{"id":"https://openalex.org/W1539628985","doi":"https://doi.org/10.1158/1538-7445.am2014-4083","title":"Abstract 4083: Opposing roles of B cells in Ras-driven squamous tumor development dependent on tissue compartment of oncogene expression and tumor phenotype","display_name":"Abstract 4083: Opposing roles of B cells in Ras-driven squamous tumor development dependent on tissue compartment of oncogene expression and tumor phenotype","publication_year":2014,"publication_date":"2014-10-01","ids":{"openalex":"https://openalex.org/W1539628985","doi":"https://doi.org/10.1158/1538-7445.am2014-4083","mag":"1539628985"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2014-4083","doi":"https://doi.org/10.1158/1538-7445.am2014-4083","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2014-4083","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017723603","display_name":"Michael A. Podolsky","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael A. Podolsky","raw_affiliation_strings":["1The Pennsylvania State University, State College, PA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The Pennsylvania State University, State College, PA;","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073917451","display_name":"Andrew J. Gunderson","orcid":"https://orcid.org/0000-0002-6316-4067","observed_orcids":["https://orcid.org/0000-0002-6316-4067"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew Gunderson","raw_affiliation_strings":["2Oregon Health & Science University, Portland, OR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Oregon Health & Science University, Portland, OR","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079412588","display_name":"Kyle Breech","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kyle Breech","raw_affiliation_strings":["1The Pennsylvania State University, State College, PA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The Pennsylvania State University, State College, PA;","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076999950","display_name":"Adam B. Glick","orcid":"https://orcid.org/0000-0002-2675-9301","observed_orcids":["https://orcid.org/0000-0002-2675-9301"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adam B. Glick","raw_affiliation_strings":["1The Pennsylvania State University, State College, PA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The Pennsylvania State University, State College, PA;","institution_ids":["https://openalex.org/I130769515"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"74","issue":"19_Supplement","first_page":"4083","last_page":"4083"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9185000061988831,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9185000061988831,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.03220000118017197,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.013100000098347664,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/b-cells","display_name":"B cells","score":0.7940000295639038},{"id":"https://openalex.org/keywords/keratinocyte-differentiation","display_name":"keratinocyte differentiation","score":0.5789999961853027},{"id":"https://openalex.org/keywords/basal-stem-cells","display_name":"basal stem cells","score":0.515999972820282},{"id":"https://openalex.org/keywords/involucrin","display_name":"involucrin","score":0.7080000042915344},{"id":"https://openalex.org/keywords/rag1-deficiency","display_name":"RAG1 deficiency","score":0.47999998927116394},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.9129999876022339},{"id":"https://openalex.org/keywords/adoptive-t-cell-therapy","display_name":"adoptive T cell therapy","score":0.8080000281333923},{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":0.8069999814033508},{"id":"https://openalex.org/keywords/th1-treg-balance","display_name":"Th1/Treg balance","score":0.7059999704360962},{"id":"https://openalex.org/keywords/tumor-infiltrating-b-cells","display_name":"tumor-infiltrating B cells","score":0.8669999837875366},{"id":"https://openalex.org/keywords/tumor-infiltrating-neutrophils","display_name":"tumor-infiltrating neutrophils","score":0.781000018119812},{"id":"https://openalex.org/keywords/tumor-immunosuppression","display_name":"tumor immunosuppression","score":0.5860000252723694}],"concepts":[{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5880717635154724},{"id":"https://openalex.org/C90375314","wikidata":"https://www.wikidata.org/wiki/Q3537484","display_name":"Adoptive cell transfer","level":4,"score":0.5531026721000671},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5390718579292297},{"id":"https://openalex.org/C2778287671","wikidata":"https://www.wikidata.org/wiki/Q7852676","display_name":"Tumor initiation","level":4,"score":0.4140397310256958},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.4108966290950775},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.392879456281662},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.36462223529815674},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.35249385237693787},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3467860221862793},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.30587732791900635},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.22913002967834473},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.18106472492218018},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2014-4083","doi":"https://doi.org/10.1158/1538-7445.am2014-4083","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2014-4083","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2504452636","https://openalex.org/W4247888350","https://openalex.org/W2741288833","https://openalex.org/W2581529409","https://openalex.org/W2255205246","https://openalex.org/W1995434582","https://openalex.org/W611224","https://openalex.org/W1535472141","https://openalex.org/W4251143845","https://openalex.org/W4239595612"],"abstract_inverted_index":{"Abstract":[0],"Studies":[1],"in":[2,42,111,150,157,174,180,231,248,255,356,412],"mouse":[3,35],"models":[4],"and":[5,15,129,197,222,273,306,373,380,424],"human":[6],"cancers":[7],"show":[8,342],"that":[9,343,359,374],"B":[10,47,236,265,276,290,294,303,313,319,344,370,381,410],"cells":[11,48,57,145,167,209,266,277,281,291,295,314,345,379,382,411],"can":[12],"both":[13,158,351],"promote":[14],"inhibit":[16],"cancer":[17],"development,":[18],"but":[19,177,251],"the":[20,53,74,87,347,360,364,369,387,431,436],"mechanisms":[21],"generating":[22],"these":[23,340],"alternate":[24],"outcomes":[25],"are":[26,49,346],"not":[27],"well":[28],"understood.":[29],"Here":[30],"we":[31,118],"have":[32],"developed":[33],"a":[34,63,115,190,216,229,242,286,390],"model":[36],"of":[37,46,56,86,108,142,163,245,261,275,302,363,389,409,421,430,435],"Ras-driven":[38,413],"epidermal":[39],"tumor":[40,121,151,172,246,253,271,283,352,365,415,425],"development":[41,284,388,416],"which":[43,225],"opposite":[44,120],"effects":[45],"manifest,":[50],"dependent":[51,417],"on":[52,105,418],"differentiation":[54,361],"state":[55,362],"expressing":[58],"oncogenic":[59,70],"Ras.":[60],"We":[61],"used":[62],"doxycycline":[64,109],"regulatable":[65],"bitransgenic":[66],"system":[67],"to":[68,72,154,202,212,285,312,327,330],"target":[69],"H-RasV12G":[71],"either":[73],"basal/stem":[75],"cell":[76,94,237,320,367,371],"(Keratin14-rTAxtetORasV12G,":[77],"K14Ras)":[78],"or":[79,354],"differentiating":[80],"(Involucrin-tTA":[81],"x":[82],"tetORasV12G,":[83],"InvRas)":[84],"compartment":[85,420],"epidermis.":[88],"K14Ras":[89,256],"mice":[90,98,125,131,188,214,250,269,298,332],"develop":[91,99],"focal":[92],"squamous":[93,100,414],"carcinoma":[95],"while":[96,160],"InvRas":[97,249],"papillomas":[101],"within":[102],"30":[103],"days":[104],"threshold":[106],"levels":[107,328],"resulting":[110],"\u223c10":[112],"tumors/mouse.":[113],"On":[114],"Rag1-/-":[116],"background":[117],"observed":[119],"responses,":[122],"with":[123,135,194,219,228,239,278],"InvRasRag1-/-":[124,181,213],"developing":[126,132],"fewer":[127],"tumors":[128,134,179],"K14RasRag1-/-":[130,175,187,268],"more":[133],"shorter":[136],"latency":[137],"than":[138,289],"Rag1+/+":[139],"controls.":[140,205,318],"Depletion":[141],"CD4+":[143,165,207,279,377],"T":[144,166,208,280,378],"caused":[146,241],"an":[147],"overall":[148],"increase":[149],"burden":[152,173,254],"compared":[153,201,311],"isotype":[155],"controls":[156],"models,":[159],"adoptive":[161,259],"transfer":[162,260],"na\u00efve":[164],"(purity":[168],"\u2265":[169],"93%)":[170],"increased":[171,198,307,323],"mice,":[176],"suppressed":[178,270],"mice.":[182,257],"Tumors":[183],"from":[184,296],"CD4":[185],"transferred":[186,204,211],"had":[189,299],"predominant":[191],"Th1":[192],"infiltrate":[193],"few":[195],"Tregs":[196],"tumor-infiltrating":[199],"neutrophils":[200],"mock":[203],"Conversely,":[206],"adoptively":[210],"displayed":[215],"regulatory":[217,304],"phenotype":[218],"low":[220],"IFN\u03b3":[221],"high":[223],"Foxp3,":[224],"was":[226],"associated":[227],"decrease":[230],"neutrophilic":[232],"infiltration.":[233],"In":[234],"contrast,":[235],"depletion":[238],"anti-CD20":[240],"significant":[243],"suppression":[244,353],"outgrowth":[247],"enhanced":[252],"Furthermore,":[258],"magnetically":[262],"purified":[263],"splenic":[264],"into":[267],"formation,":[272],"co-transfer":[274,321],"reduced":[282],"greater":[287,300],"extent":[288],"alone.":[292],"Tumor-infiltrating":[293],"co-transferred":[297],"percentage":[301,326],"cells,":[305],"costimulatory":[308],"molecule":[309],"expression":[310,423],"alone,":[315],"resembling":[316],"K14RasRag1+/+":[317,331],"significantly":[322],"Foxp3+":[324],"Treg":[325],"similar":[329],"as":[333],"measured":[334],"by":[335],"flow":[336],"cytometry.":[337],"Taken":[338],"together":[339],"results":[341],"critical":[348],"lymphocyte":[349],"driving":[350],"promotion":[355],"this":[357],"model,":[358],"initiating":[366],"determines":[368],"response,":[372],"interactions":[375],"between":[376],"may":[383],"be":[384],"important":[385],"for":[386,439],"proper":[391],"anti-tumor":[392],"immune":[393],"response.":[394],"Citation":[395],"Format:":[396],"Michael":[397],"A.":[398],"Podolsky,":[399],"Andrew":[400],"Gunderson,":[401],"Kyle":[402],"Breech,":[403],"Adam":[404],"B.":[405],"Glick.":[406],"Opposing":[407],"roles":[408],"tissue":[419],"oncogene":[422],"phenotype.":[426],"[abstract].":[427],"In:":[428],"Proceedings":[429],"105th":[432],"Annual":[433],"Meeting":[434],"American":[437],"Association":[438],"Cancer":[440,451],"Research;":[441],"2014":[442],"Apr":[443],"5-9;":[444],"San":[445],"Diego,":[446],"CA.":[447],"Philadelphia":[448],"(PA):":[449],"AACR;":[450],"Res":[452],"2014;74(19":[453],"Suppl):Abstract":[454],"nr":[455],"4083.":[456],"doi:10.1158/1538-7445.AM2014-4083":[457]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}