{"id":"https://openalex.org/W154256647","doi":null,"title":"The invasive front of carcinomas. The most important area for tumour prognosis?","display_name":"The invasive front of carcinomas. The most important area for tumour prognosis?","publication_year":1998,"publication_date":"1998-11-01","ids":{"openalex":"https://openalex.org/W154256647","mag":"154256647","pmid":"https://pubmed.ncbi.nlm.nih.gov/9891553"},"language":"en","primary_location":{"id":"pmid:9891553","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9891553","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075988137","display_name":"Magne Bryne","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Bryne","raw_affiliation_strings":["Department of Pathology, Norwegian Radiumhospital, Oslo, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Norwegian Radiumhospital, Oslo, Norway","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108612255","display_name":"Morten Boysen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Boysen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056209017","display_name":"Glenny Cecilie Alfsen","orcid":"https://orcid.org/0000-0003-3121-7192","observed_orcids":["https://orcid.org/0000-0003-3121-7192"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C G Alfsen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111613888","display_name":"Vera Maria Abeler","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"V M Abeler","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044099421","display_name":"Jon Sudb\u00f8","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Sudb\u00f8","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113568554","display_name":"Jahn Martin Nesland","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J M Nesland","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018546041","display_name":"Gunnar Balle Kristensen","orcid":"https://orcid.org/0000-0001-6231-7247","observed_orcids":["https://orcid.org/0000-0001-6231-7247"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G B Kristensen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008103291","display_name":"J\u00f3zsef Piffk\u00f2","orcid":"https://orcid.org/0000-0001-7119-2685","observed_orcids":["https://orcid.org/0000-0001-7119-2685"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Piffko","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5032378325","display_name":"\u00c1gnes B\u00e1nkfalvi","orcid":"https://orcid.org/0000-0003-0632-077X","observed_orcids":["https://orcid.org/0000-0003-0632-077X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Bankfalvi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.5396,"has_fulltext":false,"cited_by_count":129,"citation_normalized_percentile":{"value":0.87911773,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"18","issue":"6B","first_page":"4757","last_page":"64"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.8109999895095825,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.8109999895095825,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.16130000352859497,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13437","display_name":"Mechanisms of cancer metastasis","score":0.00419999985024333,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/invasive-front","display_name":"invasion front","score":0.8119999766349792},{"id":"https://openalex.org/keywords/head-and-neck-squamous-cell-carcinoma","display_name":"head and neck squamous cell carcinoma","score":0.8659999966621399},{"id":"https://openalex.org/keywords/malignancy-grading","display_name":"malignancy grading","score":0.6430000066757202},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8450000286102295},{"id":"https://openalex.org/keywords/cell-adhesion-molecules","display_name":"adhesion molecules","score":0.7630000114440918},{"id":"https://openalex.org/keywords/protease","display_name":"proteolytic enzymes","score":0.9570000171661377},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.9110000133514404},{"id":"https://openalex.org/keywords/adenocarcinoma","display_name":"adenocarcinoma","score":0.8190000057220459},{"id":"https://openalex.org/keywords/tumor-aggressiveness","display_name":"tumor aggressiveness","score":0.8109999895095825}],"concepts":[{"id":"https://openalex.org/C2777286243","wikidata":"https://www.wikidata.org/wiki/Q5591926","display_name":"Grading (engineering)","level":2,"score":0.7558934688568115},{"id":"https://openalex.org/C2779399171","wikidata":"https://www.wikidata.org/wiki/Q1483951","display_name":"Malignancy","level":2,"score":0.6685576438903809},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.6447160840034485},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.6048858761787415},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4633842706680298},{"id":"https://openalex.org/C3018411727","wikidata":"https://www.wikidata.org/wiki/Q3867488","display_name":"Head and neck","level":2,"score":0.43295568227767944},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.40372663736343384},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.35462838411331177},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.0},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006258","descriptor_name":"Head and Neck Neoplasms","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D006258","descriptor_name":"Head and Neck Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D006258","descriptor_name":"Head and Neck Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009361","descriptor_name":"Neoplasm Invasiveness","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:9891553","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9891553","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Journal Article"},{"id":"mag:154256647","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9891553","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2078664608","https://openalex.org/W1995190590","https://openalex.org/W1969558225","https://openalex.org/W1971759252","https://openalex.org/W2316982389","https://openalex.org/W2514785988","https://openalex.org/W2113078044","https://openalex.org/W2070191682","https://openalex.org/W784951810","https://openalex.org/W2946230540"],"abstract_inverted_index":{"Various":[0],"molecular":[1,39],"events":[2],"of":[3,13,17,26,48,59,78,111,142,153,172,174],"importance":[4],"in":[5,116,158],"tumour":[6,53,165],"spread,":[7],"like":[8],"the":[9,24,30,44,60,73,95,107,112,129,132,143,163,169],"gain":[10],"and":[11,23,80,131],"loss":[12],"adhesion":[14],"molecules,":[15],"secretion":[16],"proteolytic":[18],"enzymes,":[19],"increased":[20],"cell":[21,83,118],"proliferation,":[22],"initiation":[25],"angiogenesis":[27],"occur":[28],"at":[29,43,120],"tumour-host":[31],"interface":[32],"(invasive":[33],"front).":[34],"We":[35],"have":[36,90,105],"hypothesised":[37],"that":[38,162],"or":[40],"morphological":[41],"characteristics":[42],"invasive":[45,75,113,155,164],"front":[46,76,114,156,166],"area":[47,77],"various":[49],"carcinomas":[50,119,173],"may":[51,167],"reflect":[52],"prognosis":[54],"better":[55],"than":[56],"other":[57],"parts":[58],"tumour.":[61],"Consequently,":[62],"we":[63,127],"recently":[64],"developed":[65],"a":[66],"simple":[67],"malignancy":[68],"grading":[69,86,115,144],"system":[70,87,130],"restricted":[71],"to":[72,89],"deep":[74],"head":[79],"neck":[81],"squamous":[82,117],"carcinomas.":[84],"This":[85],"proved":[88],"additional":[91],"prognostic":[92,97,109],"value":[93],"over":[94],"established":[96],"factors.":[98],"All":[99],"similar":[100,154],"studies":[101],"performed":[102],"so":[103],"far":[104],"confirmed":[106],"high":[108],"significance":[110],"different":[121,159],"locations.":[122],"In":[123],"this":[124],"review":[125],"paper":[126],"describe":[128],"hypothesis":[133],"on":[134],"which":[135],"it":[136],"has":[137],"been":[138],"developed.":[139],"The":[140],"reproducibility":[141],"is":[145],"acceptable":[146],"for":[147],"further":[148],"extended":[149],"studies.":[150],"Interestingly,":[151],"observations":[152],"alterations":[157],"adenocarcinomas":[160],"suggest":[161],"underlie":[168],"biological":[170],"aggressiveness":[171],"glandular":[175],"origin,":[176],"as":[177],"well.":[178]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}