I176790772"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Conference or Workshop Item"},"volume":null,"type":"conference-paper","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009573818","display_name":"Lyudmila Kostenko","orcid":"https://orcid.org/0000-0002-8466-7966","observed_orcids":["https://orcid.org/0000-0002-8466-7966"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lyudmila Kostenko","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8466-7966","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103251975","display_name":"Andrew Lucas","orcid":"https://orcid.org/0000-0003-2899-1806","observed_orcids":["https://orcid.org/0000-0003-2899-1806"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrew Lucas","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2899-1806","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017677707","display_name":"Lars Kjer\u2010Nielsen","orcid":"https://orcid.org/0000-0003-3215-2888","observed_orcids":["https://orcid.org/0000-0003-3215-2888"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lars Kjer\u2010Nielsen","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3215-2888","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009794386","display_name":"Bree A. Foley","orcid":"https://orcid.org/0000-0003-3826-2682","observed_orcids":["https://orcid.org/0000-0003-3826-2682"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bree Foley","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3826-2682","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027856503","display_name":"I. Nicholson","orcid":"https://orcid.org/0000-0001-6654-2548","observed_orcids":["https://orcid.org/0000-0001-6654-2548"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"I. Nicholson","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6654-2548","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112776011","display_name":"Brian D. Tait","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B. Tait","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083036702","display_name":"Rhonda F. Holdsworth","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rhonda Holdsworth","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081880237","display_name":"Jamie Rossjohn","orcid":"https://orcid.org/0000-0002-2020-7522","observed_orcids":["https://orcid.org/0000-0002-2020-7522"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jamie Rossjohn","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2020-7522","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070165631","display_name":"Simon Alexander Mallal","orcid":"https://orcid.org/0000-0002-7036-1309","observed_orcids":["https://orcid.org/0000-0002-7036-1309"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S. Mallal","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7036-1309","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5023421955","display_name":"James McCluskey","orcid":"https://orcid.org/0000-0002-8597-815X","observed_orcids":["https://orcid.org/0000-0002-8597-815X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"James McCluskey","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":5.241,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.93548387,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11117","display_name":"Drug-Induced Adverse Reactions","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11117","display_name":"Drug-Induced Adverse Reactions","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10373","display_name":"Renal Transplantation Outcomes and Treatments","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hla-b-57-01","display_name":"HLA-B*57:01","score":0.9229999780654907},{"id":"https://openalex.org/keywords/hla-b-57","display_name":"HLA-B*57","score":0.6819999814033508},{"id":"https://openalex.org/keywords/hla-b-58","display_name":"HLA-B*58","score":0.9869999885559082},{"id":"https://openalex.org/keywords/abacavir-hypersensitivity","display_name":"abacavir hypersensitivity","score":0.9900000095367432},{"id":"https://openalex.org/keywords/hla-typing","display_name":"HLA typing","score":0.5130000114440918},{"id":"https://openalex.org/keywords/hiv-1","display_name":"HIV-1","score":0.6169999837875366},{"id":"https://openalex.org/keywords/pre-treatment-screening","display_name":"pre-treatment screening","score":0.7369999885559082},{"id":"https://openalex.org/keywords/point-of-care-testing","display_name":"point-of-care testing","score":0.8429999947547913}],"concepts":[{"id":"https://openalex.org/C2779465607","wikidata":"https://www.wikidata.org/wiki/Q304330","display_name":"Abacavir","level":5,"score":0.9726870059967041},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.650161862373352},{"id":"https://openalex.org/C188280979","wikidata":"https://www.wikidata.org/wiki/Q911125","display_name":"Human leukocyte antigen","level":3,"score":0.6245136260986328},{"id":"https://openalex.org/C2781209916","wikidata":"https://www.wikidata.org/wiki/Q3215756","display_name":"Typing","level":2,"score":0.5896519422531128},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5094690918922424},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4236084520816803},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.27745211124420166},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.18151482939720154},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17799076437950134},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.15699389576911926},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07631424069404602},{"id":"https://openalex.org/C2993143319","wikidata":"https://www.wikidata.org/wiki/Q583050","display_name":"Antiretroviral therapy","level":4,"score":0.06888824701309204}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:alma.61MUN_INST:11136460970007891","doi":null,"is_oa":false,"landing_page_url":"https://researchportal.murdoch.edu.au/esploro/outputs/conferencePresentation/A-rapid-and-sensitive-flow-based-screening/991005544704207891","pdf_url":null,"source":{"id":"https://openalex.org/S4306400274","display_name":"Murdoch University Research Portal","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I176790772","host_organization_name":"Murdoch University","host_organization_lineage":["https://openalex.org/I176790772"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Conference or Workshop Item"},{"id":"pmh:oai:researchrepository.murdoch.edu.au:15739","doi":null,"is_oa":false,"landing_page_url":"http://researchrepository.murdoch.edu.au/id/eprint/15739/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400274","display_name":"Murdoch University Research Portal","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I176790772","host_organization_name":"Murdoch University","host_organization_lineage":["https://openalex.org/I176790772"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Conference Item"},{"id":"mag:1542647666","doi":null,"is_oa":false,"landing_page_url":"https://researchrepository.murdoch.edu.au/id/eprint/15739/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2009516154","https://openalex.org/W1270735497","https://openalex.org/W1990901334","https://openalex.org/W2098800451","https://openalex.org/W2025094382","https://openalex.org/W1970844378","https://openalex.org/W2130673730","https://openalex.org/W2161001135","https://openalex.org/W3208901292","https://openalex.org/W2125399507"],"abstract_inverted_index":{"Objectives:":[0],"About":[1],"5-10%":[2],"of":[3,25,31,36,43,50,89,108,120,146,191,231,247,274],"HIV-1":[4],"patients":[5,37,175,218,248],"treated":[6],"with":[7,67,87,114,124,219,224,241],"Abacavir":[8,32,44],"develop":[9],"a":[10,28,77,150,208,211],"hypersensitivity":[11,33],"reaction":[12],"characterised":[13],"by":[14,59],"systemic":[15],"symptoms":[16],"which":[17],"resolve":[18],"when":[19,65],"treatment":[20,223],"is":[21,27,238],"discontinued.":[22],"The":[23,164,189,268],"presence":[24],"HLA-B*5701":[26,39],"strong":[29],"predictor":[30],"and":[34,56,74,92,99,118,158,182,233,276],"pre-screening":[35],"for":[38,101,137,210,259,265,281],"reduces":[40],"the":[41,68,90,131,144,147,178,192,204,227,260,272],"incidence":[42],"hypersensitivity.":[45],"However,":[46],"current":[47],"DNA-based":[48,266],"methods":[49],"HLA-B*57":[51],"typing":[52,187,194],"(SBT)":[53],"are":[54],"slow":[55],"expensive.":[57],"Screening":[58,107],"Flow":[60],"cytometry":[61],"offers":[62,271],"logistical":[63],"advantages":[64],"combined":[66,228],"routine":[69],"CD4":[70],"T":[71],"cell":[72],"enumeration":[73],"potentially":[75],"provides":[76,207],"1-2":[78],"day":[79],"turnaround.":[80],"\\n":[81,105,198],"\\nMethods:":[82],"A":[83,139],"mAb":[84,148,165,193,206,242,261],"that":[85,203],"reacts":[86],"members":[88],"HLA-B57":[91,232],"B58":[93,234],"serological":[94],"group":[95],"(anti-HLA-B17)":[96],"was":[97,166,195],"generated":[98],"optimised":[100],"flow":[102,152],"cytometry-based":[103,153],"assay.":[104],"\\nResults:":[106],"~70":[109],"consecutive":[110],"normal":[111],"blood":[112,157],"donors":[113],"known":[115],"HLA":[116,126,186],"genotype":[117],"staining":[119],"Labscreen":[121],"beads":[122],"coated":[123],"disparate":[125],"class":[127],"I":[128],"allotypes":[129],"verified":[130],"mAb,":[132],"3E12,":[133],"has":[134],"100%":[135],"sensitivity":[136,190],"HLA-B57/B58.":[138],"pilot":[140],"exchange":[141],"program":[142],"confirmed":[143],"utility":[145],"in":[149,177,235],"single-step":[151],"assay,":[154],"using":[155],"whole":[156],"either":[159],"fresh":[160],"or":[161],"frozen/thawed":[162],"PBMCs.":[163],"used":[167],"to":[168,184,216,222,249],"screen":[169,269],"frozen":[170],"PBMCs":[171],"from":[172],"601":[173],"HIV-infected":[174],"participating":[176],"PREDICT-1":[179],"clinical":[180],"trial":[181],"compared":[183],"sequence-based":[185],".":[188],"again":[196],"100%.":[197],"\\nConclusions:":[199],"Our":[200],"findings":[201],"suggest":[202],"3E12":[205,243],"basis":[209],"rapid":[212,275],"Flow-based":[213],"screening":[214,240],"test":[215,279],"identify":[217],"HLA-B57/B58":[220],"prior":[221],"abacavir.":[225],"Given":[226],"phenotype":[229],"frequency":[230],"most":[236],"populations":[237],"5-8%,":[239],"would":[244,262],"allow":[245],">90%":[246],"start":[250],"therapy":[251],"without":[252],"further":[253],"HLA-testing.":[254],"Patients":[255],"who":[256],"screened":[257],"positive":[258],"be":[263],"referred":[264],"HLA-genotyping.":[267],"also":[270],"possibility":[273],"simple":[277],"point-of-care":[278],"adaptable":[280],"developing":[282],"nations.":[283]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}