{"id":"https://openalex.org/W1540845865","doi":null,"title":"Cellular Functions of the 26S Proteasome","display_name":"Cellular Functions of the 26S Proteasome","publication_year":2004,"publication_date":"2004-01-01","ids":{"openalex":"https://openalex.org/W1540845865","mag":"1540845865"},"language":"en","primary_location":{"id":"pmh:oai:dergipark.gov.tr:article/140057","doi":null,"is_oa":false,"landing_page_url":"http://dergipark.gov.tr/tbtkbiology/issue/11732/140057","pdf_url":null,"source":{"id":"https://openalex.org/S4306401840","display_name":"DergiPark (Istanbul University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67581229","host_organization_name":"Istanbul University","host_organization_lineage":["https://openalex.org/I67581229"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"\\n Volume: 28, Issue: 1\\n 31-38\\n \\n","raw_type":"info:eu-repo/semantics/article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001871651","display_name":"Azmi Yerlikaya","orcid":"https://orcid.org/0000-0002-0678-0701","observed_orcids":["https://orcid.org/0000-0002-0678-0701"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Azmi Yerlikaya","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0678-0701","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5001871651"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"28","issue":"1","first_page":"31","last_page":"38"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/26s-proteasome","display_name":"26S proteasome","score":1.0},{"id":"https://openalex.org/keywords/proteasome-structure","display_name":"proteasome structure","score":0.890999972820282},{"id":"https://openalex.org/keywords/substrate-targeting","display_name":"substrate targeting","score":0.7860000133514404},{"id":"https://openalex.org/keywords/proteasome-inhibition","display_name":"proteasome inhibition","score":0.9179999828338623},{"id":"https://openalex.org/keywords/immune-response","display_name":"immune response","score":0.8550000190734863},{"id":"https://openalex.org/keywords/cell-cycle","display_name":"cell cycle","score":0.8190000057220459},{"id":"https://openalex.org/keywords/transcription","display_name":"transcription","score":0.7289999723434448},{"id":"https://openalex.org/keywords/heat-shock-proteins","display_name":"heat shock proteins","score":0.6809999942779541},{"id":"https://openalex.org/keywords/hsp70","display_name":"HSP70","score":0.9750000238418579},{"id":"https://openalex.org/keywords/protein-degradation","display_name":"protein degradation","score":0.7269999980926514},{"id":"https://openalex.org/keywords/global-protein-synthesis","display_name":"global protein synthesis","score":0.8299999833106995}],"concepts":[{"id":"https://openalex.org/C27740335","wikidata":"https://www.wikidata.org/wiki/Q14878333","display_name":"Proteasome","level":2,"score":0.9607433080673218},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7881557941436768},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6887025833129883},{"id":"https://openalex.org/C205260736","wikidata":"https://www.wikidata.org/wiki/Q418939","display_name":"Heat shock protein","level":3,"score":0.5270583629608154},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.4854651093482971},{"id":"https://openalex.org/C137984847","wikidata":"https://www.wikidata.org/wiki/Q1621258","display_name":"Heat shock","level":4,"score":0.4490427076816559},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.32230663299560547},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12109410762786865}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:dergipark.gov.tr:article/140057","doi":null,"is_oa":false,"landing_page_url":"http://dergipark.gov.tr/tbtkbiology/issue/11732/140057","pdf_url":null,"source":{"id":"https://openalex.org/S4306401840","display_name":"DergiPark (Istanbul University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67581229","host_organization_name":"Istanbul University","host_organization_lineage":["https://openalex.org/I67581229"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"\\n Volume: 28, Issue: 1\\n 31-38\\n \\n","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:dergipark.org.tr:article/140057","doi":null,"is_oa":false,"landing_page_url":"https://dergipark.org.tr/tr/pub/tbtkbiology/issue/11732/140057","pdf_url":null,"source":{"id":"https://openalex.org/S4306401840","display_name":"DergiPark (Istanbul University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67581229","host_organization_name":"Istanbul University","host_organization_lineage":["https://openalex.org/I67581229"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"\\n Volume: 28, Issue: 1\\n 31-38\\n \\n","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:1540845865","doi":null,"is_oa":false,"landing_page_url":"http://journals.tubitak.gov.tr/biology/issues/biy-04-28-1/biy-28-1-5-0308-3.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S116550310","display_name":"TURKISH JOURNAL OF BIOLOGY","issn_l":"1300-0152","issn":["1300-0152","1303-6092"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","ddh","doaj","dongbi-c","jufo-1","norway-1","poland-40","russia-white-list-1","tr-dizin"],"host_organization":"https://openalex.org/P4310318422","host_organization_name":"Scientific and Technological Research Council of Turkey (TUBITAK)","host_organization_lineage":["https://openalex.org/P4310318422"],"host_organization_lineage_names":["Scientific and Technological Research Council of Turkey (TUBITAK)"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"TURKISH JOURNAL OF BIOLOGY","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.4043000042438507}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":60,"referenced_works":["https://openalex.org/W1258228527","https://openalex.org/W1503078944","https://openalex.org/W1515229511","https://openalex.org/W1515490675","https://openalex.org/W1558846872","https://openalex.org/W1563724009","https://openalex.org/W1599671902","https://openalex.org/W1782287000","https://openalex.org/W1964819733","https://openalex.org/W1964931840","https://openalex.org/W1968229731","https://openalex.org/W1975462016","https://openalex.org/W1978726512","https://openalex.org/W1983970621","https://openalex.org/W1994806672","https://openalex.org/W1995204703","https://openalex.org/W1995997074","https://openalex.org/W2001728435","https://openalex.org/W2005768995","https://openalex.org/W2008744347","https://openalex.org/W2011827928","https://openalex.org/W2019672253","https://openalex.org/W2021457628","https://openalex.org/W2029276835","https://openalex.org/W2029959408","https://openalex.org/W2036356274","https://openalex.org/W2045896552","https://openalex.org/W2050432515","https://openalex.org/W2058106838","https://openalex.org/W2060316418","https://openalex.org/W2060736209","https://openalex.org/W2061050157","https://openalex.org/W2066284211","https://openalex.org/W2067634043","https://openalex.org/W2074126694","https://openalex.org/W2077086653","https://openalex.org/W2077405632","https://openalex.org/W2078877797","https://openalex.org/W2089735593","https://openalex.org/W2091823485","https://openalex.org/W2095324208","https://openalex.org/W2096784679","https://openalex.org/W2099198727","https://openalex.org/W2101759139","https://openalex.org/W2106869142","https://openalex.org/W2114734298","https://openalex.org/W2114953435","https://openalex.org/W2115909676","https://openalex.org/W2118617212","https://openalex.org/W2123781000","https://openalex.org/W2132024812","https://openalex.org/W2142316927","https://openalex.org/W2145216906","https://openalex.org/W2150632173","https://openalex.org/W2159011164","https://openalex.org/W2160380481","https://openalex.org/W2165055107","https://openalex.org/W2166781237","https://openalex.org/W2166987747","https://openalex.org/W2395044773"],"related_works":["https://openalex.org/W2941687841","https://openalex.org/W1977266560","https://openalex.org/W2155273482","https://openalex.org/W162532464","https://openalex.org/W1562077781","https://openalex.org/W2079123938","https://openalex.org/W2113938063","https://openalex.org/W2018949795","https://openalex.org/W2798011605","https://openalex.org/W2409883494"],"abstract_inverted_index":{"The":[0,61],"26S":[1,35,92,111],"proteasome":[2,25,36,62,93,112],"plays":[3],"a":[4,13,116,125],"critical":[5],"role":[6],"in":[7,65,95,124],"many":[8],"cellular":[9,46,67,81],"processes":[10,68],"by":[11],"degrading":[12],"wide":[14],"range":[15],"of":[16,30,53,90,98,101,119],"both":[17],"short-lived":[18,73],"and":[19,27,59,75],"long-lived":[20],"proteins.":[21],"In":[22,39],"this":[23,41],"review,":[24],"structure":[26],"the":[28,34,45,54,91,96,99],"mechanisms":[29],"substrates":[31],"targeting":[32],"to":[33],"are":[37,49],"described.":[38],"addition,":[40],"review":[42],"focuses":[43],"on":[44],"functions":[47],"that":[48,78,88,110],"affected":[50],"after":[51],"inhibition":[52,89,113],"proteasome,":[55],"including":[56],"immune-response,":[57],"cell-cycle,":[58],"transcription.":[60],"is":[63,86],"involved":[64],"these":[66,80],"because":[69],"it":[70,85],"degrades":[71],"numerous":[72],"proteins":[74,77,103],"regulatory":[76],"control":[79],"functions.":[82],"Even":[83],"though":[84],"known":[87],"results":[94],"induction":[97],"synthesis":[100,122],"heat-shock":[102],"(e.g.,":[104],"Hsp":[105],"70),":[106],"several":[107],"groups":[108],"indicated":[109],"also":[114],"causes":[115],"significant":[117],"loss":[118],"global":[120],"protein":[121],"activity":[123],"very":[126],"short":[127],"time.":[128]},"counts_by_year":[],"updated_date":"2026-08-18T07:49:30.821534","created_date":"2016-06-24T00:00:00"}