{"id":"https://openalex.org/W1541685281","doi":null,"title":"Regulation of carbonyl-reducing enzymes in rat liver by chemoprotectors.","display_name":"Regulation of carbonyl-reducing enzymes in rat liver by chemoprotectors.","publication_year":1996,"publication_date":"1996-06-15","ids":{"openalex":"https://openalex.org/W1541685281","mag":"1541685281","pmid":"https://pubmed.ncbi.nlm.nih.gov/8665510"},"language":"en","primary_location":{"id":"pmid:8665510","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8665510","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103516690","display_name":"Elizabeth M. Ellis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802526638","display_name":"Ninewells Hospital","ror":"https://ror.org/039c6rk82","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800860831","https://openalex.org/I2802526638"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"E M Ellis","raw_affiliation_strings":["Biomedical Research Centre, Ninewells Hospital, Dundee, Scotland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Research Centre, Ninewells Hospital, Dundee, Scotland","institution_ids":["https://openalex.org/I2802526638"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024761896","display_name":"David J. Judah","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D J Judah","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113405183","display_name":"Gordon E. Neal","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G E Neal","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"T O'Connor","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T O'Connor","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5046024649","display_name":"John D. Hayes","orcid":"https://orcid.org/0000-0002-2927-5548","observed_orcids":["https://orcid.org/0000-0002-2927-5548"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J D Hayes","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.0456,"has_fulltext":false,"cited_by_count":39,"citation_normalized_percentile":{"value":0.84330413,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"56","issue":"12","first_page":"2758","last_page":"66"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.42239999771118164,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.42239999771118164,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.26489999890327454,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.1103999987244606,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/synthetic-antioxidants","display_name":"synthetic antioxidants","score":0.7419999837875366},{"id":"https://openalex.org/keywords/ethoxyquin","display_name":"ethoxyquin","score":0.9259999990463257},{"id":"https://openalex.org/keywords/butylated-hydroxyanisole","display_name":"butylated hydroxyanisole","score":0.9980000257492065},{"id":"https://openalex.org/keywords/oltipraz","display_name":"oltipraz","score":0.9990000128746033},{"id":"https://openalex.org/keywords/9-10-phenanthraquinone","display_name":"9,10-phenanthraquinone","score":0.9160000085830688},{"id":"https://openalex.org/keywords/enzyme-induction","display_name":"enzyme induction","score":0.8550000190734863},{"id":"https://openalex.org/keywords/nad-p-h-quinone-oxidoreductase","display_name":"NAD(P)H:quinone oxidoreductase","score":0.8579999804496765},{"id":"https://openalex.org/keywords/phenobarbital","display_name":"phenobarbital","score":0.6620000004768372},{"id":"https://openalex.org/keywords/3-methylcholanthrene","display_name":"3-methylcholanthrene","score":0.9300000071525574},{"id":"https://openalex.org/keywords/reactive-carbonyl-compounds","display_name":"reactive carbonyl compounds","score":0.6570000052452087}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6394834518432617},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.6350042819976807},{"id":"https://openalex.org/C2777883389","wikidata":"https://www.wikidata.org/wiki/Q1657816","display_name":"Ethoxyquin","level":3,"score":0.6304769515991211},{"id":"https://openalex.org/C2781418880","wikidata":"https://www.wikidata.org/wiki/Q409401","display_name":"Butylated hydroxyanisole","level":3,"score":0.6070866584777832},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5676644444465637},{"id":"https://openalex.org/C2777486698","wikidata":"https://www.wikidata.org/wiki/Q24782718","display_name":"Aldo-keto reductase","level":4,"score":0.5540628433227539},{"id":"https://openalex.org/C2779268744","wikidata":"https://www.wikidata.org/wiki/Q407479","display_name":"Oxidoreductase","level":3,"score":0.500267505645752},{"id":"https://openalex.org/C134651460","wikidata":"https://www.wikidata.org/wiki/Q3100717","display_name":"Reductase","level":3,"score":0.4948553442955017},{"id":"https://openalex.org/C75520062","wikidata":"https://www.wikidata.org/wiki/Q15321392","display_name":"NAD+ kinase","level":3,"score":0.47181689739227295},{"id":"https://openalex.org/C40758303","wikidata":"https://www.wikidata.org/wiki/Q212936","display_name":"Aflatoxin","level":2,"score":0.4686918258666992},{"id":"https://openalex.org/C114246631","wikidata":"https://www.wikidata.org/wiki/Q187661","display_name":"Carcinogen","level":2,"score":0.4614578187465668},{"id":"https://openalex.org/C2778793413","wikidata":"https://www.wikidata.org/wiki/Q407241","display_name":"Phenobarbital","level":2,"score":0.4499758183956146},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.3933711349964142},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22676673531532288},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.13852661848068237},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000449","descriptor_name":"Aldehyde Reductase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000449","descriptor_name":"Aldehyde Reductase","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001463","descriptor_name":"Barbiturates","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002083","descriptor_name":"Butylated Hydroxyanisole","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002273","descriptor_name":"Carcinogens","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004790","descriptor_name":"Enzyme Induction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005015","descriptor_name":"Ethoxyquin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D008748","descriptor_name":"Methylcholanthrene","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010634","descriptor_name":"Phenobarbital","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011719","descriptor_name":"Pyrazines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013871","descriptor_name":"Thiones","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013876","descriptor_name":"Thiophenes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:8665510","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8665510","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"pmh:oai:discovery.dundee.ac.uk:openaire_cris_publications/b6c99c75-5568-4de7-9947-68c66c14bb5c","doi":null,"is_oa":false,"landing_page_url":"https://discovery.dundee.ac.uk/en/publications/b6c99c75-5568-4de7-9947-68c66c14bb5c","pdf_url":null,"source":{"id":"https://openalex.org/S4306400523","display_name":"Discovery Research Portal (University of Dundee)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I177639307","host_organization_name":"University of Dundee","host_organization_lineage":["https://openalex.org/I177639307"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ellis, E M, Judah, D J, Neal, G E, O'Connor, T & Hayes, J D 1996, 'Regulation of carbonyl-reducing enzymes in rat liver by chemoprotectors', Cancer Research, vol. 56, no. 12, pp. 2758-66.","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:1541685281","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8665510","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1999057078","https://openalex.org/W1562806827","https://openalex.org/W2188815277","https://openalex.org/W1921020344","https://openalex.org/W1593719909","https://openalex.org/W2416162336","https://openalex.org/W2012690460","https://openalex.org/W1794299169","https://openalex.org/W2133565675","https://openalex.org/W2053293903"],"abstract_inverted_index":{"Feeding":[0],"rats":[1,35],"on":[2,159],"diets":[3],"containing":[4],"the":[5,22,39,54,112,128,202],"synthetic":[6,106,197],"antioxidants":[7,107,198],"ethoxyquin,":[8,182],"butylated":[9],"hydroxyanisole,":[10],"and":[11,17,108,183],"oltipraz":[12],"results":[13,45],"in":[14,21,46,53,58,68,79,100,169],"15-,":[15],"9-,":[16],"6-fold":[18],"increases,":[19],"respectively,":[20],"hepatic":[23,71],"levels":[24,69],"of":[25,34,38,50,56,70,83,130,204],"aflatoxin":[26,118],"B1-dialdehyde":[27,119],"reductase":[28,114],"(AFAR)":[29],"protein.":[30],"By":[31],"contrast,":[32],"treatment":[33],"with":[36,105],"either":[37],"inducing":[40],"agents":[41],"phenobarbital":[42],"or":[43],"3-methylcholanthrene":[44],"an":[47],"approximate":[48],"increase":[49],"only":[51],"1.4-fold":[52],"amount":[55],"AFAR":[57,72,80,84,92],"rat":[59,86,147,175,205],"liver.":[60],"Northern":[61],"blotting":[62],"has":[63,89,149,163],"shown":[64],"that":[65,91,109,115,184,196],"these":[66,185,193],"increases":[67,78],"protein":[73],"are":[74,179,186],"accompanied":[75],"by":[76,156,181],"corresponding":[77],"mRNA.":[81],"Immunodepletion":[82],"from":[85,102,146,188],"liver":[87,148,176,206],"extracts":[88],"revealed":[90,127],"makes":[93],"a":[94,121],"considerable":[95],"contribution":[96],"to":[97,166,171,207],"carbonyl":[98],"metabolism":[99],"livers":[101],"animals":[103],"treated":[104],"it":[110],"is":[111],"major":[113],"can":[116,141,199],"utilize":[117],"as":[120],"substrate.":[122],"The":[123],"immunodepletion":[124],"experiments":[125],"also":[126],"presence":[129],"at":[131],"least":[132],"one":[133],"other":[134,174],"inducible":[135],"carbonyl-reducing":[136,177],"enzyme":[137],"that,":[138,168],"like":[139],"AFAR,":[140,172],"metabolize":[142,208],"9,10-phenanthraquinone.":[143],"Carbonyl-reducing":[144],"activity":[145],"been":[150,164],"resolved":[151],"into":[152],"six":[153],"enzyme-containing":[154],"peaks":[155],"anion-exchange":[157],"chromatography":[158],"Q-Sepharose.":[160],"This":[161],"method":[162],"used":[165],"show":[167,195],"addition":[170],"two":[173],"enzymes":[178],"induced":[180],"distinct":[187],"NAD(P)H:":[189],"quinone":[190],"oxidoreductase.":[191],"Collectively,":[192],"data":[194],"influence":[200],"substantially":[201],"capacity":[203],"reactive":[209],"carbonyl-containing":[210],"compounds.":[211]},"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
