{"id":"https://openalex.org/W1542201358","doi":null,"title":"Developmental aspects of endothelial function.","display_name":"Developmental aspects of endothelial function.","publication_year":1991,"publication_date":"1991-02-01","ids":{"openalex":"https://openalex.org/W1542201358","mag":"1542201358","pmid":"https://pubmed.ncbi.nlm.nih.gov/1648268"},"language":"en","primary_location":{"id":"pmid:1648268","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1648268","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Seminars in perinatology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082259652","display_name":"William J. Pearce","orcid":"https://orcid.org/0000-0002-5331-5677","observed_orcids":["https://orcid.org/0000-0002-5331-5677"]},"institutions":[{"id":"https://openalex.org/I26347476","display_name":"Loma Linda University","ror":"https://ror.org/04bj28v14","country_code":"US","type":"education","lineage":["https://openalex.org/I26347476"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W J Pearce","raw_affiliation_strings":["Department of Physiology, Loma Linda University School of Medicine, CA 92350"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Loma Linda University School of Medicine, CA 92350","institution_ids":["https://openalex.org/I26347476"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109048794","display_name":"L. D. Longo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L D Longo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6688,"has_fulltext":false,"cited_by_count":28,"citation_normalized_percentile":{"value":0.66760061,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"15","issue":"1","first_page":"40","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10924","display_name":"Cardiovascular Health and Disease Prevention","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endothelial-function","display_name":"endothelial function","score":0.972000002861023},{"id":"https://openalex.org/keywords/cerebral-arteries","display_name":"cerebral arteries","score":0.8080000281333923},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.7480000257492065},{"id":"https://openalex.org/keywords/guanylate-cyclase","display_name":"guanylate cyclase","score":0.9679999947547913},{"id":"https://openalex.org/keywords/cgmp","display_name":"cyclic GMP","score":0.9610000252723694},{"id":"https://openalex.org/keywords/vasorelaxation","display_name":"vasorelaxation","score":0.7570000290870667},{"id":"https://openalex.org/keywords/perinatal-development","display_name":"perinatal development","score":0.8119999766349792},{"id":"https://openalex.org/keywords/fetal-sheep","display_name":"fetal sheep","score":0.8989999890327454},{"id":"https://openalex.org/keywords/a23187","display_name":"A23187","score":0.921999990940094},{"id":"https://openalex.org/keywords/common-carotid-artery","display_name":"common carotid artery","score":0.847000002861023},{"id":"https://openalex.org/keywords/receptor-distribution","display_name":"receptor distribution","score":0.375}],"concepts":[{"id":"https://openalex.org/C171614378","wikidata":"https://www.wikidata.org/wiki/Q5064093","display_name":"Cerebral arteries","level":2,"score":0.8074020147323608},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6943752765655518},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.6712571382522583},{"id":"https://openalex.org/C120770815","wikidata":"https://www.wikidata.org/wiki/Q14859627","display_name":"Vasodilation","level":2,"score":0.6318323612213135},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.5908428430557251},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5334579944610596},{"id":"https://openalex.org/C2987047532","wikidata":"https://www.wikidata.org/wiki/Q214275","display_name":"Carotid arteries","level":2,"score":0.4568437337875366},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.44913214445114136},{"id":"https://openalex.org/C72859922","wikidata":"https://www.wikidata.org/wiki/Q11068","display_name":"Circulatory system","level":2,"score":0.44876572489738464},{"id":"https://openalex.org/C119671327","wikidata":"https://www.wikidata.org/wiki/Q886843","display_name":"Cerebral circulation","level":2,"score":0.44366562366485596},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3656524419784546},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.24037855863571167},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1404544711112976},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000001","descriptor_name":"Calcimycin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000244","descriptor_name":"Adenosine Diphosphate","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000831","descriptor_name":"Animals, Newborn","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002536","descriptor_name":"Cerebral Arteries","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002536","descriptor_name":"Cerebral Arteries","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":true},{"descriptor_ui":"D002536","descriptor_name":"Cerebral Arteries","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002560","descriptor_name":"Cerebrovascular Circulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D005333","descriptor_name":"Fetus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005996","descriptor_name":"Nitroglycerin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006152","descriptor_name":"Cyclic GMP","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010396","descriptor_name":"Penicillamine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D010396","descriptor_name":"Penicillamine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D012756","descriptor_name":"Sheep","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014661","descriptor_name":"Vasoconstriction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014664","descriptor_name":"Vasodilation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D026423","descriptor_name":"S-Nitroso-N-Acetylpenicillamine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:1648268","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1648268","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Seminars in perinatology","raw_type":"Journal Article"},{"id":"mag:1542201358","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1648268","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8371999859809875}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3381963926","display_name":"MECHANISMS OF HYPOXIC CEREBRAL VASODILATATION IN NEWBORN","funder_award_id":"R01HL041347","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G874190830","display_name":"Cerebral Artery Alpha1 Adrenergic and PKC Regulatory Mechanisms","funder_award_id":"R01HD003807","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W1497678563","https://openalex.org/W1509564023","https://openalex.org/W1812961065","https://openalex.org/W1815236483","https://openalex.org/W1894522898","https://openalex.org/W1907994445","https://openalex.org/W2018610641","https://openalex.org/W2018688418","https://openalex.org/W2022868687","https://openalex.org/W2034056296","https://openalex.org/W2043782147","https://openalex.org/W2071421302","https://openalex.org/W2098108865","https://openalex.org/W2109694249","https://openalex.org/W2187176375","https://openalex.org/W2434440537","https://openalex.org/W2465190780","https://openalex.org/W2498116650"],"related_works":["https://openalex.org/W1996429447","https://openalex.org/W2055351612","https://openalex.org/W2138278822","https://openalex.org/W1997957551","https://openalex.org/W2064112349","https://openalex.org/W2087548199","https://openalex.org/W2052366845","https://openalex.org/W309736758","https://openalex.org/W2394512335","https://openalex.org/W2043466169"],"abstract_inverted_index":{"We":[0],"believe":[1],"that":[2,129],"the":[3,23,30,40,50,84,99,109,132,136,153,172,180,202,212,217],"mechanisms":[4],"through":[5],"which":[6],"nitric":[7],"oxide":[8],"and":[9,26,39,48,70,81,83,96,126,156,184,226,230],"guanylate":[10],"cyclase":[11],"produce":[12],"relaxation":[13,43],"are":[14,149],"fully":[15],"functional":[16],"in":[17,22,29,53,75,108,189,192,201,211,223,228],"cerebral":[18,113,182,213],"arteries":[19],"at":[20],"term":[21,31],"fetal":[24,95,190],"sheep":[25],"probably":[27],"also":[28],"human":[32],"infant.":[33],"The":[34,58],"relation":[35],"between":[36],"cGMP":[37],"levels":[38],"degree":[41],"of":[42,86,101,144],"varies":[44],"both":[45],"with":[46,49,161,199],"age":[47,162,200],"relaxant":[51],"used":[52],"a":[54,64,92,119],"vessel":[55],"specific":[56],"manner.":[57],"factors":[59],"underlying":[60],"this":[61,185],"variability":[62],"constitute":[63],"fruitful":[65],"area":[66],"for":[67],"future":[68],"research":[69],"include":[71],"possible":[72],"age-related":[73],"changes":[74,128,222],"membrane":[76],"potential,":[77],"calcium":[78],"channel":[79],"density":[80],"currents,":[82],"participation":[85],"cGMP-independent":[87],"mechanisms,":[88],"to":[89,104,121,140,176,196],"name":[90],"only":[91],"few.":[93],"Between":[94],"newborn":[97],"life,":[98],"biotransformation":[100],"nitroglycerin":[102],"appears":[103],"improve":[105],"significantly,":[106],"particularly":[107],"smaller":[110,181],"more":[111],"distal":[112],"arteries.":[114,165,194],"This":[115],"improvement":[116],"may":[117],"be":[118],"clue":[120],"other":[122],"important":[123],"vascular":[124],"metabolic":[125],"enzymatic":[127],"occur":[130],"during":[131],"perinatal":[133,154],"period.":[134],"At":[135],"endothelial":[137,146],"level,":[138],"responses":[139],"A23187,":[141],"an":[142],"index":[143],"maximum":[145],"vasodilator":[147],"capacity,":[148],"relatively":[150],"stable":[151],"across":[152,163],"period":[155],"do":[157],"not":[158],"change":[159],"consistently":[160],"all":[164],"More":[166],"importantly,":[167],"large":[168],"arteries,":[169,183,214],"such":[170],"as":[171],"common":[173,203],"carotid,":[174,204],"appear":[175],"relax":[177],"better":[178],"than":[179,191],"difference":[186],"is":[187],"greater":[188],"adult":[193],"Responses":[195],"ADP":[197],"disappear":[198],"but":[205],"remain":[206],"or":[207],"even":[208],"become":[209],"enhanced":[210],"thus":[215],"illustrating":[216],"key":[218],"role":[219],"played":[220],"by":[221],"receptor":[224],"type":[225],"distribution":[227],"development":[229],"maturation.":[231]},"counts_by_year":[{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":2}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}