{"id":"https://openalex.org/W1541015458","doi":"https://doi.org/10.4049/jimmunol.0900071","title":"Concentration-Dependent Noncysteinyl Leukotriene Type 1 Receptor-Mediated Inhibitory Activity of Leukotriene Receptor Antagonists","display_name":"Concentration-Dependent Noncysteinyl Leukotriene Type 1 Receptor-Mediated Inhibitory Activity of Leukotriene Receptor Antagonists","publication_year":2010,"publication_date":"2010-01-18","ids":{"openalex":"https://openalex.org/W1541015458","doi":"https://doi.org/10.4049/jimmunol.0900071","mag":"1541015458","pmid":"https://pubmed.ncbi.nlm.nih.gov/20083671","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2826199"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.0900071","doi":"https://doi.org/10.4049/jimmunol.0900071","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.0900071","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2826199","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084056844","display_name":"Grzegorz Woszczek","orcid":"https://orcid.org/0000-0003-0675-085X","observed_orcids":["https://orcid.org/0000-0003-0675-085X"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]},{"id":"https://openalex.org/I4210141571","display_name":"Asthma UK","ror":"https://ror.org/03z7xev21","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2801572420","https://openalex.org/I4210141571"]},{"id":"https://openalex.org/I4210155647","display_name":"National Institutes of Health Clinical Center","ror":"https://ror.org/04vfsmv21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210155647"]},{"id":"https://openalex.org/I90344618","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517","country_code":"GB","type":"government","lineage":["https://openalex.org/I4210087105","https://openalex.org/I90344618"]}],"countries":["GB","US"],"is_corresponding":true,"raw_author_name":"Grzegorz Woszczek","raw_affiliation_strings":["Critical Care Medicine Department, Clinical Center, National Institutes of Health , Bethesda, MD 20892","Medical Research Council and Asthma UK Centre in Allergic Mechanisms of Asthma, King's College London , London,","*Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD 20892; and","\u2020Medical Research Council and Asthma UK Centre in Allergic Mechanisms of Asthma, King's College London, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Critical Care Medicine Department, Clinical Center, National Institutes of Health , Bethesda, MD 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210155647"]},{"raw_affiliation_string":"Medical Research Council and Asthma UK Centre in Allergic Mechanisms of Asthma, King's College London , London,","institution_ids":["https://openalex.org/I183935753","https://openalex.org/I4210141571","https://openalex.org/I90344618"]},{"raw_affiliation_string":"*Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD 20892; and","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210155647"]},{"raw_affiliation_string":"\u2020Medical Research Council and Asthma UK Centre in Allergic Mechanisms of Asthma, King's College London, London, United Kingdom","institution_ids":["https://openalex.org/I183935753","https://openalex.org/I4210141571","https://openalex.org/I90344618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100715500","display_name":"Li\u2010Yuan Chen","orcid":"https://orcid.org/0000-0002-3596-4577","observed_orcids":["https://orcid.org/0000-0002-3596-4577"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210155647","display_name":"National Institutes of Health Clinical Center","ror":"https://ror.org/04vfsmv21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210155647"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Li-Yuan Chen","raw_affiliation_strings":["Critical Care Medicine Department, Clinical Center, National Institutes of Health , Bethesda, MD 20892","*Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD 20892; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Critical Care Medicine Department, Clinical Center, National Institutes of Health , Bethesda, MD 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210155647"]},{"raw_affiliation_string":"*Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD 20892; and","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210155647"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010222951","display_name":"Sara Alsaaty","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210155647","display_name":"National Institutes of Health Clinical Center","ror":"https://ror.org/04vfsmv21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210155647"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Sara Alsaaty","raw_affiliation_strings":["Critical Care Medicine Department, Clinical Center, National Institutes of Health , Bethesda, MD 20892","*Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD 20892; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Critical Care Medicine Department, Clinical Center, National Institutes of Health , Bethesda, MD 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210155647"]},{"raw_affiliation_string":"*Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD 20892; and","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210155647"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087042209","display_name":"Sahrudaya Nagineni","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210155647","display_name":"National Institutes of Health Clinical Center","ror":"https://ror.org/04vfsmv21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210155647"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Sahrudaya Nagineni","raw_affiliation_strings":["Critical Care Medicine Department, Clinical Center, National Institutes of Health , Bethesda, MD 20892","*Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD 20892; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Critical Care Medicine Department, Clinical Center, National Institutes of Health , Bethesda, MD 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210155647"]},{"raw_affiliation_string":"*Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD 20892; and","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210155647"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108085040","display_name":"James H. Shelhamer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210155647","display_name":"National Institutes of Health Clinical Center","ror":"https://ror.org/04vfsmv21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210155647"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James H Shelhamer","raw_affiliation_strings":["Critical Care Medicine Department, Clinical Center, National Institutes of Health , Bethesda, MD 20892","*Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD 20892; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Critical Care Medicine Department, Clinical Center, National Institutes of Health , Bethesda, MD 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210155647"]},{"raw_affiliation_string":"*Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD 20892; and","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210155647"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5010222951","https://openalex.org/A5084056844","https://openalex.org/A5087042209"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I183935753","https://openalex.org/I4210141571","https://openalex.org/I4210155647","https://openalex.org/I90344618"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":3.0478,"has_fulltext":false,"cited_by_count":38,"citation_normalized_percentile":{"value":0.90206276,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"184","issue":"4","first_page":"2219","last_page":"2225"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.6973000168800354,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.6973000168800354,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.18299999833106995,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.04520000144839287,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cysteinyl-leukotriene-receptor-antagonist","display_name":"cysteinyl leukotriene receptor antagonist","score":0.9229999780654907},{"id":"https://openalex.org/keywords/montelukast","display_name":"montelukast","score":0.9150000214576721},{"id":"https://openalex.org/keywords/zafirlukast","display_name":"zafirlukast","score":1.0},{"id":"https://openalex.org/keywords/leukotriene-d4","display_name":"leukotriene D4","score":0.9409999847412109},{"id":"https://openalex.org/keywords/calcium-mobilization","display_name":"calcium mobilization","score":0.8830000162124634},{"id":"https://openalex.org/keywords/il-8-production","display_name":"IL-8 production","score":0.8579999804496765},{"id":"https://openalex.org/keywords/5-lipoxygenase-inhibition","display_name":"5-lipoxygenase inhibition","score":0.9210000038146973},{"id":"https://openalex.org/keywords/monocytes","display_name":"monocytes","score":0.7229999899864197},{"id":"https://openalex.org/keywords/asthma","display_name":"asthma","score":0.46299999952316284},{"id":"https://openalex.org/keywords/interpatient-variability","display_name":"interpatient variability","score":0.8679999709129333},{"id":"https://openalex.org/keywords/receptor-desensitization","display_name":"receptor desensitization","score":0.7139999866485596},{"id":"https://openalex.org/keywords/leukotriene-b4","display_name":"leukotriene B4","score":0.8090000152587891},{"id":"https://openalex.org/keywords/leukotriene-c4","display_name":"leukotriene C4","score":0.9990000128746033}],"concepts":[{"id":"https://openalex.org/C17077164","wikidata":"https://www.wikidata.org/wiki/Q1185869","display_name":"Inhibitory postsynaptic potential","level":2,"score":0.6279509663581848},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.589484453201294},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5032715201377869},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4871220588684082},{"id":"https://openalex.org/C2776452501","wikidata":"https://www.wikidata.org/wiki/Q424190","display_name":"Leukotriene","level":3,"score":0.46554291248321533},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2102605402469635},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.18232011795043945},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16906824707984924},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.1660037338733673},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.030396878719329834}],"mesh":[{"descriptor_ui":"D000085","descriptor_name":"Acetates","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002464","descriptor_name":"Cell Migration Inhibition","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002464","descriptor_name":"Cell Migration Inhibition","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002634","descriptor_name":"Chemotaxis, Leukocyte","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002634","descriptor_name":"Chemotaxis, Leukocyte","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D003521","descriptor_name":"Cyclopropanes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007424","descriptor_name":"Intracellular Fluid","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007424","descriptor_name":"Intracellular Fluid","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007424","descriptor_name":"Intracellular Fluid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011804","descriptor_name":"Quinolines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013440","descriptor_name":"Sulfides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013449","descriptor_name":"Sulfonamides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014105","descriptor_name":"Tosyl Compounds","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014530","descriptor_name":"Uridine Diphosphate","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018077","descriptor_name":"Receptors, Leukotriene","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018448","descriptor_name":"Models, Immunological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018836","descriptor_name":"Inflammation Mediators","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018836","descriptor_name":"Inflammation Mediators","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D020013","descriptor_name":"Calcium Signaling","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D020013","descriptor_name":"Calcium Signaling","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D020024","descriptor_name":"Leukotriene Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D048448","descriptor_name":"Phenylcarbamates","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.4049/jimmunol.0900071","doi":"https://doi.org/10.4049/jimmunol.0900071","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.0900071","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},{"id":"pmid:20083671","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20083671","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of immunology (Baltimore, Md. : 1950)","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2826199","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2826199","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Immunol","raw_type":"Text"},{"id":"pmh:oai:kclpure.kcl.ac.uk:publications/8662eacf-5329-41f7-bca8-5f1666d039ab","doi":null,"is_oa":false,"landing_page_url":"https://kclpure.kcl.ac.uk/portal/en/publications/8662eacf-5329-41f7-bca8-5f1666d039ab","pdf_url":null,"source":{"id":"https://openalex.org/S4306400216","display_name":"Research Portal (King's College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I183935753","host_organization_name":"King's College London","host_organization_lineage":["https://openalex.org/I183935753"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Woszczek, G, Chen, L-Y, Alsaaty, S, Nagineni, S & Shelhamer, J H 2010, 'Concentration-Dependent Noncysteinyl Leukotriene Type 1 Receptor-Mediated Inhibitory Activity of Leukotriene Receptor Antagonists', Journal of Immunology, vol. 184, no. 4, pp. 2219 - 2225. https://doi.org/10.4049/jimmunol.0900071","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2826199","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2826199","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Immunol","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1403082599","display_name":"Control of Cysteinyl Leukotriene Receptor Expression in Human Cells","funder_award_id":"Z01CL008071","funder_id":"https://openalex.org/F4320337376","funder_display_name":"NIH Clinical Center"},{"id":"https://openalex.org/G2328569791","display_name":"NIHR Senior Investigator Award","funder_award_id":"NF-SI-0508-10212","funder_id":"https://openalex.org/F4320319990","funder_display_name":"National Institute for Health and Care Research"},{"id":"https://openalex.org/G6531450551","display_name":"Control of Cysteinyl Leukotriene Receptor Expression in Human Cells","funder_award_id":"ZIACL008071","funder_id":"https://openalex.org/F4320337376","funder_display_name":"NIH Clinical Center"}],"funders":[{"id":"https://openalex.org/F4320319990","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337376","display_name":"NIH Clinical Center","ror":"https://ror.org/04vfsmv21"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W53646502","https://openalex.org/W1558807891","https://openalex.org/W1828494242","https://openalex.org/W1951370517","https://openalex.org/W1963981548","https://openalex.org/W1968660451","https://openalex.org/W1969871007","https://openalex.org/W1996982788","https://openalex.org/W2011221727","https://openalex.org/W2012121740","https://openalex.org/W2024596729","https://openalex.org/W2032213160","https://openalex.org/W2046094936","https://openalex.org/W2046208572","https://openalex.org/W2048675742","https://openalex.org/W2059457442","https://openalex.org/W2059660970","https://openalex.org/W2063803056","https://openalex.org/W2073802634","https://openalex.org/W2083566457","https://openalex.org/W2085355988","https://openalex.org/W2087584115","https://openalex.org/W2096539359","https://openalex.org/W2100452437","https://openalex.org/W2112468123","https://openalex.org/W2114103296","https://openalex.org/W2116594128","https://openalex.org/W2120012059","https://openalex.org/W2122784936","https://openalex.org/W2150091964","https://openalex.org/W2150570905","https://openalex.org/W2151049164","https://openalex.org/W2157725620","https://openalex.org/W2160428606","https://openalex.org/W2163744692","https://openalex.org/W2171451814","https://openalex.org/W2172149963","https://openalex.org/W2626246102"],"related_works":["https://openalex.org/W2410924651","https://openalex.org/W43157500","https://openalex.org/W1975106734","https://openalex.org/W2144831051","https://openalex.org/W2082143983","https://openalex.org/W2166559145","https://openalex.org/W2790499245","https://openalex.org/W2049666632","https://openalex.org/W4206533360","https://openalex.org/W2134254398"],"abstract_inverted_index":{"The":[0],"use":[1],"of":[2,18,26,48,54,67,94,129,136,210,221],"cysteinyl":[3],"leukotriene":[4,34,103,144,169,173],"receptor":[5,37],"antagonists":[6],"(LTRAs)":[7],"for":[8,45,133,201,228,233],"asthma":[9],"therapy":[10,232],"has":[11],"been":[12,43],"associated":[13],"with":[14],"a":[15,52,189,225],"significant":[16],"degree":[17],"interpatient":[19,202],"variability":[20,28,203],"in":[21,57,80,188,204],"response":[22,205],"to":[23,32,60,206],"treatment.":[24,207],"Some":[25],"that":[27,41,99,116,149,183],"may":[29,223],"be":[30],"attributable":[31],"noncysteinyl":[33],"type":[35],"1":[36],"(CysLT(1))-mediated":[38],"inhibitory":[39,178],"mechanisms":[40],"have":[42],"demonstrated":[44],"this":[46,219],"group":[47],"drugs.":[49],"We":[50,180],"used":[51],"model":[53],"CysLT(1)":[55,89,95,101],"signaling":[56],"human":[58],"monocytes":[59,81],"characterize":[61],"CysLT(1)-dependent":[62],"and":[63,75,82,86,88,105,115,123,172,185],"-independent":[64],"anti-inflammatory":[65],"activity":[66],"two":[68],"chemically":[69],"different,":[70],"clinically":[71],"relevant":[72,200],"LTRAs":[73,130,164,213],"(montelukast":[74],"zafirlukast).":[76],"Using":[77],"receptor-desensitization":[78],"experiments":[79],"CysLT(1)-transfected":[83],"HEK293":[84],"cells":[85],"IL-10-":[87],"small":[90],"interfering":[91],"RNA-induced":[92],"downregulation":[93],"expression,":[96],"we":[97],"showed":[98],"reported":[100],"agonists":[102],"D(4)":[104],"UDP":[106],"signal":[107],"through":[108],"calcium":[109,167],"mobilization,":[110],"acting":[111,187],"on":[112],"separate":[113],"receptors,":[114],"both":[117,154,163],"pathways":[118],"were":[119,131],"inhibited":[120,152,166],"by":[121,153],"montelukast":[122,184],"zafirlukast.":[124],"However,":[125],"3-log":[126],"greater":[127],"concentrations":[128],"required":[132],"the":[134],"inhibition":[135],"UDP-induced":[137],"signaling.":[138],"In":[139],"monocytes,":[140],"UDP,":[141],"but":[142],"not":[143],"D(4),":[145],"induced":[146],"IL-8":[147],"production":[148],"was":[150],"significantly":[151],"drugs":[155,222],"at":[156],"micromolar":[157,161],"concentrations.":[158],"At":[159],"low":[160],"concentrations,":[162],"also":[165],"ionophore-induced":[168],"(leukotriene":[170],"B(4)":[171],"C(4))":[174],"production,":[175],"indicating":[176],"5-lipoxygenase":[177],"activities.":[179],"report":[181],"herein":[182],"zafirlukast,":[186],"concentration-dependent":[190],"manner,":[191],"can":[192],"inhibit":[193],"non-CysLT(1)-mediated":[194],"proinflammatory":[195],"reactions,":[196],"suggesting":[197],"activities":[198],"potentially":[199],"Higher":[208],"doses":[209],"currently":[211],"known":[212],"or":[214],"new":[215,226],"compounds":[216],"derived":[217],"from":[218],"class":[220],"represent":[224],"strategy":[227],"finding":[229],"more":[230],"efficient":[231],"bronchial":[234],"asthma.":[235]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}