{"id":"https://openalex.org/W1542266246","doi":null,"title":"Ocular pathogenesis and immune reaction after intravitreal dispase injection in mice.","display_name":"Ocular pathogenesis and immune reaction after intravitreal dispase injection in mice.","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W1542266246","mag":"1542266246","pmid":"https://pubmed.ncbi.nlm.nih.gov/22511850","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3327440"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3327440","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3327440/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3327440/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Vis","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3327440/pdf/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088471540","display_name":"Juan Tan","orcid":"https://orcid.org/0000-0001-6446-2982","observed_orcids":["https://orcid.org/0000-0001-6446-2982"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4391768270","display_name":"State Key Laboratory of Ophthalmology","ror":"https://ror.org/003mfbe21","country_code":"CN","type":"facility","lineage":["https://openalex.org/I157773358","https://openalex.org/I4391768270"]},{"id":"https://openalex.org/I4401726874","display_name":"Zhongshan Ophthalmic Center, Sun Yat-sen University","ror":"https://ror.org/02z2yec16","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I157773358","https://openalex.org/I4401726874"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Juan Tan","raw_affiliation_strings":["State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4391768270","https://openalex.org/I4401726874"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101441458","display_name":"Yaqin Liu","orcid":"https://orcid.org/0000-0002-6982-1849","observed_orcids":["https://orcid.org/0000-0002-6982-1849","https://orcid.org/0009-0005-1649-4070"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yaqin Liu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100318325","display_name":"W\u011bi Li","orcid":"https://orcid.org/0000-0002-9522-4474","observed_orcids":["https://orcid.org/0000-0002-9522-4474","https://orcid.org/0000-0003-4136-3409","https://orcid.org/0009-0009-9141-6389"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wei Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5028372785","display_name":"Qianying Gao","orcid":"https://orcid.org/0000-0003-2083-0653","observed_orcids":["https://orcid.org/0000-0003-2083-0653"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Qianying Gao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.1292,"has_fulltext":true,"cited_by_count":10,"citation_normalized_percentile":{"value":0.76323876,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"18","issue":null,"first_page":"887","last_page":"900"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11377","display_name":"Retinal and Macular Surgery","score":0.4496999979019165,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11377","display_name":"Retinal and Macular Surgery","score":0.4496999979019165,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.25459998846054077,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11194","display_name":"Ocular Diseases and Beh\u00e7et\u2019s Syndrome","score":0.1454000025987625,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dispase","display_name":"dispase","score":0.7979999780654907},{"id":"https://openalex.org/keywords/intravitreal-injection","display_name":"intravitreal injection","score":0.9769999980926514},{"id":"https://openalex.org/keywords/proliferative-vitreoretinopathy","display_name":"proliferative vitreoretinopathy","score":0.9750000238418579},{"id":"https://openalex.org/keywords/ocular-inflammation","display_name":"ocular inflammation","score":0.7549999952316284},{"id":"https://openalex.org/keywords/neutrophils","display_name":"neutrophils","score":0.7620000243186951},{"id":"https://openalex.org/keywords/anterior-chamber","display_name":"anterior chamber","score":0.6790000200271606},{"id":"https://openalex.org/keywords/retinitis","display_name":"retinal inflammation","score":0.6019999980926514},{"id":"https://openalex.org/keywords/immune-response","display_name":"immune response","score":0.6650000214576721},{"id":"https://openalex.org/keywords/t-cells","display_name":"T cells","score":0.7279999852180481},{"id":"https://openalex.org/keywords/b-wave-amplitude","display_name":"b-wave amplitude","score":0.5899999737739563},{"id":"https://openalex.org/keywords/electroretinography","display_name":"electroretinogram","score":0.6629999876022339},{"id":"https://openalex.org/keywords/mouse-model","display_name":"mouse model","score":0.4320000112056732}],"concepts":[{"id":"https://openalex.org/C2780374859","wikidata":"https://www.wikidata.org/wiki/Q5282540","display_name":"Dispase","level":4,"score":0.9259740114212036},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.8473402261734009},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6651962995529175},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4788496494293213},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4661129117012024},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.37565168738365173},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.34127819538116455},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1269114911556244},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.11138421297073364},{"id":"https://openalex.org/C2778394429","wikidata":"https://www.wikidata.org/wiki/Q304956","display_name":"Collagenase","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000867","descriptor_name":"Anterior Chamber","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D000867","descriptor_name":"Anterior Chamber","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000867","descriptor_name":"Anterior Chamber","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004596","descriptor_name":"Electroretinography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004801","descriptor_name":"Eosine Yellowish-(YS)","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006416","descriptor_name":"Hematoxylin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010450","descriptor_name":"Endopeptidases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012160","descriptor_name":"Retina","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D012160","descriptor_name":"Retina","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D012160","descriptor_name":"Retina","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D018630","descriptor_name":"Vitreoretinopathy, Proliferative","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D018630","descriptor_name":"Vitreoretinopathy, Proliferative","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018630","descriptor_name":"Vitreoretinopathy, Proliferative","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D020556","descriptor_name":"Neutrophil Infiltration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058449","descriptor_name":"Intravitreal Injections","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:3327440","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3327440/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3327440/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Vis","raw_type":"Text"},{"id":"pmh:oai:europepmc.org:2333799","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3327440","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:22511850","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22511850","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular vision","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.271.1102","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.271.1102","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/de/b6/Mol_Vis_2012_Apr_7_18_887-900.tar.gz","raw_type":"text"},{"id":"mag:1542266246","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22511850","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3327440","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3327440/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3327440/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Vis","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1542266246.pdf","grobid_xml":"https://content.openalex.org/works/W1542266246.grobid-xml"},"referenced_works_count":44,"referenced_works":["https://openalex.org/W23729290","https://openalex.org/W161719027","https://openalex.org/W321326367","https://openalex.org/W1273791148","https://openalex.org/W1493481594","https://openalex.org/W1497840515","https://openalex.org/W1502603270","https://openalex.org/W1909876475","https://openalex.org/W1966657187","https://openalex.org/W1970734543","https://openalex.org/W1970735494","https://openalex.org/W1971467230","https://openalex.org/W1972541040","https://openalex.org/W1988395804","https://openalex.org/W2004665329","https://openalex.org/W2008074098","https://openalex.org/W2014262440","https://openalex.org/W2016828078","https://openalex.org/W2017934171","https://openalex.org/W2024776857","https://openalex.org/W2028064396","https://openalex.org/W2031345232","https://openalex.org/W2032421668","https://openalex.org/W2033269379","https://openalex.org/W2038411947","https://openalex.org/W2043251036","https://openalex.org/W2046756621","https://openalex.org/W2051812986","https://openalex.org/W2051924783","https://openalex.org/W2052697275","https://openalex.org/W2055164201","https://openalex.org/W2055774678","https://openalex.org/W2065790323","https://openalex.org/W2067192388","https://openalex.org/W2073739822","https://openalex.org/W2081195149","https://openalex.org/W2114136101","https://openalex.org/W2114232337","https://openalex.org/W2132161893","https://openalex.org/W2133816760","https://openalex.org/W2164468733","https://openalex.org/W2165142928","https://openalex.org/W2409345224","https://openalex.org/W2412183443"],"related_works":["https://openalex.org/W2004665329","https://openalex.org/W2032421668","https://openalex.org/W2993841671","https://openalex.org/W2062566516","https://openalex.org/W2112067151","https://openalex.org/W2010190768","https://openalex.org/W7099150409","https://openalex.org/W2367041483","https://openalex.org/W1164900380","https://openalex.org/W2588021509"],"abstract_inverted_index":{"PURPOSE:":[0],"The":[1],"purpose":[2],"of":[3,25,30,39,50,67,70,100],"the":[4,10,36,51,71,88,95,118,160,193,200],"current":[5],"study":[6],"was":[7,151],"to":[8,56,75],"examine":[9],"ocular":[11,58],"pathogenesis":[12],"and":[13,43,48,60,64,143,162,168,175,196,204],"immune":[14,77,207],"reaction":[15],"in":[16,117,123,156,183,192,199,216],"mice":[17,125],"after":[18,129,212],"intravitreal":[19,213],"dispase":[20,26,214],"injection.":[21,130],"METHODS:":[22],"Three":[23],"microliters":[24],"at":[27,94,137,147],"a":[28,152],"concentration":[29],"0.2":[31],"U/\u03bcl":[32],"were":[33,53,73,87,115,180,202,209],"injected":[34],"into":[35],"vitreal":[37,119],"cavities":[38,120],"4-6-week-old":[40],"mice.":[41,185,217],"Hematoxylin":[42],"eosin":[44],"staining,":[45],"immunofluorescence":[46],"analysis,":[47],"electroretinograms":[49],"eyes":[52],"then":[54],"performed":[55],"assess":[57],"changes,":[59],"enzyme-linked":[61],"immunospot":[62,166],"assays":[63,167],"intracellular":[65,169],"staining":[66,170],"single-cell":[68],"suspensions":[69],"spleens":[72],"used":[74],"detect":[76],"changes":[78],"during":[79],"an":[80],"8":[81,148],"week":[82],"observation":[83],"period.":[84],"RESULTS:":[85],"Neutrophils":[86],"main":[89],"inflammatory":[90],"infiltrating":[91],"cells":[92,114,179],"appearing":[93],"anterior":[96,194],"chamber.":[97],"No":[98],"cluster":[99],"differentiation":[101],"(CD)3+":[102],"labeled":[103,107,111,177],"T":[104,178],"cells,":[105],"F4/80+":[106],"macrophages,":[108],"or":[109,121],"CD56+":[110],"natural":[112],"killer":[113],"found":[116],"retinas":[122,201],"dispase-injected":[124,184],"within":[126],"5":[127],"days":[128],"Proliferative":[131],"vitreoretinopathy":[132],"(PVR)-like":[133],"signs":[134,198],"first":[135],"appeared":[136],"2":[138],"weeks,":[139],"gradually":[140],"increased":[141],"thereafter,":[142],"reached":[144],"peak":[145],"values":[146],"weeks.":[149],"There":[150],"statistically":[153],"significant":[154],"difference":[155],"b-wave":[157],"amplitudes":[158],"between":[159],"PVR":[161],"saline-control":[163],"eyes.":[164],"Enzyme-linked":[165],"showed":[171],"that":[172,190,205],"specific":[173,206],"CD4+":[174],"CD8+":[176],"not":[181,210],"involved":[182,211],"CONCLUSIONS:":[186],"Our":[187],"data":[188],"show":[189],"neutrophils":[191],"chamber":[195],"PVR-like":[197],"found,":[203],"reactions":[208],"injection":[215]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2016-06-24T00:00:00"}
