{"id":"https://openalex.org/W1542054541","doi":"https://doi.org/10.1016/s0021-9258(19)69799-1","title":"Novel variants in benzo(a)pyrene metabolism. Isolation by fluorescence-activated cell sorting.","display_name":"Novel variants in benzo(a)pyrene metabolism. Isolation by fluorescence-activated cell sorting.","publication_year":1981,"publication_date":"1981-03-01","ids":{"openalex":"https://openalex.org/W1542054541","doi":"https://doi.org/10.1016/s0021-9258(19)69799-1","mag":"1542054541","pmid":"https://pubmed.ncbi.nlm.nih.gov/7462248"},"language":"en","primary_location":{"id":"doi:10.1016/s0021-9258(19)69799-1","doi":"https://doi.org/10.1016/s0021-9258(19)69799-1","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(19)69799-1","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/s0021-9258(19)69799-1","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026763137","display_name":"A. Dusty Miller","orcid":"https://orcid.org/0000-0002-3736-3660","observed_orcids":["https://orcid.org/0000-0002-3736-3660"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A.G. Miller","raw_affiliation_strings":["From the Department of Pharmacology, Stanford University School of Medicine, Stanford, California 94305"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Pharmacology, Stanford University School of Medicine, Stanford, California 94305","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112727836","display_name":"James P. Whitlock","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J.P. Whitlock","raw_affiliation_strings":["From the Department of Pharmacology, Stanford University School of Medicine, Stanford, California 94305"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Pharmacology, Stanford University School of Medicine, Stanford, California 94305","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":2.4444,"has_fulltext":false,"cited_by_count":39,"citation_normalized_percentile":{"value":0.87462823,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"256","issue":"5","first_page":"2433","last_page":"2437"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10122","display_name":"Toxic Organic Pollutants Impact","score":0.0038999998942017555,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/benzo-a-pyrene","display_name":"benzo[a]pyrene","score":0.9350000023841858},{"id":"https://openalex.org/keywords/polycyclic-aromatic-hydrocarbons","display_name":"polycyclic aromatic hydrocarbons","score":0.871999979019165},{"id":"https://openalex.org/keywords/benzo-a-pyrene-metabolism","display_name":"benzo[a]pyrene metabolism","score":0.9200000166893005},{"id":"https://openalex.org/keywords/fluorescence-activated-cell-sorting","display_name":"fluorescence-activated cell sorting","score":0.8799999952316284},{"id":"https://openalex.org/keywords/hepa-1c1c7-cells","display_name":"Hepa1c1c7 cells","score":0.8650000095367432},{"id":"https://openalex.org/keywords/mouse-hepatoma-cells","display_name":"mouse hepatoma cells","score":0.7329999804496765},{"id":"https://openalex.org/keywords/aryl-hydrocarbon-hydroxylase","display_name":"aryl hydrocarbon hydroxylase","score":0.9300000071525574},{"id":"https://openalex.org/keywords/carcinogen-metabolism","display_name":"carcinogen metabolism","score":0.5830000042915344},{"id":"https://openalex.org/keywords/fluorescence-quenching","display_name":"fluorescence quenching","score":0.527999997138977}],"concepts":[{"id":"https://openalex.org/C2778951431","wikidata":"https://www.wikidata.org/wiki/Q415723","display_name":"Pyrene","level":2,"score":0.8890190720558167},{"id":"https://openalex.org/C2777538855","wikidata":"https://www.wikidata.org/wiki/Q306051","display_name":"Benzo(a)pyrene","level":3,"score":0.804313063621521},{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.7846814393997192},{"id":"https://openalex.org/C114246631","wikidata":"https://www.wikidata.org/wiki/Q187661","display_name":"Carcinogen","level":2,"score":0.7171441912651062},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6554983854293823},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.6497743725776672},{"id":"https://openalex.org/C2778630268","wikidata":"https://www.wikidata.org/wiki/Q17113277","display_name":"Cell sorting","level":3,"score":0.5963041186332703},{"id":"https://openalex.org/C2779229383","wikidata":"https://www.wikidata.org/wiki/Q1501961","display_name":"Benzopyrene","level":4,"score":0.5878100395202637},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5248087644577026},{"id":"https://openalex.org/C2777207669","wikidata":"https://www.wikidata.org/wiki/Q43648","display_name":"Hydrocarbon","level":2,"score":0.4897339344024658},{"id":"https://openalex.org/C2779033964","wikidata":"https://www.wikidata.org/wiki/Q407212","display_name":"Polycyclic aromatic hydrocarbon","level":2,"score":0.47364509105682373},{"id":"https://openalex.org/C33594762","wikidata":"https://www.wikidata.org/wiki/Q155750","display_name":"Aryl hydrocarbon receptor","level":4,"score":0.42706650495529175},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.41156718134880066},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.35515305399894714},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3227217197418213},{"id":"https://openalex.org/C107872376","wikidata":"https://www.wikidata.org/wiki/Q321355","display_name":"Environmental chemistry","level":1,"score":0.17554634809494019},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.13209214806556702},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.11263084411621094},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001189","descriptor_name":"Aryl Hydrocarbon Hydroxylases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001580","descriptor_name":"Benzopyrenes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001580","descriptor_name":"Benzopyrenes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008114","descriptor_name":"Liver Neoplasms, Experimental","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013050","descriptor_name":"Spectrometry, Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0021-9258(19)69799-1","doi":"https://doi.org/10.1016/s0021-9258(19)69799-1","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(19)69799-1","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:7462248","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7462248","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/s0021-9258(19)69799-1","doi":"https://doi.org/10.1016/s0021-9258(19)69799-1","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(19)69799-1","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.6240000128746033,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W16337247","https://openalex.org/W1492383398","https://openalex.org/W1515756335","https://openalex.org/W1556673553","https://openalex.org/W1562777547","https://openalex.org/W1606916058","https://openalex.org/W1775964807","https://openalex.org/W1973349939","https://openalex.org/W1980065068","https://openalex.org/W1982962554","https://openalex.org/W1984713897","https://openalex.org/W1989267015","https://openalex.org/W1989852001","https://openalex.org/W1992240306","https://openalex.org/W1993351113","https://openalex.org/W1994800122","https://openalex.org/W2004002258","https://openalex.org/W2007815078","https://openalex.org/W2017204918","https://openalex.org/W2023628193","https://openalex.org/W2024534471","https://openalex.org/W2031698412","https://openalex.org/W2036291378","https://openalex.org/W2040185588","https://openalex.org/W2048368181","https://openalex.org/W2069172157","https://openalex.org/W2121705744","https://openalex.org/W2133854140","https://openalex.org/W2136182130","https://openalex.org/W2166114408","https://openalex.org/W2173347944","https://openalex.org/W2188702955","https://openalex.org/W2327350179"],"related_works":["https://openalex.org/W1770714218","https://openalex.org/W2112785180","https://openalex.org/W1982962554","https://openalex.org/W2024534471","https://openalex.org/W2282478905","https://openalex.org/W4255055275","https://openalex.org/W6981918286","https://openalex.org/W2020561792","https://openalex.org/W2012066762","https://openalex.org/W7099900148"],"abstract_inverted_index":{"We":[0,59],"have":[1],"used":[2],"the":[3,9,12,52,65,73,76,90,99],"fluorescence-activated":[4],"cell":[5],"sorter":[6],"to":[7,28,40,42,72,81],"measure":[8],"metabolism":[10,74],"of":[11,46,54,56,67,75,84,86],"carcinogenic":[13],"polycyclic":[14],"aromatic":[15],"hydrocarbon,":[16],"benzo(a)pyrene":[17],"(BP),":[18],"in":[19,93],"individual,":[20],"viable":[21],"mouse":[22],"hepatoma":[23],"(Hepa":[24],"1c1c7)":[25],"cells":[26],"and":[27,50],"physically":[29],"select":[30],"variants":[31],"with":[32],"either":[33],"markedly":[34,37],"elevated":[35],"or":[36],"decreased":[38],"ability":[39],"metabolize":[41],"low,":[43],"nontoxic":[44],"concentrations":[45],"BP":[47,57,68,87],"(25":[48],"nM)":[49],"measuring":[51],"rate":[53],"disappearance":[55,66],"fluorescence.":[58],"show":[60],"by":[61,98],"several":[62],"criteria":[63],"that":[64],"fluorescence":[69,88],"is":[70],"due":[71],"carcinogen.":[77],"Cells":[78],"sorted":[79],"according":[80],"their":[82],"rae":[83],"loss":[85],"exhibit":[89],"predicted":[91],"phenotypes":[92],"BP-metabolizing":[94],"activity,":[95],"as":[96],"measured":[97],"aryl":[100],"hydrocarbon":[101],"hydroxylase":[102],"assay.":[103]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}