{"id":"https://openalex.org/W1542512495","doi":null,"title":"Novelly Synthesized Coumarin Derivative as a Pro-inflammatory Cytokines Inhibitor","display_name":"Novelly Synthesized Coumarin Derivative as a Pro-inflammatory Cytokines Inhibitor","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W1542512495","mag":"1542512495"},"language":"th","primary_location":{"id":"pmh:oai:li01.tci-thaijo.org:article/35752","doi":null,"is_oa":true,"landing_page_url":"https://li01.tci-thaijo.org/index.php/JBAP/article/view/35752","pdf_url":"https://li01.tci-thaijo.org/index.php/JBAP/article/download/35752/29721","source":{"id":"https://openalex.org/S7407065993","display_name":"Journal of Basic and Applied Pharmacology","issn_l":"2774-0854","issn":["2774-0854"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2774-0854","raw_type":"info:eu-repo/semantics/article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://li01.tci-thaijo.org/index.php/JBAP/article/download/35752/29721","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042711973","display_name":"Prayuth Poowaruttanawiwit","orcid":"https://orcid.org/0000-0003-0191-9978","observed_orcids":["https://orcid.org/0000-0003-0191-9978"]},"institutions":[{"id":"https://openalex.org/I66200439","display_name":"Naresuan University","ror":"https://ror.org/03e2qe334","country_code":"TH","type":"education","lineage":["https://openalex.org/I66200439"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Prayuth Poowaruttanawiwit","raw_affiliation_strings":["Department of Pharmacy Practice, Faculty of Pharmaceutical Sciences, Naresuan University , Phitsanulok , Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy Practice, Faculty of Pharmaceutical Sciences, Naresuan University , Phitsanulok , Thailand","institution_ids":["https://openalex.org/I66200439"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015883685","display_name":"Thippatai Hiranyaekaphap","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I66200439","display_name":"Naresuan University","ror":"https://ror.org/03e2qe334","country_code":"TH","type":"education","lineage":["https://openalex.org/I66200439"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Thippatai Hiranyaekaphap","raw_affiliation_strings":["Department of Pharmaceutical Chemistry and Pharmacognosy, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Chemistry and Pharmacognosy, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok, Thailand","institution_ids":["https://openalex.org/I66200439"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056297696","display_name":"Nanteetip Limpeanchob","orcid":"https://orcid.org/0000-0002-6285-9393","observed_orcids":["https://orcid.org/0000-0002-6285-9393"]},"institutions":[{"id":"https://openalex.org/I66200439","display_name":"Naresuan University","ror":"https://ror.org/03e2qe334","country_code":"TH","type":"education","lineage":["https://openalex.org/I66200439"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Nanteetip Limpeanchob","raw_affiliation_strings":["Department of Pharmacy Practice, Faculty of Pharmaceutical Sciences, Naresuan University , Phitsanulok , Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy Practice, Faculty of Pharmaceutical Sciences, Naresuan University , Phitsanulok , Thailand","institution_ids":["https://openalex.org/I66200439"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078593164","display_name":"Ruengwit Kitbunnadaj","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I66200439","display_name":"Naresuan University","ror":"https://ror.org/03e2qe334","country_code":"TH","type":"education","lineage":["https://openalex.org/I66200439"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Ruengwit Kitbunnadaj","raw_affiliation_strings":["Department of Pharmaceutical Chemistry and Pharmacognosy, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Chemistry and Pharmacognosy, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok, Thailand","institution_ids":["https://openalex.org/I66200439"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061732861","display_name":"Kwanchai Rattanamanee","orcid":"https://orcid.org/0009-0000-1188-0099","observed_orcids":["https://orcid.org/0009-0000-1188-0099"]},"institutions":[{"id":"https://openalex.org/I66200439","display_name":"Naresuan University","ror":"https://ror.org/03e2qe334","country_code":"TH","type":"education","lineage":["https://openalex.org/I66200439"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Kwanchai Rattanamanee","raw_affiliation_strings":["Department of Pharmacy Practice, Faculty of Pharmaceutical Sciences, Naresuan University , Phitsanulok , Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy Practice, Faculty of Pharmaceutical Sciences, Naresuan University , Phitsanulok , Thailand","institution_ids":["https://openalex.org/I66200439"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I66200439"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"37","issue":"1","first_page":"5","last_page":"15"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.9779999852180481,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.9779999852180481,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.012299999594688416,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13026","display_name":"Natural Compounds in Disease Treatment","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/coumarins","display_name":"coumarins","score":0.7990000247955322},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.8790000081062317},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":1.0},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.9710000157356262},{"id":"https://openalex.org/keywords/dexamethasone-comparison","display_name":"dexamethasone comparison","score":0.8659999966621399},{"id":"https://openalex.org/keywords/cytokine-production","display_name":"cytokine production","score":0.45100000500679016}],"concepts":[{"id":"https://openalex.org/C2781338262","wikidata":"https://www.wikidata.org/wiki/Q111812","display_name":"Coumarin","level":2,"score":0.785651683807373},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.6918118000030518},{"id":"https://openalex.org/C2780401358","wikidata":"https://www.wikidata.org/wiki/Q422252","display_name":"Dexamethasone","level":2,"score":0.6235673427581787},{"id":"https://openalex.org/C2777752497","wikidata":"https://www.wikidata.org/wiki/Q286779","display_name":"IC50","level":3,"score":0.6165862083435059},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6100413203239441},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6043437123298645},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.44918689131736755},{"id":"https://openalex.org/C17077164","wikidata":"https://www.wikidata.org/wiki/Q1185869","display_name":"Inhibitory postsynaptic potential","level":2,"score":0.4464437961578369},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4378225803375244},{"id":"https://openalex.org/C11988809","wikidata":"https://www.wikidata.org/wiki/Q412889","display_name":"Interleukin 6","level":3,"score":0.43574416637420654},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.316035658121109},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.31396961212158203},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2553839385509491},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2525192201137543},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.23689723014831543},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:li01.tci-thaijo.org:article/35752","doi":null,"is_oa":true,"landing_page_url":"https://li01.tci-thaijo.org/index.php/JBAP/article/view/35752","pdf_url":"https://li01.tci-thaijo.org/index.php/JBAP/article/download/35752/29721","source":{"id":"https://openalex.org/S7407065993","display_name":"Journal of Basic and Applied Pharmacology","issn_l":"2774-0854","issn":["2774-0854"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2774-0854","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:1542512495","doi":null,"is_oa":false,"landing_page_url":"https://www.tci-thaijo.org/index.php/TJP/article/download/35752/29721","pdf_url":null,"source":{"id":"https://openalex.org/S4306531941","display_name":"\u0e27\u0e32\u0e23\u0e2a\u0e32\u0e23\u0e40\u0e20\u0e2a\u0e31\u0e0a\u0e27\u0e34\u0e17\u0e22\u0e32 (Thai Journal of Pharmacology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\u0e27\u0e32\u0e23\u0e2a\u0e32\u0e23\u0e40\u0e20\u0e2a\u0e31\u0e0a\u0e27\u0e34\u0e17\u0e22\u0e32 (Thai Journal of Pharmacology)","raw_type":null}],"best_oa_location":{"id":"pmh:oai:li01.tci-thaijo.org:article/35752","doi":null,"is_oa":true,"landing_page_url":"https://li01.tci-thaijo.org/index.php/JBAP/article/view/35752","pdf_url":"https://li01.tci-thaijo.org/index.php/JBAP/article/download/35752/29721","source":{"id":"https://openalex.org/S7407065993","display_name":"Journal of Basic and Applied Pharmacology","issn_l":"2774-0854","issn":["2774-0854"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2774-0854","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320309823","display_name":"Higher Education Research Promotion","ror":"https://ror.org/02wa0fq92"},{"id":"https://openalex.org/F4320322614","display_name":"Thailand Research Fund","ror":"https://ror.org/03gd1bh37"},{"id":"https://openalex.org/F4320323020","display_name":"Naresuan University","ror":"https://ror.org/03e2qe334"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1542512495.pdf","grobid_xml":"https://content.openalex.org/works/W1542512495.grobid-xml"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W111387551","https://openalex.org/W1555113073","https://openalex.org/W1976845082","https://openalex.org/W1981384391","https://openalex.org/W2007794513","https://openalex.org/W2011123924","https://openalex.org/W2014509727","https://openalex.org/W2015759485","https://openalex.org/W2020499020","https://openalex.org/W2020538532","https://openalex.org/W2021009440","https://openalex.org/W2030872956","https://openalex.org/W2036976990","https://openalex.org/W2049733399","https://openalex.org/W2061590643","https://openalex.org/W2072237144","https://openalex.org/W2080946103","https://openalex.org/W2089431648","https://openalex.org/W2094941678","https://openalex.org/W2107376426","https://openalex.org/W2116784956","https://openalex.org/W2119995276","https://openalex.org/W2122873209","https://openalex.org/W2129470375","https://openalex.org/W2146249493","https://openalex.org/W2171576082","https://openalex.org/W2399952587","https://openalex.org/W2408523866","https://openalex.org/W2623695599"],"related_works":["https://openalex.org/W2904450881","https://openalex.org/W4301878239","https://openalex.org/W2345692631","https://openalex.org/W4385690952","https://openalex.org/W2944982338","https://openalex.org/W4380486361","https://openalex.org/W2913582882","https://openalex.org/W2793999320","https://openalex.org/W7112491796","https://openalex.org/W2067916786"],"abstract_inverted_index":{"The":[0,22,38],"purpose":[1],"of":[2,10,44,65,70],"this":[3,92],"study":[4],"was":[5,75],"to":[6,110],"investigate":[7],"the":[8,11,61,68],"effect":[9],"novelly":[12],"synthesized":[13],"coumarin":[14],"derivative,":[15],"RKNU026":[16,26,45,71,84,98],"on":[17,72,88],"pro-inflammatory":[18,103],"cytokine":[19,104],"inhibitory":[20,41],"efficacy.":[21],"results":[23],"demonstrated":[24],"that":[25,97],"could":[27],"inhibit":[28],"IL-1\u03b2":[29,47,73,113],"and":[30,48,53],"TNF-\u03b1":[31,49,89,118],"production":[32],"in":[33],"a":[34,117],"concentration":[35,64],"dependent":[36],"pattern.":[37],"half":[39],"maximal":[40],"concentrations":[42],"(IC50)":[43],"for":[46],"were":[50],"0.024":[51],"\u00b5M":[52],"729":[54],"\u00b5M,":[55,67],"respectively.":[56],"Compared":[57],"with":[58],"dexamethasone":[59,79],"at":[60,91],"same":[62],"final":[63],"1":[66],"efficacy":[69,87,101],"inhibition":[74,90],"still":[76],"lower":[77],"than":[78,116],"(70.78%":[80],"versus":[81],"89.53%)":[82],"while":[83],"had":[85],"no":[86],"concentration.":[93],"Our":[94],"work":[95],"suggests":[96],"has":[99],"anti-inflammatory":[100],"through":[102],"inhibition.":[105],"Furthermore,":[106],"it":[107],"is":[108],"considered":[109],"be":[111],"an":[112],"inhibitor":[114],"rather":[115],"inhibitor.":[119]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}