{"id":"https://openalex.org/W154074485","doi":null,"title":"Abstract 3859: WNT1 Inducible Signaling Pathway Protein-1 Blocks Doxorubicin-mediated Cardiomyocyte Death by Suppressing p53, Bax and Bcl-XS, and Activating PI3K-Akt-p70S6K-Survivin Signaling","display_name":"Abstract 3859: WNT1 Inducible Signaling Pathway Protein-1 Blocks Doxorubicin-mediated Cardiomyocyte Death by Suppressing p53, Bax and Bcl-XS, and Activating PI3K-Akt-p70S6K-Survivin Signaling","publication_year":2009,"publication_date":"2009-11-03","ids":{"openalex":"https://openalex.org/W154074485","mag":"154074485"},"language":"en","primary_location":{"id":"mag:154074485","doi":null,"is_oa":false,"landing_page_url":"http://circ.ahajournals.org/cgi/content/meeting_abstract/120/18_MeetingAbstracts/S873-c","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Circulation","raw_type":null},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002679685","display_name":"Balachandar A. Venkatesan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Balachandar Venkatesan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019346470","display_name":"Srinivas Mummidi","orcid":"https://orcid.org/0000-0002-4068-6380","observed_orcids":["https://orcid.org/0000-0002-4068-6380"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Srinivas Mummidi","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4068-6380","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034515720","display_name":"Anthony J. Valente","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anthony J. Valente","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5062659962","display_name":"Bysani Chandrasekar","orcid":"https://orcid.org/0000-0002-8212-5354","observed_orcids":["https://orcid.org/0000-0002-8212-5354"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bysani Chandrasekar","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8212-5354","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"120","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11535","display_name":"Chemotherapy-induced cardiotoxicity and mitigation","score":0.9771000146865845,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11535","display_name":"Chemotherapy-induced cardiotoxicity and mitigation","score":0.9771000146865845,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.015399999916553497,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/wisp1","display_name":"WISP1","score":0.7480000257492065},{"id":"https://openalex.org/keywords/doxorubicin-induced-cardiotoxicity","display_name":"doxorubicin cardiotoxicity","score":0.9620000123977661},{"id":"https://openalex.org/keywords/cardiomyocyte-death","display_name":"cardiomyocyte death","score":0.9670000076293945},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.9639999866485596},{"id":"https://openalex.org/keywords/bax","display_name":"Bax","score":0.9990000128746033},{"id":"https://openalex.org/keywords/bcl-x","display_name":"Bcl-x","score":0.8600000143051147},{"id":"https://openalex.org/keywords/pi3k-akt-signaling","display_name":"PI3K/Akt signaling","score":0.9629999995231628},{"id":"https://openalex.org/keywords/p70s6k","display_name":"p70S6K","score":0.9750000238418579},{"id":"https://openalex.org/keywords/survivin","display_name":"survivin","score":0.9599999785423279},{"id":"https://openalex.org/keywords/cardioprotection","display_name":"cardioprotection","score":0.7350000143051147}],"concepts":[{"id":"https://openalex.org/C2775975398","wikidata":"https://www.wikidata.org/wiki/Q906904","display_name":"Survivin","level":3,"score":0.8844327926635742},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8405934572219849},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.6959875822067261},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.6847754120826721},{"id":"https://openalex.org/C2781303535","wikidata":"https://www.wikidata.org/wiki/Q18936","display_name":"Doxorubicin","level":3,"score":0.586487889289856},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5711381435394287},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5343735814094543},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.487387478351593},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.4284585118293762},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2590745687484741},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.13240915536880493},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09645551443099976},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.09184905886650085},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.05830484628677368}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:154074485","doi":null,"is_oa":false,"landing_page_url":"http://circ.ahajournals.org/cgi/content/meeting_abstract/120/18_MeetingAbstracts/S873-c","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Circulation","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2118318796","https://openalex.org/W4387772319","https://openalex.org/W140306722","https://openalex.org/W4393862192","https://openalex.org/W2015289628","https://openalex.org/W2089923455","https://openalex.org/W4396779613","https://openalex.org/W4402581261","https://openalex.org/W7001326291","https://openalex.org/W2091708864"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-06-24T00:00:00"}