{"id":"https://openalex.org/W1538913089","doi":null,"title":"Modulation of IKK\u03b2/NF-\u03baB and TGF-\u03b21/Smad via Fuzheng Huayu recipe involves in prevention of nutritional steatohepatitis and fibrosis in mice.","display_name":"Modulation of IKK\u03b2/NF-\u03baB and TGF-\u03b21/Smad via Fuzheng Huayu recipe involves in prevention of nutritional steatohepatitis and fibrosis in mice.","publication_year":2015,"publication_date":"2015-04-01","ids":{"openalex":"https://openalex.org/W1538913089","mag":"1538913089","pmid":"https://pubmed.ncbi.nlm.nih.gov/26019805","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4439457"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4439457","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4439457/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4439457/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Iran J Basic Med Sci","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4439457/pdf/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102815610","display_name":"Rongqi Wang","orcid":"https://orcid.org/0000-0002-1824-3751","observed_orcids":["https://orcid.org/0000-0002-1824-3751","https://orcid.org/0000-0002-2563-3352"]},"institutions":[{"id":"https://openalex.org/I4210088328","display_name":"Third Hospital of Hebei Medical University","ror":"https://ror.org/004eknx63","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210088328"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Rong-Qi Wang","raw_affiliation_strings":["Department of Traditional and Western Medical Hepatology, Third Hospital of Hebei Medical University, Shijiazhuang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Traditional and Western Medical Hepatology, Third Hospital of Hebei Medical University, Shijiazhuang, China","institution_ids":["https://openalex.org/I4210088328"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078689173","display_name":"Hong-mei Mi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210088328","display_name":"Third Hospital of Hebei Medical University","ror":"https://ror.org/004eknx63","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210088328"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hong-Mei Mi","raw_affiliation_strings":["Department of Traditional and Western Medical Hepatology, Third Hospital of Hebei Medical University, Shijiazhuang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Traditional and Western Medical Hepatology, Third Hospital of Hebei Medical University, Shijiazhuang, China","institution_ids":["https://openalex.org/I4210088328"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100680794","display_name":"Hui Li","orcid":"https://orcid.org/0000-0003-4745-4838","observed_orcids":["https://orcid.org/0000-0003-4745-4838","https://orcid.org/0009-0000-8127-7340"]},"institutions":[{"id":"https://openalex.org/I4210088328","display_name":"Third Hospital of Hebei Medical University","ror":"https://ror.org/004eknx63","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210088328"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hui Li","raw_affiliation_strings":["Department of Traditional and Western Medical Hepatology, Third Hospital of Hebei Medical University, Shijiazhuang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Traditional and Western Medical Hepatology, Third Hospital of Hebei Medical University, Shijiazhuang, China","institution_ids":["https://openalex.org/I4210088328"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109862044","display_name":"Su-Xian Zhao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210088328","display_name":"Third Hospital of Hebei Medical University","ror":"https://ror.org/004eknx63","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210088328"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Su-Xian Zhao","raw_affiliation_strings":["Department of Traditional and Western Medical Hepatology, Third Hospital of Hebei Medical University, Shijiazhuang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Traditional and Western Medical Hepatology, Third Hospital of Hebei Medical University, Shijiazhuang, China","institution_ids":["https://openalex.org/I4210088328"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110149899","display_name":"Yan-hong JIA","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210088328","display_name":"Third Hospital of Hebei Medical University","ror":"https://ror.org/004eknx63","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210088328"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yan-Hong Jia","raw_affiliation_strings":["Department of Traditional and Western Medical Hepatology, Third Hospital of Hebei Medical University, Shijiazhuang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Traditional and Western Medical Hepatology, Third Hospital of Hebei Medical University, Shijiazhuang, China","institution_ids":["https://openalex.org/I4210088328"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090903647","display_name":"Yuemin Nan","orcid":"https://orcid.org/0000-0003-4192-099X","observed_orcids":["https://orcid.org/0000-0003-4192-099X"]},"institutions":[{"id":"https://openalex.org/I4210088328","display_name":"Third Hospital of Hebei Medical University","ror":"https://ror.org/004eknx63","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210088328"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yue-Min Nan","raw_affiliation_strings":["Department of Traditional and Western Medical Hepatology, Third Hospital of Hebei Medical University, Shijiazhuang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Traditional and Western Medical Hepatology, Third Hospital of Hebei Medical University, Shijiazhuang, China","institution_ids":["https://openalex.org/I4210088328"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210088328"],"apc_list":null,"apc_paid":null,"fwci":1.0173,"has_fulltext":true,"cited_by_count":20,"citation_normalized_percentile":{"value":0.75212252,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"18","issue":"4","first_page":"404","last_page":"11"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.8525000214576721,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.8525000214576721,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.13379999995231628,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/liver-fibrosis","display_name":"liver fibrosis","score":0.9879999756813049},{"id":"https://openalex.org/keywords/tgf-beta1-smad-signaling-pathway","display_name":"TGF-\u03b21/Smad signaling","score":0.9959999918937683},{"id":"https://openalex.org/keywords/heme-oxygenase-1","display_name":"heme oxygenase-1","score":0.9169999957084656},{"id":"https://openalex.org/keywords/hemin","display_name":"hemin","score":0.8989999890327454},{"id":"https://openalex.org/keywords/methionine-and-choline-deficient-diet","display_name":"methionine-choline-deficient diet","score":0.9049999713897705},{"id":"https://openalex.org/keywords/hepatic-stellate-cells","display_name":"hepatic stellate cells","score":0.9620000123977661},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9779999852180481},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.6940000057220459},{"id":"https://openalex.org/keywords/smad7","display_name":"Smad7","score":0.9269999861717224},{"id":"https://openalex.org/keywords/traditional-chinese-medicine","display_name":"traditional Chinese medicine","score":0.7490000128746033}],"concepts":[{"id":"https://openalex.org/C2779478299","wikidata":"https://www.wikidata.org/wiki/Q2335423","display_name":"Steatohepatitis","level":4,"score":0.711054801940918},{"id":"https://openalex.org/C2781080636","wikidata":"https://www.wikidata.org/wiki/Q700000","display_name":"SMAD","level":3,"score":0.5555863976478577},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.5155272483825684},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.5084940195083618},{"id":"https://openalex.org/C2777723881","wikidata":"https://www.wikidata.org/wiki/Q107315604","display_name":"Hemin","level":4,"score":0.49635225534439087},{"id":"https://openalex.org/C2993667909","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Hepatic fibrosis","level":3,"score":0.4954153299331665},{"id":"https://openalex.org/C100175707","wikidata":"https://www.wikidata.org/wiki/Q6103519","display_name":"I\u03baB kinase","level":4,"score":0.49122852087020874},{"id":"https://openalex.org/C176891718","wikidata":"https://www.wikidata.org/wiki/Q1997459","display_name":"Hepatic stellate cell","level":2,"score":0.46591711044311523},{"id":"https://openalex.org/C118131993","wikidata":"https://www.wikidata.org/wiki/Q423671","display_name":"Transforming growth factor","level":2,"score":0.45288941264152527},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.44344109296798706},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4124809503555298},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3609183132648468},{"id":"https://openalex.org/C2777730290","wikidata":"https://www.wikidata.org/wiki/Q411114","display_name":"NF-\u03baB","level":3,"score":0.3535236716270447},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.336406409740448},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3340582251548767},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3250831365585327},{"id":"https://openalex.org/C2778772119","wikidata":"https://www.wikidata.org/wiki/Q6058862","display_name":"Fatty liver","level":3,"score":0.32149165868759155},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3023586869239807},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15159937739372253},{"id":"https://openalex.org/C2776217839","wikidata":"https://www.wikidata.org/wiki/Q189621","display_name":"Heme","level":3,"score":0.09024569392204285},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:4439457","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4439457/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4439457/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Iran J Basic Med Sci","raw_type":"Text"},{"id":"pmh:oai:europepmc.org:3407247","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4439457","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:26019805","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26019805","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Iranian journal of basic medical sciences","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:b44eefefd0bf4799b03a53e16cd4525d","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/b44eefefd0bf4799b03a53e16cd4525d","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Iranian Journal of Basic Medical Sciences, Vol 18, Iss 4, Pp 404-411 (2015)","raw_type":"article"},{"id":"mag:1538913089","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26019805","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4439457","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4439457/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4439457/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Iran J Basic Med Sci","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1538913089.pdf","grobid_xml":"https://content.openalex.org/works/W1538913089.grobid-xml"},"referenced_works_count":37,"referenced_works":["https://openalex.org/W1544316290","https://openalex.org/W1605509766","https://openalex.org/W1964026988","https://openalex.org/W1976777085","https://openalex.org/W1977168314","https://openalex.org/W1979062185","https://openalex.org/W1982998620","https://openalex.org/W1991047372","https://openalex.org/W1991971843","https://openalex.org/W1992728833","https://openalex.org/W1995466366","https://openalex.org/W1996829989","https://openalex.org/W1999799383","https://openalex.org/W2005876023","https://openalex.org/W2008368975","https://openalex.org/W2009135929","https://openalex.org/W2010145160","https://openalex.org/W2011826749","https://openalex.org/W2025780125","https://openalex.org/W2029020203","https://openalex.org/W2031866941","https://openalex.org/W2047026952","https://openalex.org/W2056853575","https://openalex.org/W2056908987","https://openalex.org/W2060388798","https://openalex.org/W2078690570","https://openalex.org/W2079440346","https://openalex.org/W2082319898","https://openalex.org/W2084310268","https://openalex.org/W2095597850","https://openalex.org/W2113918081","https://openalex.org/W2120362599","https://openalex.org/W2129589468","https://openalex.org/W2155849004","https://openalex.org/W2158852128","https://openalex.org/W2161310336","https://openalex.org/W2164906049"],"related_works":["https://openalex.org/W2113918081","https://openalex.org/W2316537586","https://openalex.org/W2383292639","https://openalex.org/W2355592640","https://openalex.org/W2069422459","https://openalex.org/W2160717378","https://openalex.org/W7160939628","https://openalex.org/W2203021851","https://openalex.org/W2368311291","https://openalex.org/W3197534294"],"abstract_inverted_index":{"OBJECTIVES:":[0],"Fuzheng":[1],"Huayu":[2],"recipe":[3],"(FZHY)":[4],"exerts":[5],"significant":[6],"protective":[7],"effects":[8,106],"against":[9],"liver":[10,29,152],"fibrosis":[11,30,71,208],"by":[12,117],"strengthening":[13],"the":[14,22,39,46,119,131,168,192,195,211,217],"body's":[15],"resistance":[16],"and":[17,53,70,110,130,137,146,172,188,190,207,219,223],"removing":[18],"blood":[19],"stasis.":[20],"However,":[21],"molecular":[23],"mechanisms":[24],"through":[25,209],"which":[26],"FZHY":[27,65,93,108,147],"affects":[28],"are":[31],"still":[32],"unclear.":[33],"In":[34],"this":[35],"study,":[36],"we":[37],"examined":[38],"expression":[40,132,169,193,212],"levels":[41],"of":[42,107,121,125,133,143,160,170,194,213],"factors":[43,214],"involved":[44],"in":[45,72,111],"inhibitor":[47],"\u03baB":[48],"kinase-\u03b2":[49],"(IKK-\u03b2)/nuclear":[50],"factor-\u03baB":[51],"(NF-\u03baB)":[52],"transforming":[54],"growth":[55],"factor":[56],"beta":[57],"1":[58],"(TGF-\u03b21)/Smad":[59],"signaling":[60,221],"pathways":[61,222],"to":[62,89,103],"elucidate":[63],"whether":[64],"could":[66],"attenuate":[67],"nutritional":[68,205],"steatohepatitis":[69,206],"mice.":[73,104],"MATERIALS":[74],"AND":[75],"METHODS:":[76],"C57BL/6J":[77],"mice":[78],"were":[79,101,115],"fed":[80],"with":[81,113,216],"methionine-choline":[82],"deficient":[83],"(MCD)":[84],"diet":[85],"for":[86],"8":[87],"weeks":[88],"induce":[90],"fibrotic":[91],"steatohepatitis.":[92],"and/or":[94],"heme":[95],"oxygenase-1":[96],"(HO-1)":[97],"chemical":[98],"inducer":[99],"(hemin)":[100],"administered":[102],"The":[105],"alone":[109],"combination":[112],"hemin":[114,145,149],"assessed":[116],"comparing":[118],"severity":[120],"hepatic":[122,126],"injury,":[123],"activation":[124],"stellate":[127],"cells":[128],"(HSCs),":[129],"oxidative":[134,165,224],"stress,":[135,166],"inflammation":[136],"fibrogenesis":[138],"related":[139,226],"genes.":[140,227],"RESULTS:":[141],"Administration":[142],"FZHY,":[144],"plus":[148],"significantly":[150,163],"ameliorated":[151],"injury.":[153],"Additionally,":[154],"our":[155],"analysis":[156],"indicated":[157],"that":[158],"administration":[159],"these":[161],"agents":[162],"attenuated":[164],"downregulated":[167],"pro-inflammatory":[171],"pro-fibrotic":[173],"genes,":[174],"including":[175],"IKK-\u03b2,":[176],"NF-\u03baB,":[177],"monocyte":[178],"chemoattractant":[179],"protein-1":[180],"(MCP-1),":[181],"\u03b1-smooth":[182],"muscle":[183],"actin":[184],"(\u03b1-SMA),":[185],"TGF-\u03b21,":[186],"Smad3":[187],"Smad4,":[189],"upregulated":[191],"antifibrogenic":[196],"gene":[197],"Smad7":[198],"(P<":[199],"0.001).":[200],"CONCLUSION:":[201],"FZHY-containing":[202],"therapies":[203],"prevented":[204],"modulating":[210],"associated":[215],"IKK\u03b2/NF-\u03baB":[218],"TGF-\u03b21/Smad":[220],"stress":[225]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2016-06-24T00:00:00"}
