{"id":"https://openalex.org/W1541006461","doi":null,"title":"Molecular Mechanisms of Odor Recognition","display_name":"Molecular Mechanisms of Odor Recognition","publication_year":2000,"publication_date":"2000-07-07","ids":{"openalex":"https://openalex.org/W1541006461","mag":"1541006461"},"language":"en","primary_location":{"id":"pmh:ADA384283","doi":null,"is_oa":false,"landing_page_url":"http://oai.dtic.mil/oai/oai?&verb=getRecord&metadataPrefix=html&identifier=ADA384283","pdf_url":null,"source":{"id":"https://openalex.org/S4406923043","display_name":"Defense Technical Information Center (DTIC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"DTIC AND NTIS","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089353484","display_name":"Robert R. H. Anholt","orcid":"https://orcid.org/0000-0001-7196-8324","observed_orcids":["https://orcid.org/0000-0001-7196-8324"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Anholt, Robert R.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5089353484"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10971","display_name":"Olfactory and Sensory Function Studies","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10971","display_name":"Olfactory and Sensory Function Studies","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10423","display_name":"Neurobiology and Insect Physiology Research","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/odor-recognition","display_name":"odor recognition","score":0.8970000147819519},{"id":"https://openalex.org/keywords/vomeronasal-organ","display_name":"vomeronasal organ","score":0.9079999923706055},{"id":"https://openalex.org/keywords/olfactory-receptor-neurons","display_name":"olfactory sensory neurons","score":0.7699999809265137},{"id":"https://openalex.org/keywords/g-proteins","display_name":"G proteins","score":0.7279999852180481},{"id":"https://openalex.org/keywords/anosmia","display_name":"anosmia","score":0.9290000200271606},{"id":"https://openalex.org/keywords/olfactory-behavior","display_name":"olfactory behavior","score":0.5720000267028809},{"id":"https://openalex.org/keywords/drosophila-melanogaster","display_name":"Drosophila melanogaster","score":0.949999988079071},{"id":"https://openalex.org/keywords/olfactory-receptors","display_name":"olfactory receptors","score":0.796999990940094},{"id":"https://openalex.org/keywords/odorant-binding-proteins","display_name":"odorant-binding proteins","score":0.9900000095367432},{"id":"https://openalex.org/keywords/sodium-channels","display_name":"sodium channels","score":0.7419999837875366},{"id":"https://openalex.org/keywords/scribble","display_name":"Scribble","score":0.734000027179718},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.9160000085830688},{"id":"https://openalex.org/keywords/glaucoma","display_name":"glaucoma","score":0.8960000276565552},{"id":"https://openalex.org/keywords/chemoreception","display_name":"chemoreception","score":0.7519999742507935}],"concepts":[{"id":"https://openalex.org/C2780104201","wikidata":"https://www.wikidata.org/wiki/Q130888","display_name":"Drosophila melanogaster","level":3,"score":0.6801933646202087},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6591341495513916},{"id":"https://openalex.org/C49878776","wikidata":"https://www.wikidata.org/wiki/Q336484","display_name":"Vomeronasal organ","level":3,"score":0.5431285500526428},{"id":"https://openalex.org/C201792869","wikidata":"https://www.wikidata.org/wiki/Q1054094","display_name":"Olfactory system","level":2,"score":0.5417819619178772},{"id":"https://openalex.org/C2781377823","wikidata":"https://www.wikidata.org/wiki/Q7086517","display_name":"Olfactory mucosa","level":3,"score":0.4936267137527466},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4622708261013031},{"id":"https://openalex.org/C158471640","wikidata":"https://www.wikidata.org/wiki/Q24739367","display_name":"Odorant-binding protein","level":3,"score":0.45933640003204346},{"id":"https://openalex.org/C2776998849","wikidata":"https://www.wikidata.org/wiki/Q3766082","display_name":"Melanogaster","level":4,"score":0.42013996839523315},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4172510802745819},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3364383578300476},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.32091355323791504}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:ADA384283","doi":null,"is_oa":false,"landing_page_url":"http://oai.dtic.mil/oai/oai?&verb=getRecord&metadataPrefix=html&identifier=ADA384283","pdf_url":null,"source":{"id":"https://openalex.org/S4406923043","display_name":"Defense Technical Information Center (DTIC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"DTIC AND NTIS","raw_type":"Text"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W1488083617","https://openalex.org/W1528612804","https://openalex.org/W1554275806","https://openalex.org/W1629103289","https://openalex.org/W1769585641","https://openalex.org/W1775749144","https://openalex.org/W1967349371","https://openalex.org/W1970256374","https://openalex.org/W1971752958","https://openalex.org/W1976286473","https://openalex.org/W1981747897","https://openalex.org/W1982351586","https://openalex.org/W1983765302","https://openalex.org/W1984068005","https://openalex.org/W1988182516","https://openalex.org/W2005637545","https://openalex.org/W2013496322","https://openalex.org/W2013978625","https://openalex.org/W2019560470","https://openalex.org/W2020791858","https://openalex.org/W2022790467","https://openalex.org/W2026965748","https://openalex.org/W2048859812","https://openalex.org/W2049518081","https://openalex.org/W2059313753","https://openalex.org/W2079755276","https://openalex.org/W2081444201","https://openalex.org/W2089193539","https://openalex.org/W2097186487","https://openalex.org/W2099073284","https://openalex.org/W2111872480","https://openalex.org/W2338582565"],"related_works":["https://openalex.org/W1877772628","https://openalex.org/W2118211758","https://openalex.org/W2005637545","https://openalex.org/W1970246514","https://openalex.org/W1992225162","https://openalex.org/W2110821548","https://openalex.org/W2134891904","https://openalex.org/W2081155230","https://openalex.org/W2059119531","https://openalex.org/W1515860051"],"abstract_inverted_index":{"The":[0],"principal":[1],"thrust":[2],"of":[3,10,25,35,57,66,94,106,164,187,191,198,205,210,223],"our":[4],"work":[5,89,101,156],"focused":[6],"on":[7,78,90,157,220],"molecular":[8],"mechanisms":[9],"chemoreception":[11],"in":[12,27,43,62,97,169,214],"the":[13,19,23,28,44,63,67,79,91,104,144,149,170,203,221],"mammalian":[14,80],"vomeronasal":[15,29],"organ.":[16],"We":[17,159],"characterized":[18,33],"transduction":[20],"pathway":[21],"for":[22,114],"recognition":[24],"pheromones":[26],"organ":[30],"and":[31,46,139,225],"also":[32],"subpopulations":[34],"olfactory":[36,48,81,95,116,137],"neurons":[37],"expressing":[38],"different":[39],"axonal":[40],"G":[41],"proteins":[42,166,182,224],"main":[45],"accessory":[47],"projections.":[49],"These":[50,180],"studies":[51,77,219],"were":[52],"extended":[53],"with":[54,148,202],"a":[55,119,122,131,162,188],"characterization":[56],"genetically":[58],"modified":[59],"mice":[60],"deficient":[61],"alpha":[64],"subunit":[65],"G-protein,":[68],"Go,":[69],"which":[70,199],"show":[71],"profound":[72],"anosmia.":[73],"In":[74],"addition":[75],"to":[76,87,103,184],"system,":[82],"grant":[83],"DAAH04-96-I-0096":[84],"enabled":[85],"us":[86],"expand":[88],"genomic":[92],"architecture":[93],"behavior":[96],"Drosophila":[98,215],"melanogaster.":[99],"This":[100],"led":[102],"discovery":[105,209],"several":[107],"new":[108],"gene":[109],"products":[110],"that":[111,161],"are":[112],"essential":[113],"processing":[115],"information,":[117],"including":[118],"sodium":[120],"channel,":[121],"novel":[123],"dual":[124],"specificity":[125],"tyrosine":[126],"phosphorylation":[127],"regulated":[128],"kinase":[129],"(Dyrk2),":[130],"postsynaptic":[132],"density":[133],"protein":[134],"(Scribble),":[135],"an":[136,140,211],"receptor,":[138],"odorant":[141],"binding":[142],"protein,":[143],"latter":[145],"two":[146],"interacting":[147],"repellent":[150],"odorant,":[151],"benzaldehyde.":[152],"Finally,":[153],"we":[154],"continued":[155],"olfactomedin.":[158],"showed":[160],"family":[163,190],"olfactomedin-related":[165,181],"is":[167,200],"encoded":[168],"human":[171],"genome":[172],"with,":[173],"thus":[174],"far,":[175],"at":[176],"least":[177],"five":[178],"members.":[179],"appear":[183],"be":[185],"members":[186],"diverse":[189],"tissue-":[192],"specific":[193],"extracellular":[194],"matrix":[195],"components.,":[196],"one":[197],"associated":[201],"pathogenesis":[204],"glaucoma.":[206],"Our":[207],"recent":[208],"olfactomedin":[212],"homologue":[213],"melanogaster":[216],"will":[217],"facilitate":[218],"functions":[222],"their":[226],"interactions.":[227]},"counts_by_year":[],"updated_date":"2026-08-26T07:47:46.906454","created_date":"2025-10-10T00:00:00"}