{"id":"https://openalex.org/W1540307019","doi":"https://doi.org/10.1158/1538-7445.am2014-823","title":"Abstract 823: Water-soluble ureidomustine (BO-1055) potently suppresses orthotopic 22Rv/HL2 prostate tumor xenografts: early preclinical studies","display_name":"Abstract 823: Water-soluble ureidomustine (BO-1055) potently suppresses orthotopic 22Rv/HL2 prostate tumor xenografts: early preclinical studies","publication_year":2014,"publication_date":"2014-10-01","ids":{"openalex":"https://openalex.org/W1540307019","doi":"https://doi.org/10.1158/1538-7445.am2014-823","mag":"1540307019"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2014-823","doi":"https://doi.org/10.1158/1538-7445.am2014-823","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2014-823","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102249675","display_name":"Tsann\u2010Long Su","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210096666","display_name":"Institute of Biomedical Sciences, Academia Sinica","ror":"https://ror.org/00tk6s776","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210096666","https://openalex.org/I84653119"]},{"id":"https://openalex.org/I84653119","display_name":"Academia Sinica","ror":"https://ror.org/05bxb3784","country_code":"TW","type":"facility","lineage":["https://openalex.org/I84653119"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Tsann-Long Su","raw_affiliation_strings":["1Academia Sinica - Institute of Biomedical Sci., Taipei, Taiwan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Academia Sinica - Institute of Biomedical Sci., Taipei, Taiwan;","institution_ids":["https://openalex.org/I4210096666","https://openalex.org/I84653119"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yi-Ren Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210146572","display_name":"Agricultural Biotechnology Research Center, Academia Sinica","ror":"https://ror.org/04zkdcw61","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210146572","https://openalex.org/I84653119"]},{"id":"https://openalex.org/I84653119","display_name":"Academia Sinica","ror":"https://ror.org/05bxb3784","country_code":"TW","type":"facility","lineage":["https://openalex.org/I84653119"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Yi-Ren Chen","raw_affiliation_strings":["2Agricultural Biotechnology Research Center, Academia Sinica, Taipei, Taiwan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Agricultural Biotechnology Research Center, Academia Sinica, Taipei, Taiwan;","institution_ids":["https://openalex.org/I4210146572","https://openalex.org/I84653119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091269790","display_name":"Jae-Hung Shieh","orcid":"https://orcid.org/0000-0001-6179-2847","observed_orcids":["https://orcid.org/0000-0001-6179-2847"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jae-Hung Shieh","raw_affiliation_strings":["3Cell Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Cell Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY;","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013341045","display_name":"Tung\u2010Hu Tsai","orcid":"https://orcid.org/0000-0002-9007-2547","observed_orcids":["https://orcid.org/0000-0002-9007-2547"]},"institutions":[{"id":"https://openalex.org/I4387156312","display_name":"National Yang Ming University","ror":"https://ror.org/009h5ks85","country_code":"TW","type":"education","lineage":["https://openalex.org/I148366613","https://openalex.org/I4387156312"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Tung-Hu Tsai","raw_affiliation_strings":["4Institute of Traditional Medicine, National Yang-Ming University, Taipei, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Institute of Traditional Medicine, National Yang-Ming University, Taipei, Taiwan","institution_ids":["https://openalex.org/I4387156312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110863459","display_name":"Malcolm A.S. Moore","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Malcolm A.S. Moore","raw_affiliation_strings":["3Cell Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Cell Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY;","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004560801","display_name":"Te\u2010Chang Lee","orcid":"https://orcid.org/0000-0003-4448-1507","observed_orcids":["https://orcid.org/0000-0003-4448-1507"]},"institutions":[{"id":"https://openalex.org/I4210096666","display_name":"Institute of Biomedical Sciences, Academia Sinica","ror":"https://ror.org/00tk6s776","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210096666","https://openalex.org/I84653119"]},{"id":"https://openalex.org/I84653119","display_name":"Academia Sinica","ror":"https://ror.org/05bxb3784","country_code":"TW","type":"facility","lineage":["https://openalex.org/I84653119"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Te-Chang Lee","raw_affiliation_strings":["1Academia Sinica - Institute of Biomedical Sci., Taipei, Taiwan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Academia Sinica - Institute of Biomedical Sci., Taipei, Taiwan;","institution_ids":["https://openalex.org/I4210096666","https://openalex.org/I84653119"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"74","issue":"19_Supplement","first_page":"823","last_page":"823"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.00430000014603138,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.9599999785423279},{"id":"https://openalex.org/keywords/orthotopic-xenograft-model","display_name":"orthotopic xenograft","score":0.8199999928474426},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.746999979019165},{"id":"https://openalex.org/keywords/cord-blood-cd34-cells","display_name":"cord blood CD34+ cells","score":0.8090000152587891},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.7250000238418579},{"id":"https://openalex.org/keywords/plasma-protein-binding","display_name":"plasma protein binding","score":0.9409999847412109},{"id":"https://openalex.org/keywords/metabolic-stability","display_name":"metabolic stability","score":0.7649999856948853},{"id":"https://openalex.org/keywords/tissue-distribution","display_name":"tissue distribution","score":0.7229999899864197}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6735153198242188},{"id":"https://openalex.org/C2781451048","wikidata":"https://www.wikidata.org/wiki/Q415588","display_name":"Carboplatin","level":4,"score":0.5695679187774658},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5301894545555115},{"id":"https://openalex.org/C10205521","wikidata":"https://www.wikidata.org/wiki/Q4035578","display_name":"CD34","level":3,"score":0.5054702758789062},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.4940474331378937},{"id":"https://openalex.org/C2781190966","wikidata":"https://www.wikidata.org/wiki/Q420436","display_name":"Docetaxel","level":3,"score":0.47191694378852844},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.4589579701423645},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.4573684334754944},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.37815743684768677},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3635615110397339},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.36239078640937805},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.35314297676086426},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.23526176810264587},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.15601369738578796},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.12184816598892212},{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.071910560131073},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0690869688987732},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2014-823","doi":"https://doi.org/10.1158/1538-7445.am2014-823","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2014-823","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2008407088","https://openalex.org/W2019540043","https://openalex.org/W3049351910","https://openalex.org/W7096416816","https://openalex.org/W7208109069","https://openalex.org/W2414063356","https://openalex.org/W2007990577","https://openalex.org/W2041205650","https://openalex.org/W583922255","https://openalex.org/W2005330092"],"abstract_inverted_index":{"Abstract":[0],"In":[1,298],"developed":[2],"countries,":[3],"prostate":[4,102,363],"cancer":[5,99],"(PCa)":[6],"is":[7,54,64,270,282],"one":[8],"of":[9,13,51,60,120,128,191,335,372,377],"the":[10,33,57,117,125,189,234,252,261,333,339,373,378],"leading":[11],"causes":[12],"death":[14],"in":[15,87,130,167,179,240,248,258,263,291,338],"men.":[16],"PCa":[17,30,44,136,165,289,337],"often":[18],"recurs":[19],"and":[20,40,68,101,112,156,197,226,260,310,319],"metastasizes":[21],"after":[22],"an":[23,140,168],"initial":[24],"response":[25],"to":[26,32,55,265,305],"hormone":[27],"therapy.":[28],"Once":[29],"progresses":[31],"castration-resistant":[34],"stage,":[35],"it":[36],"becomes":[37],"incurable.":[38],"New":[39],"effective":[41],"agents":[42],"against":[43,163,193,214,287],"are":[45],"therefore":[46],"urgently":[47],"needed.":[48],"The":[49,143,205,277],"objective":[50],"this":[52,121,209,268,300],"study":[53],"evaluate":[56],"antitumor":[58,118],"activity":[59],"ureidomustine":[61,82,129,147,175,192,281,328,357],"(BO-1055),":[62],"which":[63],"a":[65,271],"chemically":[66],"stable":[67],"water-soluble":[69],"phenyl":[70],"N-mustard-benzamide":[71],"conjugate":[72],"previously":[73,79],"synthesized":[74],"from":[75],"our":[76],"laboratory.":[77],"We":[78,186],"demonstrated":[80],"that":[81,146,174,208,280,327],"exhibited":[83,176,211],"potent":[84,158,284],"therapeutic":[85,126],"efficacy":[86,127],"nude":[88,131],"mice":[89,132],"bearing":[90,133],"various":[91],"human":[92,97,135,198,215,223,306],"tumor":[93,154,364],"xenografts,":[94],"such":[95,313],"as":[96,149,151,283,285,314],"colon":[98],"HCT-116":[100],"adenocarcinoma":[103],"PC-3":[104],"xenografts":[105],"(subcutaneous":[106],"implantation),":[107],"inhibiting":[108],"growth":[109],"by":[110],">95%":[111],">99%,":[113],"respectively.":[114],"To":[115],"broaden":[116],"spectrum":[119],"agent,":[122],"we":[123,232],"evaluated":[124],"22Rv/HL2":[134,164,288,362],"tumors":[137,166],"implanted":[138],"at":[139],"orthotopic":[141,169,292,361],"site.":[142],"results":[144,206,278],"showed":[145,207],"was":[148],"efficacious":[150],"docetaxel":[152,286],"(>92%":[153],"suppression)":[155,162],"more":[157],"than":[159],"carboplatin":[160],"(62%":[161],"xenograft":[170,293],"model.":[171],"It":[172],"revealed":[173],"low":[177,212,296,303],"toxicity":[178,257,304],"mice,":[180,259],"with":[181,295],"no":[182],"apparent":[183],"pathological":[184],"changes.":[185],"also":[187],"studied":[188],"cytotoxicity":[190,213],"normal":[194],"murine":[195],"cells":[196,201,218,229,290,309,312,317],"hematopoietic":[199,216,307],"stem":[200,217,228],"(cord":[202,219],"blood":[203,220],"CD34+).":[204],"agent":[210,269,301],"CD34+),":[221],"primary":[222],"endothelial":[224,316],"cells,":[225],"mesenchymal":[227],"(BSC).":[230],"Moreover,":[231],"performed":[233],"early":[235,322,366],"preclinical":[236,323,367],"studies":[237,324],"including":[238],"pharmacokinetics":[239],"rats,":[241],"rat":[242,249],"plasma":[243],"protein":[244],"binding,":[245],"metabolic":[246],"stability":[247],"liver":[250],"microsomes,":[251],"14":[253],"day":[254],"intravenous":[255],"acute":[256],"biodistribution":[262],"rat,":[264],"determine":[266],"whether":[267],"candidate":[272],"for":[273,332,381],"future":[274],"clinical":[275],"studies.":[276,368],"indicate":[279],"models":[294],"toxicity.":[297],"addition,":[299],"has":[302,329],"stem/progenitor":[308],"stromal":[311],"BM-derived":[315],"(BMEC)":[318],"MSC.":[320],"Furthermore,":[321],"(ADME)":[325],"suggest":[326],"high":[330],"potential":[331],"treatment":[334],"advanced":[336],"clinic.":[340],"Citation":[341],"Format:":[342],"Tsann-Long":[343],"Su,":[344],"Yi-Ren":[345],"Chen,":[346],"Jae-Hung":[347],"Shieh,":[348],"Tung-Hu":[349],"Tsai,":[350],"Malcolm":[351],"A.S.":[352],"Moore,":[353],"Te-Chang":[354],"Lee.":[355],"Water-soluble":[356],"(BO-1055)":[358],"potently":[359],"suppresses":[360],"xenografts:":[365],"[abstract].":[369],"In:":[370],"Proceedings":[371],"105th":[374],"Annual":[375],"Meeting":[376],"American":[379],"Association":[380],"Cancer":[382,393],"Research;":[383],"2014":[384],"Apr":[385],"5-9;":[386],"San":[387],"Diego,":[388],"CA.":[389],"Philadelphia":[390],"(PA):":[391],"AACR;":[392],"Res":[394],"2014;74(19":[395],"Suppl):Abstract":[396],"nr":[397],"823.":[398],"doi:10.1158/1538-7445.AM2014-823":[399]},"counts_by_year":[{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}