{"id":"https://openalex.org/W1539284","doi":null,"title":"Understanding the age dependency of breast cancer biomarkers.","display_name":"Understanding the age dependency of breast cancer biomarkers.","publication_year":2003,"publication_date":"2003-01-01","ids":{"openalex":"https://openalex.org/W1539284","mag":"1539284","pmid":"https://pubmed.ncbi.nlm.nih.gov/12820531"},"language":"en","primary_location":{"id":"pmid:12820531","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12820531","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in gerontology = Uspekhi gerontologii","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109115781","display_name":"Chris C. Benz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1337826666","display_name":"Buck Institute for Research on Aging","ror":"https://ror.org/050sv4x28","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1337826666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C C Benz","raw_affiliation_strings":["Buck Institute for Age Research, 8001 Redwood Blvd., Novato, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Buck Institute for Age Research, 8001 Redwood Blvd., Novato, CA, USA","institution_ids":["https://openalex.org/I1337826666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013400628","display_name":"Ann D. Thor","orcid":"https://orcid.org/0000-0001-7725-1869","observed_orcids":["https://orcid.org/0000-0001-7725-1869"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A D Thor","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031592069","display_name":"Serenella Eppenberger\u2010Castori","orcid":"https://orcid.org/0000-0003-2194-2913","observed_orcids":["https://orcid.org/0000-0003-2194-2913"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Eppenberger-Castori","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071113287","display_name":"Urs Eppenberger","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"U Eppenberger","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5059617881","display_name":"Dan H. Moore","orcid":"https://orcid.org/0000-0002-5860-0127","observed_orcids":["https://orcid.org/0000-0002-5860-0127"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D Moore","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.124,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.45433071,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"11","issue":null,"first_page":"117","last_page":"20"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.9506999850273132,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.9506999850273132,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11134","display_name":"Breast Lesions and Carcinomas","score":0.02250000089406967,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12103","display_name":"Cancer Risks and Factors","score":0.006300000008195639,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9789999723434448},{"id":"https://openalex.org/keywords/patient-age","display_name":"patient age","score":0.7170000076293945},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.75},{"id":"https://openalex.org/keywords/tumor-markers","display_name":"tumor markers","score":0.7009999752044678},{"id":"https://openalex.org/keywords/genomic-instability","display_name":"genomic instability","score":0.9559999704360962},{"id":"https://openalex.org/keywords/tumor-invasion","display_name":"tumor invasion","score":0.8489999771118164},{"id":"https://openalex.org/keywords/metastatic-potential","display_name":"metastatic potential","score":0.9629999995231628},{"id":"https://openalex.org/keywords/tumor-growth","display_name":"tumor growth","score":0.9700000286102295}],"concepts":[{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.8713994026184082},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5543721914291382},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5431728363037109},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4706118702888489},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4661266803741455},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.4139120280742645},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3415106534957886},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2647203803062439},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:12820531","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12820531","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in gerontology = Uspekhi gerontologii","raw_type":"Journal Article"},{"id":"mag:1539284","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12820531","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G7626107934","display_name":"Mass spectrometry to decode PTM patterns and enhance the Biomarker utility of ER","funder_award_id":"R01CA071468","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2168953808","https://openalex.org/W2331799855","https://openalex.org/W2033425796","https://openalex.org/W4367367363","https://openalex.org/W3137581816","https://openalex.org/W2894551052","https://openalex.org/W4416273781","https://openalex.org/W2891752881","https://openalex.org/W3177010564","https://openalex.org/W2613668881"],"abstract_inverted_index":{"This":[0],"review":[1],"and":[2,39,43,56],"study":[3],"of":[4,36,70],"nearly":[5],"4,000":[6],"primary":[7],"breast":[8,19,25,52],"cancers":[9],"evaluates":[10],"the":[11,49,71],"hypothesis":[12],"that":[13,51],"human":[14],"aging":[15],"not":[16],"only":[17],"increases":[18],"cancer":[20,26,53],"incidence":[21],"but":[22,64],"also":[23],"alters":[24],"biology.":[27],"Clinically":[28],"validated":[29],"biomarkers":[30],"were":[31],"chosen":[32],"as":[33],"surrogate":[34],"measures":[35],"genetic":[37],"instability":[38],"tumor":[40],"growth,":[41],"invasiveness":[42],"metastatic":[44],"potential.":[45],"Our":[46],"results":[47],"support":[48],"premise":[50],"clinical":[54],"behavior":[55],"biology":[57],"are":[58],"significantly":[59],"affected":[60],"by":[61],"patient":[62],"age,":[63],"call":[65],"into":[66],"question":[67],"key":[68],"aspects":[69],"current":[72],"cancer-aging":[73],"paradigm.":[74]},"counts_by_year":[{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
