{"id":"https://openalex.org/W1541233718","doi":"https://doi.org/10.4049/jimmunol.134.1.151","title":"Defective in vitro T cell colony formation in the acquired immunodeficiency syndrome.","display_name":"Defective in vitro T cell colony formation in the acquired immunodeficiency syndrome.","publication_year":1985,"publication_date":"1985-01-01","ids":{"openalex":"https://openalex.org/W1541233718","doi":"https://doi.org/10.4049/jimmunol.134.1.151","mag":"1541233718","pmid":"https://pubmed.ncbi.nlm.nih.gov/3871098"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.134.1.151","doi":"https://doi.org/10.4049/jimmunol.134.1.151","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.134.1.151","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086528422","display_name":"Alan Winkelstein","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I4210138181","display_name":"UPMC Montefiore","ror":"https://ror.org/03bzbh797","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210134769","https://openalex.org/I4210138181"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A Winkelstein","raw_affiliation_strings":["Clinical Immunology Unit, Department of Medicine, Montefiore Hospital, University of Pittsburgh School of Medicine , Pittsburgh, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Immunology Unit, Department of Medicine, Montefiore Hospital, University of Pittsburgh School of Medicine , Pittsburgh, PA","institution_ids":["https://openalex.org/I170201317","https://openalex.org/I4210138181"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046722897","display_name":"Robyn S. Klein","orcid":"https://orcid.org/0000-0003-0281-1352","observed_orcids":["https://orcid.org/0000-0003-0281-1352"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]},{"id":"https://openalex.org/I1335289525","display_name":"Montefiore Medical Center","ror":"https://ror.org/044ntvm43","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1335289525","https://openalex.org/I19772626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R S Klein","raw_affiliation_strings":["Division of Infectious Diseases, Department of Medicine, Montefiore Medical Center, and North Central Bronx Hospital, and the Department of Medicine, Albert Einstein College of Medicine , Bronx, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Infectious Diseases, Department of Medicine, Montefiore Medical Center, and North Central Bronx Hospital, and the Department of Medicine, Albert Einstein College of Medicine , Bronx, New York, NY","institution_ids":["https://openalex.org/I129975664","https://openalex.org/I1335289525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004285760","display_name":"T L Evans","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I4210138181","display_name":"UPMC Montefiore","ror":"https://ror.org/03bzbh797","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210134769","https://openalex.org/I4210138181"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T L Evans","raw_affiliation_strings":["Clinical Immunology Unit, Department of Medicine, Montefiore Hospital, University of Pittsburgh School of Medicine , Pittsburgh, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Immunology Unit, Department of Medicine, Montefiore Hospital, University of Pittsburgh School of Medicine , Pittsburgh, PA","institution_ids":["https://openalex.org/I170201317","https://openalex.org/I4210138181"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077925205","display_name":"Bruce W. Dixon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I2802898700","display_name":"Allegheny County","ror":"https://ror.org/04bf30x64","country_code":"US","type":"government","lineage":["https://openalex.org/I2802898700"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B W Dixon","raw_affiliation_strings":["Department of Medicine, University of Pittsburgh School of Medicine and the Allegheny County Department of Health , Pittsburgh, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Pittsburgh School of Medicine and the Allegheny County Department of Health , Pittsburgh, PA","institution_ids":["https://openalex.org/I170201317","https://openalex.org/I2802898700"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035855695","display_name":"William Holder","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I2802898700","display_name":"Allegheny County","ror":"https://ror.org/04bf30x64","country_code":"US","type":"government","lineage":["https://openalex.org/I2802898700"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W L Holder","raw_affiliation_strings":["Department of Medicine, University of Pittsburgh School of Medicine and the Allegheny County Department of Health , Pittsburgh, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Pittsburgh School of Medicine and the Allegheny County Department of Health , Pittsburgh, PA","institution_ids":["https://openalex.org/I170201317","https://openalex.org/I2802898700"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010731358","display_name":"Leslie D. Weaver","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I4210138181","display_name":"UPMC Montefiore","ror":"https://ror.org/03bzbh797","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210134769","https://openalex.org/I4210138181"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L D Weaver","raw_affiliation_strings":["Clinical Immunology Unit, Department of Medicine, Montefiore Hospital, University of Pittsburgh School of Medicine , Pittsburgh, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Immunology Unit, Department of Medicine, Montefiore Hospital, University of Pittsburgh School of Medicine , Pittsburgh, PA","institution_ids":["https://openalex.org/I170201317","https://openalex.org/I4210138181"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":1.4855,"has_fulltext":false,"cited_by_count":33,"citation_normalized_percentile":{"value":0.84173505,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"134","issue":"1","first_page":"151","last_page":"156"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13761","display_name":"HIV/AIDS oral health manifestations","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3500","display_name":"General Dentistry"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aids","display_name":"AIDS","score":0.9599999785423279},{"id":"https://openalex.org/keywords/aids-related-complex","display_name":"AIDS-related complex","score":0.8579999804496765},{"id":"https://openalex.org/keywords/t-cell-colony-formation","display_name":"T-cell colony formation","score":0.8899999856948853},{"id":"https://openalex.org/keywords/t-cell-proliferation","display_name":"T cell proliferation","score":0.6790000200271606},{"id":"https://openalex.org/keywords/interleukin-2","display_name":"interleukin-2","score":0.8539999723434448},{"id":"https://openalex.org/keywords/t-cell-mediated-immunity","display_name":"T cell immunity","score":0.652999997138977},{"id":"https://openalex.org/keywords/opportunistic-infections","display_name":"opportunistic infections","score":0.8330000042915344},{"id":"https://openalex.org/keywords/lymphadenopathy","display_name":"lymphadenopathy","score":0.5299999713897705},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.4860000014305115}],"concepts":[{"id":"https://openalex.org/C2779127605","wikidata":"https://www.wikidata.org/wiki/Q4651855","display_name":"AIDS-related complex","level":4,"score":0.8583382964134216},{"id":"https://openalex.org/C2781005381","wikidata":"https://www.wikidata.org/wiki/Q7208633","display_name":"Pokeweed mitogen","level":4,"score":0.7789021730422974},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.642253041267395},{"id":"https://openalex.org/C83415579","wikidata":"https://www.wikidata.org/wiki/Q161973","display_name":"Arc (geometry)","level":2,"score":0.5518227815628052},{"id":"https://openalex.org/C2777607303","wikidata":"https://www.wikidata.org/wiki/Q641307","display_name":"Immunodeficiency","level":3,"score":0.5215984582901001},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.46358156204223633},{"id":"https://openalex.org/C50965678","wikidata":"https://www.wikidata.org/wiki/Q2724302","display_name":"Abnormality","level":2,"score":0.45168620347976685},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.4336022436618805},{"id":"https://openalex.org/C3017875465","wikidata":"https://www.wikidata.org/wiki/Q189146","display_name":"Cellular immunity","level":3,"score":0.418000727891922},{"id":"https://openalex.org/C2780648854","wikidata":"https://www.wikidata.org/wiki/Q2745824","display_name":"Immunopathology","level":2,"score":0.4172399640083313},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.4079653024673462},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.38024798035621643},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.35722804069519043},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3557279109954834},{"id":"https://openalex.org/C2780727368","wikidata":"https://www.wikidata.org/wiki/Q1928978","display_name":"Viral disease","level":3,"score":0.2755216956138611},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.18561109900474548},{"id":"https://openalex.org/C137061746","wikidata":"https://www.wikidata.org/wiki/Q736033","display_name":"Peripheral blood mononuclear cell","level":3,"score":0.11010086536407471},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000163","descriptor_name":"Acquired Immunodeficiency Syndrome","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004261","descriptor_name":"DNA Replication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006716","descriptor_name":"Homosexuality","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007119","descriptor_name":"Immunoblastic Lymphadenopathy","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D007119","descriptor_name":"Immunoblastic Lymphadenopathy","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012016","descriptor_name":"Reference Values","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012306","descriptor_name":"Risk","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D019966","descriptor_name":"Substance-Related Disorders","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.4049/jimmunol.134.1.151","doi":"https://doi.org/10.4049/jimmunol.134.1.151","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.134.1.151","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},{"id":"pmid:3871098","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3871098","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of immunology (Baltimore, Md. : 1950)","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G3895677908","display_name":null,"funder_award_id":"CA24429-09","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2405333006","https://openalex.org/W2294121480","https://openalex.org/W2022854476","https://openalex.org/W1978765123","https://openalex.org/W94755039","https://openalex.org/W2403676576","https://openalex.org/W2417268331","https://openalex.org/W1513452110","https://openalex.org/W2475340180","https://openalex.org/W2196900213"],"abstract_inverted_index":{"Depressed":[0],"T":[1,45],"cell":[2,46],"immunity":[3],"is":[4,190],"a":[5,65,191],"universal":[6],"characteristic":[7],"of":[8,43,56,67,150,158],"the":[9,15,44,74,86,119,140,154,159,171,175,187],"acquired":[10],"immunodeficiency":[11],"syndrome":[12],"(AIDS).":[13],"In":[14],"present":[16],"study,":[17],"25":[18],"patients":[19,93,104,108,121],"with":[20,27,64,132],"AIDS":[21,103,120,172],"and":[22,35,105],"opportunistic":[23],"infections,":[24],"22":[25],"individuals":[26],"AIDS-related":[28],"complex":[29],"(ARC,":[30],"or":[31,135,205],"chronic":[32],"lymphadenopathy":[33],"syndrome),":[34],"20":[36,75],"healthy":[37,50,76,136],"homosexuals":[38,77],"were":[39,143],"evaluated":[40],"by":[41],"means":[42],"colony":[47,110,168,188],"assay.":[48],"Forty-seven":[49],"heterosexual":[51],"controls":[52,134],"showed":[53],"an":[54],"average":[55],"3964":[57],"+/-":[58,79,125,146],"319":[59],"colonies/7.5":[60],"X":[61],"10(5)":[62],"cells,":[63],"range":[66],"880":[68],"to":[69,153,201],"9340.":[70],"The":[71,115,148],"mean":[72,116,176],"in":[73,88,139,162,170,208],"(3173":[78],"483)":[80],"did":[81],"not":[82],"differ":[83],"significantly":[84,180],"from":[85],"controls;":[87],"this":[89],"group,":[90,173],"only":[91,123],"three":[92],"had":[94,109],"values":[95,138],"less":[96,112,128,181],"than":[97,113,129,182,199],"1000":[98],"colonies/plate.":[99],"By":[100],"contrast,":[101],"all":[102],"14":[106],"ARC":[107,141,163],"counts":[111],"1000.":[114],"value":[117,177],"for":[118,195],"was":[122,178],"24":[124],"15":[126],"(p":[127],"0.0005":[130],"compared":[131],"either":[133],"homosexuals);":[137],"group":[142],"intermediate":[144],"(1180":[145],"360).":[147],"addition":[149],"interleukin":[151,166],"2":[152],"plates":[155],"promoted":[156],"correction":[157],"proliferative":[160,197],"abnormality":[161],"patients.":[164],"This":[165],"increased":[167],"scores":[169],"but":[174],"still":[179],"controls.":[183],"Comparison":[184],"indicated":[185],"that":[186],"assay":[189],"more":[192],"sensitive":[193],"indicator":[194],"detecting":[196],"abnormalities":[198],"responses":[200],"PHA,":[202],"Con":[203],"A,":[204],"pokeweed":[206],"mitogen":[207],"suspension":[209],"cultures.":[210]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}