{"id":"https://openalex.org/W153874932","doi":null,"title":"The Role of CASQ2 D307H Mutant protein in Catecholamine Induced Polymorphic Ventricular Tachycardia (CPVT)","display_name":"The Role of CASQ2 D307H Mutant protein in Catecholamine Induced Polymorphic Ventricular Tachycardia (CPVT)","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W153874932","mag":"153874932"},"language":"en","primary_location":{"id":"mag:153874932","doi":null,"is_oa":false,"landing_page_url":"http://europepmc.org/theses/ETH/4921","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008970921","display_name":"Anuradha Kalyanasundaram","orcid":"https://orcid.org/0000-0003-2432-458X","observed_orcids":["https://orcid.org/0000-0003-2432-458X"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Anuradha Kalyanasundaram","raw_affiliation_strings":["the Ohio State University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Ohio State University","institution_ids":["https://openalex.org/I52357470"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5008970921"],"corresponding_institution_ids":["https://openalex.org/I52357470"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11922","display_name":"Cardiovascular Effects of Exercise","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/casq2","display_name":"CASQ2","score":0.9559999704360962},{"id":"https://openalex.org/keywords/calsequestrin","display_name":"calsequestrin","score":0.8190000057220459},{"id":"https://openalex.org/keywords/catecholaminergic-polymorphic-ventricular-tachycardia","display_name":"catecholaminergic polymorphic ventricular tachycardia","score":0.9229999780654907},{"id":"https://openalex.org/keywords/cardiac-excitation-contraction-coupling","display_name":"cardiac excitation-contraction coupling","score":0.8069999814033508},{"id":"https://openalex.org/keywords/sarcoplasmic-reticulum-calcium-handling","display_name":"sarcoplasmic reticulum calcium handling","score":0.890999972820282},{"id":"https://openalex.org/keywords/calcium-buffering","display_name":"calcium buffering","score":0.609000027179718},{"id":"https://openalex.org/keywords/sarcoplasmic-reticulum-calcium-release","display_name":"sarcoplasmic reticulum calcium release","score":0.6420000195503235},{"id":"https://openalex.org/keywords/transgene-overexpression","display_name":"transgenic overexpression","score":0.8019999861717224}],"concepts":[{"id":"https://openalex.org/C2775953344","wikidata":"https://www.wikidata.org/wiki/Q24774223","display_name":"Calsequestrin","level":4,"score":0.9843602180480957},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.49389344453811646},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.4697476029396057},{"id":"https://openalex.org/C10447831","wikidata":"https://www.wikidata.org/wiki/Q7392918","display_name":"SR protein","level":5,"score":0.45904985070228577},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.4585229754447937},{"id":"https://openalex.org/C182704531","wikidata":"https://www.wikidata.org/wiki/Q1364740","display_name":"Knockout mouse","level":3,"score":0.43992969393730164},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.39632028341293335},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3933452069759369},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3661617934703827},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3539732098579407},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.32431209087371826},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3118225336074829},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.25143691897392273},{"id":"https://openalex.org/C113217602","wikidata":"https://www.wikidata.org/wiki/Q416781","display_name":"Ryanodine receptor","level":3,"score":0.24654453992843628},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.23702791333198547},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.17487749457359314},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08462974429130554},{"id":"https://openalex.org/C41282012","wikidata":"https://www.wikidata.org/wiki/Q3928341","display_name":"RNA-binding protein","level":4,"score":0.07979607582092285},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:153874932","doi":null,"is_oa":false,"landing_page_url":"http://europepmc.org/theses/ETH/4921","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":88,"referenced_works":["https://openalex.org/W30756424","https://openalex.org/W96750190","https://openalex.org/W162876264","https://openalex.org/W1508243224","https://openalex.org/W1508381160","https://openalex.org/W1509611865","https://openalex.org/W1515292518","https://openalex.org/W1517573369","https://openalex.org/W1524149821","https://openalex.org/W1531532159","https://openalex.org/W1531765690","https://openalex.org/W1580765123","https://openalex.org/W1967658895","https://openalex.org/W1971833900","https://openalex.org/W1974535915","https://openalex.org/W1979810647","https://openalex.org/W1983707293","https://openalex.org/W1985771103","https://openalex.org/W1986652655","https://openalex.org/W1988998632","https://openalex.org/W1989553550","https://openalex.org/W1991605997","https://openalex.org/W1992127649","https://openalex.org/W1994290400","https://openalex.org/W1994681182","https://openalex.org/W1994693592","https://openalex.org/W1996439106","https://openalex.org/W1996615016","https://openalex.org/W1997194414","https://openalex.org/W2001749475","https://openalex.org/W2007709380","https://openalex.org/W2009059892","https://openalex.org/W2009412256","https://openalex.org/W2012751980","https://openalex.org/W2014782236","https://openalex.org/W2017415739","https://openalex.org/W2023609755","https://openalex.org/W2028421228","https://openalex.org/W2030507367","https://openalex.org/W2031267215","https://openalex.org/W2032894671","https://openalex.org/W2033012987","https://openalex.org/W2036181485","https://openalex.org/W2039932112","https://openalex.org/W2041410896","https://openalex.org/W2041768145","https://openalex.org/W2045720972","https://openalex.org/W2046073283","https://openalex.org/W2046176223","https://openalex.org/W2050824263","https://openalex.org/W2051673088","https://openalex.org/W2053330560","https://openalex.org/W2056668609","https://openalex.org/W2060727804","https://openalex.org/W2071234680","https://openalex.org/W2073352540","https://openalex.org/W2073442720","https://openalex.org/W2073472013","https://openalex.org/W2074777877","https://openalex.org/W2074946691","https://openalex.org/W2075970710","https://openalex.org/W2080955459","https://openalex.org/W2081524260","https://openalex.org/W2090362748","https://openalex.org/W2090820454","https://openalex.org/W2095062180","https://openalex.org/W2095224851","https://openalex.org/W2100477955","https://openalex.org/W2103737595","https://openalex.org/W2106083090","https://openalex.org/W2108764665","https://openalex.org/W2110997367","https://openalex.org/W2111394029","https://openalex.org/W2114329647","https://openalex.org/W2114438447","https://openalex.org/W2116297568","https://openalex.org/W2125849261","https://openalex.org/W2129115366","https://openalex.org/W2132976594","https://openalex.org/W2137662702","https://openalex.org/W2140313980","https://openalex.org/W2140661076","https://openalex.org/W2145101952","https://openalex.org/W2147913395","https://openalex.org/W2150075279","https://openalex.org/W2153947452","https://openalex.org/W2163547302","https://openalex.org/W2413510246"],"related_works":["https://openalex.org/W2019668085","https://openalex.org/W1980074022","https://openalex.org/W2073472013","https://openalex.org/W2073442720","https://openalex.org/W79088658","https://openalex.org/W3130831742","https://openalex.org/W2072663300","https://openalex.org/W2121902325","https://openalex.org/W2111394029","https://openalex.org/W2041410896"],"abstract_inverted_index":{"ii":[0],"ACKNOWLEDGEMENTS":[1],"iv":[3],"VITA":[4],"viii":[6],"LIST":[7,12,17],"OF":[8,13,18],"TABLES":[9],"xvi":[11],"FIGURES":[14],"xvii":[16],"ABBREVIATIONS":[19],"xix":[21],"CHAPTERS":[22],"Chapter":[23],"1:":[24],"INTRODUCTION":[25],"1":[27],"1.1":[28],"Cardiac":[29],"E-C":[30],"Coupling":[31],"1.1.1":[32],"The":[33],"Action":[34],"Potential":[35],"3":[37,50],"1.1.2":[38],"Role":[39],"of":[40,81,86,92],"SR":[41,69],"Proteins":[42],"in":[43],"calcium":[44],"Storage,":[45],"Release":[46],"and":[47,55],"Uptake":[48],"1.2":[51],"Calsequestrin":[52,56,61],"1.2.1":[53],"Calcium":[54],"polymerization":[57],"6":[59],"1.2.2":[60],"not":[62],"only":[63],"buffers":[64],"Ca":[65,70],"but":[66],"also":[67],"modulates":[68],"release.....":[71],"7":[72],"1.3":[73],"Mouse":[74,95],"models":[75,96],"to":[76],"better":[77],"understand":[78],"the":[79],"role":[80],"CASQ2":[82,87],"1.3.1":[83],"Transgenic":[84],"Overexpression":[85],"9":[89],"1.3.2":[90],"Absence":[91],"CASQ:":[93],"Knockout":[94],"10":[98]},"counts_by_year":[],"updated_date":"2025-11-06T04:12:42.849631","created_date":"2016-06-24T00:00:00"}