{"id":"https://openalex.org/W1540720871","doi":"https://doi.org/10.1016/s0021-9258(18)51604-5","title":"Evolutionarily Conserved Sequences of Striated Muscle Myosin Heavy Chain Isoforms","display_name":"Evolutionarily Conserved Sequences of Striated Muscle Myosin Heavy Chain Isoforms","publication_year":1989,"publication_date":"1989-08-01","ids":{"openalex":"https://openalex.org/W1540720871","doi":"https://doi.org/10.1016/s0021-9258(18)51604-5","mag":"1540720871","pmid":"https://pubmed.ncbi.nlm.nih.gov/2473986"},"language":"en","primary_location":{"id":"doi:10.1016/s0021-9258(18)51604-5","doi":"https://doi.org/10.1016/s0021-9258(18)51604-5","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(18)51604-5","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/s0021-9258(18)51604-5","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028430310","display_name":"Jeffrey B. Miller","orcid":"https://orcid.org/0000-0001-5273-2201","observed_orcids":["https://orcid.org/0000-0001-5273-2201"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J B Miller","raw_affiliation_strings":["Department of Medicine, Stanford University School of Medicine, California 94305-5306"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Stanford University School of Medicine, California 94305-5306","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025228190","display_name":"Stuart Teal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S B Teal","raw_affiliation_strings":["Department of Medicine, Stanford University School of Medicine, California 94305-5306"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Stanford University School of Medicine, California 94305-5306","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002727073","display_name":"Frank E. Stockdale","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"F E Stockdale","raw_affiliation_strings":["Department of Medicine, Stanford University School of Medicine, California 94305-5306"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Stanford University School of Medicine, California 94305-5306","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":4.2246,"has_fulltext":false,"cited_by_count":81,"citation_normalized_percentile":{"value":0.93789121,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"264","issue":"22","first_page":"13122","last_page":"13130"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10882","display_name":"Cardiomyopathy and Myosin Studies","score":0.7157999873161316,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10882","display_name":"Cardiomyopathy and Myosin Studies","score":0.7157999873161316,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.23250000178813934,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.030700000002980232,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/myosin-heavy-chain","display_name":"myosin heavy chain","score":0.9639999866485596},{"id":"https://openalex.org/keywords/monoclonal-antibodies","display_name":"monoclonal antibodies","score":0.753000020980835},{"id":"https://openalex.org/keywords/epitope-mapping","display_name":"epitope mapping","score":0.9359999895095825},{"id":"https://openalex.org/keywords/vertebrate-evolution","display_name":"vertebrate evolution","score":0.6740000247955322},{"id":"https://openalex.org/keywords/sequence-conservation","display_name":"sequence conservation","score":0.6050000190734863},{"id":"https://openalex.org/keywords/chickens","display_name":"chickens","score":0.35100001096725464},{"id":"https://openalex.org/keywords/rats","display_name":"rats","score":0.8270000219345093},{"id":"https://openalex.org/keywords/amphioxus","display_name":"amphioxus","score":0.7590000033378601},{"id":"https://openalex.org/keywords/nematodes","display_name":"nematodes","score":0.8429999947547913},{"id":"https://openalex.org/keywords/dictyostelium","display_name":"Dictyostelium","score":0.9980000257492065}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8264704942703247},{"id":"https://openalex.org/C195616568","wikidata":"https://www.wikidata.org/wiki/Q128711","display_name":"Epitope","level":3,"score":0.8256088495254517},{"id":"https://openalex.org/C53345823","wikidata":"https://www.wikidata.org/wiki/Q5531554","display_name":"Gene isoform","level":3,"score":0.7237482070922852},{"id":"https://openalex.org/C6997183","wikidata":"https://www.wikidata.org/wiki/Q271727","display_name":"Myosin","level":2,"score":0.6602523922920227},{"id":"https://openalex.org/C187882448","wikidata":"https://www.wikidata.org/wiki/Q283478","display_name":"Complementary DNA","level":3,"score":0.6442959308624268},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5907192230224609},{"id":"https://openalex.org/C207936829","wikidata":"https://www.wikidata.org/wiki/Q423163","display_name":"Major histocompatibility complex","level":3,"score":0.528315007686615},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.5114337801933289},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.4351041615009308},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.24172145128250122},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.23345473408699036},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.18978974223136902},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.18064993619918823},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.16876932978630066}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000918","descriptor_name":"Antibody Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000939","descriptor_name":"Epitopes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000939","descriptor_name":"Epitopes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000939","descriptor_name":"Epitopes","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D002645","descriptor_name":"Chickens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002918","descriptor_name":"Chymotrypsin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D005075","descriptor_name":"Biological Evolution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006868","descriptor_name":"Hydrolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009218","descriptor_name":"Myosins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010449","descriptor_name":"Peptide Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D012689","descriptor_name":"Sequence Homology, Nucleic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014714","descriptor_name":"Vertebrates","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0021-9258(18)51604-5","doi":"https://doi.org/10.1016/s0021-9258(18)51604-5","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(18)51604-5","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:2473986","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2473986","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Comparative Study"}],"best_oa_location":{"id":"doi:10.1016/s0021-9258(18)51604-5","doi":"https://doi.org/10.1016/s0021-9258(18)51604-5","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(18)51604-5","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":73,"referenced_works":["https://openalex.org/W124255977","https://openalex.org/W195324004","https://openalex.org/W301591301","https://openalex.org/W587239253","https://openalex.org/W1484478020","https://openalex.org/W1494248838","https://openalex.org/W1503210396","https://openalex.org/W1512374553","https://openalex.org/W1513717105","https://openalex.org/W1538991359","https://openalex.org/W1549735471","https://openalex.org/W1553430361","https://openalex.org/W1556101864","https://openalex.org/W1558285759","https://openalex.org/W1561552296","https://openalex.org/W1567369841","https://openalex.org/W1569283491","https://openalex.org/W1569849804","https://openalex.org/W1578752164","https://openalex.org/W1609528353","https://openalex.org/W1844573359","https://openalex.org/W1889122512","https://openalex.org/W1964200801","https://openalex.org/W1968547041","https://openalex.org/W1970948283","https://openalex.org/W1975259832","https://openalex.org/W1975722845","https://openalex.org/W1982867922","https://openalex.org/W1984684797","https://openalex.org/W1990069550","https://openalex.org/W1990379370","https://openalex.org/W1991487165","https://openalex.org/W1997497266","https://openalex.org/W1998303820","https://openalex.org/W2001709063","https://openalex.org/W2002265951","https://openalex.org/W2002420959","https://openalex.org/W2003585900","https://openalex.org/W2005831153","https://openalex.org/W2008700537","https://openalex.org/W2016560835","https://openalex.org/W2023089345","https://openalex.org/W2026199531","https://openalex.org/W2031332665","https://openalex.org/W2031540833","https://openalex.org/W2035089215","https://openalex.org/W2037427273","https://openalex.org/W2042053845","https://openalex.org/W2042960754","https://openalex.org/W2044225421","https://openalex.org/W2045425113","https://openalex.org/W2058295628","https://openalex.org/W2058918550","https://openalex.org/W2062405903","https://openalex.org/W2077074448","https://openalex.org/W2078792023","https://openalex.org/W2080498410","https://openalex.org/W2080861205","https://openalex.org/W2088867009","https://openalex.org/W2097014018","https://openalex.org/W2100256775","https://openalex.org/W2107385913","https://openalex.org/W2117832434","https://openalex.org/W2119327575","https://openalex.org/W2119528854","https://openalex.org/W2130207697","https://openalex.org/W2140994672","https://openalex.org/W2144634347","https://openalex.org/W2151812504","https://openalex.org/W2168530814","https://openalex.org/W2173088997","https://openalex.org/W2226209910","https://openalex.org/W2470139704"],"related_works":["https://openalex.org/W1505451971","https://openalex.org/W2060569257","https://openalex.org/W2018246442","https://openalex.org/W1984684797","https://openalex.org/W7097208264","https://openalex.org/W2026917209","https://openalex.org/W2110808326","https://openalex.org/W1979224160","https://openalex.org/W2090074298","https://openalex.org/W2064001673"],"abstract_inverted_index":{"A":[0],"cDNA":[1,231,250,260,298,315],"expression":[2,232,312],"strategy":[3],"was":[4,104,118,158,238,337],"used":[5,239],"to":[6,18,120,145,196,240,339,363],"localize":[7],"amino":[8,340,364],"acid":[9],"sequences":[10,372],"which":[11,31,132],"were":[12,32,48,88,171,193,226,252,262,275,291,307,361],"specific":[13],"for":[14,279],"fast,":[15],"as":[16,264],"opposed":[17],"slow,":[19],"isoforms":[20,60],"of":[21,54,67,94,113,129,154,209,212,220,244,288,296,313,317,325,343,369],"the":[22,55,68,90,95,98,106,124,127,136,139,147,155,224,256,269,272,282,285,289,294,297,322,326,331,344,350,377],"chicken":[23,57,70,246,345],"skeletal":[24,151],"muscle":[25,75],"myosin":[26],"heavy":[27],"chain":[28],"(MHC)":[29],"and":[30,46,86,150,168,184,202,215,284,349,359],"conserved":[33],"in":[34,123,204],"vertebrate":[35,200],"evolution.":[36],"Five":[37],"monoclonal":[38],"antibodies":[39],"(mAbs),":[40],"termed":[41],"F18,":[42,83,357],"F27,":[43],"F30,":[44,84,358],"F47,":[45,85],"F59,":[47,131],"prepared":[49],"that":[50,251,300,320],"reacted":[51,134],"with":[52,65,73,126,135,281],"all":[53,114],"known":[56,69,318],"fast":[58,121,248,347],"MHC":[59,76,142,249,348],"but":[61],"did":[62],"not":[63],"react":[64],"any":[66],"slow":[71,141],"nor":[72],"smooth":[74],"isoforms.":[77],"The":[78,166,187,218,305],"epitopes":[79,157,170,188,222,290,306,353],"recognized":[80,100,189,333,354],"by":[81,101,190,277,311,334,355],"mAbs":[82,116,192,356],"F59":[87,169,336],"on":[89,105,160,173,223],"globular":[91],"head":[92,225],"fragment":[93],"MHC,":[96,138],"whereas":[97],"epitope":[99,332,371],"mAb":[102,130,335],"F27":[103,167],"helical":[107],"tail":[108],"or":[109,163,375],"rod":[110],"fragment.":[111],"Reactivity":[112],"five":[115,156],"also":[117,133],"confined":[119],"MHCs":[122,214],"rat,":[125],"exception":[128],"beta-cardiac":[137],"single":[140],"isoform":[143],"common":[144],"both":[146],"rat":[148,185],"heart":[149],"muscle.":[152],"None":[153],"expressed":[159,263],"amphioxus,":[161],"nematode,":[162],"Dictyostelium":[164],"MHC.":[165],"found":[172],"shark,":[174],"electric":[175],"ray,":[176],"goldfish,":[177],"newt,":[178],"frog,":[179],"turtle,":[180],"chicken,":[181],"quail,":[182],"rabbit,":[183],"MHCs.":[186],"these":[191,370],"conserved,":[194],"therefore,":[195],"varying":[197],"degrees":[198],"through":[199],"evolution":[201],"differed":[203],"sequence":[205,219,319],"from":[206,255,293],"homologous":[207],"regions":[208],"a":[210,229,245,302],"number":[211],"invertebrate":[213],"myosin-like":[216],"proteins.":[217],"those":[221],"mapped":[227,310,338,362],"using":[228,268],"two-part":[230],"strategy.":[233],"First,":[234],"Bal31":[235],"exonuclease":[236],"digestion":[237],"rapidly":[241],"generate":[242],"fragments":[243,261,299,316],"embryonic":[247,346],"progressively":[253],"deleted":[254],"3'":[257],"end.":[258],"These":[259],"beta-galactosidase/MHC":[265],"fusion":[266,273],"proteins":[267,274],"pUR290":[270],"vector;":[271],"tested":[276],"immunoblotting":[278],"reactivity":[280],"mAbs;":[283],"approximate":[286,323],"locations":[287],"determined":[292],"sizes":[295],"encoded":[301],"particular":[303],"epitope.":[304],"then":[308],"precisely":[309],"overlapping":[314],"covered":[321],"location":[324],"epitopes.":[327],"With":[328],"this":[329],"method,":[330],"acids":[341,365],"211-231":[342],"three":[351],"distinct":[352],"F47":[360],"approximately":[366],"65-92.":[367],"Each":[368],"is":[373],"at":[374],"near":[376],"ATPase":[378],"active":[379],"site.":[380]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
