{"id":"https://openalex.org/W1541300577","doi":"https://doi.org/10.1111/j.1365-2133.2010.10198.x","title":"Impaired IFN-\u03b1 secretion by plasmacytoid dendritic cells induced by TLR9 activation in chronic idiopathic urticaria","display_name":"Impaired IFN-\u03b1 secretion by plasmacytoid dendritic cells induced by TLR9 activation in chronic idiopathic urticaria","publication_year":2010,"publication_date":"2010-12-27","ids":{"openalex":"https://openalex.org/W1541300577","doi":"https://doi.org/10.1111/j.1365-2133.2010.10198.x","mag":"1541300577","pmid":"https://pubmed.ncbi.nlm.nih.gov/21198536"},"language":"en","primary_location":{"id":"doi:10.1111/j.1365-2133.2010.10198.x","doi":"https://doi.org/10.1111/j.1365-2133.2010.10198.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1365-2133.2010.10198.x","pdf_url":null,"source":{"id":"https://openalex.org/S45720283","display_name":"British Journal of Dermatology","issn_l":"0007-0963","issn":["0007-0963","1365-2133"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Dermatology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060906687","display_name":"Eliana Akemi Futata","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"E. Futata","raw_affiliation_strings":["University of S\u00e3o Paulo, Department of Dermatology, S\u00e3o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of S\u00e3o Paulo, Department of Dermatology, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113161061","display_name":"M H Azor","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"M. Azor","raw_affiliation_strings":["University of S\u00e3o Paulo, Department of Dermatology, S\u00e3o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of S\u00e3o Paulo, Department of Dermatology, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":null,"display_name":"J. Dos Santos","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"J. Dos Santos","raw_affiliation_strings":["University of S\u00e3o Paulo, Department of Dermatology, S\u00e3o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of S\u00e3o Paulo, Department of Dermatology, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004761071","display_name":"Celina Wakisaka Maruta","orcid":"https://orcid.org/0000-0002-0541-5526","observed_orcids":["https://orcid.org/0000-0002-0541-5526"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C. Maruta","raw_affiliation_strings":["Dermatological Outpatient Clinic, S\u00e3o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dermatological Outpatient Clinic, S\u00e3o Paulo, Brazil","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039985657","display_name":"M\u00edrian Nacagami Sotto","orcid":"https://orcid.org/0000-0001-6380-7192","observed_orcids":["https://orcid.org/0000-0001-6380-7192"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Sotto","raw_affiliation_strings":["Dermatological Outpatient Clinic, S\u00e3o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dermatological Outpatient Clinic, S\u00e3o Paulo, Brazil","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005189442","display_name":"Fernanda Guedes","orcid":"https://orcid.org/0000-0001-8575-9988","observed_orcids":["https://orcid.org/0000-0001-8575-9988"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F. Guedes","raw_affiliation_strings":["Dermatological Outpatient Clinic, S\u00e3o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dermatological Outpatient Clinic, S\u00e3o Paulo, Brazil","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006989107","display_name":"Evandro Ararigboia Rivitti","orcid":"https://orcid.org/0000-0003-2454-1728","observed_orcids":["https://orcid.org/0000-0003-2454-1728"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E. Rivitti","raw_affiliation_strings":["Dermatological Outpatient Clinic, S\u00e3o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dermatological Outpatient Clinic, S\u00e3o Paulo, Brazil","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"A. Duarte","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. Duarte","raw_affiliation_strings":["Dermatological Outpatient Clinic, S\u00e3o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dermatological Outpatient Clinic, S\u00e3o Paulo, Brazil","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103085747","display_name":"Maria Notomi Sato","orcid":"https://orcid.org/0000-0002-7911-1824","observed_orcids":["https://orcid.org/0000-0002-7911-1824"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"M. Sato","raw_affiliation_strings":["University of S\u00e3o Paulo, Department of Dermatology, S\u00e3o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of S\u00e3o Paulo, Department of Dermatology, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I17974374"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5103085747"],"corresponding_institution_ids":["https://openalex.org/I17974374"],"apc_list":{"value":3731,"currency":"GBP","value_usd":4920},"apc_paid":null,"fwci":1.0995,"has_fulltext":false,"cited_by_count":31,"citation_normalized_percentile":{"value":0.75782057,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"164","issue":"6","first_page":"1271","last_page":"1279"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12438","display_name":"Urticaria and Related Conditions","score":0.8651999831199646,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12438","display_name":"Urticaria and Related Conditions","score":0.8651999831199646,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.055799998342990875,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":0.020800000056624413,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-spontaneous-urticaria","display_name":"chronic spontaneous urticaria","score":1.0},{"id":"https://openalex.org/keywords/plasmacytoid-dendritic-cells","display_name":"plasmacytoid dendritic cells","score":1.0},{"id":"https://openalex.org/keywords/tlr9-activation","display_name":"TLR9 activation","score":0.890999972820282},{"id":"https://openalex.org/keywords/cpg-a","display_name":"CpG-A","score":0.7940000295639038},{"id":"https://openalex.org/keywords/stat1-phosphorylation","display_name":"STAT1 phosphorylation","score":0.9549999833106995},{"id":"https://openalex.org/keywords/stat4","display_name":"STAT4","score":0.7699999809265137},{"id":"https://openalex.org/keywords/innate-immunity","display_name":"innate immunity","score":0.8240000009536743},{"id":"https://openalex.org/keywords/immune-dysregulation","display_name":"immune dysregulation","score":0.9010000228881836},{"id":"https://openalex.org/keywords/skin-lesions","display_name":"skin lesions","score":0.6949999928474426}],"concepts":[{"id":"https://openalex.org/C2779138994","wikidata":"https://www.wikidata.org/wiki/Q15332550","display_name":"TLR9","level":5,"score":0.9344437122344971},{"id":"https://openalex.org/C22801619","wikidata":"https://www.wikidata.org/wiki/Q477471","display_name":"CpG Oligodeoxynucleotide","level":5,"score":0.6164488792419434},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5815216898918152},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.576789915561676},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.5656783580780029},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5023415088653564},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.47358137369155884},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.46374544501304626},{"id":"https://openalex.org/C2778170410","wikidata":"https://www.wikidata.org/wiki/Q506253","display_name":"Dendritic cell","level":3,"score":0.4466535747051239},{"id":"https://openalex.org/C2776178377","wikidata":"https://www.wikidata.org/wiki/Q188269","display_name":"Interferon","level":2,"score":0.43136218190193176},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.41270560026168823},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.4106212556362152},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3879151940345764},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3766249418258667},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.32844823598861694},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.27804118394851685},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.18825474381446838},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0816417932510376},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002908","descriptor_name":"Chronic Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007113","descriptor_name":"Immunity, Innate","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007963","descriptor_name":"Leukocytes, Mononuclear","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009838","descriptor_name":"Oligodeoxyribonucleotides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014581","descriptor_name":"Urticaria","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016898","descriptor_name":"Interferon-alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D050794","descriptor_name":"STAT1 Transcription Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050797","descriptor_name":"STAT4 Transcription Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051217","descriptor_name":"Toll-Like Receptor 9","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D051217","descriptor_name":"Toll-Like Receptor 9","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1111/j.1365-2133.2010.10198.x","doi":"https://doi.org/10.1111/j.1365-2133.2010.10198.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1365-2133.2010.10198.x","pdf_url":null,"source":{"id":"https://openalex.org/S45720283","display_name":"British Journal of Dermatology","issn_l":"0007-0963","issn":["0007-0963","1365-2133"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Dermatology","raw_type":"journal-article"},{"id":"pmid:21198536","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21198536","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The British journal of dermatology","raw_type":"Journal Article"},{"id":"pmh:oai:www.producao.usp.br:BDPI/23439","doi":null,"is_oa":false,"landing_page_url":"http://producao.usp.br/handle/BDPI/23439","pdf_url":null,"source":{"id":"https://openalex.org/S4306401373","display_name":"Scientific Electronic Library Online (S\u00e3o Paulo Research Foundation, Latin American and Caribbean Center on Health Sciences Information, Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2982035970","host_organization_name":"Costa Rican Department of Social Security","host_organization_lineage":["https://openalex.org/I2982035970"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9907000064849854}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W1494863872","https://openalex.org/W1503066288","https://openalex.org/W1600202512","https://openalex.org/W1743787976","https://openalex.org/W1896136626","https://openalex.org/W1966319576","https://openalex.org/W1978171344","https://openalex.org/W1978741561","https://openalex.org/W1982636859","https://openalex.org/W1986315531","https://openalex.org/W1986954270","https://openalex.org/W1989990915","https://openalex.org/W1992834431","https://openalex.org/W1993355778","https://openalex.org/W2000668449","https://openalex.org/W2013381060","https://openalex.org/W2014981688","https://openalex.org/W2015549117","https://openalex.org/W2022072838","https://openalex.org/W2026485577","https://openalex.org/W2032260378","https://openalex.org/W2038908978","https://openalex.org/W2046204077","https://openalex.org/W2053248858","https://openalex.org/W2058649253","https://openalex.org/W2060923907","https://openalex.org/W2062435665","https://openalex.org/W2069981713","https://openalex.org/W2078540443","https://openalex.org/W2080003147","https://openalex.org/W2080945886","https://openalex.org/W2087419410","https://openalex.org/W2095928788","https://openalex.org/W2098751820","https://openalex.org/W2107277218","https://openalex.org/W2108916769","https://openalex.org/W2109491705","https://openalex.org/W2116150353","https://openalex.org/W2122696789","https://openalex.org/W2133779525","https://openalex.org/W2140734388","https://openalex.org/W2148052042","https://openalex.org/W2161162286","https://openalex.org/W2165617398","https://openalex.org/W2167763092","https://openalex.org/W2169514045"],"related_works":["https://openalex.org/W7120018908","https://openalex.org/W7120688546","https://openalex.org/W2087395407","https://openalex.org/W2107761817","https://openalex.org/W2125867265","https://openalex.org/W2353326614","https://openalex.org/W2095928788","https://openalex.org/W2026485577","https://openalex.org/W2075070747","https://openalex.org/W2056018865"],"abstract_inverted_index":{"BACKGROUND:":[0],"Understanding":[1],"the":[2,6,10,24,44,48,77,82,142,168,197,207,213,257],"early":[3],"events":[4],"of":[5,12,26,50,103,112,139,145,194,199,210,229,256],"immune":[7,27,249],"response,":[8],"through":[9],"activation":[11,195,236],"plasmacytoid":[13],"dendritic":[14],"cells":[15],"(pDC)":[16],"by":[17,54,98,122,133,161,164,179,196,254],"Toll-like":[18],"receptor":[19],"(TLR)9-sensing,":[20],"could":[21],"contribute":[22],"to":[23,37,94,167,260],"evaluation":[25],"dysregulation":[28],"in":[29,41,47,76,141,174,204,212,239,251],"chronic":[30],"idiopathic":[31],"urticaria":[32],"(CIU).":[33],"OBJECTIVES:":[34],"We":[35],"decided":[36],"investigate":[38],"innate":[39,248],"immunity":[40],"CIU":[42,62,252],"and":[43,66,107,110,117,126,192,226],"mechanisms":[45],"implicated":[46],"modulation":[49],"interferon":[51],"(IFN)-\u03b1":[52],"production":[53],"pDC":[55,140,173,190,211,258],"upon":[56],"TLR9":[57,83,125,230,261],"activation.":[58,262],"METHODS:":[59],"Patients":[60],"with":[61,81,89,149,206,241],"(n":[63],"=":[64,72],"31)":[65],"healthy":[67],"control":[68],"subjects":[69],"(HC,":[70],"n":[71],"36)":[73],"were":[74,92,120,131,237],"enrolled":[75],"study.":[78],"Leucocytes":[79],"cultured":[80],"ligand,":[84],"CpG":[85,162,234],"type":[86],"A,":[87],"or":[88],"inhibitory-oligodeoxynucleotide":[90],"(ODN)":[91],"used":[93],"determine":[95],"IFN-\u03b1":[96,106,158,170,186],"secretion":[97,159],"enzyme-linked":[99],"immunosorbent":[100],"assay.":[101],"Enumeration":[102],"pDC,":[104],"intracellular":[105],"signal":[108],"transducers":[109],"activators":[111],"transcription":[113],"protein":[114],"(STAT)":[115],"(1":[116],"4)":[118],"phosphorylation":[119,222],"assessed":[121],"flow":[123],"cytometry.":[124],"regulatory":[127],"factor-7":[128],"mRNA":[129,231],"transcripts":[130,232],"evaluated":[132],"real-time":[134],"polymerase":[135],"chain":[136],"reaction.":[137],"Evidence":[138],"skin":[143,214],"lesions":[144],"patients":[146,240],"was":[147,177,202],"analysed":[148],"immunohistochemistry":[150],"staining.":[151],"RESULTS:":[152],"The":[153,244],"findings":[154,245],"show":[155],"a":[156,227],"decreased":[157],"induced":[160],"A":[163,188,235],"leucocytes,":[165],"due":[166],"diminished":[169],"expression":[171,198],"on":[172,223],"CIU.":[175,242],"It":[176],"mediated":[178],"TLR9-activation":[180],"since":[181],"inhibitory-ODN":[182],"further":[183],"suppressed":[184],"TLR9-induced":[185],"secretion.":[187],"normal":[189],"percentage":[191],"degree":[193],"costimulatory":[200],"molecules":[201],"observed":[203],"CIU,":[205],"rare":[208],"presence":[209],"lesion.":[215],"In":[216],"addition,":[217],"an":[218,247],"increased":[219],"constitutive":[220],"STAT1":[221],"nonstimulated":[224],"lymphocytes":[225],"downregulation":[228],"after":[233],"verified":[238],"CONCLUSIONS:":[243],"showed":[246],"response":[250,259],"disturbed":[253],"impairment":[255]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":6},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
