{"id":"https://openalex.org/W1542032127","doi":"https://doi.org/10.1016/s0021-9258(17)44565-0","title":"Pyrroline-5-carboxylate stimulates the conversion of purine antimetabolites to their nucleotide forms by a redox-dependent mechanism.","display_name":"Pyrroline-5-carboxylate stimulates the conversion of purine antimetabolites to their nucleotide forms by a redox-dependent mechanism.","publication_year":1983,"publication_date":"1983-08-01","ids":{"openalex":"https://openalex.org/W1542032127","doi":"https://doi.org/10.1016/s0021-9258(17)44565-0","mag":"1542032127","pmid":"https://pubmed.ncbi.nlm.nih.gov/6193109"},"language":"en","primary_location":{"id":"doi:10.1016/s0021-9258(17)44565-0","doi":"https://doi.org/10.1016/s0021-9258(17)44565-0","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(17)44565-0","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/s0021-9258(17)44565-0","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113593232","display_name":"Grace Chao Yeh","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G C Yeh","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5041646089","display_name":"James Ming Phang","orcid":"https://orcid.org/0000-0001-6707-0693","observed_orcids":["https://orcid.org/0000-0001-6707-0693"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J M Phang","raw_affiliation_strings":["From the Endocrinology Section, Metabolism Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20205"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Endocrinology Section, Metabolism Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20205","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":1.5883,"has_fulltext":false,"cited_by_count":33,"citation_normalized_percentile":{"value":0.8201084,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"258","issue":"16","first_page":"9774","last_page":"9779"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pyrroline-5-carboxylate","display_name":"pyrroline-5-carboxylate","score":1.0},{"id":"https://openalex.org/keywords/purine-analogs","display_name":"purine analogues","score":0.9660000205039978},{"id":"https://openalex.org/keywords/nucleotide-activation","display_name":"nucleotide activation","score":0.8399999737739563},{"id":"https://openalex.org/keywords/5-phosphoribosyl-1-pyrophosphate","display_name":"5-phosphoribosyl-1-pyrophosphate","score":0.9810000061988831},{"id":"https://openalex.org/keywords/erythrocytes","display_name":"erythrocytes","score":0.8209999799728394},{"id":"https://openalex.org/keywords/6-thioguanine","display_name":"6-thioguanine","score":0.8830000162124634},{"id":"https://openalex.org/keywords/azathioprine","display_name":"azathioprine","score":0.9940000176429749},{"id":"https://openalex.org/keywords/hypoxanthine","display_name":"hypoxanthine","score":0.7839999794960022},{"id":"https://openalex.org/keywords/inosine-monophosphate","display_name":"inosine monophosphate","score":0.9819999933242798},{"id":"https://openalex.org/keywords/purine-metabolism","display_name":"purine metabolism","score":0.6610000133514404}],"concepts":[{"id":"https://openalex.org/C2776476023","wikidata":"https://www.wikidata.org/wiki/Q188261","display_name":"Purine","level":3,"score":0.7316077947616577},{"id":"https://openalex.org/C512185932","wikidata":"https://www.wikidata.org/wiki/Q28745","display_name":"Nucleotide","level":3,"score":0.6902402639389038},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6875677108764648},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.5820662975311279},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5427129864692688},{"id":"https://openalex.org/C2778074193","wikidata":"https://www.wikidata.org/wiki/Q3498942","display_name":"Carboxylate","level":2,"score":0.4967706799507141},{"id":"https://openalex.org/C55904794","wikidata":"https://www.wikidata.org/wiki/Q82682","display_name":"Redox","level":2,"score":0.46805256605148315},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.40634220838546753},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.2499770224094391},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0876375138759613},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001379","descriptor_name":"Azathioprine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D004912","descriptor_name":"Erythrocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004912","descriptor_name":"Erythrocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007291","descriptor_name":"Inosine Monophosphate","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D007291","descriptor_name":"Inosine Monophosphate","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D007292","descriptor_name":"Inosine Nucleotides","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010710","descriptor_name":"Phosphates","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010754","descriptor_name":"Phosphoribosyl Pyrophosphate","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D011758","descriptor_name":"Pyrroles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013866","descriptor_name":"Thioguanine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013873","descriptor_name":"Thionucleotides","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D015122","descriptor_name":"Mercaptopurine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0021-9258(17)44565-0","doi":"https://doi.org/10.1016/s0021-9258(17)44565-0","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(17)44565-0","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:6193109","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6193109","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/s0021-9258(17)44565-0","doi":"https://doi.org/10.1016/s0021-9258(17)44565-0","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(17)44565-0","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W4864661","https://openalex.org/W54361237","https://openalex.org/W86082087","https://openalex.org/W1481382906","https://openalex.org/W1847066503","https://openalex.org/W1973915116","https://openalex.org/W1979379426","https://openalex.org/W1988073381","https://openalex.org/W1990033842","https://openalex.org/W1998084168","https://openalex.org/W2015105801","https://openalex.org/W2019656714","https://openalex.org/W2029560821","https://openalex.org/W2029878690","https://openalex.org/W2036607440","https://openalex.org/W2042256278","https://openalex.org/W2052828897","https://openalex.org/W2086313251","https://openalex.org/W2087926339","https://openalex.org/W2092164978","https://openalex.org/W2092309388","https://openalex.org/W2139040913","https://openalex.org/W2149426159","https://openalex.org/W2404589459","https://openalex.org/W2406145164","https://openalex.org/W2417915247","https://openalex.org/W2430330519","https://openalex.org/W2751763644","https://openalex.org/W4243353774"],"related_works":["https://openalex.org/W2087926339","https://openalex.org/W1522034871","https://openalex.org/W1560350848","https://openalex.org/W2310020101","https://openalex.org/W1992514797","https://openalex.org/W2028875508","https://openalex.org/W2412455471","https://openalex.org/W1990033842","https://openalex.org/W2417915247","https://openalex.org/W1973915116"],"abstract_inverted_index":{"The":[0,100],"activation":[1,86,131],"of":[2,52,66,87,102,113,124,132,155],"purine":[3,24,70],"antimetabolites":[4],"to":[5,13,92,115,139,160],"their":[6,14,21,93,140],"respective":[7,94],"nucleotides":[8,95],"is":[9],"a":[10,29,46,119],"step":[11],"critical":[12],"effectiveness":[15],"as":[16,28,118],"chemotherapeutic":[17,134],"agents.":[18,162],"Erythrocytes,":[19],"with":[20],"relatively":[22],"simple":[23],"metabolism,":[25],"are":[26],"useful":[27],"model":[30,120],"for":[31,121],"identifying":[32],"mechanisms":[33],"which":[34],"enhance":[35],"this":[36,103],"5-phosphoribosyl":[37],"1-pyrophosphate":[38],"(P-Rib-PP)-dependent":[39],"activation.":[40],"We":[41,74],"previously":[42],"showed":[43],"that":[44,77],"pyrroline-5-carboxylate,":[45],"physiologic":[47],"intermediate":[48],"in":[49,96,108],"the":[50,59,64,78,85,111,129,143,153],"interconversions":[51],"proline,":[53],"ornithine,":[54],"and":[55,68,90,158],"glutamate,":[56],"markedly":[57,83],"stimulated":[58],"pentose":[60],"phosphate":[61],"pathway,":[62],"increased":[63,69,84],"formation":[65],"P-Rib-PP,":[67],"incorporation":[71],"into":[72,152],"nucleotides.":[73],"now":[75],"report":[76],"events":[79,144],"initiated":[80,145],"by":[81,146],"pyrroline-5-carboxylate":[82,147],"6-thiohypoxanthine,":[88],"6-thioguanine,":[89],"azathioprine":[91],"intact":[97],"human":[98],"erythrocytes.":[99],"mechanism":[101],"effect":[104],"was":[105],"directly":[106],"demonstrated":[107],"studies":[109],"using":[110],"conversion":[112],"hypoxanthine":[114],"inosine":[116],"monophosphate":[117],"pyrroline-5-carboxylate-mediated":[122],"stimulation":[123],"P-Rib-PP-dependent":[125,130],"nucleotide":[126],"formation.":[127],"Since":[128],"these":[133,161],"agents":[135],"may":[136,148],"be":[137],"important":[138],"clinical":[141],"effectiveness,":[142],"provide":[149],"new":[150],"insight":[151],"nature":[154],"tumor":[156],"sensitivity":[157],"resistance":[159]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}