{"id":"https://openalex.org/W1542055898","doi":null,"title":"El fibrin\u00f3geno como factor de riesgo de enfermedad aterotromb\u00f3tica","display_name":"El fibrin\u00f3geno como factor de riesgo de enfermedad aterotromb\u00f3tica","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W1542055898","mag":"1542055898"},"language":"es","primary_location":{"id":"pmh:oai:revista.cnic.cu:article/660","doi":null,"is_oa":true,"landing_page_url":"https://revista.cnic.edu.cu/index.php/RevBiol/article/view/660","pdf_url":null,"source":{"id":"https://openalex.org/S4306526263","display_name":"Revista CENIC. Ciencias biol\u00f3gicas","issn_l":"0253-5688","issn":["0253-5688","2221-2450"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["latindex","scielo"],"host_organization":"https://openalex.org/I4210132269","host_organization_name":"Centro Nacional de Investigaciones Cient\u00edficas","host_organization_lineage":["https://openalex.org/I4210132269"],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"0253-5688","raw_type":"info:eu-repo/semantics/article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://revista.cnic.edu.cu/index.php/RevBiol/article/view/660","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101451571","display_name":"Julio C\u00e9sar Fern\u00e1ndez Travieso","orcid":"https://orcid.org/0000-0001-8144-4129","observed_orcids":["https://orcid.org/0000-0001-8144-4129"]},"institutions":[{"id":"https://openalex.org/I4210132269","display_name":"Centro Nacional de Investigaciones Cient\u00edficas","ror":"https://ror.org/03zxtdc90","country_code":"CU","type":"facility","lineage":["https://openalex.org/I4210132269"]}],"countries":["CU"],"is_corresponding":true,"raw_author_name":"Fern\u00e1ndez Travieso, Julio C\u00e9sar","raw_affiliation_strings":["Centro Nacional de Investigaciones Cient\u00edficas, Centro de Productos Naturales, La Habana, Cuba"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro Nacional de Investigaciones Cient\u00edficas, Centro de Productos Naturales, La Habana, Cuba","institution_ids":["https://openalex.org/I4210132269"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5101451571"],"corresponding_institution_ids":["https://openalex.org/I4210132269"],"apc_list":null,"apc_paid":null,"fwci":0.218,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.57302036,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11721","display_name":"Blood properties and coagulation","score":0.9711999893188477,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11721","display_name":"Blood properties and coagulation","score":0.9711999893188477,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.014299999922513962,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.010700000450015068,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fibrinogen","display_name":"fibrinogen","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cardiovascular-risk-factors","display_name":"cardiovascular risk factors","score":0.9539999961853027},{"id":"https://openalex.org/keywords/atherothrombosis","display_name":"atherothrombosis","score":0.8700000047683716},{"id":"https://openalex.org/keywords/endothelial-dysfunction","display_name":"endothelial dysfunction","score":0.8560000061988831},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.9279999732971191},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.8199999928474426},{"id":"https://openalex.org/keywords/acute-coronary-syndrome","display_name":"acute coronary syndrome","score":0.9100000262260437},{"id":"https://openalex.org/keywords/thrombosis","display_name":"thrombosis","score":0.972000002861023},{"id":"https://openalex.org/keywords/c-reactive-protein","display_name":"C-reactive protein","score":0.9079999923706055},{"id":"https://openalex.org/keywords/lipoprotein-a","display_name":"lipoprotein(a)","score":0.9940000176429749},{"id":"https://openalex.org/keywords/homocysteine","display_name":"homocysteine","score":1.0},{"id":"https://openalex.org/keywords/genetic-polymorphism","display_name":"genetic polymorphism","score":0.8500000238418579},{"id":"https://openalex.org/keywords/cardiovascular-disease-prevention","display_name":"cardiovascular disease prevention","score":0.4620000123977661}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33221983909606934}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:revista.cnic.cu:article/660","doi":null,"is_oa":true,"landing_page_url":"https://revista.cnic.edu.cu/index.php/RevBiol/article/view/660","pdf_url":null,"source":{"id":"https://openalex.org/S4306526263","display_name":"Revista CENIC. Ciencias biol\u00f3gicas","issn_l":"0253-5688","issn":["0253-5688","2221-2450"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["latindex","scielo"],"host_organization":"https://openalex.org/I4210132269","host_organization_name":"Centro Nacional de Investigaciones Cient\u00edficas","host_organization_lineage":["https://openalex.org/I4210132269"],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"0253-5688","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:redalyc.org:181221574001","doi":null,"is_oa":false,"landing_page_url":"https://www.redalyc.org/articulo.oa?id=181221574001","pdf_url":null,"source":{"id":"https://openalex.org/S4377196100","display_name":"Redalyc (Universidad Aut\u00f3noma del Estado de M\u00e9xico)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I179647637","host_organization_name":"Universidad Aut\u00f3noma del Estado de M\u00e9xico","host_organization_lineage":["https://openalex.org/I179647637"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Revista CENIC. Ciencias Biol\u00f3gicas (Cuba) Num.1 Vol.40","raw_type":"art\u00edculo cient\u00edfico"}],"best_oa_location":{"id":"pmh:oai:revista.cnic.cu:article/660","doi":null,"is_oa":true,"landing_page_url":"https://revista.cnic.edu.cu/index.php/RevBiol/article/view/660","pdf_url":null,"source":{"id":"https://openalex.org/S4306526263","display_name":"Revista CENIC. Ciencias biol\u00f3gicas","issn_l":"0253-5688","issn":["0253-5688","2221-2450"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["latindex","scielo"],"host_organization":"https://openalex.org/I4210132269","host_organization_name":"Centro Nacional de Investigaciones Cient\u00edficas","host_organization_lineage":["https://openalex.org/I4210132269"],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"0253-5688","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":79,"referenced_works":["https://openalex.org/W14467786","https://openalex.org/W88483538","https://openalex.org/W123736616","https://openalex.org/W1485063133","https://openalex.org/W1651383390","https://openalex.org/W1714887617","https://openalex.org/W1881469946","https://openalex.org/W1964001795","https://openalex.org/W1975161958","https://openalex.org/W1975246522","https://openalex.org/W1978188576","https://openalex.org/W1979615936","https://openalex.org/W1981690614","https://openalex.org/W1985765463","https://openalex.org/W1990535091","https://openalex.org/W1990848510","https://openalex.org/W1991509131","https://openalex.org/W1995043636","https://openalex.org/W1997609133","https://openalex.org/W1999658872","https://openalex.org/W2010545674","https://openalex.org/W2014367374","https://openalex.org/W2025001402","https://openalex.org/W2025782661","https://openalex.org/W2029152303","https://openalex.org/W2029644331","https://openalex.org/W2031626620","https://openalex.org/W2037352227","https://openalex.org/W2037491832","https://openalex.org/W2039157107","https://openalex.org/W2049950622","https://openalex.org/W2058610272","https://openalex.org/W2064871885","https://openalex.org/W2068255829","https://openalex.org/W2078132464","https://openalex.org/W2084025765","https://openalex.org/W2087967133","https://openalex.org/W2090750056","https://openalex.org/W2094592108","https://openalex.org/W2096449975","https://openalex.org/W2097788818","https://openalex.org/W2105299705","https://openalex.org/W2110195698","https://openalex.org/W2110248987","https://openalex.org/W2110460030","https://openalex.org/W2113037319","https://openalex.org/W2113842550","https://openalex.org/W2114126536","https://openalex.org/W2115419527","https://openalex.org/W2118338607","https://openalex.org/W2118937344","https://openalex.org/W2121074435","https://openalex.org/W2121315901","https://openalex.org/W2126722781","https://openalex.org/W2126953591","https://openalex.org/W2129457140","https://openalex.org/W2129658376","https://openalex.org/W2131803294","https://openalex.org/W2143321563","https://openalex.org/W2143415523","https://openalex.org/W2148278067","https://openalex.org/W2150512600","https://openalex.org/W2151368992","https://openalex.org/W2153573310","https://openalex.org/W2156882114","https://openalex.org/W2164864729","https://openalex.org/W2167223166","https://openalex.org/W2167362639","https://openalex.org/W2183393419","https://openalex.org/W2313159400","https://openalex.org/W2319045532","https://openalex.org/W2320403440","https://openalex.org/W2321632942","https://openalex.org/W2408903103","https://openalex.org/W2409597142","https://openalex.org/W2474963153","https://openalex.org/W2770231726","https://openalex.org/W2913967451","https://openalex.org/W3001171228"],"related_works":["https://openalex.org/W7019424477","https://openalex.org/W4404840417","https://openalex.org/W2129457140","https://openalex.org/W2289384619","https://openalex.org/W1565339375","https://openalex.org/W1965881611","https://openalex.org/W7153096051","https://openalex.org/W302001711","https://openalex.org/W1910221177","https://openalex.org/W2102528825"],"abstract_inverted_index":{"Both":[0],"endothelial":[1],"dsyfunction":[2],"and":[3,37,58,78,88,95,105,117,128,148,157,168,171],"inflammation":[4],"play":[5],"a":[6,83,189,197],"crucial":[7],"role":[8,202],"from":[9,125],"early":[10],"stages":[11],"of":[12,18,91,108,111,119,173,185,192,200,203,208],"atherosclerosis":[13],"up":[14],"to":[15,27,41,99],"the":[16,72,86,106,109,115,183,201,206],"triggering":[17],"acute":[19],"coronary":[20],"syndromes,":[21],"in":[22,176,205],"which":[23],"fibrinogen":[24,32,51,76,102,136,167,174,204],"has":[25,39],"shown":[26],"participate":[28],"actively.":[29],"Besides,":[30],"elevated":[31,49,100,134],"is":[33,122,137,152,180],"related":[34],"with":[35,53,144],"thrombosis":[36],"it":[38],"proven":[40],"be":[42],"an":[43,138],"independent":[44,139],"cardiovascular":[45,64,79,140,186,209],"risk":[46,65,141,146,178],"factor.":[47],"Nowadays":[48],"level":[50],"together":[52],"C-reactive":[54],"protein,":[55],"lipoprotein":[56],"(a)":[57],"homocysteine":[59],"are":[60,103,194],"considered":[61],"as":[62],"emerging":[63],"factors.":[66],"The":[67],"present":[68],"work":[69],"reviews":[70],"briefly":[71],"association":[73],"between":[74],"high":[75,165,177],"levels":[77,175],"trombosis":[80],"risk,":[81],"including":[82],"look":[84],"on":[85],"structure":[87],"biological":[89],"functions":[90],"fibrinogen.":[92],"Also,":[93],"modificable":[94,113],"non-modificable":[96],"factors":[97,147],"leading":[98],"plasma":[101,135,166],"presented":[104],"relevance":[107],"control":[110,162],"those":[112],"for":[114,196],"prevention":[116,184],"management":[118],"atherothrombotic":[120],"diseases":[121],"discussed.":[123],"Data":[124],"observational":[126],"epidemiological":[127],"randomized":[129],"clinical":[130],"studies":[131,193],"support":[132],"that":[133,154,169],"factor,":[142],"associated":[143],"conventional":[145],"genetic":[149],"polymorphisms.":[150],"It":[151],"concluded":[153],"lifestyle":[155],"changes":[156],"pharmacological":[158],"treatment":[159],"can":[160],"help":[161],"or":[163],"reduce":[164],"determination":[170],"assessing":[172],"individuals":[179],"encouraged":[181],"within":[182],"events.":[187],"Likewise,":[188],"larger":[190],"number":[191],"necessary":[195],"better":[198],"understanding":[199],"increase":[207],"thrombotic":[210],"risk.":[211]},"counts_by_year":[{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2016-06-24T00:00:00"}
