{"id":"https://openalex.org/W154257828","doi":null,"title":"[Effect of Zuoguiyin on expression of ovarian VEGF and SPARC in rats during peri-menopausal period].","display_name":"[Effect of Zuoguiyin on expression of ovarian VEGF and SPARC in rats during peri-menopausal period].","publication_year":2009,"publication_date":"2009-11-01","ids":{"openalex":"https://openalex.org/W154257828","mag":"154257828","pmid":"https://pubmed.ncbi.nlm.nih.gov/20209964"},"language":"en","primary_location":{"id":"pmid:20209964","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20209964","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica","raw_type":"English Abstract"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100409238","display_name":"Wei Zhao","orcid":"https://orcid.org/0000-0001-8440-2274","observed_orcids":["https://orcid.org/0000-0001-8440-2274"]},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Zhao","raw_affiliation_strings":["Department of Physiology, Harbin Medical University, Harbin 150086, China. paradise1100@sina.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Harbin Medical University, Harbin 150086, China. paradise1100@sina.com","institution_ids":["https://openalex.org/I156144747"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Haixia Wen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Haixia Wen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102730931","display_name":"Huili Zheng","orcid":"https://orcid.org/0000-0003-3030-2950","observed_orcids":["https://orcid.org/0000-0003-3030-2950"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Huili Zheng","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Shixiao Sun","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shixiao Sun","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5060909813","display_name":"Jiang Ni","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jiang Ni","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.02458949,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"34","issue":"22","first_page":"2932","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.26829999685287476,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.26829999685287476,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10390","display_name":"Ovarian function and disorders","score":0.20479999482631683,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10694","display_name":"Menopause: Health Impacts and Treatments","score":0.16110000014305115,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ovarian-aging","display_name":"ovarian aging","score":0.5540000200271606},{"id":"https://openalex.org/keywords/perimenopause","display_name":"perimenopause","score":0.9279999732971191},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.9710000157356262},{"id":"https://openalex.org/keywords/sparc","display_name":"SPARC","score":0.9610000252723694},{"id":"https://openalex.org/keywords/chinese-herbal-medicine","display_name":"Chinese herbal medicine","score":0.7940000295639038},{"id":"https://openalex.org/keywords/ovarian-vascularization","display_name":"ovarian vascularization","score":0.5120000243186951},{"id":"https://openalex.org/keywords/ovarian-gene-expression","display_name":"ovarian gene expression","score":0.46700000762939453}],"concepts":[{"id":"https://openalex.org/C2777025900","wikidata":"https://www.wikidata.org/wiki/Q29725","display_name":"Vascular endothelial growth factor","level":3,"score":0.6429935097694397},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.5802105665206909},{"id":"https://openalex.org/C167734588","wikidata":"https://www.wikidata.org/wiki/Q4356503","display_name":"VEGF receptors","level":2,"score":0.5796425342559814},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5785502791404724},{"id":"https://openalex.org/C2778324911","wikidata":"https://www.wikidata.org/wiki/Q9631","display_name":"Ovary","level":2,"score":0.569762647151947},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.566108226776123},{"id":"https://openalex.org/C2781291010","wikidata":"https://www.wikidata.org/wiki/Q178580","display_name":"Period (music)","level":2,"score":0.5587589740753174},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.5028066635131836},{"id":"https://openalex.org/C2778562196","wikidata":"https://www.wikidata.org/wiki/Q177708","display_name":"Menopause","level":2,"score":0.48138073086738586},{"id":"https://openalex.org/C2778374610","wikidata":"https://www.wikidata.org/wiki/Q1542990","display_name":"Peri","level":2,"score":0.43925657868385315},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.43226397037506104},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.4254707098007202},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4228841960430145},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3520964980125427},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.13271507620811462},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004365","descriptor_name":"Drugs, Chinese Herbal","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010053","descriptor_name":"Ovary","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010053","descriptor_name":"Ovary","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015676","descriptor_name":"Osteonectin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015676","descriptor_name":"Osteonectin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023421","descriptor_name":"Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D047648","descriptor_name":"Perimenopause","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D047648","descriptor_name":"Perimenopause","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":1,"locations":[{"id":"pmid:20209964","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20209964","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica","raw_type":"English Abstract"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger","score":0.41999998688697815}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2343677601","https://openalex.org/W2366714773","https://openalex.org/W2414217120","https://openalex.org/W2374705299","https://openalex.org/W1991205303","https://openalex.org/W2392401596","https://openalex.org/W4387420773","https://openalex.org/W2383737217","https://openalex.org/W2381400588","https://openalex.org/W2070362550"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"investigate":[2],"the":[3,16,35,107,137,147,172,211,232,238],"effect":[4],"of":[5,8,18,37,43,77,83,99,113,132,139,143,157,182,191,201,214,219,234,240],"one":[6,217],"kind":[7,218],"regulating-qi":[9,220],"and":[10,26,70,85,116,129,146,179,203,221],"Nourishing-yin":[11,222],"Chinese":[12,223],"herbs":[13],"Zuoguiyin":[14,78,133,183],"on":[15],"expression":[17,97,111,138,190,233,239],"rats":[19,45,52,120,193],"ovarian":[20,110,187,227],"vascular":[21,228],"endothelial":[22],"growth":[23],"factor":[24],"(VEGF)":[25],"secreted":[27],"protein":[28,118],"acidic":[29],"rich":[30],"in":[31,106,119,141,160,171,210],"cysteine":[32],"(SPARC)":[33],"during":[34,121,163],"period":[36,165],"peri-menopause.":[38],"METHOD:":[39],"The":[40,198],"animal":[41],"models":[42],"perimenopause":[44],"were":[46,53,88],"established":[47],"by":[48,55,90,247],"natural":[49],"aging.":[50],"Perimenopause":[51],"treated":[54],"intragastric":[56],"administration":[57],"(ig)":[58],"with":[59,104],"low":[60],"(13.78":[61],"g":[62,67,73],"x":[63,68,74],"kg(-1)),":[64],"middle":[65],"(20.67":[66],"kg(-1))":[69,75],"high":[71,130,180],"(31":[72],"dose":[76,131,181],"for":[79],"8":[80],"weeks.":[81],"Expression":[82,155],"VEGF":[84,100,114,140,202,235],"SPARC":[86,158,188,204],"mRNA":[87,115,159,189],"detected":[89],"RT-PCR.":[91],"Immunohistochemistry":[92],"was":[93],"used":[94],"to":[95,169],"evaluate":[96],"levels":[98,112,156],"protein.":[101],"RESULT:":[102],"Compared":[103],"that":[105,170],"control":[108,173],"group,":[109],"its":[117],"peri-menopause":[122],"increased":[123],"significantly":[124],"(P":[125,152,175,194],"<":[126,153,176,195],"0.01).":[127,154,177,196],"Middle":[128,178],"could":[134,184],"both":[135],"down-regulate":[136],"ovaries":[142,162],"praesenilis":[144,192],"rats,":[145],"difference":[148],"has":[149],"statistical":[150],"significance":[151],"rat":[161],"peri-menopausal":[164],"decreased":[166],"obviously":[167],"compared":[168],"group":[174],"greatly":[185],"promote":[186],"CONCLUSION:":[197],"abnormal":[199],"changes":[200],"may":[205,244],"play":[206],"an":[207],"important":[208],"role":[209],"aging":[212,246],"process":[213],"ovary.":[215],"Zuoguiyin,":[216],"herbs,":[224],"can":[225],"improve":[226],"formation":[229],"through":[230],"down-regulating":[231],"meanwhile":[236],"up-regulating":[237],"SPARC.":[241],"And":[242],"it":[243],"delay":[245],"this":[248],"way.":[249]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
