{"id":"https://openalex.org/W1541586041","doi":"https://doi.org/10.1016/s0021-9258(17)42815-8","title":"Platelet activation induces the formation of a stable gelsolin-actin complex from monomeric gelsolin.","display_name":"Platelet activation induces the formation of a stable gelsolin-actin complex from monomeric gelsolin.","publication_year":1984,"publication_date":"1984-06-01","ids":{"openalex":"https://openalex.org/W1541586041","doi":"https://doi.org/10.1016/s0021-9258(17)42815-8","mag":"1541586041","pmid":"https://pubmed.ncbi.nlm.nih.gov/6330059"},"language":"en","primary_location":{"id":"doi:10.1016/s0021-9258(17)42815-8","doi":"https://doi.org/10.1016/s0021-9258(17)42815-8","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(17)42815-8","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/s0021-9258(17)42815-8","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"M C Kurth","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M C Kurth","raw_affiliation_strings":["From the Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086767351","display_name":"Joseph Bryan","orcid":"https://orcid.org/0000-0003-3476-858X","observed_orcids":["https://orcid.org/0000-0003-3476-858X"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J Bryan","raw_affiliation_strings":["From the Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030","institution_ids":["https://openalex.org/I181547552"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I181547552"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":6.4051,"has_fulltext":false,"cited_by_count":87,"citation_normalized_percentile":{"value":0.9722323,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"259","issue":"12","first_page":"7473","last_page":"7479"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.6445000171661377,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.6445000171661377,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.2207999974489212,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.10300000011920929,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gelsolin","display_name":"gelsolin","score":0.9940000176429749},{"id":"https://openalex.org/keywords/actin","display_name":"actin","score":0.8740000128746033},{"id":"https://openalex.org/keywords/platelet-activation","display_name":"platelet activation","score":0.9900000095367432},{"id":"https://openalex.org/keywords/actin-filament-nucleation","display_name":"actin filament nucleation","score":0.8579999804496765},{"id":"https://openalex.org/keywords/calcium","display_name":"calcium","score":0.38100001215934753},{"id":"https://openalex.org/keywords/ternary-complex","display_name":"ternary complex","score":0.718999981880188},{"id":"https://openalex.org/keywords/actin-monomer","display_name":"actin monomer","score":0.5009999871253967},{"id":"https://openalex.org/keywords/platelets","display_name":"platelets","score":0.44999998807907104},{"id":"https://openalex.org/keywords/skeletal-muscle-actin","display_name":"skeletal muscle actin","score":0.6520000100135803}],"concepts":[{"id":"https://openalex.org/C80722340","wikidata":"https://www.wikidata.org/wiki/Q18297560","display_name":"Gelsolin","level":3,"score":0.971757173538208},{"id":"https://openalex.org/C2777658833","wikidata":"https://www.wikidata.org/wiki/Q408437","display_name":"EGTA","level":3,"score":0.89673912525177},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6812199950218201},{"id":"https://openalex.org/C3018697912","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Platelet activation","level":3,"score":0.6748614311218262},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.6587234735488892},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5986575484275818},{"id":"https://openalex.org/C74884574","wikidata":"https://www.wikidata.org/wiki/Q171407","display_name":"Divalent","level":2,"score":0.596431314945221},{"id":"https://openalex.org/C125705527","wikidata":"https://www.wikidata.org/wiki/Q185269","display_name":"Actin","level":2,"score":0.5148626565933228},{"id":"https://openalex.org/C163994747","wikidata":"https://www.wikidata.org/wiki/Q2916358","display_name":"Sephadex","level":3,"score":0.4641035795211792},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4595552682876587},{"id":"https://openalex.org/C7623868","wikidata":"https://www.wikidata.org/wiki/Q1967135","display_name":"Centrifugation","level":2,"score":0.4430503845214844},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.40569937229156494},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.37026944756507874},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18679189682006836},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.09345921874046326},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.08115306496620178},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000001","descriptor_name":"Calcimycin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000199","descriptor_name":"Actins","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D000244","descriptor_name":"Adenosine Diphosphate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001241","descriptor_name":"Aspirin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001792","descriptor_name":"Blood Platelets","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001792","descriptor_name":"Blood Platelets","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D002135","descriptor_name":"Calcium-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004533","descriptor_name":"Egtazic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008970","descriptor_name":"Molecular Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013748","descriptor_name":"Tetracaine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013917","descriptor_name":"Thrombin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018260","descriptor_name":"Gelsolin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0021-9258(17)42815-8","doi":"https://doi.org/10.1016/s0021-9258(17)42815-8","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(17)42815-8","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:6330059","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6330059","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/s0021-9258(17)42815-8","doi":"https://doi.org/10.1016/s0021-9258(17)42815-8","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(17)42815-8","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.4043000042438507}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W233456458","https://openalex.org/W1491833339","https://openalex.org/W1494103965","https://openalex.org/W1522015108","https://openalex.org/W1538692246","https://openalex.org/W1542913394","https://openalex.org/W1543300438","https://openalex.org/W1558484374","https://openalex.org/W1589699489","https://openalex.org/W1611482599","https://openalex.org/W1670889273","https://openalex.org/W1980966579","https://openalex.org/W1982014176","https://openalex.org/W1983914474","https://openalex.org/W1989054182","https://openalex.org/W2020240409","https://openalex.org/W2021436466","https://openalex.org/W2028214469","https://openalex.org/W2050192530","https://openalex.org/W2050332669","https://openalex.org/W2060468969","https://openalex.org/W2068397682","https://openalex.org/W2072901474","https://openalex.org/W2089461338","https://openalex.org/W2093104985","https://openalex.org/W2100837269","https://openalex.org/W2101108802","https://openalex.org/W2128635872","https://openalex.org/W2155181132","https://openalex.org/W2239163925","https://openalex.org/W2266841529","https://openalex.org/W2400599012","https://openalex.org/W2401677012"],"related_works":["https://openalex.org/W2020323660","https://openalex.org/W1670889273","https://openalex.org/W7097517831","https://openalex.org/W1589470240","https://openalex.org/W2071574336","https://openalex.org/W2024464799","https://openalex.org/W2005866635","https://openalex.org/W1911473345","https://openalex.org/W1494103965","https://openalex.org/W1863376287"],"abstract_inverted_index":{"We":[0,138],"have":[1,139],"studied":[2],"the":[3,52,99,120,143,162,179,182,187,193,237,251,255,298],"interactions":[4],"between":[5],"gelsolin":[6,23,227,275],"and":[7,14,17,24,43,75,81,111,132,156,171,214,220,228],"actin":[8,82,155,232,247,288,296],"in":[9,18,89,98,119,174,186,192,254,289],"crude":[10],"extracts":[11,60,91,100,121,163],"from":[12,34,101,125,164],"activated":[13,126],"unactivated":[15,102,165,290],"platelets":[16,36,103,127,166,291],"mixtures":[19],"of":[20,109,153,161,181,189,195,211,236,257],"purified":[21,225,266],"platelet":[22,226],"muscle":[25,231],"actin.":[26],"Extracts":[27],"were":[28,61],"prepared":[29,122],"using":[30,78,224],"10":[31],"mM":[32,45],"EGTA":[33,124,268],"human":[35],"treated":[37],"either":[38,277],"with":[39,51,94,105,123,207,287,295],"100":[40,168,196],"microM":[41,169,197],"aspirin":[42],"2.5":[44],"tetracaine":[46],"to":[47,56,167,250,264],"retard":[48],"activation":[49],"or":[50,69,281],"calcium":[53],"ionophore":[54],"A23187":[55],"effect":[57],"activation.":[58,305],"The":[59,86,96,117,271],"fractionated":[62],"by":[63,70],"gel":[64,221],"filtration":[65,222],"on":[66,72],"Sephadex":[67],"G-150":[68],"sedimentation":[71,209],"sucrose":[73],"gradients":[74],"then":[76],"analyzed":[77],"anti-gelsolin":[79],"immunoblots":[80],"filament":[83],"nucleation":[84,87],"assays.":[85],"activity":[88,97,118],"both":[90],"was":[92],"associated":[93],"gelsolin.":[95,158],"sedimented":[104,128],"an":[106,113,134,149,215],"S":[107,131,213],"value":[108],"5.2":[110],"had":[112,133],"Mr":[114,135,144,216],"=":[115,136,145,217],"90,000.":[116],"at":[129],"6.8":[130],"130,000.":[137],"shown":[140],"previously":[141],"that":[142,178,234,274,302],"130,000":[146],"species":[147],"is":[148,248,260,269],"EGTA-stable":[150,238],"binary":[151,183,239,252],"complex":[152,184,206,240,253,286],"one":[154,157,245],"Transient":[159],"exposure":[160],"Ca2+":[170,198,300],"subsequent":[172],"fractionation":[173],"EGTA-containing":[175],"buffers":[176],"demonstrated":[177,199,233],"formation":[180,235],"occurs":[185,303],"presence":[188,194,256],"Ca2+.":[190,242],"Fractionation":[191],"higher":[200],"order":[201],"complexes":[202,293],"including":[203],"a":[204,208,279,284],"ternary":[205],"constant":[210],"8.2":[212],"165,000.":[218],"Sedimentation":[219],"experiments":[223],"rabbit":[229],"skeletal":[230],"required":[241],"At":[243],"least":[244],"additional":[246],"bound":[249],"Ca2+,":[258],"but":[259,292],"not":[261],"sufficiently":[262],"stable":[263],"be":[265],"when":[267],"added.":[270],"results":[272],"suggest":[273],"exists":[276],"as":[278,283],"monomer":[280],"perhaps":[282],"weak":[285],"tightly":[294],"during":[297,304],"transient":[299],"rise":[301]},"counts_by_year":[{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}