{"id":"https://openalex.org/W1542485172","doi":"https://doi.org/10.4049/jimmunol.117.3.990","title":"The Primary Structure of Porcine C3a Anaphylatoxin","display_name":"The Primary Structure of Porcine C3a Anaphylatoxin","publication_year":1976,"publication_date":"1976-09-01","ids":{"openalex":"https://openalex.org/W1542485172","doi":"https://doi.org/10.4049/jimmunol.117.3.990","mag":"1542485172","pmid":"https://pubmed.ncbi.nlm.nih.gov/956663"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.117.3.990","doi":"https://doi.org/10.4049/jimmunol.117.3.990","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.117.3.990","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057124651","display_name":"Neal C. Corbin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210146328","display_name":"Scripps Clinic","ror":"https://ror.org/05kwjwj05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1311914864","https://openalex.org/I4210146328"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Neal C Corbin","raw_affiliation_strings":["Scripps Clinic and Research Foundation, Department of Molecular Immunology , La Jolla, California 92037"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Scripps Clinic and Research Foundation, Department of Molecular Immunology , La Jolla, California 92037","institution_ids":["https://openalex.org/I4210146328"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073248837","display_name":"Tony E. Hugli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210146328","display_name":"Scripps Clinic","ror":"https://ror.org/05kwjwj05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1311914864","https://openalex.org/I4210146328"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tony E Hugli","raw_affiliation_strings":["Scripps Clinic and Research Foundation, Department of Molecular Immunology , La Jolla, California 92037"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Scripps Clinic and Research Foundation, Department of Molecular Immunology , La Jolla, California 92037","institution_ids":["https://openalex.org/I4210146328"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210146328"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":1.9556,"has_fulltext":false,"cited_by_count":47,"citation_normalized_percentile":{"value":0.83487028,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":"117","issue":"3","first_page":"990","last_page":"995"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11917","display_name":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/c3a-anaphylatoxin","display_name":"C3a anaphylatoxin","score":0.9760000109672546},{"id":"https://openalex.org/keywords/amino-acid-sequence","display_name":"amino acid sequence","score":0.7929999828338623},{"id":"https://openalex.org/keywords/alternative-complement-pathway","display_name":"alternative complement pathway","score":0.9380000233650208},{"id":"https://openalex.org/keywords/disulfide-bonds","display_name":"disulfide bonds","score":0.7289999723434448},{"id":"https://openalex.org/keywords/immunological-cross-reactivity","display_name":"immunological cross-reactivity","score":0.8539999723434448},{"id":"https://openalex.org/keywords/circular-dichroism","display_name":"circular dichroism","score":0.7770000100135803}],"concepts":[{"id":"https://openalex.org/C90582226","wikidata":"https://www.wikidata.org/wiki/Q424292","display_name":"Anaphylatoxin","level":4,"score":0.9740469455718994},{"id":"https://openalex.org/C2781338088","wikidata":"https://www.wikidata.org/wiki/Q903495","display_name":"Residue (chemistry)","level":2,"score":0.6645207405090332},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.6252351999282837},{"id":"https://openalex.org/C92825506","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Protein primary structure","level":4,"score":0.5752587914466858},{"id":"https://openalex.org/C108477463","wikidata":"https://www.wikidata.org/wiki/Q426367","display_name":"Carboxypeptidase","level":3,"score":0.5590062737464905},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.5053644776344299},{"id":"https://openalex.org/C65961981","wikidata":"https://www.wikidata.org/wiki/Q5156511","display_name":"Complete protein","level":3,"score":0.48059436678886414},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.44991207122802734},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.42872220277786255},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3837270140647888},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.32566696405410767},{"id":"https://openalex.org/C111684460","wikidata":"https://www.wikidata.org/wiki/Q334848","display_name":"Complement system","level":3,"score":0.21781742572784424},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09978225827217102},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.08261337876319885},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0784061849117279}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003165","descriptor_name":"Complement System Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D003176","descriptor_name":"Complement C3","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D003488","descriptor_name":"Cyanogen Bromide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008722","descriptor_name":"Methods","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014357","descriptor_name":"Trypsin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.4049/jimmunol.117.3.990","doi":"https://doi.org/10.4049/jimmunol.117.3.990","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.117.3.990","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},{"id":"pmid:956663","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/956663","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of immunology (Baltimore, Md. : 1950)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.504800021648407}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1579863360","https://openalex.org/W2096494712","https://openalex.org/W2013651278","https://openalex.org/W2411776841","https://openalex.org/W4313310264","https://openalex.org/W1661062552","https://openalex.org/W2093320520","https://openalex.org/W1517436631","https://openalex.org/W1255332801","https://openalex.org/W2337078309"],"abstract_inverted_index":{"Porcine":[0,62],"C3a":[1,19,38,63,84,99,115,166,211,234,246],"was":[2,21,39,175],"generated":[3],"in":[4,45,142,194,209,241],"whole":[5],"porcine":[6,37,98,114,165,198,233],"serum":[7],"by":[8,29,169],"inulin":[9],"activation":[10],"of":[11,13,59,66,79,88,111,129,147,162,181,225,261],"enzymes":[12],"the":[14,25,107,118,137,159,178,182,204,214,245,259],"alternative":[15],"complement":[16],"pathway.":[17],"The":[18,31,93],"anaphylatoxin":[20,144,221],"isolated":[22,60],"according":[23],"to":[24,47,153,220],"procedures":[26],"previously":[27],"described":[28],"Hugli.":[30],"complete":[32],"amino":[33,72,108],"acid":[34,73,109],"sequence":[35,215],"for":[36,97,237],"determined":[40],"utilizing":[41],"automatic":[42],"sequencing":[43],"techniques":[44],"addition":[46],"manual":[48],"subtractive":[49],"Edman":[50],"degradation":[51],"and":[52,75,91,113,121,164,197,213,232],"carboxypeptidase":[53],"A,":[54],"B,":[55],"or":[56],"Y":[57],"digestion":[58],"peptides.":[61],"is":[64,86,100,191],"composed":[65],"a":[67,77,155,238,262],"polypeptide":[68],"chain":[69],"containing":[70],"77":[71,190],"residues":[74],"has":[76],"m.w.":[78],"approximately":[80],"9,000":[81],"daltons.":[82],"This":[83],"molecule":[85],"devoid":[87],"threonine,":[89],"tryptophan,":[90],"carbohydrates.":[92],"proposed":[94],"primary":[95,242],"structure":[96],"as":[101,167],"follows:":[102],"(see":[103],"article)":[104],"Comparisons":[105],"between":[106,158,230],"sequences":[110],"human":[112,163,196,231],"reveal":[116],"that":[117,136],"six":[119,131],"half-cystinyl":[120,132],"five":[122],"aromatic":[123],"residue":[124,133,187,201,227],"positions":[125,134,202],"are":[126],"conserved.":[127],"Conservation":[128],"these":[130],"suggest":[135],"disulfide":[138,150],"arrangement":[139],"remains":[140],"identical":[141,249],"both":[143,195,210],"molecules.":[145],"Maintenance":[146],"three":[148],"interconnected":[149],"linkages":[151],"helps":[152],"explain":[154],"near":[156],"identity":[157],"secondary":[160],"structures":[161],"indicated":[168],"circular":[170],"dichroism":[171],"measurements.":[172],"Particular":[173],"attention":[174],"focused":[176],"on":[177],"COOH-terminal":[179],"region":[180],"anaphylatoxins":[183],"since":[184],"an":[185],"arginyl":[186],"at":[188,203],"position":[189],"functionally":[192],"essential":[193],"C3a.":[199],"Five":[200],"carboxy":[205],"termini":[206],"were":[207],"conserved":[208],"molecules,":[212],"Leu-Gly-Leu-Ala-Arg":[216],"probably":[217],"relates":[218],"directly":[219],"activity.":[222],"A":[223],"total":[224],"23":[226],"replacements":[228],"occur":[229],"which":[235],"accounts":[236],"30%":[239],"difference":[240,256],"structure.":[243],"Although":[244],"molecules":[247],"exhibit":[248],"biologic":[250],"activity,":[251],"this":[252],"rather":[253],"large":[254],"structural":[255],"readily":[257],"explains":[258],"absence":[260],"detectable":[263],"immunologic":[264],"cross-reactivity.":[265]},"counts_by_year":[{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
