{"id":"https://openalex.org/W154207206","doi":"https://doi.org/10.4049/jimmunol.178.supp.48.19","title":"Immunization with PSA/anti-PSA complexes induces T and B cell responses to PSA in PSA-transgenic mice (48.19)","display_name":"Immunization with PSA/anti-PSA complexes induces T and B cell responses to PSA in PSA-transgenic mice (48.19)","publication_year":2007,"publication_date":"2007-04-01","ids":{"openalex":"https://openalex.org/W154207206","doi":"https://doi.org/10.4049/jimmunol.178.supp.48.19","mag":"154207206"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.178.supp.48.19","doi":"https://doi.org/10.4049/jimmunol.178.supp.48.19","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.178.supp.48.19","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050867417","display_name":"Birgit C. Schultes","orcid":"https://orcid.org/0000-0002-2275-3383","observed_orcids":["https://orcid.org/0000-0002-2275-3383"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Birgit Corinna Schultes","raw_affiliation_strings":["Research , 15 Walnut Street, Suite 300, Wellesley, MA, 02481","1Research,","Research,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research , 15 Walnut Street, Suite 300, Wellesley, MA, 02481","institution_ids":[]},{"raw_affiliation_string":"1Research,","institution_ids":[]},{"raw_affiliation_string":"Research,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071819814","display_name":"Fuxiang Hou","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fuxiang Hou","raw_affiliation_strings":["Research , 15 Walnut Street, Suite 300, Wellesley, MA, 02481","1Research,","Research,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research , 15 Walnut Street, Suite 300, Wellesley, MA, 02481","institution_ids":[]},{"raw_affiliation_string":"1Research,","institution_ids":[]},{"raw_affiliation_string":"Research,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034623041","display_name":"Lori Smith","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L Mary Smith","raw_affiliation_strings":["Clinical R&D, Unither Pharmaceuticals , 15 Walnut Street, Suite 300, Wellesley, MA, 02481","2Clinical R&D, Unither Pharmaceuticals, 15 Walnut Street, Suite 300, Wellesley, MA, 02481,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical R&D, Unither Pharmaceuticals , 15 Walnut Street, Suite 300, Wellesley, MA, 02481","institution_ids":[]},{"raw_affiliation_string":"2Clinical R&D, Unither Pharmaceuticals, 15 Walnut Street, Suite 300, Wellesley, MA, 02481,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027346475","display_name":"Christopher F. Nicodemus","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christopher F Nicodemus","raw_affiliation_strings":["Clinical R&D, Unither Pharmaceuticals , 15 Walnut Street, Suite 300, Wellesley, MA, 02481","2Clinical R&D, Unither Pharmaceuticals, 15 Walnut Street, Suite 300, Wellesley, MA, 02481,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical R&D, Unither Pharmaceuticals , 15 Walnut Street, Suite 300, Wellesley, MA, 02481","institution_ids":[]},{"raw_affiliation_string":"2Clinical R&D, Unither Pharmaceuticals, 15 Walnut Street, Suite 300, Wellesley, MA, 02481,","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051184941","display_name":"John G. Frelinger","orcid":"https://orcid.org/0000-0002-1841-4688","observed_orcids":["https://orcid.org/0000-0002-1841-4688"]},"institutions":[{"id":"https://openalex.org/I28792581","display_name":"University of Rochester Medicine","ror":"https://ror.org/00trqv719","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I28792581","https://openalex.org/I5388228"]},{"id":"https://openalex.org/I5388228","display_name":"University of Rochester","ror":"https://ror.org/022kthw22","country_code":"US","type":"education","lineage":["https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John F Frelinger","raw_affiliation_strings":["Microbiology and Immunology, University of Rochester Medical Center , 601 Elmwood Ave, Kornberg Building, Room 2-9816, Rochester, NY, 14642","3Microbiology and Immunology, University of Rochester Medical Center, 601 Elmwood Ave, Kornberg Building, Room 2-9816, Rochester, NY, 14642"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Microbiology and Immunology, University of Rochester Medical Center , 601 Elmwood Ave, Kornberg Building, Room 2-9816, Rochester, NY, 14642","institution_ids":["https://openalex.org/I28792581","https://openalex.org/I5388228"]},{"raw_affiliation_string":"3Microbiology and Immunology, University of Rochester Medical Center, 601 Elmwood Ave, Kornberg Building, Room 2-9816, Rochester, NY, 14642","institution_ids":["https://openalex.org/I28792581","https://openalex.org/I5388228"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"178","issue":"1_Supplement","first_page":"S78","last_page":"S78"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prostate-specific-antigen","display_name":"prostate-specific antigen","score":0.9750000238418579},{"id":"https://openalex.org/keywords/immune-complexes","display_name":"immune complexes","score":0.6449999809265137},{"id":"https://openalex.org/keywords/t-cell-response","display_name":"T cell response","score":0.6880000233650208},{"id":"https://openalex.org/keywords/b-cell-response","display_name":"B cell response","score":0.9279999732971191},{"id":"https://openalex.org/keywords/cytotoxic-t-lymphocytes","display_name":"cytotoxic T lymphocytes","score":0.9570000171661377},{"id":"https://openalex.org/keywords/autoantigens","display_name":"autoantigens","score":0.5289999842643738}],"concepts":[{"id":"https://openalex.org/C195616568","wikidata":"https://www.wikidata.org/wiki/Q128711","display_name":"Epitope","level":3,"score":0.6298139691352844},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.5987450480461121},{"id":"https://openalex.org/C956191","wikidata":"https://www.wikidata.org/wiki/Q930144","display_name":"Polyclonal antibodies","level":3,"score":0.5763312578201294},{"id":"https://openalex.org/C2776946954","wikidata":"https://www.wikidata.org/wiki/Q420291","display_name":"Ovalbumin","level":3,"score":0.547224223613739},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5437953472137451},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5181921124458313},{"id":"https://openalex.org/C147969180","wikidata":"https://www.wikidata.org/wiki/Q5014579","display_name":"CTL*","level":4,"score":0.4808564782142639},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.47516247630119324},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4729335606098175},{"id":"https://openalex.org/C2780801004","wikidata":"https://www.wikidata.org/wiki/Q1415366","display_name":"Immunization","level":3,"score":0.4497803747653961},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.4181111752986908},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3865700960159302},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.37335288524627686},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.3622502088546753}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.4049/jimmunol.178.supp.48.19","doi":"https://doi.org/10.4049/jimmunol.178.supp.48.19","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.178.supp.48.19","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1972777297","https://openalex.org/W1779344671","https://openalex.org/W2040153392","https://openalex.org/W2003927412","https://openalex.org/W2037562298","https://openalex.org/W2912097398","https://openalex.org/W2335627417","https://openalex.org/W2042474090","https://openalex.org/W2386105346","https://openalex.org/W2032934787"],"abstract_inverted_index":{"Abstract":[0],"The":[1,124],"murine":[2,23],"MAb-AR47.47":[3,89,95],"(IgG1\u03ba)":[4],"recognizes":[5],"all":[6],"circulating":[7],"forms":[8],"of":[9,66,94],"PSA":[10,27,46,49,79,87,97,137,160,208,215],"and":[11,22,39,88,96,113,143,146,161,202],"targets":[12],"the":[13,64,81,103,162,205],"epitope":[14],"EPEEFLT.":[15],"In":[16],"vitro":[17],"studies":[18],"showed":[19],"that":[20,192],"human":[21,78],"dendritic":[24],"cells":[25,201],"process":[26],"more":[28],"efficiently":[29],"in":[30,72,80,108,122,151,180,209,211],"immune":[31,68,110],"complexes":[32],"(IC)":[33],"with":[34,51,70,86,136,154,159,187],"MAb-AR47.47.":[35,188],"IC":[36,71,92,158,186,194],"induced":[37,150,170],"CD4+":[38,57],"CD8+":[40],"IFN-\u03b3":[41],"producing":[42],"T":[43,58,130,140,172,199],"cells,":[44,198],"whereas":[45],"alone":[47,90],"or":[48,91,118,165,168],"combined":[50],"a":[52,128,212,217],"non-specific":[53],"antibody":[54,107,147],"mainly":[55],"stimulated":[56],"cells.":[59],"We":[60],"have":[61],"further":[62],"investigated":[63],"activation":[65],"PSA-specific":[67],"responses":[69,148,175],"male":[73],"PSA-transgenic":[74],"mice,":[75],"which":[76],"express":[77],"prostate.":[82],"Mice":[83],"were":[84,120,149],"immunized":[85,153],"consisting":[93],"at":[98],"various":[99],"concentrations.":[100],"To":[101],"investigate":[102],"need":[104],"for":[105],"foreign":[106],"inducing":[109],"responses,":[111],"rabbit":[112,166],"goat":[114,164],"polyclonal":[115,163],"anti-PSA":[116],"antibodies":[117,167],"MAb-AR47.47-ovalbumin":[119,169],"tested":[121],"parallel.":[123],"mice":[125,152],"only":[126],"generated":[127],"weak":[129],"helper":[131,141,173,200],"2":[132],"response":[133],"to":[134,176,185],"immunization":[135],"alone.":[138],"Robust":[139],"1":[142],"2,":[144],"CTL":[145,182,203],"AR47.47-PSA":[155,193],"IC.":[156],"Interestingly,":[157],"stronger":[171],"cell":[174],"PSA,":[177],"but":[178],"resulted":[179],"weaker":[181],"induction":[183],"relative":[184],"This":[189],"data":[190],"indicates":[191],"can":[195],"prime":[196],"B":[197],"against":[204],"tumor":[206],"antigen":[207],"vivo":[210],"setting":[213],"where":[214],"is":[216],"self":[218],"antigen.":[219]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2016-06-24T00:00:00"}