{"id":"https://openalex.org/W1542045064","doi":"https://doi.org/10.1016/s0021-9258(17)36979-x","title":"cDNA cloning of a mouse prostacyclin receptor. Multiple signaling pathways and expression in thymic medulla","display_name":"cDNA cloning of a mouse prostacyclin receptor. Multiple signaling pathways and expression in thymic medulla","publication_year":1994,"publication_date":"1994-04-01","ids":{"openalex":"https://openalex.org/W1542045064","doi":"https://doi.org/10.1016/s0021-9258(17)36979-x","mag":"1542045064","pmid":"https://pubmed.ncbi.nlm.nih.gov/7511597"},"language":"en","primary_location":{"id":"doi:10.1016/s0021-9258(17)36979-x","doi":"https://doi.org/10.1016/s0021-9258(17)36979-x","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(17)36979-x","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/s0021-9258(17)36979-x","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"T. Namba","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"T. Namba","raw_affiliation_strings":["Department of Pharmacology, Faculty of Medicine, Kyoto University, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Faculty of Medicine, Kyoto University, Japan","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017210229","display_name":"Hiroji Oida","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"H. Oida","raw_affiliation_strings":["Department of Pharmacology, Faculty of Medicine, Kyoto University, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Faculty of Medicine, Kyoto University, Japan","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053545534","display_name":"Yukihiko Sugimoto","orcid":"https://orcid.org/0000-0001-6973-932X","observed_orcids":["https://orcid.org/0000-0001-6973-932X"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Y. Sugimoto","raw_affiliation_strings":["Department of Pharmacology, Faculty of Medicine, Kyoto University, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Faculty of Medicine, Kyoto University, Japan","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055094058","display_name":"Akira Kakizuka","orcid":"https://orcid.org/0000-0003-3513-0334","observed_orcids":["https://orcid.org/0000-0003-3513-0334"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"A. Kakizuka","raw_affiliation_strings":["Department of Pharmacology, Faculty of Medicine, Kyoto University, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Faculty of Medicine, Kyoto University, Japan","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089629096","display_name":"Masahiko Negishi","orcid":"https://orcid.org/0000-0002-2076-8928","observed_orcids":["https://orcid.org/0000-0002-2076-8928"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"M. Negishi","raw_affiliation_strings":["Department of Pharmacology, Faculty of Medicine, Kyoto University, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Faculty of Medicine, Kyoto University, Japan","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036189941","display_name":"Atsushi Ichikawa","orcid":"https://orcid.org/0009-0000-2175-2963","observed_orcids":["https://orcid.org/0009-0000-2175-2963"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"A. Ichikawa","raw_affiliation_strings":["Department of Pharmacology, Faculty of Medicine, Kyoto University, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Faculty of Medicine, Kyoto University, Japan","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024624058","display_name":"Shuh Narumiya","orcid":"https://orcid.org/0000-0001-8062-6529","observed_orcids":["https://orcid.org/0000-0001-8062-6529"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"S. Narumiya","raw_affiliation_strings":["Department of Pharmacology, Faculty of Medicine, Kyoto University, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Faculty of Medicine, Kyoto University, Japan","institution_ids":["https://openalex.org/I22299242"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I22299242"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":8.3508,"has_fulltext":false,"cited_by_count":252,"citation_normalized_percentile":{"value":0.98472615,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"269","issue":"13","first_page":"9986","last_page":"9992"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.5479000210762024,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.5479000210762024,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.2667999863624573,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.10260000079870224,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prostacyclin-receptor","display_name":"prostacyclin receptor","score":1.0},{"id":"https://openalex.org/keywords/cdna-cloning","display_name":"cDNA cloning","score":0.8790000081062317},{"id":"https://openalex.org/keywords/seven-transmembrane-domains","display_name":"seven transmembrane domains","score":0.7120000123977661},{"id":"https://openalex.org/keywords/g-protein-coupled-receptors","display_name":"G protein-coupled receptors","score":0.8450000286102295},{"id":"https://openalex.org/keywords/camp-signaling","display_name":"cAMP signaling","score":0.8579999804496765},{"id":"https://openalex.org/keywords/inositol-phosphates","display_name":"inositol phosphates","score":0.8970000147819519},{"id":"https://openalex.org/keywords/thymic-medulla","display_name":"thymic medulla","score":0.906000018119812},{"id":"https://openalex.org/keywords/mice","display_name":"mice","score":0.5490000247955322}],"concepts":[{"id":"https://openalex.org/C121050878","wikidata":"https://www.wikidata.org/wiki/Q5135020","display_name":"Cloning (programming)","level":2,"score":0.6567027568817139},{"id":"https://openalex.org/C187882448","wikidata":"https://www.wikidata.org/wiki/Q283478","display_name":"Complementary DNA","level":3,"score":0.6266002655029297},{"id":"https://openalex.org/C2777187973","wikidata":"https://www.wikidata.org/wiki/Q5421703","display_name":"Expression cloning","level":4,"score":0.5487488508224487},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4828910827636719},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4651784598827362},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4366445541381836},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4257274270057678},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.35819387435913086},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.20880591869354248},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.16750413179397583},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001667","descriptor_name":"Binding, Competitive","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006224","descriptor_name":"Cricetinae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009928","descriptor_name":"Organ Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010716","descriptor_name":"Phosphatidylinositols","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011464","descriptor_name":"Epoprostenol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011982","descriptor_name":"Receptors, Prostaglandin","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D011982","descriptor_name":"Receptors, Prostaglandin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011982","descriptor_name":"Receptors, Prostaglandin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013950","descriptor_name":"Thymus Gland","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016285","descriptor_name":"Iloprost","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016466","descriptor_name":"CHO Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017403","descriptor_name":"In Situ Hybridization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017931","descriptor_name":"DNA Primers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018076","descriptor_name":"DNA, Complementary","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D044006","descriptor_name":"Receptors, Epoprostenol","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0021-9258(17)36979-x","doi":"https://doi.org/10.1016/s0021-9258(17)36979-x","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(17)36979-x","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:7511597","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7511597","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Comparative Study"}],"best_oa_location":{"id":"doi:10.1016/s0021-9258(17)36979-x","doi":"https://doi.org/10.1016/s0021-9258(17)36979-x","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(17)36979-x","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W1484354452","https://openalex.org/W1520575681","https://openalex.org/W1523969239","https://openalex.org/W1536429130","https://openalex.org/W1539862553","https://openalex.org/W1540911990","https://openalex.org/W1546944401","https://openalex.org/W1550626060","https://openalex.org/W1555809376","https://openalex.org/W1563725780","https://openalex.org/W1572397475","https://openalex.org/W1590040857","https://openalex.org/W1802980406","https://openalex.org/W1964377967","https://openalex.org/W1966434299","https://openalex.org/W1971290197","https://openalex.org/W1972365005","https://openalex.org/W1972995848","https://openalex.org/W1975304761","https://openalex.org/W1986603676","https://openalex.org/W1993097923","https://openalex.org/W2005934241","https://openalex.org/W2009311419","https://openalex.org/W2024541964","https://openalex.org/W2032221545","https://openalex.org/W2047524808","https://openalex.org/W2048009051","https://openalex.org/W2060764228","https://openalex.org/W2073824580","https://openalex.org/W2080120821","https://openalex.org/W2081688069","https://openalex.org/W2082091333","https://openalex.org/W2084914309","https://openalex.org/W2134812217","https://openalex.org/W2135814861","https://openalex.org/W2143404508","https://openalex.org/W2167859431","https://openalex.org/W2334410629","https://openalex.org/W2395167429","https://openalex.org/W2412250516","https://openalex.org/W2596171374","https://openalex.org/W4248634331","https://openalex.org/W4294216491"],"related_works":["https://openalex.org/W2038909466","https://openalex.org/W2010498514","https://openalex.org/W1558210941","https://openalex.org/W2088146922","https://openalex.org/W2130049045","https://openalex.org/W4238437238","https://openalex.org/W2084914309","https://openalex.org/W1557147130","https://openalex.org/W1546944401","https://openalex.org/W7097339709"],"abstract_inverted_index":{"A":[0],"functional":[1],"cDNA":[2,13,25,90],"for":[3],"a":[4,11,27,72,121,132],"mouse":[5,12,61],"prostacyclin":[6,74,111],"receptor":[7,65,75,148],"was":[8,98],"isolated":[9],"from":[10],"library":[14],"by":[15,169],"reverse":[16],"transcription":[17],"polymerase":[18],"chain":[19],"reaction":[20],"and":[21,39,67,138,172,187],"hybridization":[22,176],"screening.":[23],"The":[24,46],"encodes":[26],"polypeptide":[28],"of":[29,44,59,82,93,106,177],"417":[30],"amino":[31,47],"acid":[32,48],"residues":[33],"with":[34,91,100],"putative":[35],"seven":[36],"transmembrane":[37,55],"domains":[38,56],"an":[40],"calculated":[41],"molecular":[42],"weight":[43],"44,722.":[45],"sequence":[49],"is":[50,162,182],"30-40%":[51],"identical":[52],"in":[53,103,131,142,166,185,189],"the":[54,60,80,89,104,147,160],"to":[57,79,150],"those":[58],"prostaglandin":[62],"(PG)":[63],"E":[64],"subtypes":[66],"thromboxane":[68,122],"A2":[69,123],"receptor.":[70],"[3H]Iloprost,":[71],"specific":[73],"radioligand,":[76],"specifically":[77],"bound":[78],"membrane":[81],"Chinese":[83],"hamster":[84],"ovary":[85],"cells":[86],"permanently":[87],"expressing":[88],"Kd":[92],"4.6":[94],"nM.":[95],"This":[96],"binding":[97],"displaced":[99],"unlabeled":[101],"prostanoids":[102],"order":[105],"cicaprost":[107],">":[108,113,115,127],"iloprost,":[109],"both":[110],"agonists":[112],"PGE1":[114],"carbacyclin":[116],">>":[117],"PGD2":[118],"approximately":[119,125],"STA2,":[120],"agonist":[124],"PGE2":[126],"PGF2":[128],"alpha.":[129],"Iloprost":[130],"concentration-dependent":[133],"fashion":[134],"increased":[135],"cAMP":[136],"level":[137],"generated":[139],"inositol":[140],"phosphates":[141],"these":[143],"cells,":[144],"indicating":[145],"that":[146,159,180],"couples":[149],"multiple":[151],"signal":[152],"transduction":[153],"pathways.":[154],"Northern":[155],"blot":[156],"analysis":[157],"revealed":[158],"mRNA":[161],"expressed":[163,183],"most":[164],"abundantly":[165],"thymus,":[167],"followed":[168],"spleen,":[170],"heart,":[171],"lung.":[173],"In":[174],"situ":[175],"thymus":[178],"showed":[179],"it":[181],"exclusively":[184],"medulla":[186],"not":[188],"cortex.":[190]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}