{"id":"https://openalex.org/W1539749869","doi":"https://doi.org/10.1046/j.1432-1033.2002.03194.x","title":"Probing the role of glutamic acid 139 of Anabaena ferredoxin\u2010NADP+ reductase in the interaction with substrates","display_name":"Probing the role of glutamic acid 139 of Anabaena ferredoxin\u2010NADP+ reductase in the interaction with substrates","publication_year":2002,"publication_date":"2002-10-01","ids":{"openalex":"https://openalex.org/W1539749869","doi":"https://doi.org/10.1046/j.1432-1033.2002.03194.x","mag":"1539749869","pmid":"https://pubmed.ncbi.nlm.nih.gov/12383252"},"language":"en","primary_location":{"id":"doi:10.1046/j.1432-1033.2002.03194.x","doi":"https://doi.org/10.1046/j.1432-1033.2002.03194.x","is_oa":false,"landing_page_url":"https://doi.org/10.1046/j.1432-1033.2002.03194.x","pdf_url":null,"source":{"id":"https://openalex.org/S4210214924","display_name":"European Journal of Biochemistry","issn_l":"0014-2956","issn":["0014-2956","0945-5795","1432-1033"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-100"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082545499","display_name":"Merche Faro","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I255234318","display_name":"Universidad de Zaragoza","ror":"https://ror.org/012a91z28","country_code":"ES","type":"education","lineage":["https://openalex.org/I255234318"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Merche Faro","raw_affiliation_strings":["Departamento de Bioqu\u00edmica y Biolog\u00eda Molecular y Celular, Facultad de Ciencias, Universidad de Zaragoza, Spain","Departamento de Bioquimica y Biolog\u00eda Molecular y Celular, Facultad de Ciencias, Universidad de Zaragoza, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Bioqu\u00edmica y Biolog\u00eda Molecular y Celular, Facultad de Ciencias, Universidad de Zaragoza, Spain","institution_ids":["https://openalex.org/I255234318"]},{"raw_affiliation_string":"Departamento de Bioquimica y Biolog\u00eda Molecular y Celular, Facultad de Ciencias, Universidad de Zaragoza, Spain","institution_ids":["https://openalex.org/I255234318"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023025738","display_name":"Susana Frago","orcid":"https://orcid.org/0000-0002-1369-1328","observed_orcids":["https://orcid.org/0000-0002-1369-1328"]},"institutions":[{"id":"https://openalex.org/I255234318","display_name":"Universidad de Zaragoza","ror":"https://ror.org/012a91z28","country_code":"ES","type":"education","lineage":["https://openalex.org/I255234318"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Susana Frago","raw_affiliation_strings":["Departamento de Bioqui\u0301mica y Biologi\u0301a Molecular y Celular, Facultad de Ciencias, Universidad de Zaragoza, Spain;","Departamento de Bioquimica y Biolog\u00eda Molecular y Celular, Facultad de Ciencias, Universidad de Zaragoza, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Bioqui\u0301mica y Biologi\u0301a Molecular y Celular, Facultad de Ciencias, Universidad de Zaragoza, Spain;","institution_ids":["https://openalex.org/I255234318"]},{"raw_affiliation_string":"Departamento de Bioquimica y Biolog\u00eda Molecular y Celular, Facultad de Ciencias, Universidad de Zaragoza, Spain","institution_ids":["https://openalex.org/I255234318"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072715855","display_name":"Tom\u00e1s Mayoral","orcid":"https://orcid.org/0000-0003-2644-1966","observed_orcids":["https://orcid.org/0000-0003-2644-1966"]},"institutions":[{"id":"https://openalex.org/I134820265","display_name":"Consejo Superior de Investigaciones Cient\u00edficas","ror":"https://ror.org/02gfc7t72","country_code":"ES","type":"government","lineage":["https://openalex.org/I134820265"]},{"id":"https://openalex.org/I4210147396","display_name":"Instituto de Qu\u00edmica F\u00edsica Blas Cabrera","ror":"https://ror.org/03xk60j79","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210147396"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Tomas Mayoral","raw_affiliation_strings":["Grupo de Cristalografi\u0301a Macromolecular y Biologi\u0301a Estructural, Instituto Qui\u0301mica-Fi\u0301sica Rocasolano, C.S.I.C. Serrano 119, Madrid, Spain","Grupo de Cristalograf\u00eda Macromolecular y Biolog\u00eda Estructural, Instituto Qu\u00edmica\u2010F\u00edsica Rocasolano, C.S.I.C. Serrano 119, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Grupo de Cristalografi\u0301a Macromolecular y Biologi\u0301a Estructural, Instituto Qui\u0301mica-Fi\u0301sica Rocasolano, C.S.I.C. Serrano 119, Madrid, Spain","institution_ids":["https://openalex.org/I134820265","https://openalex.org/I4210147396"]},{"raw_affiliation_string":"Grupo de Cristalograf\u00eda Macromolecular y Biolog\u00eda Estructural, Instituto Qu\u00edmica\u2010F\u00edsica Rocasolano, C.S.I.C. Serrano 119, Madrid, Spain","institution_ids":["https://openalex.org/I134820265","https://openalex.org/I4210147396"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021295789","display_name":"J.A. Hermoso","orcid":"https://orcid.org/0000-0002-1862-8950","observed_orcids":["https://orcid.org/0000-0002-1862-8950"]},"institutions":[{"id":"https://openalex.org/I134820265","display_name":"Consejo Superior de Investigaciones Cient\u00edficas","ror":"https://ror.org/02gfc7t72","country_code":"ES","type":"government","lineage":["https://openalex.org/I134820265"]},{"id":"https://openalex.org/I4210147396","display_name":"Instituto de Qu\u00edmica F\u00edsica Blas Cabrera","ror":"https://ror.org/03xk60j79","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210147396"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Juan A. Hermoso","raw_affiliation_strings":["Grupo de Cristalografi\u0301a Macromolecular y Biologi\u0301a Estructural, Instituto Qui\u0301mica-Fi\u0301sica Rocasolano, C.S.I.C. Serrano 119, Madrid, Spain","Grupo de Cristalograf\u00eda Macromolecular y Biolog\u00eda Estructural, Instituto Qu\u00edmica\u2010F\u00edsica Rocasolano, C.S.I.C. Serrano 119, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Grupo de Cristalografi\u0301a Macromolecular y Biologi\u0301a Estructural, Instituto Qui\u0301mica-Fi\u0301sica Rocasolano, C.S.I.C. Serrano 119, Madrid, Spain","institution_ids":["https://openalex.org/I134820265","https://openalex.org/I4210147396"]},{"raw_affiliation_string":"Grupo de Cristalograf\u00eda Macromolecular y Biolog\u00eda Estructural, Instituto Qu\u00edmica\u2010F\u00edsica Rocasolano, C.S.I.C. Serrano 119, Madrid, Spain","institution_ids":["https://openalex.org/I134820265","https://openalex.org/I4210147396"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046441942","display_name":"Julia Sanz\u2010Aparicio","orcid":"https://orcid.org/0000-0002-6849-8621","observed_orcids":["https://orcid.org/0000-0002-6849-8621"]},"institutions":[{"id":"https://openalex.org/I134820265","display_name":"Consejo Superior de Investigaciones Cient\u00edficas","ror":"https://ror.org/02gfc7t72","country_code":"ES","type":"government","lineage":["https://openalex.org/I134820265"]},{"id":"https://openalex.org/I4210147396","display_name":"Instituto de Qu\u00edmica F\u00edsica Blas Cabrera","ror":"https://ror.org/03xk60j79","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210147396"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Julia Sanz\u2010Aparicio","raw_affiliation_strings":["Grupo de Cristalografi\u0301a Macromolecular y Biologi\u0301a Estructural, Instituto Qui\u0301mica-Fi\u0301sica Rocasolano, C.S.I.C. Serrano 119, Madrid, Spain","Grupo de Cristalograf\u00eda Macromolecular y Biolog\u00eda Estructural, Instituto Qu\u00edmica\u2010F\u00edsica Rocasolano, C.S.I.C. Serrano 119, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Grupo de Cristalografi\u0301a Macromolecular y Biologi\u0301a Estructural, Instituto Qui\u0301mica-Fi\u0301sica Rocasolano, C.S.I.C. Serrano 119, Madrid, Spain","institution_ids":["https://openalex.org/I134820265","https://openalex.org/I4210147396"]},{"raw_affiliation_string":"Grupo de Cristalograf\u00eda Macromolecular y Biolog\u00eda Estructural, Instituto Qu\u00edmica\u2010F\u00edsica Rocasolano, C.S.I.C. Serrano 119, Madrid, Spain","institution_ids":["https://openalex.org/I134820265","https://openalex.org/I4210147396"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047721604","display_name":"Carlos G\u00f3mez\u2010Moreno","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I255234318","display_name":"Universidad de Zaragoza","ror":"https://ror.org/012a91z28","country_code":"ES","type":"education","lineage":["https://openalex.org/I255234318"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Carlos G\u00f3mez\u2010Moreno","raw_affiliation_strings":["Departamento de Bioqui\u0301mica y Biologi\u0301a Molecular y Celular, Facultad de Ciencias, Universidad de Zaragoza, Spain;","Departamento de Bioquimica y Biolog\u00eda Molecular y Celular, Facultad de Ciencias, Universidad de Zaragoza, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Bioqui\u0301mica y Biologi\u0301a Molecular y Celular, Facultad de Ciencias, Universidad de Zaragoza, Spain;","institution_ids":["https://openalex.org/I255234318"]},{"raw_affiliation_string":"Departamento de Bioquimica y Biolog\u00eda Molecular y Celular, Facultad de Ciencias, Universidad de Zaragoza, Spain","institution_ids":["https://openalex.org/I255234318"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021335979","display_name":"Milagros Medina","orcid":"https://orcid.org/0000-0001-8743-0182","observed_orcids":["https://orcid.org/0000-0001-8743-0182"]},"institutions":[{"id":"https://openalex.org/I255234318","display_name":"Universidad de Zaragoza","ror":"https://ror.org/012a91z28","country_code":"ES","type":"education","lineage":["https://openalex.org/I255234318"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Milagros Medina","raw_affiliation_strings":["Departamento de Bioqui\u0301mica y Biologi\u0301a Molecular y Celular, Facultad de Ciencias, Universidad de Zaragoza, Spain;","Departamento de Bioquimica y Biolog\u00eda Molecular y Celular, Facultad de Ciencias, Universidad de Zaragoza, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Bioqui\u0301mica y Biologi\u0301a Molecular y Celular, Facultad de Ciencias, Universidad de Zaragoza, Spain;","institution_ids":["https://openalex.org/I255234318"]},{"raw_affiliation_string":"Departamento de Bioquimica y Biolog\u00eda Molecular y Celular, Facultad de Ciencias, Universidad de Zaragoza, Spain","institution_ids":["https://openalex.org/I255234318"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.9765,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.77333671,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"269","issue":"20","first_page":"4938","last_page":"4947"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11626","display_name":"Metalloenzymes and iron-sulfur proteins","score":0.7509999871253967,"subfield":{"id":"https://openalex.org/subfields/2105","display_name":"Renewable Energy, Sustainability and the Environment"},"field":{"id":"https://openalex.org/fields/21","display_name":"Energy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11626","display_name":"Metalloenzymes and iron-sulfur proteins","score":0.7509999871253967,"subfield":{"id":"https://openalex.org/subfields/2105","display_name":"Renewable Energy, Sustainability and the Environment"},"field":{"id":"https://openalex.org/fields/21","display_name":"Energy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.1378999948501587,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.05869999900460243,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ferredoxin-nadp-reductase","display_name":"ferredoxin-NADP+ reductase","score":0.9539999961853027},{"id":"https://openalex.org/keywords/anabaena","display_name":"Anabaena","score":0.9359999895095825},{"id":"https://openalex.org/keywords/electron-transfer","display_name":"electron transfer","score":0.628000020980835},{"id":"https://openalex.org/keywords/ferredoxin","display_name":"ferredoxin","score":0.9760000109672546},{"id":"https://openalex.org/keywords/flavodoxin","display_name":"flavodoxin","score":1.0},{"id":"https://openalex.org/keywords/nadp-h","display_name":"NADP(H)","score":0.8970000147819519},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.7080000042915344},{"id":"https://openalex.org/keywords/enzyme-substrate-docking","display_name":"enzyme-substrate docking","score":0.7269999980926514},{"id":"https://openalex.org/keywords/charge-reversal","display_name":"charge reversal","score":0.4779999852180481},{"id":"https://openalex.org/keywords/protein-conformation","display_name":"protein conformation","score":0.4830000102519989}],"concepts":[{"id":"https://openalex.org/C134621786","wikidata":"https://www.wikidata.org/wiki/Q415215","display_name":"Ferredoxin","level":3,"score":0.953336238861084},{"id":"https://openalex.org/C2776961318","wikidata":"https://www.wikidata.org/wiki/Q307550","display_name":"Ferredoxin\u2014NADP(+) reductase","level":4,"score":0.9134560823440552},{"id":"https://openalex.org/C107563273","wikidata":"https://www.wikidata.org/wiki/Q95352045","display_name":"Flavodoxin","level":4,"score":0.898939847946167},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.6414874792098999},{"id":"https://openalex.org/C2777530773","wikidata":"https://www.wikidata.org/wiki/Q133353","display_name":"Anabaena","level":4,"score":0.6315659284591675},{"id":"https://openalex.org/C134651460","wikidata":"https://www.wikidata.org/wiki/Q3100717","display_name":"Reductase","level":3,"score":0.5520095825195312},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.5115357637405396},{"id":"https://openalex.org/C2779268744","wikidata":"https://www.wikidata.org/wiki/Q407479","display_name":"Oxidoreductase","level":3,"score":0.43615174293518066},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.41992995142936707},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.40197205543518066},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36403363943099976},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3442744314670563},{"id":"https://openalex.org/C2779669040","wikidata":"https://www.wikidata.org/wiki/Q93315","display_name":"Cyanobacteria","level":3,"score":0.06475061178207397},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001224","descriptor_name":"Aspartic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004579","descriptor_name":"Electron Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005287","descriptor_name":"Ferredoxin-NADP Reductase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005287","descriptor_name":"Ferredoxin-NADP Reductase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005287","descriptor_name":"Ferredoxin-NADP Reductase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D005418","descriptor_name":"Flavodoxin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009249","descriptor_name":"NADP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017033","descriptor_name":"Anabaena","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D017354","descriptor_name":"Point Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018698","descriptor_name":"Glutamic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1046/j.1432-1033.2002.03194.x","doi":"https://doi.org/10.1046/j.1432-1033.2002.03194.x","is_oa":false,"landing_page_url":"https://doi.org/10.1046/j.1432-1033.2002.03194.x","pdf_url":null,"source":{"id":"https://openalex.org/S4210214924","display_name":"European Journal of Biochemistry","issn_l":"0014-2956","issn":["0014-2956","0945-5795","1432-1033"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-100"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Biochemistry","raw_type":"journal-article"},{"id":"pmid:12383252","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12383252","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of biochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W656827624","https://openalex.org/W1277473924","https://openalex.org/W1422649125","https://openalex.org/W1505834253","https://openalex.org/W1514245212","https://openalex.org/W1857192229","https://openalex.org/W1903986304","https://openalex.org/W1976992577","https://openalex.org/W2001409372","https://openalex.org/W2001641653","https://openalex.org/W2003232395","https://openalex.org/W2006369456","https://openalex.org/W2013083986","https://openalex.org/W2015084282","https://openalex.org/W2016276202","https://openalex.org/W2028231353","https://openalex.org/W2039019077","https://openalex.org/W2052056054","https://openalex.org/W2054394193","https://openalex.org/W2055459602","https://openalex.org/W2067433926","https://openalex.org/W2079153495","https://openalex.org/W2080476827","https://openalex.org/W2080528351","https://openalex.org/W2082749740","https://openalex.org/W2085929985","https://openalex.org/W2086347059","https://openalex.org/W2090830593","https://openalex.org/W2092651356","https://openalex.org/W2095346321","https://openalex.org/W2109252569","https://openalex.org/W2115249998","https://openalex.org/W2131048602","https://openalex.org/W2148779396","https://openalex.org/W2167587785","https://openalex.org/W2168855632","https://openalex.org/W3086983054","https://openalex.org/W4236861131","https://openalex.org/W4247943239","https://openalex.org/W4300612080"],"related_works":["https://openalex.org/W2054394193","https://openalex.org/W2034601849","https://openalex.org/W2096078205","https://openalex.org/W1277473924","https://openalex.org/W2038780558","https://openalex.org/W2055459602","https://openalex.org/W2167587785","https://openalex.org/W2109252569","https://openalex.org/W2039019077","https://openalex.org/W2082276631"],"abstract_inverted_index":{"The":[0],"role":[1],"of":[2,6,10,37,43,69,82,88,106,129,150,170,177,241],"the":[3,7,46,49,67,77,80,83,92,97,107,127,130,134,138,151,157,171,195,208,217,232,239,249],"negative":[4,172,229],"charge":[5,173],"E139":[8,39,44,59,209],"side-chain":[9,111,210],"Anabaena":[11,89,178],"Ferredoxin-NADP+":[12],"reductase":[13],"(FNR)":[14],"in":[15,53,66,133,142,184,212,231,247],"steering":[16],"appropriate":[17],"docking":[18],"with":[19,48,96,122,153,160,188,198],"its":[20,185,258],"substrates":[21,52],"ferredoxin,":[22],"flavodoxin":[23,103],"and":[24,71,75,79,102,155,165,244,257],"NADP+/H,":[25,76],"that":[26,118],"leads":[27],"to":[28,63,162,193],"efficient":[29,253],"electron":[30],"transfer":[31],"(ET)":[32],"is":[33,205],"analysed":[34],"by":[35],"characterization":[36],"several":[38],"FNR":[40,51,74,90,179,214,256],"mutants.":[41],"Replacement":[42],"affects":[45],"interaction":[47,95,148],"different":[50,55,213],"very":[54],"ways.":[56],"Thus,":[57],"while":[58],"does":[60],"not":[61],"appear":[62],"be":[64],"involved":[65],"processes":[68,197],"binding":[70],"ET":[72,124,186,196,254],"between":[73,255],"nature":[78],"conformation":[81],"residue":[84],"at":[85,112,174],"position":[86,113,175],"139":[87,114,176],"modulates":[91],"precise":[93],"enzyme":[94,117,152],"protein":[98,259],"carriers":[99],"ferredoxin":[100],"(Fd)":[101],"(Fld).":[104],"Introduction":[105],"shorter":[108],"aspartic":[109],"acid":[110],"produces":[115,180],"an":[116],"interacts":[119],"more":[120,163],"weakly":[121],"both":[123,242],"proteins.":[125],"Moreover,":[126],"removal":[128,169],"charge,":[131],"as":[132,141],"E139Q":[135],"mutant,":[136],"or":[137],"charge-reversal":[139],"mutation,":[140],"E139K":[143,218],"FNR,":[144],"apparently":[145],"enhances":[146],"additional":[147],"modes":[149],"Fd,":[154],"reduces":[156],"possible":[158],"orientations":[159],"Fld":[161],"productive":[164],"stronger":[166],"ones.":[167],"Hence,":[168],"a":[181,201,223,228],"deleterious":[182],"effect":[183],"reactions":[187],"Fd":[189],"whereas":[190],"it":[191],"appears":[192],"enhance":[194],"Fld.":[199],"Significantly,":[200],"large":[202],"structural":[203],"variation":[204],"observed":[206],"for":[207,252],"conformer":[211],"structures,":[215],"including":[216],"mutant.":[219],"In":[220],"this":[221],"case,":[222],"positive":[224],"potential":[225],"region":[226],"replaces":[227],"one":[230],"wild-type":[233],"enzyme.":[234],"Our":[235],"observations":[236],"further":[237],"confirm":[238],"contribution":[240],"attractive":[243],"repulsive":[245],"interactions":[246],"achieving":[248],"optimal":[250],"orientation":[251],"carriers.":[260]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}