{"id":"https://openalex.org/W1540733241","doi":"https://doi.org/10.1016/s0021-9258(19)39150-1","title":"Transcription initiated by RNA polymerase II and purified transcription factors from liver. Transcription factors alpha, beta gamma, and delta promote formation of intermediates in assembly of the functional preinitiation complex.","display_name":"Transcription initiated by RNA polymerase II and purified transcription factors from liver. Transcription factors alpha, beta gamma, and delta promote formation of intermediates in assembly of the functional preinitiation complex.","publication_year":1990,"publication_date":"1990-05-01","ids":{"openalex":"https://openalex.org/W1540733241","doi":"https://doi.org/10.1016/s0021-9258(19)39150-1","mag":"1540733241","pmid":"https://pubmed.ncbi.nlm.nih.gov/1692022"},"language":"en","primary_location":{"id":"doi:10.1016/s0021-9258(19)39150-1","doi":"https://doi.org/10.1016/s0021-9258(19)39150-1","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(19)39150-1","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/s0021-9258(19)39150-1","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054486813","display_name":"Ronald Conaway","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R C Conaway","raw_affiliation_strings":["Department of Chemistry, University of Texas, Austin 78712-1096"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Texas, Austin 78712-1096","institution_ids":["https://openalex.org/I86519309"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060208809","display_name":"Joan Weliky Conaway","orcid":"https://orcid.org/0000-0002-2786-0663","observed_orcids":["https://orcid.org/0000-0002-2786-0663"]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J W Conaway","raw_affiliation_strings":["Department of Chemistry, University of Texas, Austin 78712-1096"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Texas, Austin 78712-1096","institution_ids":["https://openalex.org/I86519309"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I86519309"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":2.5119,"has_fulltext":false,"cited_by_count":40,"citation_normalized_percentile":{"value":0.89803864,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"265","issue":"13","first_page":"7559","last_page":"7563"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11841","display_name":"Nuclear Structure and Function","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rna-polymerase-ii","display_name":"RNA polymerase II","score":0.9779999852180481},{"id":"https://openalex.org/keywords/transcription-initiation","display_name":"transcription initiation","score":0.8299999833106995},{"id":"https://openalex.org/keywords/preinitiation-complex-assembly","display_name":"preinitiation complex assembly","score":0.8920000195503235},{"id":"https://openalex.org/keywords/transcription-factors","display_name":"transcription factors","score":0.7950000166893005},{"id":"https://openalex.org/keywords/liver","display_name":"liver","score":0.5630000233650208},{"id":"https://openalex.org/keywords/rna-chain-initiation","display_name":"RNA chain initiation","score":0.5799999833106995}],"concepts":[{"id":"https://openalex.org/C188740287","wikidata":"https://www.wikidata.org/wiki/Q423333","display_name":"Transcription preinitiation complex","level":5,"score":0.9810757637023926},{"id":"https://openalex.org/C156951783","wikidata":"https://www.wikidata.org/wiki/Q21110793","display_name":"Transcription factor II E","level":5,"score":0.9500863552093506},{"id":"https://openalex.org/C154816499","wikidata":"https://www.wikidata.org/wiki/Q21120535","display_name":"Transcription factor II F","level":5,"score":0.9090322852134705},{"id":"https://openalex.org/C44498088","wikidata":"https://www.wikidata.org/wiki/Q14878255","display_name":"Transcription factor II A","level":5,"score":0.5909885168075562},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5104459524154663},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.5001347064971924},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4370129108428955},{"id":"https://openalex.org/C172768829","wikidata":"https://www.wikidata.org/wiki/Q14817959","display_name":"Transcription factor II D","level":5,"score":0.43289878964424133},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.4150731861591339},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.36260586977005005},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.3388332724571228},{"id":"https://openalex.org/C2776449523","wikidata":"https://www.wikidata.org/wiki/Q272631","display_name":"RNA polymerase","level":4,"score":0.33180487155914307},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.31040340662002563},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.2503686547279358},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08946669101715088},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006493","descriptor_name":"Heparin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012319","descriptor_name":"RNA Polymerase II","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0021-9258(19)39150-1","doi":"https://doi.org/10.1016/s0021-9258(19)39150-1","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(19)39150-1","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:1692022","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1692022","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/s0021-9258(19)39150-1","doi":"https://doi.org/10.1016/s0021-9258(19)39150-1","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(19)39150-1","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1675169588","display_name":null,"funder_award_id":"GM-41628","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W83871711","https://openalex.org/W1441914411","https://openalex.org/W1480274265","https://openalex.org/W1486089217","https://openalex.org/W1503198992","https://openalex.org/W1507803138","https://openalex.org/W1514077182","https://openalex.org/W1520380437","https://openalex.org/W1522425622","https://openalex.org/W1523193009","https://openalex.org/W1545776085","https://openalex.org/W1573717060","https://openalex.org/W1578846821","https://openalex.org/W1586160554","https://openalex.org/W1590412289","https://openalex.org/W1591820793","https://openalex.org/W1596038925","https://openalex.org/W1603193251","https://openalex.org/W1605064581","https://openalex.org/W1617139585","https://openalex.org/W1990786675","https://openalex.org/W1992315201","https://openalex.org/W2005097302","https://openalex.org/W2008656832","https://openalex.org/W2010049199","https://openalex.org/W2026741378","https://openalex.org/W2033997324","https://openalex.org/W2040193953","https://openalex.org/W2071802835","https://openalex.org/W2083951909","https://openalex.org/W2104671220","https://openalex.org/W2106426729","https://openalex.org/W2107624922","https://openalex.org/W2154841372","https://openalex.org/W2265406928"],"related_works":["https://openalex.org/W1523193009","https://openalex.org/W1590600623","https://openalex.org/W1513276314","https://openalex.org/W2075431354","https://openalex.org/W1480274265","https://openalex.org/W1481479057","https://openalex.org/W1617139585","https://openalex.org/W2322970637","https://openalex.org/W1964002038","https://openalex.org/W2010049199"],"abstract_inverted_index":{"Accurate":[0],"initiation":[1,82],"at":[2],"promoters":[3],"by":[4,53,201],"RNA":[5,54,125],"polymerase":[6,55],"II":[7,56],"in":[8,73,109,120,164,178],"a":[9,48,121,131,224],"highly":[10],"purified":[11],"transcription":[12,190],"system":[13],"from":[14],"rat":[15],"liver":[16],"depends":[17],"on":[18],"five":[19],"accessory":[20],"factors,":[21,30,62],"which":[22,35,69,78],"comprise":[23],"two":[24,207],"functional":[25,132,215],"classes:":[26],"(i)":[27],"\"promoter":[28],"recognition\"":[29],"designated":[31,63],"tau":[32],"and":[33,57,67,88,107,174,193,218],"epsilon,":[34],"interact":[36,172],"with":[37,149,176],"template":[38],"DNA":[39],"to":[40,124,127,171],"form":[41],"an":[42,202],"initial":[43,74],"complex":[44,75,152,200,217],"that":[45,115,142,189,220],"serves":[46],"as":[47],"recognition":[49],"site":[50],"for":[51,81,211],"binding":[52],"(ii)":[58],"\"RNA":[59],"chain":[60],"initiation\"":[61],"alpha,":[64,104,157],"beta":[65,105,158,194],"gamma,":[66,106,159],"delta,":[68],"do":[70],"not":[71],"participate":[72],"formation,":[76],"but":[77],"are":[79],"essential":[80],"(Conaway,":[83],"J.":[84,93],"W.,":[85],"Reines,":[86],"D.,":[87],"Conaway,":[89],"R.":[90],"C.":[91],"(1990)":[92],"Biol.":[94],"Chem.":[95],"265,":[96],"7552-7558).":[97],"Here":[98],"we":[99],"investigate":[100],"the":[101,150,181,198,214],"roles":[102],"of":[103,130,137,180,185,213,227],"delta":[108,161],"accurate":[110],"initiation.":[111],"Kinetic":[112],"evidence":[113],"indicates":[114],"all":[116,143],"three":[117,144],"factors":[118,145,191],"act":[119],"stage":[122],"prior":[123],"synthesis":[126],"facilitate":[128],"formation":[129],"preinitiation":[133,151,182,199,216],"complex.":[134,183],"Moreover,":[135],"results":[136],"\"template":[138],"challenge\"":[139],"experiments":[140,187],"argue":[141,219],"become":[146],"stably":[147],"associated":[148],"during":[153],"this":[154,165],"stage.":[155],"Neither":[156],"nor":[160],"functions":[162],"catalytically":[163],"process;":[166],"instead,":[167],"each":[168],"factor":[169],"appears":[170],"directly":[173],"stoichiometrically":[175],"intermediates":[177],"assembly":[179,212],"Order":[184],"addition":[186],"reveal":[188],"alpha":[192],"gamma":[195],"assemble":[196],"into":[197],"\"ordered\"":[203],"mechanism.":[204],"We":[205],"discuss":[206],"recently":[208],"proposed":[209],"models":[210],"our":[221],"findings":[222],"provide":[223],"plausible":[225],"means":[226],"reconciling":[228],"them.":[229]},"counts_by_year":[{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
