{"id":"https://openalex.org/W15388408","doi":null,"title":"Iron uptake and homeostasis in microorganisms","display_name":"Iron uptake and homeostasis in microorganisms","publication_year":2010,"publication_date":"2010-06-01","ids":{"openalex":"https://openalex.org/W15388408","mag":"15388408"},"language":"en","primary_location":{"id":"pmh:oai:centaur.reading.ac.uk:7728","doi":null,"is_oa":false,"landing_page_url":"https://centaur.reading.ac.uk/7728/","pdf_url":null,"source":{"id":"https://openalex.org/S4306402273","display_name":"CentAUR (University of Reading)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I71052956","host_organization_name":"University of Reading","host_organization_lineage":["https://openalex.org/I71052956"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Book"},"volume":null,"type":"book","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048740360","display_name":"Pierre Corn\u00e9lis","orcid":"https://orcid.org/0000-0002-3179-4654","observed_orcids":["https://orcid.org/0000-0002-3179-4654"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pierre Corn\u00e9lis","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3179-4654","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5023667918","display_name":"Simon Colin Andrews","orcid":"https://orcid.org/0000-0003-4295-2686","observed_orcids":["https://orcid.org/0000-0003-4295-2686"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Simon C. Andrews","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4295-2686","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":16.8861,"has_fulltext":false,"cited_by_count":121,"citation_normalized_percentile":{"value":0.99130435,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":0.39160001277923584,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":0.39160001277923584,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.2619999945163727,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11626","display_name":"Metalloenzymes and iron-sulfur proteins","score":0.09610000252723694,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/iron-absorption","display_name":"iron absorption","score":0.9160000085830688},{"id":"https://openalex.org/keywords/iron-homeostasis","display_name":"iron homeostasis","score":0.9950000047683716},{"id":"https://openalex.org/keywords/iron-acquisition","display_name":"iron acquisition","score":0.43299999833106995},{"id":"https://openalex.org/keywords/siderophores","display_name":"siderophores","score":0.847000002861023},{"id":"https://openalex.org/keywords/iron-limitation","display_name":"iron limitation","score":0.3370000123977661},{"id":"https://openalex.org/keywords/iron-dependent-enzymes","display_name":"iron-dependent enzymes","score":0.3319999873638153},{"id":"https://openalex.org/keywords/iron-cofactor","display_name":"iron cofactor","score":0.47600001096725464},{"id":"https://openalex.org/keywords/magnetotactic-bacteria","display_name":"magnetotactic bacteria","score":0.7770000100135803},{"id":"https://openalex.org/keywords/banded-iron-formations","display_name":"banded iron formations","score":0.8569999933242798},{"id":"https://openalex.org/keywords/great-oxidation-event","display_name":"Great Oxidation Event","score":0.7829999923706055}],"concepts":[{"id":"https://openalex.org/C2911035656","wikidata":"https://www.wikidata.org/wiki/Q5925744","display_name":"Iron homeostasis","level":3,"score":0.8008122444152832},{"id":"https://openalex.org/C175605896","wikidata":"https://www.wikidata.org/wiki/Q39833","display_name":"Microorganism","level":3,"score":0.6877553462982178},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.5868486762046814},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.42348480224609375},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.3468467593193054},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3444451689720154},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2700260281562805},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.21189308166503906},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.19232520461082458},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.17852836847305298},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0802677571773529}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:centaur.reading.ac.uk:7728","doi":null,"is_oa":false,"landing_page_url":"https://centaur.reading.ac.uk/7728/","pdf_url":null,"source":{"id":"https://openalex.org/S4306402273","display_name":"CentAUR (University of Reading)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I71052956","host_organization_name":"University of Reading","host_organization_lineage":["https://openalex.org/I71052956"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Book"},{"id":"pmh:oai:aleph.bib-bvb.de:BVB01-020533999","doi":null,"is_oa":false,"landing_page_url":"https://bvbr.bib-bvb.de:443/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=020533999&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},{"id":"mag:15388408","doi":null,"is_oa":false,"landing_page_url":"https://www.caister.com/hsp/pdf/flyer/iron.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S4306466997","display_name":"Caister Academic eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"ebook platform"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Caister Academic eBooks","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2038572183","https://openalex.org/W4252153794","https://openalex.org/W14400392","https://openalex.org/W7095369411","https://openalex.org/W2584489872","https://openalex.org/W7029504884","https://openalex.org/W7171450188","https://openalex.org/W4200396174","https://openalex.org/W1968155650","https://openalex.org/W134081711"],"abstract_inverted_index":{"Preface.":[0],"\\n":[1,1102,1109],"\\nIron":[2],"is":[3,25,65,121,150,209,225,349,391,603,632,659,671,686,721,736,797,827,853,865,1061,1083],"considered":[4,226,350],"to":[5,67,155,181,227,275,287,337,343,379,404,420,423,443,450,507,604,639,696,772,814,891],"be":[6,130,418,441,650,697,785],"a":[7,12,46,71,96,187,306,310,326,339,371,430,570,594,618,633,662,748,762,809,946,1006,1037],"minor":[8],"element":[9],"employed,":[10],"in":[11,27,58,125,132,157,161,183,296,432,497,554,564,574,617,645,717,787,970,1009],"variety":[13],"of":[14,35,43,63,80,84,135,138,145,153,174,190,204,212,332,356,363,413,479,487,529,533,542,549,560,581,590,609,668,676,682,703,725,733,741,759,782,794,804,811,818,832,845,850,878,910,914,921,930,948,978,994,1002,1005],"forms,":[15],"by":[16,51,393,688,738,889],"nearly":[17],"all":[18,460,636],"living":[19],"organisms.":[20],"In":[21,448],"some":[22,251,383],"cases,":[23],"it":[24,120,199,348,428,896,1034,1060,1095],"utilised":[26],"large":[28],"quantities,":[29],"for":[30,32,142,382,389,396,552,627,790,923,1039,1051],"instance":[31],"the":[33,61,77,107,133,139,143,151,163,195,213,218,249,258,263,289,301,315,330,344,353,360,394,433,464,470,477,485,526,530,540,543,547,555,579,588,598,613,642,656,665,677,700,713,723,739,788,799,830,842,856,875,886,952,967,976,1000,1003,1010,1021,1069,1075,1092],"formation":[34],"magnetosomes":[36],"within":[37,217,248,265,612,747,808,867,1018,1056],"magnetotactic":[38],"bacteria":[39,890],"or":[40,49,54,73,756,761],"during":[41],"use":[42,69,977,993],"iron":[44,52,64,94,154,180,264,291,333,366,390,409,416,462,475,481,509,515,561,583,611,670,706,719,727,743,760,774,783,805,821,852,863,899,972,997],"as":[45,70,95,241,257,518,883,897,943,945,992],"respiratory":[47],"donor":[48],"acceptor":[50],"oxidising":[53],"reducing":[55],"bacteria.":[56],"However,":[57,240,502,692],"most":[59,214,714],"cases":[60],"role":[62,559],"restricted":[66],"its":[68,126,271,276],"cofactor":[72,97],"prosthetic":[74],"group":[75],"assisting":[76],"biological":[78],"activity":[79],"many":[81,989,1070],"different":[82,654,705,753,763,995],"types":[83,909,996],"protein.":[85],"The":[86,172,731,869,901,964],"key":[87,915],"metabolic":[88,628],"processes":[89,483,807],"that":[90,123,341,352,373,439,512,596,620,635,840,912,1015,1033,1041,1063,1094],"are":[91,98,504,615,823,913],"dependent":[92],"on":[93,194,235,375,835,907],"numerous;":[99],"they":[100],"include":[101],"respiration,":[102],"light":[103],"harvesting,":[104],"nitrogen":[105],"fixation,":[106],"Krebs":[108],"cycle,":[109],"redox":[110,159,184,757],"stress":[111],"resistance,":[112],"amino":[113],"acid":[114],"synthesis":[115],"and":[116,168,223,256,422,454,489,521,523,680,685,813,861,885,894,926,939,941,962,982,999,1019,1029,1046,1066,1091,1106],"oxygen":[117,242],"transport.":[118],"Indeed,":[119],"clear":[122],"Life":[124,146,233,374],"current":[127,843],"form":[128,274,288],"would":[129,1097],"impossible":[131],"absence":[134],"iron.":[136],"One":[137,600],"main":[140],"reasons":[141],"reliance":[144,412],"upon":[147,415],"this":[148,397,492,631,647,734,795,1025,1057,1081,1089],"metal":[149,398],"ability":[152],"exist":[156],"multiple":[158],"states,":[160],"particular":[162],"relatively":[164],"stable":[165,176],"ferrous":[166],"(Fe2+)":[167],"ferric":[169,279],"(Fe3+)":[170],"forms.":[171],"availability":[173],"these":[175,704],"oxidation":[177,246],"states":[178],"allows":[179],"engage":[182],"reactions":[185],"over":[186,328],"wide":[188],"range":[189,810],"midpoint":[191],"potentials,":[192],"depending":[193],"coordination":[196],"environment,":[197],"making":[198],"an":[200,437,494,802,816,898,919,1048],"extremely":[201],"adaptable":[202],"mediator":[203],"electron":[205],"exchange":[206],"processes.":[207,585,708],"Iron":[208],"also":[210,324,987],"one":[211],"common":[215,361,968],"elements":[216],"Earth\u2019s":[219],"crust":[220],"(5%":[221],"abundance)":[222],"thus":[224,524],"have":[228,638,1073,1099],"been":[229,569,1100],"readily":[230],"available":[231,474,683],"when":[232],"evolved":[234],"our":[236,424,498,848],"early,":[237],"anaerobic":[238,317],"planet.":[239],"accumulated":[243],"(the":[244],"\u2018Great":[245],"event\u2019)":[247],"atmosphere":[250],"2.4":[252],"billion":[253,284,385],"years":[254,285],"ago,":[255],"oceans":[259,267],"became":[260],"less":[261],"acidic,":[262],"primordial":[266],"was":[268],"converted":[269],"from":[270,314,335,367,463,728,775,1079],"soluble":[272],"reduced":[273],"weakly-soluble":[277],"oxidised":[278],"form,":[280],"which":[281,329,1080],"precipitated":[282],"(~1.8":[283],"ago)":[286],"\u2018banded":[290],"formations\u2019":[292],"(BIFs)":[293],"observed":[294],"today":[295],"Precambrian":[297],"sedimentary":[298],"rocks":[299],"around":[300],"world.":[302],"These":[303],"BIFs":[304],"provide":[305,798,815,1036,1047],"geological":[307],"record":[308],"marking":[309],"transition":[311],"point":[312,1050],"away":[313],"ancient":[316],"world":[318],"towards":[319],"modern":[320,345],"aerobic":[321],"Earth.":[322],"They":[323],"indicate":[325],"period":[327],"bio-availability":[331],"shifted":[334],"abundance":[336],"limitation,":[338],"condition":[340],"extends":[342],"day.":[346],"Thus,":[347,766],"likely":[351],"vast":[354],"majority":[355],"extant":[357],"organisms":[358,637],"face":[359],"problem":[362,372,735],"securing":[364,773],"sufficient":[365,625,726],"their":[368,461,776,1054,1086],"environment":[369],"\u2013":[370,491,630],"Earth":[376],"has":[377,568],"had":[378],"cope":[380],"with":[381,801],"2":[384],"years.":[386],"This":[387,825],"struggle":[388],"exemplified":[392],"competition":[395,789],"amongst":[399,653],"co-habiting":[400],"microorganisms":[401,812],"who":[402,1072],"resort":[403],"stealing":[405],"(pirating)":[406],"each":[407,751],"others":[408],"supplies!":[410],"\\nThe":[411,558,792],"micro-organisms":[414],"can":[417,440,649,784],"disadvantageous":[419],"them,":[421],"innate":[425],"immune":[426],"system":[427],"represents":[429,493],"chink":[431],"microbial":[434,566,582,820,879,971],"armour,":[435],"offering":[436],"opportunity":[438],"exploited":[442],"ward":[444],"off":[445],"pathogenic":[446],"invaders.":[447],"order":[449],"infect":[451],"body":[452],"tissues":[453],"cause":[455],"disease,":[456],"pathogens":[457,503,922],"must":[458],"secure":[459],"host.":[465,531],"To":[466],"fight":[467],"such":[468,517,534,591,601],"infections,":[469],"host":[471,514],"specifically":[472],"withdraws":[473],"through":[476,673,829],"action":[478],"various":[480],"depleting":[482],"(e.g.":[484,928,951,975],"release":[486],"lactoferrin":[488,520],"lipocalin-2)":[490],"important":[495,1062],"strategy":[496,658],"defence":[499],"against":[500],"disease.":[501],"frequently":[505],"able":[506],"deploy":[508],"acquisition":[510,781],"systems":[511,537,563,592,643],"target":[513],"sources":[516],"transferrin,":[519],"hemoproteins,":[522],"counteract":[525],"iron-withdrawal":[527],"approaches":[528,974],"Inactivation":[532],"host-targeting":[535],"iron-uptake":[536],"often":[538,745],"attenuates":[539],"pathogenicity":[541],"invading":[544],"microbe,":[545],"illustrating":[546],"importance":[548,732],"\u2018the":[550],"battle":[551],"iron\u2019":[553],"infection":[556],"process.":[557],"sequestration":[562],"facilitating":[565],"infections":[567],"major":[571],"driving":[572],"force":[573],"research":[575],"aimed":[576],"at":[577],"unravelling":[578],"complexities":[580],"transport":[584,806,984],"But":[586],"also,":[587],"intricacy":[589],"offers":[593],"challenge":[595,602],"stimulates":[597],"curiosity.":[599],"understand":[605],"how":[606,779,819,851,862],"balanced":[607],"levels":[608,626,822],"free":[610],"cytosol":[614],"achieved":[616],"way":[619],"avoids":[621],"toxicity":[622],"whilst":[623],"providing":[624],"purposes":[629],"requirement":[634],"meet.":[640],"Although":[641],"involved":[644],"achieving":[646],"balance":[648],"highly":[651],"variable":[652],"microorganisms,":[655],"overall":[657],"common.":[660],"On":[661],"coarse":[663],"level,":[664],"homeostatic":[666],"control":[667,675],"cellular":[669,770],"maintained":[672],"strict":[674],"uptake,":[678],"storage":[679],"utilisation":[681],"iron,":[684],"co-ordinated":[687],"integrated":[689],"iron-regulatory":[690],"networks.":[691],"much":[693],"yet":[694],"remains":[695],"discovered":[698],"concerning":[699,847],"fine":[701],"details":[702],"regulatory":[707],"As":[709],"already":[710],"indicated,":[711],"perhaps":[712],"difficult":[715],"task":[716],"maintaining":[718],"homeostasis":[720,864],"simply":[722],"procurement":[724],"external":[729],"sources.":[730],"demonstrated":[737],"plethora":[740],"distinct":[742],"transporters":[744],"found":[746],"single":[749],"bacterium,":[750],"targeting":[752],"forms":[754],"(complex":[755],"state)":[758],"environmental":[764],"condition.":[765],"microbes":[767],"devote":[768],"considerable":[769,1087],"resource":[771],"surroundings,":[777],"reflecting":[778],"successful":[780],"crucial":[786],"survival.":[791],"aim":[793,826],"book":[796,1026,1082],"reader":[800],"overview":[803],"indication":[817],"controlled.":[824],"promoted":[828],"inclusion":[831],"expert":[833],"reviews":[834],"several":[836],"well":[837,944],"studied":[838],"examples":[839],"illustrate":[841],"state":[844],"play":[846],"comprehension":[849],"translocated":[854],"into":[855],"bacterial":[857],"(or":[858],"fungal)":[859],"cell":[860,1007],"controlled":[866],"microbes.":[868],"first":[870],"two":[871],"chapters":[872,904,965,1078],"(1-2)":[873],"consider":[874],"general":[876],"properties":[877],"iron-chelating":[880],"compounds":[881],"(known":[882],"\u2018siderophores\u2019),":[884],"mechanisms":[887],"used":[888],"acquire":[892],"haem":[893],"utilise":[895],"source.":[900],"following":[902],"twelve":[903],"(3-14)":[905],"focus":[906],"specific":[908],"microorganism":[911],"interest,":[916],"covering":[917],"both":[918,1017],"array":[920],"humans,":[924],"animals":[925],"plants":[927],"species":[929],"Bordetella,":[931],"Shigella,":[932],",":[933],"Erwinia,":[934],"Vibrio,":[935],"Aeromonas,":[936],"Francisella,":[937],"Campylobacter":[938],"Staphylococci,":[940],"EHEC)":[942],"number":[947],"prominent":[949],"non-pathogens":[950],"rhizobia,":[953],"E.":[954],"coli":[955],"K-12,":[956],"Bacteroides":[957],"spp.,":[958],"cyanobacteria,":[959],"Bacillus":[960],"spp.":[961],"yeasts).":[963],"relay":[966],"themes":[969],"uptake":[973],"siderophores,":[979],"TonB-dependent":[980],"transporters,":[981],"ABC":[983],"systems),":[985],"but":[986],"highlight":[988],"distinctions":[990],"(such":[991],"regulator":[998],"impact":[1001],"presence/absence":[1004],"wall)":[1008],"strategies":[1011],"employed.":[1012],"\\nWe":[1013],"hope":[1014],"those":[1016,1052],"outside":[1020],"field":[1022],"will":[1023,1035,1042],"find":[1024],"useful,":[1027],"stimulating":[1028],"interesting.":[1030],"We":[1031],"intend":[1032],"source":[1038],"reference":[1040],"assist":[1043],"relevant":[1044],"researchers":[1045],"entry":[1049],"initiating":[1053],"studies":[1055],"subject.":[1058],"Finally,":[1059],"we":[1064],"acknowledge":[1065],"thank":[1067],"wholeheartedly":[1068],"contributors":[1071],"provided":[1074],"14":[1076],"excellent":[1077],"composed.":[1084],"Without":[1085],"efforts,":[1088],"book,":[1090],"understanding":[1093],"relays,":[1096],"not":[1098],"possible.":[1101],"\\nSimon":[1103],"C":[1104],"Andrews":[1105],"Pierre":[1107],"Cornelis":[1108]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":17},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":18},{"year":2012,"cited_by_count":18}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}