{"id":"https://openalex.org/W1542213034","doi":"https://doi.org/10.1542/peds.90.4.537","title":"Oral Ketamine Premedication to Alleviate the Distress of Invasive Procedures in Pediatric Oncology Patients","display_name":"Oral Ketamine Premedication to Alleviate the Distress of Invasive Procedures in Pediatric Oncology Patients","publication_year":1992,"publication_date":"1992-10-01","ids":{"openalex":"https://openalex.org/W1542213034","doi":"https://doi.org/10.1542/peds.90.4.537","mag":"1542213034","pmid":"https://pubmed.ncbi.nlm.nih.gov/1408506"},"language":"en","primary_location":{"id":"doi:10.1542/peds.90.4.537","doi":"https://doi.org/10.1542/peds.90.4.537","is_oa":false,"landing_page_url":"https://doi.org/10.1542/peds.90.4.537","pdf_url":null,"source":{"id":"https://openalex.org/S77494981","display_name":"PEDIATRICS","issn_l":"0031-4005","issn":["0031-4005","1098-4275"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315734","host_organization_name":"American Academy of Pediatrics","host_organization_lineage":["https://openalex.org/P4310315734"],"host_organization_lineage_names":["American Academy of Pediatrics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatrics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048394709","display_name":"Joseph Drew Tobias","orcid":"https://orcid.org/0000-0003-0550-6951","observed_orcids":["https://orcid.org/0000-0003-0550-6951"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph D. Tobias","raw_affiliation_strings":["Department of Anesthesiology, Vanderbilt University, Nashville, TN. 37232"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Vanderbilt University, Nashville, TN. 37232","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017370535","display_name":"Sean Phipps","orcid":"https://orcid.org/0000-0002-2995-8162","observed_orcids":["https://orcid.org/0000-0002-2995-8162"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sean Phipps","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Bruce Smith","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bruce Smith","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5058866129","display_name":"Raymond K. Mulhern","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Raymond K. Mulhern","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":5.091,"has_fulltext":false,"cited_by_count":145,"citation_normalized_percentile":{"value":0.95297889,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"90","issue":"4","first_page":"537","last_page":"541"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.6942999958992004,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.6942999958992004,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11292","display_name":"Pediatric Pain Management Techniques","score":0.3009999990463257,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11768","display_name":"Music Therapy and Health","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/3207","display_name":"Social Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oral-ketamine","display_name":"oral ketamine","score":0.9539999961853027},{"id":"https://openalex.org/keywords/procedural-sedation","display_name":"procedural sedation","score":0.9520000219345093},{"id":"https://openalex.org/keywords/pediatric-oncology","display_name":"pediatric oncology","score":0.6200000047683716},{"id":"https://openalex.org/keywords/behavioral-distress","display_name":"behavioral distress","score":0.6880000233650208},{"id":"https://openalex.org/keywords/midazolam","display_name":"midazolam","score":0.7799999713897705},{"id":"https://openalex.org/keywords/sedation-recovery","display_name":"sedation recovery","score":0.8230000138282776}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9609767198562622},{"id":"https://openalex.org/C2780795376","wikidata":"https://www.wikidata.org/wiki/Q243547","display_name":"Ketamine","level":2,"score":0.8944565057754517},{"id":"https://openalex.org/C2778300832","wikidata":"https://www.wikidata.org/wiki/Q1589604","display_name":"Premedication","level":2,"score":0.7466199398040771},{"id":"https://openalex.org/C2776814716","wikidata":"https://www.wikidata.org/wiki/Q574801","display_name":"Sedation","level":2,"score":0.6439179182052612},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.6413869857788086},{"id":"https://openalex.org/C139265228","wikidata":"https://www.wikidata.org/wiki/Q5283089","display_name":"Distress","level":2,"score":0.6208249926567078},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.5740524530410767},{"id":"https://openalex.org/C2778000748","wikidata":"https://www.wikidata.org/wiki/Q423071","display_name":"Midazolam","level":3,"score":0.4911205470561981},{"id":"https://openalex.org/C2777397205","wikidata":"https://www.wikidata.org/wiki/Q275792","display_name":"Saline","level":2,"score":0.42322078347206116},{"id":"https://openalex.org/C23131810","wikidata":"https://www.wikidata.org/wiki/Q818574","display_name":"Observational study","level":2,"score":0.41694432497024536},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3019329905509949},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C70410870","wikidata":"https://www.wikidata.org/wiki/Q199906","display_name":"Clinical psychology","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001707","descriptor_name":"Biopsy, Needle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002652","descriptor_name":"Child Behavior","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007649","descriptor_name":"Ketamine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013129","descriptor_name":"Spinal Puncture","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016292","descriptor_name":"Procedural Sedation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1542/peds.90.4.537","doi":"https://doi.org/10.1542/peds.90.4.537","is_oa":false,"landing_page_url":"https://doi.org/10.1542/peds.90.4.537","pdf_url":null,"source":{"id":"https://openalex.org/S77494981","display_name":"PEDIATRICS","issn_l":"0031-4005","issn":["0031-4005","1098-4275"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315734","host_organization_name":"American Academy of Pediatrics","host_organization_lineage":["https://openalex.org/P4310315734"],"host_organization_lineage_names":["American Academy of Pediatrics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatrics","raw_type":"journal-article"},{"id":"pmid:1408506","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1408506","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatrics","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1933019395","https://openalex.org/W2406554239","https://openalex.org/W2945271458","https://openalex.org/W2061893314","https://openalex.org/W1966499493","https://openalex.org/W2061576705","https://openalex.org/W1852716069","https://openalex.org/W2025354628","https://openalex.org/W2979604969","https://openalex.org/W2403503985"],"abstract_inverted_index":{"This":[0],"study":[1,95,121],"prospectively":[2],"evaluated":[3,44],"the":[4,50,91,104,108,125,140,152,170,175,199],"efficacy":[5],"of":[6,53,59,90,103,107,116,151,169,189],"oral":[7,112,146,156,203],"ketamine":[8,113,157,184,204],"in":[9,13,29,142,174,209],"alleviating":[10],"procedure-related":[11,207],"distress":[12,42,76,135,208],"pediatric":[14,210],"oncology":[15,211],"patients.":[16,212],"Ketamine":[17],"(10":[18],"mg/kg)":[19],"was":[20,43,96],"administered":[21],"orally":[22],"to":[23,34,80,183],"35":[24],"children":[25,60,143],"and":[26,49,67],"adolescents,":[27],"ranging":[28],"age":[30],"from":[31,193],"14":[32],"months":[33],"17":[35],"years":[36],"(mean":[37],"=":[38],"6.5":[39],"years).":[40],"Procedure-related":[41],"by":[45],"using":[46,129],"parent/clinician":[47],"ratings":[48,69],"Observational":[51],"Scale":[52],"Behavioral":[54],"Distress":[55],"(OSBD-R).":[56],"Eighty-seven":[57],"percent":[58],"were":[61,70,85,158,185],"sedated":[62],"within":[63,195],"45":[64],"minutes.":[65],"Clinician":[66],"parent":[68],"similar,":[71],"with":[72,114],"77%":[73],"rating":[74],"procedural":[75],"as":[77],"low":[78,86],"(0":[79],"3).":[81],"The":[82,187],"OSBD-R":[83,105,149],"scores":[84,106,150],"throughout":[87],"all":[88,165],"phases":[89,166],"study.":[92,177],"Although":[93],"this":[94],"neither":[97],"randomized":[98],"nor":[99],"placebo-controlled,":[100],"statistical":[101],"comparison":[102],"patients":[109,153,190],"who":[110,144,154],"received":[111,145,155],"those":[115,168],"historical":[117],"controls":[118],"(from":[119],"a":[120],"previously":[122],"performed":[123],"at":[124],"same":[126],"institution":[127],"but":[128],"intravenous":[130],"midazolam)":[131],"showed":[132,191],"significantly":[133,159],"less":[134],"(P":[136,161],"<":[137,162],".001)":[138,163],"during":[139,164],"procedure":[141],"ketamine.":[147],"Additionally,":[148],"lower":[160],"than":[167],"saline":[171],"placebo":[172],"group":[173],"other":[176],"No":[178],"cardiorespiratory":[179],"side":[180],"effects":[181],"related":[182],"noted.":[186],"majority":[188],"recovery":[192],"sedation":[194],"2":[196],"hours":[197],"following":[198],"procedure.":[200],"In":[201],"conclusion,":[202],"effectively":[205],"alleviated":[206]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}