{"id":"https://openalex.org/W1541088669","doi":"https://doi.org/10.1158/1538-7445.am2014-3035","title":"Abstract 3035: Cripto/GRP78 signaling promotes the stem cell phenotype in normal and neoplastic mammary epithelial cells","display_name":"Abstract 3035: Cripto/GRP78 signaling promotes the stem cell phenotype in normal and neoplastic mammary epithelial cells","publication_year":2014,"publication_date":"2014-10-01","ids":{"openalex":"https://openalex.org/W1541088669","doi":"https://doi.org/10.1158/1538-7445.am2014-3035","mag":"1541088669"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2014-3035","doi":"https://doi.org/10.1158/1538-7445.am2014-3035","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2014-3035","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070881090","display_name":"Benjamin T. Spike","orcid":"https://orcid.org/0000-0002-0893-3302","observed_orcids":["https://orcid.org/0000-0002-0893-3302"]},"institutions":[{"id":"https://openalex.org/I1307098950","display_name":"Salk Institute for Biological Studies","ror":"https://ror.org/03xez1567","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1307098950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Benjamin T. Spike","raw_affiliation_strings":["1Salk Institute for Biological Studies, La Jolla, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Salk Institute for Biological Studies, La Jolla, CA;","institution_ids":["https://openalex.org/I1307098950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056918379","display_name":"Jonathan A. Kelber","orcid":"https://orcid.org/0000-0002-4606-1445","observed_orcids":["https://orcid.org/0000-0002-4606-1445"]},"institutions":[{"id":"https://openalex.org/I157638225","display_name":"California State University, Northridge","ror":"https://ror.org/005f5hv41","country_code":"US","type":"education","lineage":["https://openalex.org/I157638225"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan A. Kelber","raw_affiliation_strings":["2California State University Northridge, Northridge, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2California State University Northridge, Northridge, CA;","institution_ids":["https://openalex.org/I157638225"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050981241","display_name":"Evan C. Booker","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1307098950","display_name":"Salk Institute for Biological Studies","ror":"https://ror.org/03xez1567","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1307098950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Evan Booker","raw_affiliation_strings":["1Salk Institute for Biological Studies, La Jolla, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Salk Institute for Biological Studies, La Jolla, CA;","institution_ids":["https://openalex.org/I1307098950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061325841","display_name":"Madhuri Kalathur","orcid":"https://orcid.org/0000-0002-1534-5664","observed_orcids":["https://orcid.org/0000-0002-1534-5664"]},"institutions":[{"id":"https://openalex.org/I1307098950","display_name":"Salk Institute for Biological Studies","ror":"https://ror.org/03xez1567","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1307098950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Madhuri Kalathur","raw_affiliation_strings":["1Salk Institute for Biological Studies, La Jolla, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Salk Institute for Biological Studies, La Jolla, CA;","institution_ids":["https://openalex.org/I1307098950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061060225","display_name":"Rose Rodewald","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1307098950","display_name":"Salk Institute for Biological Studies","ror":"https://ror.org/03xez1567","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1307098950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rose Rodewald","raw_affiliation_strings":["1Salk Institute for Biological Studies, La Jolla, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Salk Institute for Biological Studies, La Jolla, CA;","institution_ids":["https://openalex.org/I1307098950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110125734","display_name":"Julia Lipianskaya","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1307098950","display_name":"Salk Institute for Biological Studies","ror":"https://ror.org/03xez1567","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1307098950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julia Lipianskaya","raw_affiliation_strings":["1Salk Institute for Biological Studies, La Jolla, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Salk Institute for Biological Studies, La Jolla, CA;","institution_ids":["https://openalex.org/I1307098950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009762642","display_name":"Justin La","orcid":"https://orcid.org/0000-0003-1596-6193","observed_orcids":["https://orcid.org/0000-0003-1596-6193","https://orcid.org/0009-0000-5310-8515"]},"institutions":[{"id":"https://openalex.org/I1307098950","display_name":"Salk Institute for Biological Studies","ror":"https://ror.org/03xez1567","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1307098950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Justin La","raw_affiliation_strings":["1Salk Institute for Biological Studies, La Jolla, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Salk Institute for Biological Studies, La Jolla, CA;","institution_ids":["https://openalex.org/I1307098950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008172241","display_name":"Marielle He","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1307098950","display_name":"Salk Institute for Biological Studies","ror":"https://ror.org/03xez1567","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1307098950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marielle He","raw_affiliation_strings":["1Salk Institute for Biological Studies, La Jolla, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Salk Institute for Biological Studies, La Jolla, CA;","institution_ids":["https://openalex.org/I1307098950"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Tracy Wright","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tracy Wright","raw_affiliation_strings":["3University of California San Diego, La Jolla, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3University of California San Diego, La Jolla, CA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091345207","display_name":"Richard L. Klemke","orcid":"https://orcid.org/0000-0001-8230-2915","observed_orcids":["https://orcid.org/0000-0001-8230-2915"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard Klemke","raw_affiliation_strings":["3University of California San Diego, La Jolla, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3University of California San Diego, La Jolla, CA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038885111","display_name":"Geoffrey M. Wahl","orcid":"https://orcid.org/0000-0003-3658-2279","observed_orcids":["https://orcid.org/0000-0003-3658-2279"]},"institutions":[{"id":"https://openalex.org/I1307098950","display_name":"Salk Institute for Biological Studies","ror":"https://ror.org/03xez1567","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1307098950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Geoffrey Wahl","raw_affiliation_strings":["1Salk Institute for Biological Studies, La Jolla, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Salk Institute for Biological Studies, La Jolla, CA;","institution_ids":["https://openalex.org/I1307098950"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108395476","display_name":"Peter Clarke Gray","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1307098950","display_name":"Salk Institute for Biological Studies","ror":"https://ror.org/03xez1567","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1307098950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter C. Gray","raw_affiliation_strings":["1Salk Institute for Biological Studies, La Jolla, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Salk Institute for Biological Studies, La Jolla, CA;","institution_ids":["https://openalex.org/I1307098950"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"74","issue":"19_Supplement","first_page":"3035","last_page":"3035"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9394999742507935,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9394999742507935,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.012400000356137753,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.008899999782443047,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cripto","display_name":"Cripto","score":0.9819999933242798},{"id":"https://openalex.org/keywords/grp78","display_name":"GRP78","score":0.9789999723434448},{"id":"https://openalex.org/keywords/mammary-stem-cells","display_name":"mammary stem cells","score":0.953000009059906},{"id":"https://openalex.org/keywords/triple-negative-breast-cancer","display_name":"triple-negative breast cancer","score":0.746999979019165},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.8539999723434448},{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.9549999833106995},{"id":"https://openalex.org/keywords/pi3k-akt-signaling","display_name":"PI3K/Akt signaling","score":0.7080000042915344},{"id":"https://openalex.org/keywords/tgf-beta-signaling","display_name":"TGF-beta signaling","score":0.9829999804496765},{"id":"https://openalex.org/keywords/hsp70","display_name":"HSP70","score":0.7120000123977661},{"id":"https://openalex.org/keywords/cancer-stem-cells","display_name":"cancer stem cells","score":0.5630000233650208}],"concepts":[{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.749436616897583},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6510947346687317},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5980178713798523},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.42467015981674194},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.42390909790992737},{"id":"https://openalex.org/C55427017","wikidata":"https://www.wikidata.org/wiki/Q1638475","display_name":"Cancer stem cell","level":3,"score":0.42298799753189087},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.41469258069992065},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.26567038893699646},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.21782034635543823},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1050766110420227}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2014-3035","doi":"https://doi.org/10.1158/1538-7445.am2014-3035","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2014-3035","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1987045730","https://openalex.org/W1989075744","https://openalex.org/W2476979789","https://openalex.org/W2169111719","https://openalex.org/W2503845404","https://openalex.org/W2809060709","https://openalex.org/W2122592342","https://openalex.org/W3099464319","https://openalex.org/W2898294743","https://openalex.org/W1570365268"],"abstract_inverted_index":{"Abstract":[0],"Microenvironmental":[1],"factors":[2,17],"are":[3,194,272],"critical":[4],"regulators":[5],"of":[6,73,93,104,187,224,248,302,360,365],"stem":[7,15,32,60,106,116,182,210,303,347],"cell":[8,11,16,33,42,61,117,137,175,211,253,348],"and":[9,21,25,40,69,75,119,157,160,184,257,270,277,295,352],"tumor":[10,264,305,308],"behavior.":[12],"However,":[13],"few":[14],"have":[18,45],"been":[19],"identified":[20,46],"targeted":[22],"in":[23,165,200,255,266,282,307,350],"breast":[24,251,294],"other":[26,278,296],"cancers.":[27],"Using":[28],"a":[29,52,65,70,81,185],"highly":[30,163],"enriched":[31],"pool":[34],"isolated":[35],"from":[36,226],"fetal":[37,179],"mammary":[38,59,105,124,181,190,203,228,234,354],"rudiments":[39],"single":[41],"analyses,":[43],"we":[44,79,219,238],"the":[47,58,89,102,115,246,287,300,346,361,366],"onco-fetal":[48],"protein":[49,68],"Cripto":[50,63,83,112,132,199,241,269],"as":[51],"potent":[53],"soluble":[54,94,198],"factor":[55],"that":[56,98,131,150,174,193,222,240,258,289],"regulates":[57],"state.":[62],"is":[64,145,151,162],"GPI-anchored/secreted":[66],"signaling":[67,133,291,344],"known":[71],"regulator":[72],"PI3K/AKT":[74],"TGF-beta":[76],"pathways.":[77],"Here,":[78],"develop":[80],"novel":[82],"antagonist,":[84],"ALK4L75A-Fc,":[85],"which":[86],"selectively":[87,195],"blocks":[88,233],"growth":[90,265],"factor-like":[91],"effects":[92],"Cripto.":[95],"We":[96,128,171],"show":[97,172,221],"this":[99,259],"antagonist":[100,260],"promotes":[101,345],"differentiation":[103],"cells":[107,183,192,205,230,306],"cultured":[108],"ex":[109,231],"vivo":[110,232],"while":[111],"treatment":[113],"maintains":[114],"phenotype":[118,349],"yields":[120],"colonies":[121],"with":[122,243],"enhanced":[123],"gland":[125,235],"reconstitution":[126],"capacity.":[127],"previously":[129],"discovered":[130],"requires":[134],"binding":[135],"to":[136,197],"surface":[138,176],"Glucose":[139],"Response":[140],"Protein":[141],"78kDa":[142],"(GRP78).":[143],"GRP78":[144,177,225,271],"an":[146],"HSP70":[147],"family":[148],"member":[149],"induced":[152,274],"by":[153,275,298],"stresses":[154],"including":[155],"hypoxia":[156,276],"glucose":[158],"deprivation":[159],"it":[161],"expressed":[164],"tumors":[166],"where":[167,310],"these":[168,311],"conditions":[169,280,312],"prevail.":[170],"here":[173],"marks":[178],"mouse":[180],"population":[186],"bipotent":[188],"adult":[189,227],"epithelial":[191,204,229,355],"responsive":[196],"vitro.":[201],"GRP78high":[202],"also":[206,262],"harbor":[207],"substantially":[208],"higher":[209],"activity":[212],"upon":[213],"transplantation":[214],"than":[215],"GRP78low":[216],"cells.":[217,356],"Consistently,":[218],"further":[220],"deletion":[223],"reconstitution.":[236],"Finally,":[237],"find":[239],"antagonism":[242],"ALK4L75A-Fc":[244],"inhibits":[245],"proliferation":[247],"triple":[249],"negative":[250],"cancer":[252],"lines":[254],"vitro":[256],"can":[261],"inhibit":[263],"vivo.":[267],"Since":[268],"both":[273],"stressful":[279],"found":[281],"tumors,":[283],"our":[284],"data":[285],"raise":[286],"possibility":[288],"Cripto/GRP78":[290,343],"may":[292],"exacerbate":[293],"cancers":[297],"increasing":[299],"number":[301],"cell-like":[304],"microenvironments":[309],"predominate.":[313],"Citation":[314],"Format:":[315],"Benjamin":[316],"T.":[317],"Spike,":[318],"Jonathan":[319],"A.":[320],"Kelber,":[321],"Evan":[322],"Booker,":[323],"Madhuri":[324],"Kalathur,":[325],"Rose":[326],"Rodewald,":[327],"Julia":[328],"Lipianskaya,":[329],"Justin":[330],"La,":[331],"Marielle":[332],"He,":[333],"Tracy":[334],"Wright,":[335],"Richard":[336],"Klemke,":[337],"Geoffrey":[338],"Wahl,":[339],"Peter":[340],"C.":[341],"Gray.":[342],"normal":[351],"neoplastic":[353],"[abstract].":[357],"In:":[358],"Proceedings":[359],"105th":[362],"Annual":[363],"Meeting":[364],"American":[367],"Association":[368],"for":[369],"Cancer":[370,381],"Research;":[371],"2014":[372],"Apr":[373],"5-9;":[374],"San":[375],"Diego,":[376],"CA.":[377],"Philadelphia":[378],"(PA):":[379],"AACR;":[380],"Res":[382],"2014;74(19":[383],"Suppl):Abstract":[384],"nr":[385],"3035.":[386],"doi:10.1158/1538-7445.AM2014-3035":[387]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}
