{"id":"https://openalex.org/W1541919983","doi":"https://doi.org/10.1182/blood.v96.9.3154","title":"Mutations of the AML1 gene in myelodysplastic syndrome and their functional implications in leukemogenesis","display_name":"Mutations of the AML1 gene in myelodysplastic syndrome and their functional implications in leukemogenesis","publication_year":2000,"publication_date":"2000-11-01","ids":{"openalex":"https://openalex.org/W1541919983","doi":"https://doi.org/10.1182/blood.v96.9.3154","mag":"1541919983","pmid":"https://pubmed.ncbi.nlm.nih.gov/11049997"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v96.9.3154","doi":"https://doi.org/10.1182/blood.v96.9.3154","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v96.9.3154","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W1541919983"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087133884","display_name":"Yoichi Imai","orcid":"https://orcid.org/0000-0002-2938-6133","observed_orcids":["https://orcid.org/0000-0002-2938-6133"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoichi Imai","raw_affiliation_strings":["From the Department of Hematology and Oncology and the Department of Pathology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Hematology and Oncology and the Department of Pathology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085709435","display_name":"Mineo Kurokawa","orcid":"https://orcid.org/0000-0002-4034-2422","observed_orcids":["https://orcid.org/0000-0002-4034-2422"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mineo Kurokawa","raw_affiliation_strings":["From the Department of Hematology and Oncology and the Department of Pathology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Hematology and Oncology and the Department of Pathology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027118202","display_name":"Koji Izutsu","orcid":"https://orcid.org/0000-0001-9129-8057","observed_orcids":["https://orcid.org/0000-0001-9129-8057"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Koji Izutsu","raw_affiliation_strings":["From the Department of Hematology and Oncology and the Department of Pathology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Hematology and Oncology and the Department of Pathology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084289729","display_name":"Akira Hangaishi","orcid":"https://orcid.org/0000-0001-6498-4166","observed_orcids":["https://orcid.org/0000-0001-6498-4166"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akira Hangaishi","raw_affiliation_strings":["From the Department of Hematology and Oncology and the Department of Pathology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Hematology and Oncology and the Department of Pathology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044544485","display_name":"Kengo Takeuchi","orcid":"https://orcid.org/0000-0002-1599-5800","observed_orcids":["https://orcid.org/0000-0002-1599-5800"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kengo Takeuchi","raw_affiliation_strings":["From the Department of Hematology and Oncology and the Department of Pathology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Hematology and Oncology and the Department of Pathology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111586214","display_name":"Kazuhiro Maki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazuhiro Maki","raw_affiliation_strings":["From the Department of Hematology and Oncology and the Department of Pathology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Hematology and Oncology and the Department of Pathology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042588749","display_name":"Seishi Ogawa","orcid":"https://orcid.org/0000-0002-7778-5374","observed_orcids":["https://orcid.org/0000-0002-7778-5374"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Seishi Ogawa","raw_affiliation_strings":["From the Department of Hematology and Oncology and the Department of Pathology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Hematology and Oncology and the Department of Pathology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067804516","display_name":"Shigeru Chiba","orcid":"https://orcid.org/0000-0001-7803-7338","observed_orcids":["https://orcid.org/0000-0001-7803-7338"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shigeru Chiba","raw_affiliation_strings":["From the Department of Hematology and Oncology and the Department of Pathology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Hematology and Oncology and the Department of Pathology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050827716","display_name":"Kinuko Mitani","orcid":"https://orcid.org/0000-0001-9736-9469","observed_orcids":["https://orcid.org/0000-0001-9736-9469"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kinuko Mitani","raw_affiliation_strings":["From the Department of Hematology and Oncology and the Department of Pathology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Hematology and Oncology and the Department of Pathology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088372604","display_name":"Hisamaru Hirai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hisamaru Hirai","raw_affiliation_strings":["From the Department of Hematology and Oncology and the Department of Pathology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Hematology and Oncology and the Department of Pathology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I74801974"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":9.7943,"has_fulltext":false,"cited_by_count":155,"citation_normalized_percentile":{"value":0.9871562,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"96","issue":"9","first_page":"3154","last_page":"3160"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/myelodysplastic-syndrome","display_name":"myelodysplastic syndrome","score":0.9380000233650208},{"id":"https://openalex.org/keywords/point-mutations","display_name":"point mutations","score":0.875},{"id":"https://openalex.org/keywords/runt-domain","display_name":"Runt domain","score":0.8579999804496765},{"id":"https://openalex.org/keywords/dominant-negative-inhibition","display_name":"dominant negative inhibition","score":0.8519999980926514},{"id":"https://openalex.org/keywords/heterodimerization","display_name":"heterodimerization","score":0.921999990940094},{"id":"https://openalex.org/keywords/leukemogenesis","display_name":"leukemogenesis","score":0.9079999923706055},{"id":"https://openalex.org/keywords/transcription-factor-mutations","display_name":"transcription factor mutations","score":0.4320000112056732}],"concepts":[{"id":"https://openalex.org/C2778220731","wikidata":"https://www.wikidata.org/wiki/Q5170186","display_name":"Core binding factor","level":4,"score":0.7694800496101379},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.6742118000984192},{"id":"https://openalex.org/C176944494","wikidata":"https://www.wikidata.org/wiki/Q1415380","display_name":"Point mutation","level":4,"score":0.6293951869010925},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5828050374984741},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5737665891647339},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5429600477218628},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.4999673366546631},{"id":"https://openalex.org/C138626823","wikidata":"https://www.wikidata.org/wiki/Q916504","display_name":"Chromosomal translocation","level":3,"score":0.4683605432510376},{"id":"https://openalex.org/C111936080","wikidata":"https://www.wikidata.org/wiki/Q913367","display_name":"Enhancer","level":4,"score":0.44248923659324646},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.429233580827713},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.40523749589920044},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.27466511726379395}],"mesh":[{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007938","descriptor_name":"Leukemia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009190","descriptor_name":"Myelodysplastic Syndromes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D017354","descriptor_name":"Point Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018807","descriptor_name":"Polymorphism, Single-Stranded Conformational","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019281","descriptor_name":"Dimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019943","descriptor_name":"Amino Acid Substitution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050656","descriptor_name":"Transcription Factor AP-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050676","descriptor_name":"Core Binding Factor Alpha 2 Subunit","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1182/blood.v96.9.3154","doi":"https://doi.org/10.1182/blood.v96.9.3154","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v96.9.3154","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},{"id":"doi:10.1182/blood.v96.9.3154.h8003154_3154_3160","doi":"https://doi.org/10.1182/blood.v96.9.3154.h8003154_3154_3160","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v96.9.3154.h8003154_3154_3160","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},{"id":"pmid:11049997","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11049997","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":62,"referenced_works":["https://openalex.org/W1740534","https://openalex.org/W15248648","https://openalex.org/W20371925","https://openalex.org/W36672729","https://openalex.org/W91818377","https://openalex.org/W123071911","https://openalex.org/W125903238","https://openalex.org/W221180449","https://openalex.org/W249476741","https://openalex.org/W277578083","https://openalex.org/W1480442988","https://openalex.org/W1481643702","https://openalex.org/W1524671781","https://openalex.org/W1560943589","https://openalex.org/W1578441131","https://openalex.org/W1739103212","https://openalex.org/W1829757075","https://openalex.org/W1875148047","https://openalex.org/W1891785401","https://openalex.org/W1945687446","https://openalex.org/W1975158369","https://openalex.org/W1980706177","https://openalex.org/W2003617876","https://openalex.org/W2008018118","https://openalex.org/W2013714561","https://openalex.org/W2036287488","https://openalex.org/W2043407148","https://openalex.org/W2045322395","https://openalex.org/W2047591593","https://openalex.org/W2054140115","https://openalex.org/W2056560239","https://openalex.org/W2068728784","https://openalex.org/W2085033687","https://openalex.org/W2088690410","https://openalex.org/W2088736283","https://openalex.org/W2113086962","https://openalex.org/W2124597426","https://openalex.org/W2130002948","https://openalex.org/W2131080367","https://openalex.org/W2132749685","https://openalex.org/W2133010718","https://openalex.org/W2137005106","https://openalex.org/W2147213204","https://openalex.org/W2148247618","https://openalex.org/W2159374958","https://openalex.org/W2161848417","https://openalex.org/W2165787335","https://openalex.org/W2171915984","https://openalex.org/W2294291334","https://openalex.org/W2301332835","https://openalex.org/W2398008690","https://openalex.org/W2402005622","https://openalex.org/W2404041716","https://openalex.org/W2474698873","https://openalex.org/W4248061090","https://openalex.org/W6603640516","https://openalex.org/W6628584756","https://openalex.org/W6638685164","https://openalex.org/W6639650241","https://openalex.org/W6698186096","https://openalex.org/W6712359498","https://openalex.org/W6712992294"],"related_works":["https://openalex.org/W1977025294","https://openalex.org/W2553260702","https://openalex.org/W2126016320","https://openalex.org/W2148033929","https://openalex.org/W2132749685","https://openalex.org/W2555822566","https://openalex.org/W1504331543","https://openalex.org/W2331898123","https://openalex.org/W2006642077","https://openalex.org/W2067835091"],"abstract_inverted_index":{"The":[0],"AML1":[1,29,75,125,140],"gene":[2],"encodes":[3],"a":[4,117,153],"DNA-binding":[5,81],"protein":[6,102],"that":[7,136],"contains":[8],"the":[9,14,28,54,68,71,80,84,94,109,112,133,146,149],"runt":[10,72],"domain":[11,73],"and":[12,36,76,145],"is":[13,132],"most":[15],"frequent":[16],"target":[17],"of":[18,27,47,53,74,79,83,139,157],"translocations":[19],"associated":[20],"with":[21,98,123,128,143],"human":[22],"leukemias.":[23],"Here,":[24],"point":[25],"mutations":[26,64,138],"gene,":[30],"V105ter":[31,90],"(single-letter":[32,38],"amino":[33,39],"acid":[34,40],"code)":[35],"R139G,":[37],"codes)":[41],"were":[42],"identified":[43],"in":[44,67,141],"2":[45],"cases":[46],"myelodysplastic":[48],"syndrome":[49],"(MDS)":[50],"by":[51,121],"means":[52],"reverse":[55],"transcriptase-polymerase":[56],"chain":[57],"reaction":[58],"single-strand":[59],"conformation":[60],"polymorphism":[61],"method.":[62],"Both":[63],"are":[65],"present":[66],"region":[69],"encoding":[70],"cause":[77],"loss":[78],"ability":[82,95],"resultant":[85],"products.":[86],"Of":[87],"these":[88],"mutants,":[89],"has":[91],"also":[92],"lost":[93],"to":[96],"heterodimerize":[97],"polyomavirus":[99],"enhancer":[100],"binding":[101,104],"2/core":[103],"factor":[105],"beta":[106],"(PEBP2beta/CBFbeta).":[107],"On":[108],"other":[110],"hand,":[111],"R139G":[113],"mutant":[114,150],"acts":[115,151],"as":[116,152],"dominant":[118,154],"negative":[119,155],"inhibitor":[120,156],"competing":[122],"wild-type":[124,158],"for":[126],"interaction":[127],"PEBP2beta/CBFbeta.":[129],"This":[130],"study":[131],"first":[134],"report":[135],"describes":[137],"patients":[142],"MDS":[144],"mechanism":[147],"whereby":[148],"AML1.":[159]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}